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Compile Data Set for Download or QSAR

Found 126 hits Enz. Inhib. hit(s) with all data for entry = 50032789   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334730
PNG
(3-(Naphthalen-1-ylsulfonyl)-5-(piperazin-1-ylmethy...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(CN3CCNCC3)cc12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,21-7-3-5-17-4-1-2-6-18(17)21)22-19-14-16(8-9-20(19)24-25-22)15-26-12-10-23-11-13-26/h1-9,14,23H,10-13,15H2,(H,24,25)
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0.240n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334734
PNG
(3-(Naphthalen-2-ylsulfonyl)-N-(piperidin-4-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(NC3CCNCC3)cc12)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,19-7-5-15-3-1-2-4-16(15)13-19)22-20-14-18(6-8-21(20)25-26-22)24-17-9-11-23-12-10-17/h1-8,13-14,17,23-24H,9-12H2,(H,25,26)
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0.600n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334731
PNG
(CHEMBL1642851 | [3-(Naphthalen-1-sulfonyl)-1H-inda...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(NC3CCNCC3)cc12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,21-7-3-5-15-4-1-2-6-18(15)21)22-19-14-17(8-9-20(19)25-26-22)24-16-10-12-23-13-11-16/h1-9,14,16,23-24H,10-13H2,(H,25,26)
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0.700n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334754
PNG
(CHEMBL1642883 | N-(Piperidin-4-yl)-3-(m-tolylsulfo...)
Show SMILES Cc1cccc(c1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C19H22N4O2S/c1-13-3-2-4-16(11-13)26(24,25)19-17-12-15(5-6-18(17)22-23-19)21-14-7-9-20-10-8-14/h2-6,11-12,14,20-21H,7-10H2,1H3,(H,22,23)
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0.800n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334733
PNG
(3-(4-Isopropylphenylsulfonyl)-N-(piperidin-4-yl)-1...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C21H26N4O2S/c1-14(2)15-3-6-18(7-4-15)28(26,27)21-19-13-17(5-8-20(19)24-25-21)23-16-9-11-22-12-10-16/h3-8,13-14,16,22-23H,9-12H2,1-2H3,(H,24,25)
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1n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334732
PNG
(3-(3-Chlorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Show SMILES Clc1cccc(c1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C18H19ClN4O2S/c19-12-2-1-3-15(10-12)26(24,25)18-16-11-14(4-5-17(16)22-23-18)21-13-6-8-20-9-7-13/h1-5,10-11,13,20-21H,6-9H2,(H,22,23)
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1n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334725
PNG
(CHEMBL1642866 | N-(3-(Naphthalen-1-ylsulfonyl)-1H-...)
Show SMILES O=C(Nc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCNCC1
Show InChI InChI=1S/C23H22N4O3S/c28-22(16-10-12-24-13-11-16)25-17-8-9-20-19(14-17)23(27-26-20)31(29,30)21-7-3-5-15-4-1-2-6-18(15)21/h1-9,14,16,24H,10-13H2,(H,25,28)(H,26,27)
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1.10n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334747
PNG
(CHEMBL1642849 | N1-(3-(Naphthalen-1-ylsulfonyl)-1H...)
Show SMILES CC(N)CNc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H20N4O2S/c1-13(21)12-22-15-9-10-18-17(11-15)20(24-23-18)27(25,26)19-8-4-6-14-5-2-3-7-16(14)19/h2-11,13,22H,12,21H2,1H3,(H,23,24)
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1.40n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334757
PNG
(CHEMBL1642887 | N-(Piperidin-4-yl)-3-(4-(trifluoro...)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C19H19F3N4O2S/c20-19(21,22)12-1-4-15(5-2-12)29(27,28)18-16-11-14(3-6-17(16)25-26-18)24-13-7-9-23-10-8-13/h1-6,11,13,23-24H,7-10H2,(H,25,26)
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1.5n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334720
PNG
(3-Amino-N-[3-(naphthalen-1-sulfonyl)-1H-indazol-5-...)
Show SMILES NCCC(=O)Nc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O3S/c21-11-10-19(25)22-14-8-9-17-16(12-14)20(24-23-17)28(26,27)18-7-3-5-13-4-1-2-6-15(13)18/h1-9,12H,10-11,21H2,(H,22,25)(H,23,24)
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1.5n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334716
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-5-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(NC3CCCNC3)cc12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,21-9-3-6-15-5-1-2-8-18(15)21)22-19-13-16(10-11-20(19)25-26-22)24-17-7-4-12-23-14-17/h1-3,5-6,8-11,13,17,23-24H,4,7,12,14H2,(H,25,26)
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1.70n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334756
PNG
(3-(4-Chlorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C18H19ClN4O2S/c19-12-1-4-15(5-2-12)26(24,25)18-16-11-14(3-6-17(16)22-23-18)21-13-7-9-20-10-8-13/h1-6,11,13,20-21H,7-10H2,(H,22,23)
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2.30n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334751
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-4-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2cccc(NC3CCNCC3)c12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,20-10-3-6-15-5-1-2-7-17(15)20)22-21-18(8-4-9-19(21)25-26-22)24-16-11-13-23-14-12-16/h1-10,16,23-24H,11-14H2,(H,25,26)
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2.80n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334727
PNG
(CHEMBL1642878 | N-[2-(Dimethylamino)ethyl]-3-(1-na...)
Show SMILES CN(C)CCNC(=O)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c1-26(2)13-12-23-21(27)16-10-11-19-18(14-16)22(25-24-19)30(28,29)20-9-5-7-15-6-3-4-8-17(15)20/h3-11,14H,12-13H2,1-2H3,(H,23,27)(H,24,25)
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2.90n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334752
PNG
(3-(Phenylsulfonyl)-N-(piperidin-4-yl)-1H-indazol-5...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(NC3CCNCC3)cc12)c1ccccc1
Show InChI InChI=1S/C18H20N4O2S/c23-25(24,15-4-2-1-3-5-15)18-16-12-14(6-7-17(16)21-22-18)20-13-8-10-19-11-9-13/h1-7,12-13,19-20H,8-11H2,(H,21,22)
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3.10n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334739
PNG
(3-Amino-N-(3-(naphthalen-1-ylsulfonyl)-1H-indazol-...)
Show SMILES NCCC(=O)Nc1cccc2c(n[nH]c12)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O3S/c21-12-11-18(25)22-16-9-4-8-15-19(16)23-24-20(15)28(26,27)17-10-3-6-13-5-1-2-7-14(13)17/h1-10H,11-12,21H2,(H,22,25)(H,23,24)
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3.40n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334718
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-4-ylmethy...)
Show SMILES O=S(=O)(c1n[nH]c2ccc(NCC3CCNCC3)cc12)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N4O2S/c28-30(29,22-7-3-5-17-4-1-2-6-19(17)22)23-20-14-18(8-9-21(20)26-27-23)25-15-16-10-12-24-13-11-16/h1-9,14,16,24-25H,10-13,15H2,(H,26,27)
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3.5n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334715
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-3-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2cccc(NC3CCCNC3)c12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,20-12-3-7-15-6-1-2-9-17(15)20)22-21-18(10-4-11-19(21)25-26-22)24-16-8-5-13-23-14-16/h1-4,6-7,9-12,16,23-24H,5,8,13-14H2,(H,25,26)
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4.20n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334748
PNG
((S)-3-Methyl-N1-[3-(naphthalen-1-sulfonyl)-1H-inda...)
Show SMILES CC(C)[C@H](N)CNc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12 |r|
Show InChI InChI=1S/C22H24N4O2S/c1-14(2)19(23)13-24-16-10-11-20-18(12-16)22(26-25-20)29(27,28)21-9-5-7-15-6-3-4-8-17(15)21/h3-12,14,19,24H,13,23H2,1-2H3,(H,25,26)/t19-/m1/s1
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4.30n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334723
PNG
(3-(Dimethylamino)-N-(3-(naphthalen-1-ylsulfonyl)-1...)
Show SMILES CN(C)CCC(=O)Nc1cccc2c(n[nH]c12)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c1-26(2)14-13-20(27)23-18-11-6-10-17-21(18)24-25-22(17)30(28,29)19-12-5-8-15-7-3-4-9-16(15)19/h3-12H,13-14H2,1-2H3,(H,23,27)(H,24,25)
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4.80n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334755
PNG
(3-(4-Fluorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C18H19FN4O2S/c19-12-1-4-15(5-2-12)26(24,25)18-16-11-14(3-6-17(16)22-23-18)21-13-7-9-20-10-8-13/h1-6,11,13,20-21H,7-10H2,(H,22,23)
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6.30n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334746
PNG
(CHEMBL1642848 | N1-3-(Napthalene-1-sulfonyl-1H-ind...)
Show SMILES NCCNc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C19H18N4O2S/c20-10-11-21-14-8-9-17-16(12-14)19(23-22-17)26(24,25)18-7-3-5-13-4-1-2-6-15(13)18/h1-9,12,21H,10-11,20H2,(H,22,23)
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6.70n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334753
PNG
(3-(3-Fluorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Show SMILES Fc1cccc(c1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C18H19FN4O2S/c19-12-2-1-3-15(10-12)26(24,25)18-16-11-14(4-5-17(16)22-23-18)21-13-6-8-20-9-7-13/h1-5,10-11,13,20-21H,6-9H2,(H,22,23)
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6.70n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334717
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-4-ylmethy...)
Show SMILES O=S(=O)(c1n[nH]c2cccc(NCC3CCNCC3)c12)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N4O2S/c28-30(29,21-10-3-6-17-5-1-2-7-18(17)21)23-22-19(8-4-9-20(22)26-27-23)25-15-16-11-13-24-14-12-16/h1-10,16,24-25H,11-15H2,(H,26,27)
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9.5n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334735
PNG
(3-(4-Methoxyphenylsulfonyl)-N-(piperidin-4-yl)-1Hi...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C19H22N4O3S/c1-26-15-3-5-16(6-4-15)27(24,25)19-17-12-14(2-7-18(17)22-23-19)21-13-8-10-20-11-9-13/h2-7,12-13,20-21H,8-11H2,1H3,(H,22,23)
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9.80n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334726
PNG
(CHEMBL1642877 | N-(3-(Naphthalen-1-ylsulfonyl)-1H-...)
Show SMILES O=C(Nc1cccc2c(n[nH]c12)S(=O)(=O)c1cccc2ccccc12)C1CCCNC1
Show InChI InChI=1S/C23H22N4O3S/c28-22(16-8-5-13-24-14-16)25-19-11-4-10-18-21(19)26-27-23(18)31(29,30)20-12-3-7-15-6-1-2-9-17(15)20/h1-4,6-7,9-12,16,24H,5,8,13-14H2,(H,25,28)(H,26,27)
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9.80n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334728
PNG
(CHEMBL1642862 | N-{[3-(1-Naphthylsulfonyl)-1H-inda...)
Show SMILES NCCNCc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H20N4O2S/c21-10-11-22-13-14-8-9-18-17(12-14)20(24-23-18)27(25,26)19-7-3-5-15-4-1-2-6-16(15)19/h1-9,12,22H,10-11,13,21H2,(H,23,24)
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12n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334722
PNG
(CHEMBL1642870 | N-(3-(Naphthalen-1-ylsulfonyl)-1H-...)
Show SMILES O=C(CCN1CCCCC1)Nc1ccc2c(n[nH]c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c30-24(13-16-29-14-4-1-5-15-29)26-19-11-12-21-22(17-19)27-28-25(21)33(31,32)23-10-6-8-18-7-2-3-9-20(18)23/h2-3,6-12,17H,1,4-5,13-16H2,(H,26,30)(H,27,28)
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12n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334729
PNG
(CHEMBL1642863 | N,N,N'-Trimethyl-N0-{[3-(1-naphthy...)
Show SMILES CN(C)CCN(C)Cc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H26N4O2S/c1-26(2)13-14-27(3)16-17-11-12-21-20(15-17)23(25-24-21)30(28,29)22-10-6-8-18-7-4-5-9-19(18)22/h4-12,15H,13-14,16H2,1-3H3,(H,24,25)
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14n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334750
PNG
(CHEMBL1642858 | N1-(3-(Naphthalene-1-ylsulfonyl)-1...)
Show SMILES NCCNc1cccc2c(n[nH]c12)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C19H18N4O2S/c20-11-12-21-16-9-4-8-15-18(16)22-23-19(15)26(24,25)17-10-3-6-13-5-1-2-7-14(13)17/h1-10,21H,11-12,20H2,(H,22,23)
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17n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334749
PNG
(CHEMBL1642854 | N1-(3-(Naphthalen-1-ylsulfonyl)-1H...)
Show SMILES NCCNc1ccc2c(n[nH]c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C19H18N4O2S/c20-10-11-21-14-8-9-16-17(12-14)22-23-19(16)26(24,25)18-7-3-5-13-4-1-2-6-15(13)18/h1-9,12,21H,10-11,20H2,(H,22,23)
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17n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334719
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-4-ylmethy...)
Show SMILES O=S(=O)(c1n[nH]c2c(NCC3CCNCC3)cccc12)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N4O2S/c28-30(29,21-10-3-6-17-5-1-2-7-18(17)21)23-19-8-4-9-20(22(19)26-27-23)25-15-16-11-13-24-14-12-16/h1-10,16,24-25H,11-15H2,(H,26,27)
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17n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334742
PNG
(CHEMBL1642875 | N-(3-(Naphthalen-1-ylsulfonyl)-1H-...)
Show SMILES O=C(CCN1CCCCC1)Nc1cccc2c(n[nH]c12)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c30-23(14-17-29-15-4-1-5-16-29)26-21-12-7-11-20-24(21)27-28-25(20)33(31,32)22-13-6-9-18-8-2-3-10-19(18)22/h2-3,6-13H,1,4-5,14-17H2,(H,26,30)(H,27,28)
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24n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334721
PNG
(3-Amino-N-(3-(naphthalen-1-ylsulfonyl)-1H-indazol-...)
Show SMILES NCCC(=O)Nc1ccc2c(n[nH]c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O3S/c21-11-10-19(25)22-14-8-9-16-17(12-14)23-24-20(16)28(26,27)18-7-3-5-13-4-1-2-6-15(13)18/h1-9,12H,10-11,21H2,(H,22,25)(H,23,24)
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24n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334724
PNG
(3-(Diethylamino)-N-(3-(naphthalen-1-ylsulfonyl)-1H...)
Show SMILES CCN(CC)CCC(=O)Nc1cccc2c(n[nH]c12)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H26N4O3S/c1-3-28(4-2)16-15-22(29)25-20-13-8-12-19-23(20)26-27-24(19)32(30,31)21-14-7-10-17-9-5-6-11-18(17)21/h5-14H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,27)
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27n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334744
PNG
(CHEMBL1642876 | N-(3-(Naphthalen-1-ylsulfonyl)-1H-...)
Show SMILES O=C(Nc1cccc2c(n[nH]c12)S(=O)(=O)c1cccc2ccccc12)C1CCNCC1
Show InChI InChI=1S/C23H22N4O3S/c28-22(16-11-13-24-14-12-16)25-19-9-4-8-18-21(19)26-27-23(18)31(29,30)20-10-3-6-15-5-1-2-7-17(15)20/h1-10,16,24H,11-14H2,(H,25,28)(H,26,27)
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28n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334759
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-4-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2c(NC3CCNCC3)cccc12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,20-10-3-6-15-5-1-2-7-17(15)20)22-18-8-4-9-19(21(18)25-26-22)24-16-11-13-23-14-12-16/h1-10,16,23-24H,11-14H2,(H,25,26)
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30n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334743
PNG
(CHEMBL1642871 | N-(3-(Naphthalen-1-ylsulfonyl)-1H-...)
Show SMILES O=C(Nc1ccc2c(n[nH]c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCNCC1
Show InChI InChI=1S/C23H22N4O3S/c28-22(16-10-12-24-13-11-16)25-17-8-9-19-20(14-17)26-27-23(19)31(29,30)21-7-3-5-15-4-1-2-6-18(15)21/h1-9,14,16,24H,10-13H2,(H,25,28)(H,26,27)
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31n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50334725
PNG
(CHEMBL1642866 | N-(3-(Naphthalen-1-ylsulfonyl)-1H-...)
Show SMILES O=C(Nc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCNCC1
Show InChI InChI=1S/C23H22N4O3S/c28-22(16-10-12-24-13-11-16)25-17-8-9-20-19(14-17)23(27-26-20)31(29,30)21-7-3-5-15-4-1-2-6-18(15)21/h1-9,14,16,24H,10-13H2,(H,25,28)(H,26,27)
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33n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2B receptor


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334740
PNG
(3-(Dimethylamino)-N-(3-(naphthalen-1-ylsulfonyl)-1...)
Show SMILES CN(C)CCC(=O)Nc1ccc2c(n[nH]c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c1-26(2)13-12-21(27)23-16-10-11-18-19(14-16)24-25-22(18)30(28,29)20-9-5-7-15-6-3-4-8-17(15)20/h3-11,14H,12-13H2,1-2H3,(H,23,27)(H,24,25)
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44n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334738
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-4-ylmethy...)
Show SMILES O=S(=O)(c1n[nH]c2cc(NCC3CCNCC3)ccc12)c1cccc2ccccc12
Show InChI InChI=1S/C23H24N4O2S/c28-30(29,22-7-3-5-17-4-1-2-6-19(17)22)23-20-9-8-18(14-21(20)26-27-23)25-15-16-10-12-24-13-11-16/h1-9,14,16,24-25H,10-13,15H2,(H,26,27)
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44n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334758
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-4-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2cc(NC3CCNCC3)ccc12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,21-7-3-5-15-4-1-2-6-18(15)21)22-19-9-8-17(14-20(19)25-26-22)24-16-10-12-23-13-11-16/h1-9,14,16,23-24H,10-13H2,(H,25,26)
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53n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334736
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-6-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2cc(NC3CCCNC3)ccc12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,21-9-3-6-15-5-1-2-8-18(15)21)22-19-11-10-16(13-20(19)25-26-22)24-17-7-4-12-23-14-17/h1-3,5-6,8-11,13,17,23-24H,4,7,12,14H2,(H,25,26)
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57n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334741
PNG
(3-(Diethylamino)-N-(3-(naphthalen-1-ylsulfonyl)-1H...)
Show SMILES CCN(CC)CCC(=O)Nc1ccc2c(n[nH]c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H26N4O3S/c1-3-28(4-2)15-14-23(29)25-18-12-13-20-21(16-18)26-27-24(20)32(30,31)22-11-7-9-17-8-5-6-10-19(17)22/h5-13,16H,3-4,14-15H2,1-2H3,(H,25,29)(H,26,27)
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65n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334737
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(piperidin-7-yl)-1H-...)
Show SMILES O=S(=O)(c1n[nH]c2c(NC3CCCNC3)cccc12)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O2S/c27-29(28,20-12-3-7-15-6-1-2-9-17(15)20)22-18-10-4-11-19(21(18)25-26-22)24-16-8-5-13-23-14-16/h1-4,6-7,9-12,16,23-24H,5,8,13-14H2,(H,25,26)
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66n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50334745
PNG
(3-(Naphthalen-1-ylsulfonyl)-N-(2-piperidin-1-yleth...)
Show SMILES O=C(NCCN1CCCCC1)c1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c30-24(26-13-16-29-14-4-1-5-15-29)19-11-12-22-21(17-19)25(28-27-22)33(31,32)23-10-6-8-18-7-2-3-9-20(18)23/h2-3,6-12,17H,1,4-5,13-16H2,(H,26,30)(H,27,28)
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107n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50334732
PNG
(3-(3-Chlorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Show SMILES Clc1cccc(c1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C18H19ClN4O2S/c19-12-2-1-3-15(10-12)26(24,25)18-16-11-14(4-5-17(16)22-23-18)21-13-6-8-20-9-7-13/h1-5,10-11,13,20-21H,6-9H2,(H,22,23)
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155n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2B receptor


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50334720
PNG
(3-Amino-N-[3-(naphthalen-1-sulfonyl)-1H-indazol-5-...)
Show SMILES NCCC(=O)Nc1ccc2[nH]nc(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O3S/c21-11-10-19(25)22-14-8-9-17-16(12-14)20(24-23-17)28(26,27)18-7-3-5-13-4-1-2-6-15(13)18/h1-9,12H,10-11,21H2,(H,22,25)(H,23,24)
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344n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2B receptor


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50334732
PNG
(3-(3-Chlorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Show SMILES Clc1cccc(c1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C18H19ClN4O2S/c19-12-2-1-3-15(10-12)26(24,25)18-16-11-14(4-5-17(16)22-23-18)21-13-6-8-20-9-7-13/h1-5,10-11,13,20-21H,6-9H2,(H,22,23)
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410n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1D receptor


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM50334732
PNG
(3-(3-Chlorophenylsulfonyl)-N-(piperidin-4-yl)-1H-i...)
Show SMILES Clc1cccc(c1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Show InChI InChI=1S/C18H19ClN4O2S/c19-12-2-1-3-15(10-12)26(24,25)18-16-11-14(4-5-17(16)22-23-18)21-13-6-8-20-9-7-13/h1-5,10-11,13,20-21H,6-9H2,(H,22,23)
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455n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1A receptor


Bioorg Med Chem 19: 650-62 (2011)


Article DOI: 10.1016/j.bmc.2010.10.033
BindingDB Entry DOI: 10.7270/Q29S1R9V
More data for this
Ligand-Target Pair
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