Compile Data Set for Download or QSAR

Found 75 hits of ec50 for UniProtKB: Q61239   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126036 (6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C29H22N4O2/c1-3-35-26-6-4-5-24(16-26)27-15-22(18-31)7-10-23(27)13-14-29(34,28-19-32-20-33(28)2)25-11-8-21(17-30)9-12-25/h4-12,15-16,19-20,34H,3H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126320 (1-{[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-m...) Show SMILES Cn1cncc1C(NN1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:14| Show InChI InChI=1S/C28H24N6/c1-33-19-31-17-27(33)28(22-11-9-20(15-29)10-12-22)32-34-14-13-23(16-30)26(18-34)25-8-4-6-21-5-2-3-7-24(21)25/h2-12,17,19,28,32H,13-14,18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of geranylgeranyltransferase-1				Bioorg Med Chem Lett 13: 1363-6 (2003) BindingDB Entry DOI: 10.7270/Q24B30PD
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50135353 (5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)c(=O)n1C)-c1cccc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H20ClN5O2/c1-31-16-30-14-23(31)25(18-8-6-17(12-28)7-9-18)34-15-24-22(19-4-3-5-21(27)10-19)11-20(13-29)26(33)32(24)2/h3-11,14,16,25H,15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against Factor Xa				Bioorg Med Chem Lett 14: 4603-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.004 BindingDB Entry DOI: 10.7270/Q27080WG
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126322 (4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-...) Show SMILES Cn1cncc1CN(Cc1ccc(C#N)c(Br)c1)C(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12 |c:27| Show InChI InChI=1S/C30H25BrN6O/c1-35-20-34-16-25(35)18-37(17-21-9-10-24(15-33)29(31)13-21)30(38)36-12-11-23(14-32)28(19-36)27-8-4-6-22-5-2-3-7-26(22)27/h2-10,13,16,20H,11-12,17-19H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of geranylgeranyltransferase-1				Bioorg Med Chem Lett 13: 1363-6 (2003) BindingDB Entry DOI: 10.7270/Q24B30PD
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153785 (4-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)-2-...) Show SMILES N#Cc1ccc(Cn2cncc2COc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C29H20N4O/c30-15-21-8-10-22(11-9-21)18-33-20-32-17-25(33)19-34-26-13-12-24(16-31)29(14-26)28-7-3-5-23-4-1-2-6-27(23)28/h1-14,17,20H,18-19H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153168 (6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1CNCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H25N5O/c1-2-34-27-5-3-4-24(13-27)28-12-23(15-30)10-11-25(28)16-31-17-26-18-32-20-33(26)19-22-8-6-21(14-29)7-9-22/h3-13,18,20,31H,2,16-17,19H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.34	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153170 (6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-me...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(C)Cc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C29H27N5O/c1-3-35-28-6-4-5-25(14-28)29-13-24(16-31)11-12-26(29)19-33(2)20-27-17-32-21-34(27)18-23-9-7-22(15-30)8-10-23/h4-14,17,21H,3,18-20H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.57	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22Cl2N4O/c1-32-13-12-31-26(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(15-19)22(16-25(34)33(24)2)17-4-3-5-21(29)14-17/h3-16H,30H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cells				Bioorg Med Chem Lett 14: 5367-70 (2004) Article DOI: 10.1016/j.bmcl.2004.08.012 BindingDB Entry DOI: 10.7270/Q2NS0TC9
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126335 (6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...) Show SMILES Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22Cl2N4O/c1-32-13-12-31-26(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(15-19)22(16-25(34)33(24)2)17-4-3-5-21(29)14-17/h3-16H,30H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153797 (6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...) Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O/c28-27(29,30)24-9-7-22(8-10-24)26-11-21(13-32)5-6-23(26)16-35-17-25-14-33-18-34(25)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153169 (3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-benzyl)-3H-i...) Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3OCOc3c2)C#N)cc1 Show InChI InChI=1S/C27H20N4O3/c28-11-19-1-3-20(4-2-19)14-31-17-30-13-24(31)16-32-15-23-6-5-21(12-29)9-25(23)22-7-8-26-27(10-22)34-18-33-26/h1-10,13,17H,14-16,18H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.65	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126041 (6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...) Show SMILES COc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H20N4O2/c1-32-19-31-18-27(32)28(33,24-10-7-20(16-29)8-11-24)13-12-22-9-6-21(17-30)14-26(22)23-4-3-5-25(15-23)34-2/h3-11,14-15,18-19,33H,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.74	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126317 (1-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetyl}...) Show SMILES O=C(Cc1cncn1Cc1ccc(cc1)C#N)N1CCC(C#N)=C(C1)c1cccc2ccccc12 |c:24| Show InChI InChI=1S/C29H23N5O/c30-15-21-8-10-22(11-9-21)18-34-20-32-17-25(34)14-29(35)33-13-12-24(16-31)28(19-33)27-7-3-5-23-4-1-2-6-26(23)27/h1-11,17,20H,12-14,18-19H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	n/a	n/a	3.90	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of geranylgeranyltransferase-1				Bioorg Med Chem Lett 13: 1363-6 (2003) BindingDB Entry DOI: 10.7270/Q24B30PD
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM16181 (1-[2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imid...) Show SMILES Cn1cncc1C(O)(CN1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:15| Show InChI InChI=1S/C29H25N5O/c1-33-20-32-17-28(33)29(35,24-11-9-21(15-30)10-12-24)19-34-14-13-23(16-31)27(18-34)26-8-4-6-22-5-2-3-7-25(22)26/h2-12,17,20,35H,13-14,18-19H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)				Bioorg Med Chem Lett 13: 1363-6 (2003) BindingDB Entry DOI: 10.7270/Q24B30PD
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM13382 (3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1-methyl-1H...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19ClN4O/c1-31-17-30-15-25(31)26(20-8-5-18(13-28)6-9-20)32-16-22-10-7-19(14-29)11-24(22)21-3-2-4-23(27)12-21/h2-12,15,17,26H,16H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.20	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor				Bioorg Med Chem Lett 14: 4603-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.004 BindingDB Entry DOI: 10.7270/Q27080WG
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153166 (3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...) Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.70	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153166 (3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...) Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.70	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50151520 (3-{4-(3-chlorophenyl)-5-[4-cyanophenyl(1-methyl-1H...) Show SMILES Cn1cncc1C(OCc1cn(Cc2cccc(c2)C#N)c(=O)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C32H24ClN5O2/c1-37-21-36-17-30(37)32(25-10-8-22(15-34)9-11-25)40-20-27-19-38(18-24-5-2-4-23(12-24)16-35)31(39)14-29(27)26-6-3-7-28(33)13-26/h2-14,17,19,21,32H,18,20H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against Factor Xa				Bioorg Med Chem Lett 14: 4603-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.004 BindingDB Entry DOI: 10.7270/Q27080WG
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50151519 (4-[[1-(3-Chloro-benzyl)-4-(3-chloro-phenyl)-6-oxo-...) Show SMILES Cn1cncc1C(OCc1cn(Cc2cccc(Cl)c2)c(=O)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C31H24Cl2N4O2/c1-36-20-35-16-29(36)31(23-10-8-21(15-34)9-11-23)39-19-25-18-37(17-22-4-2-6-26(32)12-22)30(38)14-28(25)24-5-3-7-27(33)13-24/h2-14,16,18,20,31H,17,19H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against Factor Xa				Bioorg Med Chem Lett 14: 4603-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.004 BindingDB Entry DOI: 10.7270/Q27080WG
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50151521 (4-(3-Chloro-phenyl)-5-[(4-cyano-phenyl)-(3-methyl-...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)n(C)c1=O)-c1cccc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H20ClN5O2/c1-31-16-30-14-24(31)25(18-8-6-17(12-28)7-9-18)34-15-23-22(19-4-3-5-20(27)10-19)11-21(13-29)32(2)26(23)33/h3-11,14,16,25H,15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against Factor Xa				Bioorg Med Chem Lett 14: 4603-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.004 BindingDB Entry DOI: 10.7270/Q27080WG
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50157246 (6''-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(...) Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)N1CCC(CO)CC1)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C32H29F3N6O2/c1-40-20-38-17-29(40)30(22-6-7-23(15-36)27(14-22)26-4-2-3-5-28(26)32(33,34)35)43-19-25-9-8-24(16-37)31(39-25)41-12-10-21(18-42)11-13-41/h2-9,14,17,20-21,30,42H,10-13,18-19H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration against H-ras processing in transformed NIH3T3 cells				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50157270 (6''-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(...) Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)N1CCCC(O)C1)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C31H27F3N6O2/c1-39-19-37-16-28(39)29(42-18-23-11-10-22(15-36)30(38-23)40-12-4-5-24(41)17-40)20-8-9-21(14-35)26(13-20)25-6-2-3-7-27(25)31(32,33)34/h2-3,6-11,13,16,19,24,29,41H,4-5,12,17-18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration against H-ras processing in transformed NIH3T3 cells				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50151516 (5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(OCc1c(cc(C#N)n(C)c1=O)-c1cc(Cl)cc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19Cl2N5O2/c1-32-15-31-13-24(32)25(17-5-3-16(11-29)4-6-17)35-14-23-22(10-21(12-30)33(2)26(23)34)18-7-19(27)9-20(28)8-18/h3-10,13,15,25H,14H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity of compound towards Factor Xa				Bioorg Med Chem Lett 14: 4603-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.004 BindingDB Entry DOI: 10.7270/Q27080WG
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50151515 (4-[[4-(3-Chloro-phenyl)-1-(3-fluoro-benzyl)-6-oxo-...) Show SMILES Cn1cncc1C(OCc1cn(Cc2cccc(F)c2)c(=O)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C31H24ClFN4O2/c1-36-20-35-16-29(36)31(23-10-8-21(15-34)9-11-23)39-19-25-18-37(17-22-4-2-7-27(33)12-22)30(38)14-28(25)24-5-3-6-26(32)13-24/h2-14,16,18,20,31H,17,19H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against Factor Xa				Bioorg Med Chem Lett 14: 4603-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.004 BindingDB Entry DOI: 10.7270/Q27080WG
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM17325 ((2S)-2-[(4-{[butyl(2-cyclohexylethyl)amino]methyl}...) Show SMILES CCCCN(CCC1CCCCC1)Cc1ccc(C(=O)N[C@@H](CCSC)C(O)=O)c(c1)-c1ccccc1C |r| Show InChI InChI=1S/C32H46N2O3S/c1-4-5-19-34(20-17-25-12-7-6-8-13-25)23-26-15-16-28(29(22-26)27-14-10-9-11-24(27)2)31(35)33-30(32(36)37)18-21-38-3/h9-11,14-16,22,25,30H,4-8,12-13,17-21,23H2,1-3H3,(H,33,35)(H,36,37)/t30-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration against H-ras processing in NIH 3T3 cells				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153783 (5-((5-((2-(benzo[d][1,3]dioxol-5-yl)-4-cyanobenzyl...) Show SMILES N#Cc1ccc(COCc2cncn2Cc2ccc(nc2)C#N)c(c1)-c1ccc2OCOc2c1 Show InChI InChI=1S/C26H19N5O3/c27-9-18-1-3-21(24(7-18)20-4-6-25-26(8-20)34-17-33-25)14-32-15-23-12-29-16-31(23)13-19-2-5-22(10-28)30-11-19/h1-8,11-12,16H,13-15,17H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153164 (CHEMBL435285 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)C(C)=O)C#N Show InChI InChI=1S/C30H27N5O2/c1-3-37-29-6-4-5-26(14-29)30-13-25(16-32)11-12-27(30)19-34(22(2)36)20-28-17-33-21-35(28)18-24-9-7-23(15-31)8-10-24/h4-14,17,21H,3,18-20H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153171 (6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1C#CC(O)c1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C29H22N4O2/c1-2-35-26-5-3-4-25(15-26)27-14-23(17-31)10-11-24(27)12-13-29(34)28-18-32-20-33(28)19-22-8-6-21(16-30)7-9-22/h3-11,14-15,18,20,29,34H,2,19H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	16.7	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153776 (5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)me...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(nc1)C#N)C#N Show InChI InChI=1S/C27H23N5O2/c1-2-34-26-5-3-4-22(11-26)27-10-20(12-28)6-8-23(27)17-33-18-25-15-30-19-32(25)16-21-7-9-24(13-29)31-14-21/h3-11,14-15,19H,2,16-18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153769 (5-(3-Chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imi...) Show SMILES Cn1c(CNCc2cncn2Cc2ccc(cc2)C#N)c(cc(C#N)c1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C26H21ClN6O/c1-32-25(24(10-21(12-29)26(32)34)20-3-2-4-22(27)9-20)15-30-13-23-14-31-17-33(23)16-19-7-5-18(11-28)6-8-19/h2-10,14,17,30H,13,15-16H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cells at 100 nM				Bioorg Med Chem Lett 14: 5367-70 (2004) Article DOI: 10.1016/j.bmcl.2004.08.012 BindingDB Entry DOI: 10.7270/Q2NS0TC9
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153173 (6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H24N4O2/c1-2-34-27-5-3-4-24(13-27)28-12-23(15-30)10-11-25(28)18-33-19-26-16-31-20-32(26)17-22-8-6-21(14-29)7-9-22/h3-13,16,20H,2,17-19H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	21.9	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126323 (1-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-propion...) Show SMILES O=C(CCc1cncn1Cc1ccc(cc1)C#N)N1CCC(C#N)=C(C1)c1cccc2ccccc12 |c:25| Show InChI InChI=1S/C30H25N5O/c31-16-22-8-10-23(11-9-22)19-35-21-33-18-26(35)12-13-30(36)34-15-14-25(17-32)29(20-34)28-7-3-5-24-4-1-2-6-27(24)28/h1-11,18,21H,12-15,19-20H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)				Bioorg Med Chem Lett 13: 1363-6 (2003) BindingDB Entry DOI: 10.7270/Q24B30PD
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153791 (6-((5-((2-(benzo[d][1,3]dioxol-5-yl)-4-cyanobenzyl...) Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3OCOc3c2)C#N)nc1 Show InChI InChI=1S/C26H19N5O3/c27-9-18-1-3-21(24(7-18)20-4-6-25-26(8-20)34-17-33-25)14-32-15-23-12-29-16-31(23)13-22-5-2-19(10-28)11-30-22/h1-8,11-12,16H,13-15,17H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50157277 (6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...) Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)N1CCN(CCO)CC1)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C32H30F3N7O2/c1-40-21-38-19-29(40)30(22-6-7-23(17-36)27(16-22)26-4-2-3-5-28(26)32(33,34)35)44-20-25-9-8-24(18-37)31(39-25)42-12-10-41(11-13-42)14-15-43/h2-9,16,19,21,30,43H,10-15,20H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration against H-ras processing in transformed NIH3T3 cells				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126326 (1-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...) Show SMILES Cn1cncc1C(N1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:13| Show InChI InChI=1S/C28H23N5/c1-32-19-31-17-27(32)28(22-11-9-20(15-29)10-12-22)33-14-13-23(16-30)26(18-33)25-8-4-6-21-5-2-3-7-24(21)25/h2-12,17,19,28H,13-14,18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)				Bioorg Med Chem Lett 13: 1363-6 (2003) BindingDB Entry DOI: 10.7270/Q24B30PD
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153175 (6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...) Show SMILES COc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H22N4O2/c1-32-26-4-2-3-23(12-26)27-11-22(14-29)9-10-24(27)17-33-18-25-15-30-19-31(25)16-21-7-5-20(13-28)6-8-21/h2-12,15,19H,16-18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153796 (6-(((1-(4-chlorobenzyl)-1H-imidazol-5-yl)methoxy)m...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(Cl)cc1)C#N Show InChI InChI=1S/C27H24ClN3O2/c1-2-33-26-5-3-4-22(13-26)27-12-21(14-29)6-9-23(27)17-32-18-25-15-30-19-31(25)16-20-7-10-24(28)11-8-20/h3-13,15,19H,2,16-18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153174 (6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...) Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-9-7-22(8-10-25)26-11-21(13-32)5-6-23(26)16-35-17-24-14-33-18-34(24)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153174 (6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...) Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-9-7-22(8-10-25)26-11-21(13-32)5-6-23(26)16-35-17-24-14-33-18-34(24)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50157238 (6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...) Show SMILES CN1CCN(CC1)c1nc(COC(c2cncn2C)c2ccc(C#N)c(c2)-c2ccccc2C(F)(F)F)ccc1C#N Show InChI InChI=1S/C31H28F3N7O/c1-39-11-13-41(14-12-39)30-23(17-36)9-10-24(38-30)19-42-29(28-18-37-20-40(28)2)21-7-8-22(16-35)26(15-21)25-5-3-4-6-27(25)31(32,33)34/h3-10,15,18,20,29H,11-14,19H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	53	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration against H-ras processing in transformed NIH3T3 cells				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153167 (6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...) Show SMILES COc1cccc(c1)-c1cc(ccc1C#CC(O)c1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H20N4O2/c1-34-25-4-2-3-24(14-25)26-13-22(16-30)9-10-23(26)11-12-28(33)27-17-31-19-32(27)18-21-7-5-20(15-29)6-8-21/h2-10,13-14,17,19,28,33H,18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	57.5	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153778 (6-((1-(4-cyano-3-(naphthalen-1-yl)benzyl)-1H-imida...) Show SMILES N#Cc1ccc(OCc2cncn2Cc2ccc(C#N)c(c2)-c2cccc3ccccc23)nc1 Show InChI InChI=1S/C28H19N5O/c29-13-21-9-11-28(32-15-21)34-18-24-16-31-19-33(24)17-20-8-10-23(14-30)27(12-20)26-7-3-5-22-4-1-2-6-25(22)26/h1-12,15-16,19H,17-18H2	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153792 (4''-Acetyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...) Show SMILES CC(=O)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H22N4O2/c1-20(33)24-8-10-25(11-9-24)28-12-23(14-30)6-7-26(28)17-34-18-27-15-31-19-32(27)16-22-4-2-21(13-29)3-5-22/h2-12,15,19H,16-18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	77	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of H-Ras transformed NIH-3T3-cell proliferation				Bioorg Med Chem Lett 14: 5371-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.011 BindingDB Entry DOI: 10.7270/Q2J102N8
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50157254 (5-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)...) Show SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C27H19F3N4O/c1-34-17-33-15-25(34)26(35-16-19-8-6-18(13-31)7-9-19)20-10-11-21(14-32)23(12-20)22-4-2-3-5-24(22)27(28,29)30/h2-12,15,17,26H,16H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	85	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration against H-ras processing in transformed NIH3T3 cells				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50157256 (6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...) Show SMILES Cn1cncc1C(OCc1ccc(C#N)c(n1)N1CCOCC1)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C30H25F3N6O2/c1-38-19-36-17-27(38)28(41-18-23-9-8-22(16-35)29(37-23)39-10-12-40-13-11-39)20-6-7-21(15-34)25(14-20)24-4-2-3-5-26(24)30(31,32)33/h2-9,14,17,19,28H,10-13,18H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	89	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration against H-ras processing in transformed NIH3T3 cells				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50157240 (6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...) Show SMILES Cn1cncc1C(OCc1ccc(cn1)C#N)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C26H18F3N5O/c1-34-16-32-14-24(34)25(35-15-20-9-6-17(11-30)13-33-20)18-7-8-19(12-31)22(10-18)21-4-2-3-5-23(21)26(27,28)29/h2-10,13-14,16,25H,15H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Effective concentration against H-ras processing in transformed NIH3T3 cells				Bioorg Med Chem Lett 15: 153-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.014 BindingDB Entry DOI: 10.7270/Q2TT4QFC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126325 (4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-...) Show SMILES Cn1cncc1CN(Cc1ccc(cc1)C#N)C(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12 |c:26| Show InChI InChI=1S/C30H26N6O/c1-34-21-33-17-26(34)19-36(18-23-11-9-22(15-31)10-12-23)30(37)35-14-13-25(16-32)29(20-35)28-8-4-6-24-5-2-3-7-27(24)28/h2-12,17,21H,13-14,18-20H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of geranylgeranyltransferase-1				Bioorg Med Chem Lett 13: 1363-6 (2003) BindingDB Entry DOI: 10.7270/Q24B30PD
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |r| Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cells				Bioorg Med Chem Lett 14: 5367-70 (2004) Article DOI: 10.1016/j.bmcl.2004.08.012 BindingDB Entry DOI: 10.7270/Q2NS0TC9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153177 (CHEMBL187809 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)S(C)(=O)=O)C#N Show InChI InChI=1S/C29H27N5O3S/c1-3-37-28-6-4-5-25(14-28)29-13-24(16-31)11-12-26(29)19-34(38(2,35)36)20-27-17-32-21-33(27)18-23-9-7-22(15-30)8-10-23/h4-14,17,21H,3,18-20H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50153176 (4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...) Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C30H28N4O/c1-30(2,3)27-12-10-25(11-13-27)29-14-24(16-32)8-9-26(29)19-35-20-28-17-33-21-34(28)18-23-6-4-22(15-31)5-7-23/h4-14,17,21H,18-20H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>100	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
					More data for this Ligand-Target Pair

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