Found 46 hits Enz. Inhib. hit(s) with all data for assayid = 3 entry = 50044598 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021717
(CHEMBL3298414)Show SMILES OC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C21H25ClFN5O3/c22-16-9-13(1-2-17(16)23)19(12-29)27-21(30)28-6-3-14-10-24-20(26-18(14)11-28)25-15-4-7-31-8-5-15/h1-2,9-10,15,19,29H,3-8,11-12H2,(H,27,30)(H,24,25,26)/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021714
(CHEMBL3298418)Show SMILES C[C@@H](NC(=O)N1CCc2cnc(Nc3ccnc(C)c3)nc2C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C22H22Cl2N6O/c1-13-9-17(5-7-25-13)28-21-26-11-16-6-8-30(12-20(16)29-21)22(31)27-14(2)15-3-4-18(23)19(24)10-15/h3-5,7,9-11,14H,6,8,12H2,1-2H3,(H,27,31)(H,25,26,28,29)/t14-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021709
(CHEMBL3298308)Show SMILES C[C@@H](CO)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](C)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C19H23Cl2N5O2/c1-11(10-27)23-18-22-8-14-5-6-26(9-17(14)25-18)19(28)24-12(2)13-3-4-15(20)16(21)7-13/h3-4,7-8,11-12,27H,5-6,9-10H2,1-2H3,(H,24,28)(H,22,23,25)/t11-,12+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021715
(CHEMBL3298419)Show SMILES C[C@@H](NC(=O)N1CCc2cnc(Nc3cn[nH]c3)nc2C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C19H19Cl2N7O/c1-11(12-2-3-15(20)16(21)6-12)25-19(29)28-5-4-13-7-22-18(27-17(13)10-28)26-14-8-23-24-9-14/h2-3,6-9,11H,4-5,10H2,1H3,(H,23,24)(H,25,29)(H,22,26,27)/t11-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021719
(CHEMBL3298982)Show SMILES OC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C21H25Cl2N5O3/c22-16-2-1-13(9-17(16)23)19(12-29)27-21(30)28-6-3-14-10-24-20(26-18(14)11-28)25-15-4-7-31-8-5-15/h1-2,9-10,15,19,29H,3-8,11-12H2,(H,27,30)(H,24,25,26)/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021716
(CHEMBL3298420)Show SMILES C[C@@H](NC(=O)N1CCc2cnc(Nc3ccn[nH]3)nc2C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C19H19Cl2N7O/c1-11(12-2-3-14(20)15(21)8-12)24-19(29)28-7-5-13-9-22-18(25-16(13)10-28)26-17-4-6-23-27-17/h2-4,6,8-9,11H,5,7,10H2,1H3,(H,24,29)(H2,22,23,25,26,27)/t11-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021721
(CHEMBL3298984)Show SMILES C[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C21H25ClFN5O2/c1-13(14-2-3-17(22)18(23)10-14)25-21(29)28-7-4-15-11-24-20(27-19(15)12-28)26-16-5-8-30-9-6-16/h2-3,10-11,13,16H,4-9,12H2,1H3,(H,25,29)(H,24,26,27)/t13-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021707
(CHEMBL3298985)Show SMILES CC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(C#N)c(Cl)c1 |r| Show InChI InChI=1S/C23H27ClN6O2/c1-2-20(15-3-4-16(12-25)19(24)11-15)29-23(31)30-8-5-17-13-26-22(28-21(17)14-30)27-18-6-9-32-10-7-18/h3-4,11,13,18,20H,2,5-10,14H2,1H3,(H,29,31)(H,26,27,28)/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021711
(CHEMBL3298310)Show SMILES CC[C@@H](NC(=O)N1CCc2cnc(N[C@@H](C)CO)nc2C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C20H25Cl2N5O2/c1-3-17(13-4-5-15(21)16(22)8-13)26-20(29)27-7-6-14-9-23-19(24-12(2)11-28)25-18(14)10-27/h4-5,8-9,12,17,28H,3,6-7,10-11H2,1-2H3,(H,26,29)(H,23,24,25)/t12-,17+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021708
(CHEMBL3298199)Show SMILES C[C@@H](NC(=O)N1CCc2cnc(N[C@H]3CCO[C@@H](CO)C3)nc2C1)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C22H27Cl2N5O3/c1-13(14-2-3-18(23)19(24)8-14)26-22(31)29-6-4-15-10-25-21(28-20(15)11-29)27-16-5-7-32-17(9-16)12-30/h2-3,8,10,13,16-17,30H,4-7,9,11-12H2,1H3,(H,26,31)(H,25,27,28)/t13-,16+,17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021720
(CHEMBL3298983)Show SMILES C[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc2cc[nH]c2c1 |r| Show InChI InChI=1S/C23H28N6O2/c1-15(17-3-2-16-4-8-24-20(16)12-17)26-23(30)29-9-5-18-13-25-22(28-21(18)14-29)27-19-6-10-31-11-7-19/h2-4,8,12-13,15,19,24H,5-7,9-11,14H2,1H3,(H,26,30)(H,25,27,28)/t15-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021718
(CHEMBL3298678)Show SMILES OC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C21H25ClFN5O3/c22-16-2-1-13(9-17(16)23)19(12-29)27-21(30)28-6-3-14-10-24-20(26-18(14)11-28)25-15-4-7-31-8-5-15/h1-2,9-10,15,19,29H,3-8,11-12H2,(H,27,30)(H,24,25,26)/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021736
(CHEMBL3297855 | US9133187, II-7)Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CN)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C19H24ClFN6O/c1-11(2)24-18-23-9-13-5-6-27(10-17(13)25-18)19(28)26-16(8-22)12-3-4-15(21)14(20)7-12/h3-4,7,9,11,16H,5-6,8,10,22H2,1-2H3,(H,26,28)(H,23,24,25)/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021733
(CHEMBL3297852)Show SMILES CC[C@H](O)[C@@H](NC(=O)N1CCc2cnc(NC(C)C)nc2C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C21H27ClFN5O2/c1-4-18(29)19(13-5-6-16(23)15(22)9-13)27-21(30)28-8-7-14-10-24-20(25-12(2)3)26-17(14)11-28/h5-6,9-10,12,18-19,29H,4,7-8,11H2,1-3H3,(H,27,30)(H,24,25,26)/t18-,19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021754
(CHEMBL3298417)Show SMILES OC[C@@H](NC(=O)N1CCc2cnc(N[C@H]3CC[C@H](O)C3)nc2C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C21H25ClFN5O3/c22-16-7-12(1-4-17(16)23)19(11-29)27-21(31)28-6-5-13-9-24-20(26-18(13)10-28)25-14-2-3-15(30)8-14/h1,4,7,9,14-15,19,29-30H,2-3,5-6,8,10-11H2,(H,27,31)(H,24,25,26)/t14-,15-,19+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021713
(CHEMBL3298312)Show SMILES CC[C@@H](NC(=O)N1CCc2cnc(N[C@@H](C)CO)nc2C1)c1ccc(OC)c(Cl)c1 |r| Show InChI InChI=1S/C21H28ClN5O3/c1-4-17(14-5-6-19(30-3)16(22)9-14)26-21(29)27-8-7-15-10-23-20(24-13(2)12-28)25-18(15)11-27/h5-6,9-10,13,17,28H,4,7-8,11-12H2,1-3H3,(H,26,29)(H,23,24,25)/t13-,17+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021731
(CHEMBL3297850)Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H]([C@@H](C)O)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C20H25ClFN5O2/c1-11(2)24-19-23-9-14-6-7-27(10-17(14)25-19)20(29)26-18(12(3)28)13-4-5-16(22)15(21)8-13/h4-5,8-9,11-12,18,28H,6-7,10H2,1-3H3,(H,26,29)(H,23,24,25)/t12-,18-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021760
(CHEMBL3298566)Show SMILES OC[C@@H](NC(=O)N1CCc2cnc(Nc3ccc(F)cc3)nc2C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C22H20ClF2N5O2/c23-17-9-13(1-6-18(17)25)20(12-31)29-22(32)30-8-7-14-10-26-21(28-19(14)11-30)27-16-4-2-15(24)3-5-16/h1-6,9-10,20,31H,7-8,11-12H2,(H,29,32)(H,26,27,28)/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021710
(CHEMBL3298309)Show SMILES CC[C@@H](NC(=O)N1CCc2cnc(N[C@@H](C)CO)nc2C1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C20H25F2N5O2/c1-3-17(13-4-5-15(21)16(22)8-13)26-20(29)27-7-6-14-9-23-19(24-12(2)11-28)25-18(14)10-27/h4-5,8-9,12,17,28H,3,6-7,10-11H2,1-2H3,(H,26,29)(H,23,24,25)/t12-,17+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021744
(CHEMBL3298415)Show SMILES CC(CO)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C19H23ClFN5O3/c1-11(9-27)23-18-22-7-13-4-5-26(8-16(13)24-18)19(29)25-17(10-28)12-2-3-15(21)14(20)6-12/h2-3,6-7,11,17,27-28H,4-5,8-10H2,1H3,(H,25,29)(H,22,23,24)/t11?,17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021712
(CHEMBL3298311)Show SMILES C[C@@H](CO)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](C)c1ccc(c(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C20H23F4N5O2/c1-11(10-30)26-18-25-8-14-5-6-29(9-17(14)28-18)19(31)27-12(2)13-3-4-15(16(21)7-13)20(22,23)24/h3-4,7-8,11-12,30H,5-6,9-10H2,1-2H3,(H,27,31)(H,25,26,28)/t11-,12+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021743
(CHEMBL3298307)Show SMILES OC[C@@H](NC(=O)N1CCc2cnc(NC3CCCC3)nc2C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C21H25ClFN5O2/c22-16-9-13(5-6-17(16)23)19(12-29)27-21(30)28-8-7-14-10-24-20(26-18(14)11-28)25-15-3-1-2-4-15/h5-6,9-10,15,19,29H,1-4,7-8,11-12H2,(H,27,30)(H,24,25,26)/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021730
(CHEMBL3297849)Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C19H23ClFN5O2/c1-11(2)23-18-22-8-13-5-6-26(9-16(13)24-18)19(28)25-17(10-27)12-3-4-15(21)14(20)7-12/h3-4,7-8,11,17,27H,5-6,9-10H2,1-2H3,(H,25,28)(H,22,23,24)/t17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021737
(CHEMBL3297856)Show SMILES CNC[C@@H](NC(=O)N1CCc2cnc(NC(C)C)nc2C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C20H26ClFN6O/c1-12(2)25-19-24-9-14-6-7-28(11-18(14)26-19)20(29)27-17(10-23-3)13-4-5-16(22)15(21)8-13/h4-5,8-9,12,17,23H,6-7,10-11H2,1-3H3,(H,27,29)(H,24,25,26)/t17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021766
(CHEMBL3298676)Show SMILES Cn1cc(Nc2ncc3CCN(Cc3n2)C(=O)N[C@H](CO)c2ccc(F)c(Cl)c2)cn1 |r| Show InChI InChI=1S/C20H21ClFN7O2/c1-28-9-14(8-24-28)25-19-23-7-13-4-5-29(10-17(13)26-19)20(31)27-18(11-30)12-2-3-16(22)15(21)6-12/h2-3,6-9,18,30H,4-5,10-11H2,1H3,(H,27,31)(H,23,25,26)/t18-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021732
(CHEMBL3297851 | US9133187, II-40)Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H]([C@H](C)O)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C20H25ClFN5O2/c1-11(2)24-19-23-9-14-6-7-27(10-17(14)25-19)20(29)26-18(12(3)28)13-4-5-16(22)15(21)8-13/h4-5,8-9,11-12,18,28H,6-7,10H2,1-3H3,(H,26,29)(H,23,24,25)/t12-,18+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021739
(CHEMBL3297858 | US9133187, II-43)Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CNS(C)(=O)=O)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C20H26ClFN6O3S/c1-12(2)25-19-23-9-14-6-7-28(11-18(14)26-19)20(29)27-17(10-24-32(3,30)31)13-4-5-16(22)15(21)8-13/h4-5,8-9,12,17,24H,6-7,10-11H2,1-3H3,(H,27,29)(H,23,25,26)/t17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021767
(CHEMBL3298677)Show SMILES Cc1cc(Nc2ncc3CCN(Cc3n2)C(=O)N[C@H](CO)c2ccc(F)c(Cl)c2)ccn1 |r| Show InChI InChI=1S/C22H22ClFN6O2/c1-13-8-16(4-6-25-13)27-21-26-10-15-5-7-30(11-19(15)28-21)22(32)29-20(12-31)14-2-3-18(24)17(23)9-14/h2-4,6,8-10,20,31H,5,7,11-12H2,1H3,(H,29,32)(H,25,26,27,28)/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021738
(CHEMBL3297857)Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CNCCO)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C21H28ClFN6O2/c1-13(2)26-20-25-10-15-5-7-29(12-19(15)27-20)21(31)28-18(11-24-6-8-30)14-3-4-17(23)16(22)9-14/h3-4,9-10,13,18,24,30H,5-8,11-12H2,1-2H3,(H,28,31)(H,25,26,27)/t18-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021742
(CHEMBL3298306)Show SMILES OCCNc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C18H21ClFN5O3/c19-13-7-11(1-2-14(13)20)16(10-27)24-18(28)25-5-3-12-8-22-17(21-4-6-26)23-15(12)9-25/h1-2,7-8,16,26-27H,3-6,9-10H2,(H,24,28)(H,21,22,23)/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021764
(CHEMBL3298568)Show SMILES CCC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C20H25ClFN5O2/c1-3-12(2)24-19-23-9-14-6-7-27(10-17(14)25-19)20(29)26-18(11-28)13-4-5-16(22)15(21)8-13/h4-5,8-9,12,18,28H,3,6-7,10-11H2,1-2H3,(H,26,29)(H,23,24,25)/t12?,18-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021734
(CHEMBL3297853)Show SMILES COC[C@@H](NC(=O)N1CCc2cnc(NC(C)C)nc2C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C20H25ClFN5O2/c1-12(2)24-19-23-9-14-6-7-27(10-17(14)25-19)20(28)26-18(11-29-3)13-4-5-16(22)15(21)8-13/h4-5,8-9,12,18H,6-7,10-11H2,1-3H3,(H,26,28)(H,23,24,25)/t18-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021741
(CHEMBL3298305)Show SMILES CCNc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C18H21ClFN5O2/c1-2-21-17-22-8-12-5-6-25(9-15(12)23-17)18(27)24-16(10-26)11-3-4-14(20)13(19)7-11/h3-4,7-8,16,26H,2,5-6,9-10H2,1H3,(H,24,27)(H,21,22,23)/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021762
(CHEMBL3298567 | US9133187, II-34)Show SMILES Cc1noc(C)c1Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C21H22ClFN6O3/c1-11-19(12(2)32-28-11)27-20-24-8-14-5-6-29(9-17(14)25-20)21(31)26-18(10-30)13-3-4-16(23)15(22)7-13/h3-4,7-8,18,30H,5-6,9-10H2,1-2H3,(H,26,31)(H,24,25,27)/t18-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021745
(CHEMBL3298416)Show SMILES CC(C)(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C20H25ClFN5O2/c1-20(2,3)26-18-23-9-13-6-7-27(10-16(13)24-18)19(29)25-17(11-28)12-4-5-15(22)14(21)8-12/h4-5,8-9,17,28H,6-7,10-11H2,1-3H3,(H,25,29)(H,23,24,26)/t17-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021740
(CHEMBL3298304)Show SMILES CNc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C17H19ClFN5O2/c1-20-16-21-7-11-4-5-24(8-14(11)22-16)17(26)23-15(9-25)10-2-3-13(19)12(18)6-10/h2-3,6-7,15,25H,4-5,8-9H2,1H3,(H,23,26)(H,20,21,22)/t15-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021729
(CHEMBL3297848)Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)NCc1ccc(F)c(Cl)c1 Show InChI InChI=1S/C18H21ClFN5O/c1-11(2)23-17-21-9-13-5-6-25(10-16(13)24-17)18(26)22-8-12-3-4-15(20)14(19)7-12/h3-4,7,9,11H,5-6,8,10H2,1-2H3,(H,22,26)(H,21,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021724
(CHEMBL3298672)Show InChI InChI=1S/C18H22FN5O/c1-12(2)22-17-20-10-14-7-8-24(11-16(14)23-17)18(25)21-9-13-3-5-15(19)6-4-13/h3-6,10,12H,7-9,11H2,1-2H3,(H,21,25)(H,20,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021728
(CHEMBL3297847)Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)NCc1ccc(Cl)c(F)c1 Show InChI InChI=1S/C18H21ClFN5O/c1-11(2)23-17-21-9-13-5-6-25(10-16(13)24-17)18(26)22-8-12-3-4-14(19)15(20)7-12/h3-4,7,9,11H,5-6,8,10H2,1-2H3,(H,22,26)(H,21,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021727
(CHEMBL3298894)Show InChI InChI=1S/C18H22ClN5O/c1-12(2)22-17-20-10-14-6-7-24(11-16(14)23-17)18(25)21-9-13-4-3-5-15(19)8-13/h3-5,8,10,12H,6-7,9,11H2,1-2H3,(H,21,25)(H,20,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021725
(CHEMBL3298673)Show InChI InChI=1S/C18H22ClN5O/c1-12(2)22-17-20-10-14-7-8-24(11-16(14)23-17)18(25)21-9-13-3-5-15(19)6-4-13/h3-6,10,12H,7-9,11H2,1-2H3,(H,21,25)(H,20,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021726
(CHEMBL3298674)Show InChI InChI=1S/C18H22FN5O/c1-12(2)22-17-20-10-14-6-7-24(11-16(14)23-17)18(25)21-9-13-4-3-5-15(19)8-13/h3-5,8,10,12H,6-7,9,11H2,1-2H3,(H,21,25)(H,20,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021765
(CHEMBL3298675)Show SMILES CC(=O)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CO)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C18H19ClFN5O3/c1-10(27)22-17-21-7-12-4-5-25(8-15(12)23-17)18(28)24-16(9-26)11-2-3-14(20)13(19)6-11/h2-3,6-7,16,26H,4-5,8-9H2,1H3,(H,24,28)(H,21,22,23,27)/t16-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021722
(CHEMBL3298565)Show InChI InChI=1S/C19H25N5O2/c1-13(2)22-18-20-11-15-8-9-24(12-17(15)23-18)19(25)21-10-14-4-6-16(26-3)7-5-14/h4-7,11,13H,8-10,12H2,1-3H3,(H,21,25)(H,20,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021735
(CHEMBL3297854)Show SMILES COCCOC[C@@H](NC(=O)N1CCc2cnc(NC(C)C)nc2C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C22H29ClFN5O3/c1-14(2)26-21-25-11-16-6-7-29(12-19(16)27-21)22(30)28-20(13-32-9-8-31-3)15-4-5-18(24)17(23)10-15/h4-5,10-11,14,20H,6-9,12-13H2,1-3H3,(H,28,30)(H,25,26,27)/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50021723
(CHEMBL3298671)Show InChI InChI=1S/C18H23N5O/c1-13(2)21-17-19-11-15-8-9-23(12-16(15)22-17)18(24)20-10-14-6-4-3-5-7-14/h3-7,11,13H,8-10,12H2,1-2H3,(H,20,24)(H,19,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 283 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... |
Bioorg Med Chem Lett 24: 2635-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.068
BindingDB Entry DOI: 10.7270/Q2FQ9Z54 |
More data for this
Ligand-Target Pair | |
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