Found 13 hits Enz. Inhib. hit(s) with Target = 'Matrix metalloproteinase-25' AND taxid = 9606 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | Reactome pathway
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CHEMBL
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| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP25 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50305842
(CHEMBL603656 | trans-4-((5-(2-(4-fluorobenzylcarba...)Show SMILES Cc1cc(cc(n1)C(=O)NCc1ccc(F)cc1)-c1nnn(C[C@H]2CC[C@@H](CC2)C(O)=O)n1 |r,wU:26.31,wD:23.24,(30.11,-12.24,;29.32,-10.92,;30.07,-9.57,;29.28,-8.26,;27.74,-8.27,;26.98,-9.62,;27.77,-10.94,;25.44,-9.64,;24.69,-10.98,;24.66,-8.31,;23.12,-8.33,;22.33,-7.01,;23.08,-5.67,;22.3,-4.34,;20.75,-4.36,;19.97,-3.04,;20,-5.72,;20.79,-7.03,;30.03,-6.91,;29.39,-5.51,;30.52,-4.46,;31.87,-5.21,;33.27,-4.57,;34.61,-5.32,;34.63,-6.85,;35.98,-7.6,;37.3,-6.81,;37.27,-5.26,;35.93,-4.52,;38.65,-7.56,;38.68,-9.1,;39.97,-6.77,;31.57,-6.73,)| Show InChI InChI=1S/C23H25FN6O3/c1-14-10-18(11-20(26-14)22(31)25-12-15-4-8-19(24)9-5-15)21-27-29-30(28-21)13-16-2-6-17(7-3-16)23(32)33/h4-5,8-11,16-17H,2-3,6-7,12-13H2,1H3,(H,25,31)(H,32,33)/t16-,17- | Reactome pathway
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| CHEMBL
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PubMed
| >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MMP25 |
Bioorg Med Chem Lett 20: 576-80 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.081
BindingDB Entry DOI: 10.7270/Q2JS9QHB |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM8465
((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO |r| Show InChI InChI=1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)/t17-/m1/s1 | Reactome pathway
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| Article
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| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human MMP25 by fluorometric assay |
Eur J Med Chem 46: 2617-29 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.033
BindingDB Entry DOI: 10.7270/Q2RN3864 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50346803
(CHEMBL1795862)Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N1Cc2ccccc2C[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C26H26N2O4S2/c1-2-3-6-19-9-11-20(12-10-19)13-14-23-15-16-25(33-23)34(31,32)28-18-22-8-5-4-7-21(22)17-24(28)26(29)27-30/h4-5,7-12,15-16,24,30H,2-3,6,17-18H2,1H3,(H,27,29)/t24-/m1/s1 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human MMP25 by fluorometric assay |
Eur J Med Chem 46: 2617-29 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.033
BindingDB Entry DOI: 10.7270/Q2RN3864 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50346797
(CHEMBL1795351)Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)NCC(=O)NO Show InChI InChI=1S/C18H20N2O4S2/c1-2-3-4-14-5-7-15(8-6-14)9-10-16-11-12-18(25-16)26(23,24)19-13-17(21)20-22/h5-8,11-12,19,22H,2-4,13H2,1H3,(H,20,21) | Reactome pathway
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human MMP25 by fluorometric assay |
Eur J Med Chem 46: 2617-29 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.033
BindingDB Entry DOI: 10.7270/Q2RN3864 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50346798
(CHEMBL1795857)Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)NO |r| Show InChI InChI=1S/C32H32N2O5S2/c1-2-3-7-24-10-12-25(13-11-24)16-19-29-20-21-31(40-29)41(37,38)34-30(32(35)33-36)22-26-14-17-28(18-15-26)39-23-27-8-5-4-6-9-27/h4-6,8-15,17-18,20-21,30,34,36H,2-3,7,22-23H2,1H3,(H,33,35)/t30-/m1/s1 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human MMP25 by fluorometric assay |
Eur J Med Chem 46: 2617-29 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.033
BindingDB Entry DOI: 10.7270/Q2RN3864 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50346800
(CHEMBL1795859)Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NO |r| Show InChI InChI=1S/C27H27N3O4S2/c1-2-3-6-19-9-11-20(12-10-19)13-14-22-15-16-26(35-22)36(33,34)30-25(27(31)29-32)17-21-18-28-24-8-5-4-7-23(21)24/h4-5,7-12,15-16,18,25,28,30,32H,2-3,6,17H2,1H3,(H,29,31)/t25-/m1/s1 | Reactome pathway
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| CHEMBL
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| Article
PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human MMP25 by fluorometric assay |
Eur J Med Chem 46: 2617-29 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.033
BindingDB Entry DOI: 10.7270/Q2RN3864 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50346802
(CHEMBL1795861)Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N1CSC[C@H]1C(=O)NO |r| Show InChI InChI=1S/C20H22N2O4S3/c1-2-3-4-15-5-7-16(8-6-15)9-10-17-11-12-19(28-17)29(25,26)22-14-27-13-18(22)20(23)21-24/h5-8,11-12,18,24H,2-4,13-14H2,1H3,(H,21,23)/t18-/m0/s1 | Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human MMP25 by fluorometric assay |
Eur J Med Chem 46: 2617-29 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.033
BindingDB Entry DOI: 10.7270/Q2RN3864 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50346801
(CHEMBL1795860)Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1csc2ccccc12)C(=O)NO |r| Show InChI InChI=1S/C27H26N2O4S3/c1-2-3-6-19-9-11-20(12-10-19)13-14-22-15-16-26(35-22)36(32,33)29-24(27(30)28-31)17-21-18-34-25-8-5-4-7-23(21)25/h4-5,7-12,15-16,18,24,29,31H,2-3,6,17H2,1H3,(H,28,30)/t24-/m1/s1 | Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human MMP25 by fluorometric assay |
Eur J Med Chem 46: 2617-29 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.033
BindingDB Entry DOI: 10.7270/Q2RN3864 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50346799
(CHEMBL1795858)Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1ccc(cc1)C(=O)c1ccccc1)C(=O)NO |r| Show InChI InChI=1S/C32H30N2O5S2/c1-2-3-7-23-10-12-24(13-11-23)16-19-28-20-21-30(40-28)41(38,39)34-29(32(36)33-37)22-25-14-17-27(18-15-25)31(35)26-8-5-4-6-9-26/h4-6,8-15,17-18,20-21,29,34,37H,2-3,7,22H2,1H3,(H,33,36)/t29-/m1/s1 | Reactome pathway
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| CHEMBL
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PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human MMP25 by fluorometric assay |
Eur J Med Chem 46: 2617-29 (2011)
Article DOI: 10.1016/j.ejmech.2011.03.033
BindingDB Entry DOI: 10.7270/Q2RN3864 |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM92488
(BI-92G11)Show InChI InChI=1S/C9H11NO4S/c11-9(10-12)6-7-15(13,14)8-4-2-1-3-5-8/h1-5,12H,6-7H2,(H,10,11) | Reactome pathway
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| PC cid
PC sid
UniChem
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| Article
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| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | 37 |
Sanford-Burnham Medical Research Institute
| Assay Description
Inhibition of IC50 using matrix metalloproteinase. |
J Biol Chem 285: 16076-86 (2010)
Article DOI: 10.1074/jbc.M110.107094
BindingDB Entry DOI: 10.7270/Q2TM78QN |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM92489
(BI-102C8)Show InChI InChI=1S/C15H15NO3/c1-2-19-12-9-7-11(8-10-12)13-5-3-4-6-14(13)15(17)16-18/h3-10,18H,2H2,1H3,(H,16,17) | Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | 37 |
Sanford-Burnham Medical Research Institute
| Assay Description
Inhibition of IC50 using matrix metalloproteinase. |
J Biol Chem 285: 16076-86 (2010)
Article DOI: 10.1074/jbc.M110.107094
BindingDB Entry DOI: 10.7270/Q2TM78QN |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50063917
((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)Show SMILES CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C |r| Show InChI InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1 | Reactome pathway
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Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MMP25 (unknown origin) catalytic domain using MCA-Arg-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-Glu-Arg-NH2 as substrate preincubated for 60 mins fol... |
J Med Chem 59: 313-27 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01434
BindingDB Entry DOI: 10.7270/Q20G3N0F |
More data for this
Ligand-Target Pair | |
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