Found 186 hits Enz. Inhib. hit(s) with all data for entry = 8255 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237939
(US9394285, 20)Show SMILES OC(=O)c1c[nH]c2cc(F)c(c(F)c12)-c1ccc(cc1)C1(O)COC1 Show InChI InChI=1S/C18H13F2NO4/c19-12-5-13-15(11(6-21-13)17(22)23)16(20)14(12)9-1-3-10(4-2-9)18(24)7-25-8-18/h1-6,21,24H,7-8H2,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 53.6 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237940
(US9394285, 21)Show SMILES CC(C)(CO)COc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C20H20ClNO4/c1-20(2,10-23)11-26-13-5-3-12(4-6-13)14-7-15-16(19(24)25)9-22-18(15)8-17(14)21/h3-9,22-23H,10-11H2,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 93.5 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237941
(US9394285, 22)Show SMILES OCC1(CC1)c1ccc(cc1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F Show InChI InChI=1S/C19H15F2NO3/c20-13-7-14-16(12(8-22-14)18(24)25)17(21)15(13)10-1-3-11(4-2-10)19(9-23)5-6-19/h1-4,7-8,22-23H,5-6,9H2,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 13.7 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237942
(US9394285, 23)Show SMILES OCC1(CC1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1C#N)C(O)=O Show InChI InChI=1S/C20H16N2O3/c21-9-13-7-18-16(17(10-22-18)19(24)25)8-15(13)12-1-3-14(4-2-12)20(11-23)5-6-20/h1-4,7-8,10,22-23H,5-6,11H2,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 16 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237943
(US9394285, 24)Show SMILES OCCOc1ccc(cc1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F Show InChI InChI=1S/C17H13F2NO4/c18-12-7-13-15(11(8-20-13)17(22)23)16(19)14(12)9-1-3-10(4-2-9)24-6-5-21/h1-4,7-8,20-21H,5-6H2,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 252 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237944
(US9394285, 25)Show SMILES COc1cc(ccc1C1(O)CCC1)-c1cc2c(c[nH]c2cc1F)C(O)=O Show InChI InChI=1S/C20H18FNO4/c1-26-18-7-11(3-4-15(18)20(25)5-2-6-20)12-8-13-14(19(23)24)10-22-17(13)9-16(12)21/h3-4,7-10,22,25H,2,5-6H2,1H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 111 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM60975
(4,6-difluoro-5-[4-(1-hydroxy-2-methylpropan-2-yl)p...)Show SMILES CC(C)(CO)c1ccc(cc1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F Show InChI InChI=1S/C19H17F2NO3/c1-19(2,9-23)11-5-3-10(4-6-11)15-13(20)7-14-16(17(15)21)12(8-22-14)18(24)25/h3-8,22-23H,9H2,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 125 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237946
(US9394285, 27)Show SMILES Cc1cc2[nH]cc(C(O)=O)c2cc1-c1ccc(cc1)C1(CO)CC1 Show InChI InChI=1S/C20H19NO3/c1-12-8-18-16(17(10-21-18)19(23)24)9-15(12)13-2-4-14(5-3-13)20(11-22)6-7-20/h2-5,8-10,21-22H,6-7,11H2,1H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 36.9 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237947
(US9394285, 28)Show SMILES OCCCOc1ccc(cc1)-c1c(F)cc2[nH]cc(C(O)=O)c2c1F Show InChI InChI=1S/C18H15F2NO4/c19-13-8-14-16(12(9-21-14)18(23)24)17(20)15(13)10-2-4-11(5-3-10)25-7-1-6-22/h2-5,8-9,21-22H,1,6-7H2,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.08E+3 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237948
(US9394285, 29)Show InChI InChI=1S/C16H12ClNO3/c1-21-10-4-2-3-9(5-10)11-6-12-13(16(19)20)8-18-15(12)7-14(11)17/h2-8,18H,1H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 383 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237949
(US9394285, 30)Show InChI InChI=1S/C18H16ClNO4/c19-16-9-17-14(15(10-20-17)18(22)23)8-13(16)11-2-4-12(5-3-11)24-7-1-6-21/h2-5,8-10,20-21H,1,6-7H2,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 30 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237950
(US9394285, 31)Show InChI InChI=1S/C17H14ClNO3/c1-2-22-11-5-3-10(4-6-11)12-7-13-14(17(20)21)9-19-16(13)8-15(12)18/h3-9,19H,2H2,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 130 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237951
(US9394285, 32)Show InChI InChI=1S/C17H12N2O3/c1-22-12-4-2-10(3-5-12)13-7-14-15(17(20)21)9-19-16(14)6-11(13)8-18/h2-7,9,19H,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 570 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237952
(US9394285, 33)Show InChI InChI=1S/C16H12ClNO3/c1-21-10-4-2-9(3-5-10)11-6-12-13(16(19)20)8-18-15(12)7-14(11)17/h2-8,18H,1H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 85.3 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237953
(US9394285, 34)Show InChI InChI=1S/C16H12FNO3/c1-21-10-4-2-9(3-5-10)11-6-12-13(16(19)20)8-18-15(12)7-14(11)17/h2-8,18H,1H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 315 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237954
(US9394285, 35)Show SMILES Cc1cc2[nH]cc(C(O)=O)c2cc1-c1ccc(cc1)C1(O)CCC1 Show InChI InChI=1S/C20H19NO3/c1-12-9-18-16(17(11-21-18)19(22)23)10-15(12)13-3-5-14(6-4-13)20(24)7-2-8-20/h3-6,9-11,21,24H,2,7-8H2,1H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 74.2 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237955
(US9394285, 36)Show SMILES CC(C)(CO)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C19H18ClNO3/c1-19(2,10-22)12-5-3-11(4-6-12)13-7-14-15(18(23)24)9-21-17(14)8-16(13)20/h3-9,21-22H,10H2,1-2H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 7.10 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237957
(US9394285, 38)Show SMILES O[C@@H]1CCC[C@H]1Oc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 106 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237958
(US9394285, 39)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCCN2CCOCC2)cc1 Show InChI InChI=1S/C22H23ClN2O4/c23-20-13-21-18(19(14-24-21)22(26)27)12-17(20)15-2-4-16(5-3-15)29-9-1-6-25-7-10-28-11-8-25/h2-5,12-14,24H,1,6-11H2,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 11.1 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237960
(US9394285, 41)Show SMILES Cc1cc(ccc1C1(O)CCC1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C20H18ClNO3/c1-11-7-12(3-4-16(11)20(25)5-2-6-20)13-8-14-15(19(23)24)10-22-18(14)9-17(13)21/h3-4,7-10,22,25H,2,5-6H2,1H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 9.60 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237961
(US9394285, 42)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(c(F)c1)C1(O)CCC1 Show InChI InChI=1S/C19H15ClFNO3/c20-15-8-17-12(13(9-22-17)18(23)24)7-11(15)10-2-3-14(16(21)6-10)19(25)4-1-5-19/h2-3,6-9,22,25H,1,4-5H2,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 21.8 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237963
(US9394285, 44)Show InChI InChI=1S/C16H11ClFNO3/c1-22-8-2-3-9(14(18)4-8)10-5-11-12(16(20)21)7-19-15(11)6-13(10)17/h2-7,19H,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 85 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237965
(US9394285, 47)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OC[C@@H]2CCCN2)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 65.3 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237966
(US9394285, 48)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCN2CCNCC2)cc1 Show InChI InChI=1S/C21H22ClN3O3/c22-19-12-20-17(18(13-24-20)21(26)27)11-16(19)14-1-3-15(4-2-14)28-10-9-25-7-5-23-6-8-25/h1-4,11-13,23-24H,5-10H2,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 111 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237968
(US9394285, 51)Show InChI InChI=1S/C16H12ClNO2/c1-9-2-4-10(5-3-9)11-6-12-13(16(19)20)8-18-15(12)7-14(11)17/h2-8,18H,1H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 320 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237969
(US9394285, 52)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCCN2CCNCC2)cc1 Show InChI InChI=1S/C22H24ClN3O3/c23-20-13-21-18(19(14-25-21)22(27)28)12-17(20)15-2-4-16(5-3-15)29-11-1-8-26-9-6-24-7-10-26/h2-5,12-14,24-25H,1,6-11H2,(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 38.1 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237971
(US9394285, 54)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCCCN2CCOCC2=O)cc1 Show InChI InChI=1S/C22H21ClN2O5/c23-19-11-20-17(18(12-24-20)22(27)28)10-16(19)14-2-4-15(5-3-14)30-8-1-6-25-7-9-29-13-21(25)26/h2-5,10-12,24H,1,6-9,13H2,(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 32.5 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237973
(US9394285, 56)Show SMILES COc1cc(ccc1C(C)(C)O)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C19H18ClNO4/c1-19(2,24)14-5-4-10(6-17(14)25-3)11-7-12-13(18(22)23)9-21-16(12)8-15(11)20/h4-9,21,24H,1-3H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 334 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237974
(US9394285, 57)Show InChI InChI=1S/C17H12ClNO3/c18-14-7-15-12(13(8-19-15)17(20)21)6-11(14)10-2-1-9-3-4-22-16(9)5-10/h1-2,5-8,19H,3-4H2,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 64.5 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237976
(US9394285, 59)Show SMILES COc1cc(ccc1OCCCO)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C19H18ClNO5/c1-25-18-7-11(3-4-17(18)26-6-2-5-22)12-8-13-14(19(23)24)10-21-16(13)9-15(12)20/h3-4,7-10,21-22H,2,5-6H2,1H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 133 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237977
(US9394285, 60 | US9394285, 61)Show SMILES COc1cc(ccc1C1(O)COC1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C19H16ClNO5/c1-25-17-4-10(2-3-14(17)19(24)8-26-9-19)11-5-12-13(18(22)23)7-21-16(12)6-15(11)20/h2-7,21,24H,8-9H2,1H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 7.80 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237979
(US9394285, 62)Show SMILES COc1cc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)C1(O)COC1 Show InChI InChI=1S/C19H16ClNO5/c1-25-17-4-10(19(24)8-26-9-19)2-3-11(17)12-5-13-14(18(22)23)7-21-16(13)6-15(12)20/h2-7,21,24H,8-9H2,1H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 33.3 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237980
(US9394285, 63)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCN1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 433 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237982
(US9394285, 65)Show SMILES CC(=O)N1CCC(CC1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C22H21ClN2O3/c1-13(26)25-8-6-15(7-9-25)14-2-4-16(5-3-14)17-10-18-19(22(27)28)12-24-21(18)11-20(17)23/h2-5,10-12,15,24H,6-9H2,1H3,(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 135 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237984
(US9394285, 67)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)-c1ccccc1O Show InChI InChI=1S/C21H14ClNO3/c22-18-10-19-16(17(11-23-19)21(25)26)9-15(18)13-7-5-12(6-8-13)14-3-1-2-4-20(14)24/h1-11,23-24H,(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237985
(US9394285, 68)Show SMILES OC(=O)c1c[nH]c2cc(Br)c(cc12)-c1ccc(cc1)-c1ccccc1O Show InChI InChI=1S/C21H14BrNO3/c22-18-10-19-16(17(11-23-19)21(25)26)9-15(18)13-7-5-12(6-8-13)14-3-1-2-4-20(14)24/h1-11,23-24H,(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.30 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237987
(US9394285, 70)Show SMILES NC(=O)COc1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C17H13ClN2O4/c18-14-6-15-12(13(7-20-15)17(22)23)5-11(14)9-1-3-10(4-2-9)24-8-16(19)21/h1-7,20H,8H2,(H2,19,21)(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 77.5 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237988
(US9394285, 71)Show InChI InChI=1S/C17H14ClNO3/c18-15-8-16-13(14(9-19-16)17(21)22)7-12(15)11-3-1-10(2-4-11)5-6-20/h1-4,7-9,19-20H,5-6H2,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 14 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237990
(US9394285, 73)Show InChI InChI=1S/C15H13ClN4O2/c1-20(2)15-18-5-8(6-19-15)9-3-10-11(14(21)22)7-17-13(10)4-12(9)16/h3-7,17H,1-2H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 790 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237992
(US9394285, 75)Show SMILES OCC1(CC1)c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C19H16ClNO3/c20-16-8-17-14(15(9-21-17)18(23)24)7-13(16)11-1-3-12(4-2-11)19(10-22)5-6-19/h1-4,7-9,21-22H,5-6,10H2,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237993
(US9394285, 76)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1cnc(nc1)N1CCOCC1 Show InChI InChI=1S/C17H15ClN4O3/c18-14-6-15-12(13(9-19-15)16(23)24)5-11(14)10-7-20-17(21-8-10)22-1-3-25-4-2-22/h5-9,19H,1-4H2,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 271 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237995
(US9394285, 78)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(CCC1)C(O)=O Show InChI InChI=1S/C20H16ClNO4/c21-16-9-17-14(15(10-22-17)18(23)24)8-13(16)11-2-4-12(5-3-11)20(19(25)26)6-1-7-20/h2-5,8-10,22H,1,6-7H2,(H,23,24)(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237996
(US9394285, 79)Show SMILES OC(=O)C1CNc2cc(Cl)c(cc12)-c1ccc(cc1)C1CNC(=O)CO1 Show InChI InChI=1S/C19H17ClN2O4/c20-15-6-16-13(14(7-21-16)19(24)25)5-12(15)10-1-3-11(4-2-10)17-8-22-18(23)9-26-17/h1-6,14,17,21H,7-9H2,(H,22,23)(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 104 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM237998
(US9394285, 81)Show InChI InChI=1S/C17H13ClFNO4/c18-13-7-15-11(12(8-20-15)17(22)23)6-10(13)9-1-2-16(14(19)5-9)24-4-3-21/h1-2,5-8,20-21H,3-4H2,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 183 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM238000
(US9394285, 83)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1CCCN1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 819 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM238001
(US9394285, 84)Show SMILES CS(=O)(=O)N1CCCC1c1ccc(cc1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 344 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM238002
(US9394285, 86)Show SMILES OCCOc1ccc(c(F)c1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O Show InChI InChI=1S/C17H13ClFNO4/c18-14-7-16-12(13(8-20-16)17(22)23)6-11(14)10-2-1-9(5-15(10)19)24-4-3-21/h1-2,5-8,20-21H,3-4H2,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 99.2 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM238003
(US9394285, 87)Show SMILES OC[C@@H]1COc2cc(ccc2O1)-c1cc2c(c[nH]c2cc1Cl)C(O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 69.5 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM238004
(US9394285, 88)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(CC1)C(O)=O Show InChI InChI=1S/C19H14ClNO4/c20-15-8-16-13(14(9-21-16)17(22)23)7-12(15)10-1-3-11(4-2-10)19(5-6-19)18(24)25/h1-4,7-9,21H,5-6H2,(H,22,23)(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 58.1 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1
(Homo sapiens (Human)) | BDBM238005
(US9394285, 89)Show SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(OCC2COC2)cc1 Show InChI InChI=1S/C19H16ClNO4/c20-17-6-18-15(16(7-21-18)19(22)23)5-14(17)12-1-3-13(4-2-12)25-10-11-8-24-9-11/h1-7,11,21H,8-10H2,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 65.4 | n/a | n/a | 7.5 | 25 |
Pfizer Inc.
US Patent
| Assay Description
The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass... |
US Patent US9394285 (2016)
BindingDB Entry DOI: 10.7270/Q2DB80Q7 |
More data for this
Ligand-Target Pair | |
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