Compile Data Set for Download or QSAR

Found 26 hits Enz. Inhib. hit(s) with all data for entry = 50000205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242394 (CHEMBL4074788) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1ccccc1Cl)N1CCOCC1 Show InChI InChI=1S/C23H22ClN5O/c1-16-27-21-22(28-10-12-30-13-11-28)25-15-26-23(21)29(16)14-17-6-8-18(9-7-17)19-4-2-3-5-20(19)24/h2-9,15H,10-14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242395 (CHEMBL4079798) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1ccnc(C)c1)N1CCOCC1 Show InChI InChI=1S/C23H24N6O/c1-16-13-20(7-8-24-16)19-5-3-18(4-6-19)14-29-17(2)27-21-22(25-15-26-23(21)29)28-9-11-30-12-10-28/h3-8,13,15H,9-12,14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242396 (CHEMBL4060352) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1cnc2[nH]ncc2c1)N1CCOCC1 Show InChI InChI=1S/C23H22N8O/c1-15-28-20-22(30-6-8-32-9-7-30)25-14-26-23(20)31(15)13-16-2-4-17(5-3-16)18-10-19-12-27-29-21(19)24-11-18/h2-5,10-12,14H,6-9,13H2,1H3,(H,24,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242387 (CHEMBL4066336) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1cccnc1)N1CCOCC1 Show InChI InChI=1S/C22H22N6O/c1-16-26-20-21(27-9-11-29-12-10-27)24-15-25-22(20)28(16)14-17-4-6-18(7-5-17)19-3-2-8-23-13-19/h2-8,13,15H,9-12,14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242383 (CHEMBL4068257) Show SMILES COc1ccc(cc1)-c1ccc(Cn2c(C)nc3c(ncnc23)N2CCOCC2)cc1 Show InChI InChI=1S/C24H25N5O2/c1-17-27-22-23(28-11-13-31-14-12-28)25-16-26-24(22)29(17)15-18-3-5-19(6-4-18)20-7-9-21(30-2)10-8-20/h3-10,16H,11-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242390 (CHEMBL4069039) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1cnn(C)c1)N1CCOCC1 Show InChI InChI=1S/C21H23N7O/c1-15-25-19-20(27-7-9-29-10-8-27)22-14-23-21(19)28(15)12-16-3-5-17(6-4-16)18-11-24-26(2)13-18/h3-6,11,13-14H,7-10,12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242371 (CHEMBL4062354) Show SMILES Cc1ccc(cc1)-c1ccc(Cn2cnc3c(ncnc23)N2CCOCC2)cc1 Show InChI InChI=1S/C23H23N5O/c1-17-2-6-19(7-3-17)20-8-4-18(5-9-20)14-28-16-26-21-22(24-15-25-23(21)28)27-10-12-29-13-11-27/h2-9,15-16H,10-14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242389 (CHEMBL4104051) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1cncnc1)N1CCOCC1 Show InChI InChI=1S/C21H21N7O/c1-15-26-19-20(27-6-8-29-9-7-27)24-14-25-21(19)28(15)12-16-2-4-17(5-3-16)18-10-22-13-23-11-18/h2-5,10-11,13-14H,6-9,12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242380 (CHEMBL4090349) Show SMILES C(c1ccc(cc1)-c1ccccc1)n1cnc2c(ncnc12)N1CCOCC1 Show InChI InChI=1S/C22H21N5O/c1-2-4-18(5-3-1)19-8-6-17(7-9-19)14-27-16-25-20-21(23-15-24-22(20)27)26-10-12-28-13-11-26/h1-9,15-16H,10-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242379 (CHEMBL4089659) Show SMILES C(c1ccc2ccccc2c1)n1cnc2c(ncnc12)N1CCOCC1 Show InChI InChI=1S/C20H19N5O/c1-2-4-17-11-15(5-6-16(17)3-1)12-25-14-23-18-19(21-13-22-20(18)25)24-7-9-26-10-8-24/h1-6,11,13-14H,7-10,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242393 (CHEMBL4081568) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1ccccc1)N1CCOCC1 Show InChI InChI=1S/C23H23N5O/c1-17-26-21-22(27-11-13-29-14-12-27)24-16-25-23(21)28(17)15-18-7-9-20(10-8-18)19-5-3-2-4-6-19/h2-10,16H,11-15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	113	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242386 (CHEMBL4087685) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1ccncc1)N1CCOCC1 Show InChI InChI=1S/C22H22N6O/c1-16-26-20-21(27-10-12-29-13-11-27)24-15-25-22(20)28(16)14-17-2-4-18(5-3-17)19-6-8-23-9-7-19/h2-9,15H,10-14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	116	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242391 (CHEMBL4096301) Show SMILES Cc1noc(C)c1-c1ccc(Cn2c(C)nc3c(ncnc23)N2CCOCC2)cc1 Show InChI InChI=1S/C22H24N6O2/c1-14-19(15(2)30-26-14)18-6-4-17(5-7-18)12-28-16(3)25-20-21(23-13-24-22(20)28)27-8-10-29-11-9-27/h4-7,13H,8-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	119	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242392 (CHEMBL4073887) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)C(=O)Nc1ccccc1)N1CCOCC1 Show InChI InChI=1S/C24H24N6O2/c1-17-27-21-22(29-11-13-32-14-12-29)25-16-26-23(21)30(17)15-18-7-9-19(10-8-18)24(31)28-20-5-3-2-4-6-20/h2-10,16H,11-15H2,1H3,(H,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242384 (CHEMBL4089435) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1ccc(Cl)cc1)N1CCOCC1 Show InChI InChI=1S/C23H22ClN5O/c1-16-27-21-22(28-10-12-30-13-11-28)25-15-26-23(21)29(16)14-17-2-4-18(5-3-17)19-6-8-20(24)9-7-19/h2-9,15H,10-14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	168	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242381 (CHEMBL4098066) Show SMILES CCc1nc2c(ncnc2n1Cc1ccc(cc1)-c1ccccc1)N1CCOCC1 Show InChI InChI=1S/C24H25N5O/c1-2-21-27-22-23(28-12-14-30-15-13-28)25-17-26-24(22)29(21)16-18-8-10-20(11-9-18)19-6-4-3-5-7-19/h3-11,17H,2,12-16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	168	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242372 (CHEMBL4068918) Show SMILES COc1ccc(CCNc2c(C)nc3c(nccn23)N2CCOCC2)c(Br)c1 Show InChI InChI=1S/C20H24BrN5O2/c1-14-18(22-6-5-15-3-4-16(27-2)13-17(15)21)26-8-7-23-19(20(26)24-14)25-9-11-28-12-10-25/h3-4,7-8,13,22H,5-6,9-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	243	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242385 (CHEMBL4101471) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(cc1)-c1cccc(Cl)c1)N1CCOCC1 Show InChI InChI=1S/C23H22ClN5O/c1-16-27-21-22(28-9-11-30-12-10-28)25-15-26-23(21)29(16)14-17-5-7-18(8-6-17)19-3-2-4-20(24)13-19/h2-8,13,15H,9-12,14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	258	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242382 (CHEMBL4059612) Show SMILES Cc1nc2c(ncnc2n1Cc1ccc(Br)cc1)N1CCOCC1 Show InChI InChI=1S/C17H18BrN5O/c1-12-21-15-16(22-6-8-24-9-7-22)19-11-20-17(15)23(12)10-13-2-4-14(18)5-3-13/h2-5,11H,6-10H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	327	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242373 (CHEMBL4079696) Show SMILES COc1ccc(CCNc2c(C)nc3c(nccn23)N2CCOCC2)c(c1)-c1ccccc1 Show InChI InChI=1S/C26H29N5O2/c1-19-24(31-13-12-28-25(26(31)29-19)30-14-16-33-17-15-30)27-11-10-21-8-9-22(32-2)18-23(21)20-6-4-3-5-7-20/h3-9,12-13,18,27H,10-11,14-17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	336	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242375 (CHEMBL4063539) Show SMILES Cc1nc2c(nccn2c1NCc1ccc(cc1)-c1ccncc1)N1CCOCC1 Show InChI InChI=1S/C23H24N6O/c1-17-21(26-16-18-2-4-19(5-3-18)20-6-8-24-9-7-20)29-11-10-25-22(23(29)27-17)28-12-14-30-15-13-28/h2-11,26H,12-16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	391	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242397 (CHEMBL4088475) Show SMILES Cc1nc2c(nccn2c1NCCc1c(Cl)cccc1Cl)N1CCOCC1 Show InChI InChI=1S/C19H21Cl2N5O/c1-13-17(22-6-5-14-15(20)3-2-4-16(14)21)26-8-7-23-18(19(26)24-13)25-9-11-27-12-10-25/h2-4,7-8,22H,5-6,9-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	447	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242378 (CHEMBL4093877) Show SMILES COc1ccc(cc1OC)-c1ccc(CNc2c(C)nc3c(nccn23)N2CCOCC2)cc1 Show InChI InChI=1S/C26H29N5O3/c1-18-24(31-11-10-27-25(26(31)29-18)30-12-14-34-15-13-30)28-17-19-4-6-20(7-5-19)21-8-9-22(32-2)23(16-21)33-3/h4-11,16,28H,12-15,17H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	452	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242376 (CHEMBL4101607) Show SMILES Cc1nc2c(nccn2c1NCc1ccc(cc1)-c1c(C)noc1C)N1CCOCC1 Show InChI InChI=1S/C23H26N6O2/c1-15-20(17(3)31-27-15)19-6-4-18(5-7-19)14-25-21-16(2)26-23-22(24-8-9-29(21)23)28-10-12-30-13-11-28/h4-9,25H,10-14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	518	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242398 (CHEMBL4091386) Show SMILES Cc1nc2c(nccn2c1NCc1ccc(cc1)-c1cccnc1)N1CCOCC1 Show InChI InChI=1S/C23H24N6O/c1-17-21(26-15-18-4-6-19(7-5-18)20-3-2-8-24-16-20)29-10-9-25-22(23(29)27-17)28-11-13-30-14-12-28/h2-10,16,26H,11-15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	529	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50242399 (CHEMBL4061536) Show SMILES Brc1ccc(Cn2cnc3c(ncnc23)N2CCOCC2)cc1 Show InChI InChI=1S/C16H16BrN5O/c17-13-3-1-12(2-4-13)9-22-11-20-14-15(18-10-19-16(14)22)21-5-7-23-8-6-21/h1-4,10-11H,5-9H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Nanchang University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged PDE10A1 (2 to 789 residues) expressed in baculovirus infected Sf9 cells using fluorescein-label...				Bioorg Med Chem 25: 3315-3329 (2017) Article DOI: 10.1016/j.bmc.2017.04.019 BindingDB Entry DOI: 10.7270/Q25X2CB8
					More data for this Ligand-Target Pair