Found 52 hits Enz. Inhib. hit(s) with all data for entry = 799 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291359
((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)Show SMILES CN(C)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H24N6O3/c1-31(2)21(33)7-6-16-14-19-22-23(35-26(19)28-15-16)25(32-10-12-34-13-11-32)30-24(29-22)18-4-3-5-20-17(18)8-9-27-20/h3-9,14-15,27H,10-13H2,1-2H3/b7-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291363
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)Show SMILES C(N1CCOCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H26N6O3/c1-2-19(18-4-5-27-21(18)3-1)24-29-22-20-14-17(16-31-6-10-33-11-7-31)15-28-26(20)35-23(22)25(30-24)32-8-12-34-13-9-32/h1-5,14-15,27H,6-13,16H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291360
(US9580442, Example H | US9938290, H | [2-(1H-Indol...)Show SMILES CN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C24H24N6O2/c1-29(2)14-15-12-18-20-21(32-24(18)26-13-15)23(30-8-10-31-11-9-30)28-22(27-20)17-4-3-5-19-16(17)6-7-25-19/h3-7,12-13,25H,8-11,14H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291358
((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)Show SMILES CN1CCN(CC1)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C29H29N7O3/c1-34-9-11-35(12-10-34)24(37)6-5-19-17-22-25-26(39-29(22)31-18-19)28(36-13-15-38-16-14-36)33-27(32-25)21-3-2-4-23-20(21)7-8-30-23/h2-8,17-18,30H,9-16H2,1H3/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291355
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C21H17N5O2/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291357
(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291365
(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3...)Show SMILES C1CN(CCO1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C25H24N6O3/c1-2-18(17-4-5-26-20(17)3-1)23-28-21-19-14-16(30-6-10-32-11-7-30)15-27-25(19)34-22(21)24(29-23)31-8-12-33-13-9-31/h1-5,14-15,26H,6-13H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291361
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291354
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3sc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C21H17N5OS/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291355
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C21H17N5O2/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291364
(US9580442, Example L | US9938290, L | [2-(1H-Indol...)Show SMILES COCCN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H28N6O3/c1-31(8-11-33-2)16-17-14-20-22-23(35-26(20)28-15-17)25(32-9-12-34-13-10-32)30-24(29-22)19-4-3-5-21-18(19)6-7-27-21/h3-7,14-15,27H,8-13,16H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291366
(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)Show SMILES N#CCCN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1 Show InChI InChI=1S/C29H30N8O2/c30-6-2-8-35-9-11-36(12-10-35)19-20-17-23-25-26(39-29(23)32-18-20)28(37-13-15-38-16-14-37)34-27(33-25)22-3-1-4-24-21(22)5-7-31-24/h1,3-5,7,17-18,31H,2,8-16,19H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291365
(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3...)Show SMILES C1CN(CCO1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C25H24N6O3/c1-2-18(17-4-5-26-20(17)3-1)23-28-21-19-14-16(30-6-10-32-11-7-30)15-27-25(19)34-22(21)24(29-23)31-8-12-33-13-9-31/h1-5,14-15,26H,6-13H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291362
(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)Show SMILES CN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1 Show InChI InChI=1S/C27H29N7O2/c1-32-7-9-33(10-8-32)17-18-15-21-23-24(36-27(21)29-16-18)26(34-11-13-35-14-12-34)31-25(30-23)20-3-2-4-22-19(20)5-6-28-22/h2-6,15-16,28H,7-14,17H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM291356
(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1ccnc2[nH]ccc12 Show InChI InChI=1S/C20H16N6O2/c1-2-14-15-16(28-20(14)23-5-1)19(26-8-10-27-11-9-26)25-18(24-15)13-4-7-22-17-12(13)3-6-21-17/h1-7H,8-11H2,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291354
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3sc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C21H17N5OS/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291356
(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1ccnc2[nH]ccc12 Show InChI InChI=1S/C20H16N6O2/c1-2-14-15-16(28-20(14)23-5-1)19(26-8-10-27-11-9-26)25-18(24-15)13-4-7-22-17-12(13)3-6-21-17/h1-7H,8-11H2,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291360
(US9580442, Example H | US9938290, H | [2-(1H-Indol...)Show SMILES CN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C24H24N6O2/c1-29(2)14-15-12-18-20-21(32-24(18)26-13-15)23(30-8-10-31-11-9-30)28-22(27-20)17-4-3-5-19-16(17)6-7-25-19/h3-7,12-13,25H,8-11,14H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291363
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)Show SMILES C(N1CCOCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H26N6O3/c1-2-19(18-4-5-27-21(18)3-1)24-29-22-20-14-17(16-31-6-10-33-11-7-31)15-28-26(20)35-23(22)25(30-24)32-8-12-34-13-9-32/h1-5,14-15,27H,6-13,16H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291357
(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291359
((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)Show SMILES CN(C)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H24N6O3/c1-31(2)21(33)7-6-16-14-19-22-23(35-26(19)28-15-16)25(32-10-12-34-13-11-32)30-24(29-22)18-4-3-5-20-17(18)8-9-27-20/h3-9,14-15,27H,10-13H2,1-2H3/b7-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291357
(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291365
(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3...)Show SMILES C1CN(CCO1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C25H24N6O3/c1-2-18(17-4-5-26-20(17)3-1)23-28-21-19-14-16(30-6-10-32-11-7-30)15-27-25(19)34-22(21)24(29-23)31-8-12-33-13-9-31/h1-5,14-15,26H,6-13H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291356
(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1ccnc2[nH]ccc12 Show InChI InChI=1S/C20H16N6O2/c1-2-14-15-16(28-20(14)23-5-1)19(26-8-10-27-11-9-26)25-18(24-15)13-4-7-22-17-12(13)3-6-21-17/h1-7H,8-11H2,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 103 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291356
(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1ccnc2[nH]ccc12 Show InChI InChI=1S/C20H16N6O2/c1-2-14-15-16(28-20(14)23-5-1)19(26-8-10-27-11-9-26)25-18(24-15)13-4-7-22-17-12(13)3-6-21-17/h1-7H,8-11H2,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291358
((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)Show SMILES CN1CCN(CC1)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C29H29N7O3/c1-34-9-11-35(12-10-34)24(37)6-5-19-17-22-25-26(39-29(22)31-18-19)28(36-13-15-38-16-14-36)33-27(32-25)21-3-2-4-23-20(21)7-8-30-23/h2-8,17-18,30H,9-16H2,1H3/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 109 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291364
(US9580442, Example L | US9938290, L | [2-(1H-Indol...)Show SMILES COCCN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H28N6O3/c1-31(8-11-33-2)16-17-14-20-22-23(35-26(20)28-15-17)25(32-9-12-34-13-10-32)30-24(29-22)19-4-3-5-21-18(19)6-7-27-21/h3-7,14-15,27H,8-13,16H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291358
((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)Show SMILES CN1CCN(CC1)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C29H29N7O3/c1-34-9-11-35(12-10-34)24(37)6-5-19-17-22-25-26(39-29(22)31-18-19)28(36-13-15-38-16-14-36)33-27(32-25)21-3-2-4-23-20(21)7-8-30-23/h2-8,17-18,30H,9-16H2,1H3/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 127 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291366
(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)Show SMILES N#CCCN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1 Show InChI InChI=1S/C29H30N8O2/c30-6-2-8-35-9-11-36(12-10-35)19-20-17-23-25-26(39-29(23)32-18-20)28(37-13-15-38-16-14-37)34-27(33-25)22-3-1-4-24-21(22)5-7-31-24/h1,3-5,7,17-18,31H,2,8-16,19H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 131 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291354
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3sc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C21H17N5OS/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 137 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291355
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C21H17N5O2/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 159 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291360
(US9580442, Example H | US9938290, H | [2-(1H-Indol...)Show SMILES CN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C24H24N6O2/c1-29(2)14-15-12-18-20-21(32-24(18)26-13-15)23(30-8-10-31-11-9-30)28-22(27-20)17-4-3-5-19-16(17)6-7-25-19/h3-7,12-13,25H,8-11,14H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 213 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291365
(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3...)Show SMILES C1CN(CCO1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C25H24N6O3/c1-2-18(17-4-5-26-20(17)3-1)23-28-21-19-14-16(30-6-10-32-11-7-30)15-27-25(19)34-22(21)24(29-23)31-8-12-33-13-9-31/h1-5,14-15,26H,6-13H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 219 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291359
((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)Show SMILES CN(C)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H24N6O3/c1-31(2)21(33)7-6-16-14-19-22-23(35-26(19)28-15-16)25(32-10-12-34-13-11-32)30-24(29-22)18-4-3-5-20-17(18)8-9-27-20/h3-9,14-15,27H,10-13H2,1-2H3/b7-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 223 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291358
((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)Show SMILES CN1CCN(CC1)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C29H29N7O3/c1-34-9-11-35(12-10-34)24(37)6-5-19-17-22-25-26(39-29(22)31-18-19)28(36-13-15-38-16-14-36)33-27(32-25)21-3-2-4-23-20(21)7-8-30-23/h2-8,17-18,30H,9-16H2,1H3/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 269 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291362
(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)Show SMILES CN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1 Show InChI InChI=1S/C27H29N7O2/c1-32-7-9-33(10-8-32)17-18-15-21-23-24(36-27(21)29-16-18)26(34-11-13-35-14-12-34)31-25(30-23)20-3-2-4-22-19(20)5-6-28-22/h2-6,15-16,28H,7-14,17H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 277 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291355
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C21H17N5O2/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 317 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291363
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)Show SMILES C(N1CCOCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H26N6O3/c1-2-19(18-4-5-27-21(18)3-1)24-29-22-20-14-17(16-31-6-10-33-11-7-31)15-28-26(20)35-23(22)25(30-24)32-8-12-34-13-9-32/h1-5,14-15,27H,6-13,16H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 355 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291360
(US9580442, Example H | US9938290, H | [2-(1H-Indol...)Show SMILES CN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C24H24N6O2/c1-29(2)14-15-12-18-20-21(32-24(18)26-13-15)23(30-8-10-31-11-9-30)28-22(27-20)17-4-3-5-19-16(17)6-7-25-19/h3-7,12-13,25H,8-11,14H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM291361
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 503 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291361
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 508 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291366
(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)Show SMILES N#CCCN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1 Show InChI InChI=1S/C29H30N8O2/c30-6-2-8-35-9-11-36(12-10-35)19-20-17-23-25-26(39-29(23)32-18-20)28(37-13-15-38-16-14-37)34-27(33-25)22-3-1-4-24-21(22)5-7-31-24/h1,3-5,7,17-18,31H,2,8-16,19H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 597 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291364
(US9580442, Example L | US9938290, L | [2-(1H-Indol...)Show SMILES COCCN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H28N6O3/c1-31(8-11-33-2)16-17-14-20-22-23(35-26(20)28-15-17)25(32-9-12-34-13-10-32)30-24(29-22)19-4-3-5-21-18(19)6-7-27-21/h3-7,14-15,27H,8-13,16H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 604 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291357
(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 627 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM291362
(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)Show SMILES CN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1 Show InChI InChI=1S/C27H29N7O2/c1-32-7-9-33(10-8-32)17-18-15-21-23-24(36-27(21)29-16-18)26(34-11-13-35-14-12-34)31-25(30-23)20-3-2-4-22-19(20)5-6-28-22/h2-6,15-16,28H,7-14,17H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291354
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3sc12)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C21H17N5OS/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 873 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291362
(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)Show SMILES CN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1 Show InChI InChI=1S/C27H29N7O2/c1-32-7-9-33(10-8-32)17-18-15-21-23-24(36-27(21)29-16-18)26(34-11-13-35-14-12-34)31-25(30-23)20-3-2-4-22-19(20)5-6-28-22/h2-6,15-16,28H,7-14,17H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291359
((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)Show SMILES CN(C)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H24N6O3/c1-31(2)21(33)7-6-16-14-19-22-23(35-26(19)28-15-16)25(32-10-12-34-13-11-32)30-24(29-22)18-4-3-5-20-17(18)8-9-27-20/h3-9,14-15,27H,10-13H2,1-2H3/b7-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291364
(US9580442, Example L | US9938290, L | [2-(1H-Indol...)Show SMILES COCCN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C26H28N6O3/c1-31(8-11-33-2)16-17-14-20-22-23(35-26(20)28-15-17)25(32-9-12-34-13-10-32)30-24(29-22)19-4-3-5-21-18(19)6-7-27-21/h3-7,14-15,27H,8-13,16H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM291366
(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)Show SMILES N#CCCN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1 Show InChI InChI=1S/C29H30N8O2/c30-6-2-8-35-9-11-36(12-10-35)19-20-17-23-25-26(39-29(23)32-18-20)28(37-13-15-38-16-14-37)34-27(33-25)22-3-1-4-24-21(22)5-7-31-24/h1,3-5,7,17-18,31H,2,8-16,19H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Karus Therapeutics Limited
US Patent
| Assay Description PI3K Isoform using biochemical assay. |
US Patent US9580442 (2017)
BindingDB Entry DOI: 10.7270/Q2J38VM2 |
More data for this Ligand-Target Pair | |