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PubMed code 15916422

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13321
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid (2-Bromoally...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC(Br)=C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C22H24BrN7O2S/c1-16(23)10-30(33(31,32)22-13-27(2)15-26-22)19-7-18-6-17(8-24)4-5-21(18)29(11-19)12-20-9-25-14-28(20)3/h4-6,9,13-15,19H,1,7,10-12H2,2-3H3
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n/an/a 0.400n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13320
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid [6-Cyano-1-(...)
Show SMILES CC(=C)CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C23H27N7O2S/c1-17(2)11-30(33(31,32)23-14-27(3)16-26-23)20-8-19-7-18(9-24)5-6-22(19)29(12-20)13-21-10-25-15-28(21)4/h5-7,10,14-16,20H,1,8,11-13H2,2-4H3
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n/an/a 0.600n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13323
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-[6-cy...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(Cc1ccccc1)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C26H27N7O2S/c1-30-17-26(29-19-30)36(34,35)33(14-20-6-4-3-5-7-20)23-11-22-10-21(12-27)8-9-25(22)32(15-23)16-24-13-28-18-31(24)2/h3-10,13,17-19,23H,11,14-16H2,1-2H3
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n/an/a 0.600n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13320
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid [6-Cyano-1-(...)
Show SMILES CC(=C)CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C23H27N7O2S/c1-17(2)11-30(33(31,32)23-14-27(3)16-26-23)20-8-19-7-18(9-24)5-6-22(19)29(12-20)13-21-10-25-15-28(21)4/h5-7,10,14-16,20H,1,8,11-13H2,2-4H3
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n/an/a 0.700n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13321
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid (2-Bromoally...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC(Br)=C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C22H24BrN7O2S/c1-16(23)10-30(33(31,32)22-13-27(2)15-26-22)19-7-18-6-17(8-24)4-5-21(18)29(11-19)12-20-9-25-14-28(20)3/h4-6,9,13-15,19H,1,7,10-12H2,2-3H3
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n/an/a 0.800n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13328
PNG
(N-{6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1...)
Show SMILES Cc1onc(c1CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1ccccn1)-c1ccccc1
Show InChI InChI=1S/C31H29N7O3S/c1-22-28(31(35-41-22)24-8-4-3-5-9-24)20-38(42(39,40)30-10-6-7-13-34-30)26-15-25-14-23(16-32)11-12-29(25)37(18-26)19-27-17-33-21-36(27)2/h3-14,17,21,26H,15,18-20H2,1-2H3
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n/an/a 0.800n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13319
PNG
(BMS-386914 | CHEMBL183536 | [[6-Cyano-1-(3-methyl-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC(=O)OC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C25H31N7O4S/c1-25(2,3)36-24(33)15-32(37(34,35)23-14-29(4)17-28-23)20-9-19-8-18(10-26)6-7-22(19)31(12-20)13-21-11-27-16-30(21)5/h6-8,11,14,16-17,20H,9,12-13,15H2,1-5H3
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n/an/a 0.900n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13325
PNG
(4-{[[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC1CCN(CC1)C(=O)OC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C30H40N8O4S/c1-30(2,3)42-29(39)36-10-8-22(9-11-36)16-38(43(40,41)28-19-34(4)21-33-28)25-13-24-12-23(14-31)6-7-27(24)37(17-25)18-26-15-32-20-35(26)5/h6-7,12,15,19-22,25H,8-11,13,16-18H2,1-5H3
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n/an/a 1.10n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13322
PNG
(N-tert-Butyl-2-[[6-cyano-1-(3-methyl-3H-imidazol-4...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC(=O)NC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C25H32N8O3S/c1-25(2,3)29-23(34)14-33(37(35,36)24-15-30(4)17-28-24)20-9-19-8-18(10-26)6-7-22(19)32(12-20)13-21-11-27-16-31(21)5/h6-8,11,15-17,20H,9,12-14H2,1-5H3,(H,29,34)
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n/an/a 1.20n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13319
PNG
(BMS-386914 | CHEMBL183536 | [[6-Cyano-1-(3-methyl-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC(=O)OC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C25H31N7O4S/c1-25(2,3)36-24(33)15-32(37(34,35)23-14-29(4)17-28-23)20-9-19-8-18(10-26)6-7-22(19)31(12-20)13-21-11-27-16-30(21)5/h6-8,11,14,16-17,20H,9,12-13,15H2,1-5H3
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Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13323
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-[6-cy...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(Cc1ccccc1)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C26H27N7O2S/c1-30-17-26(29-19-30)36(34,35)33(14-20-6-4-3-5-7-20)23-11-22-10-21(12-27)8-9-25(22)32(15-23)16-24-13-28-18-31(24)2/h3-10,13,17-19,23H,11,14-16H2,1-2H3
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Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13331
PNG
(N-tert-butyl-2-({6-isocyano-1-[(1-methyl-1H-imidaz...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)[N+]#[C-])N(CC(=O)NC(C)(C)C)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)30-24(34)17-33(37(35,36)25-8-6-7-11-29-25)21-13-19-12-20(27-4)9-10-23(19)32(15-21)16-22-14-28-18-31(22)5/h6-12,14,18,21H,13,15-17H2,1-3,5H3,(H,30,34)
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n/an/a 1.40n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13322
PNG
(N-tert-Butyl-2-[[6-cyano-1-(3-methyl-3H-imidazol-4...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC(=O)NC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C25H32N8O3S/c1-25(2,3)29-23(34)14-33(37(35,36)24-15-30(4)17-28-24)20-9-19-8-18(10-26)6-7-22(19)32(12-20)13-21-11-27-16-31(21)5/h6-8,11,15-17,20H,9,12-14H2,1-5H3,(H,29,34)
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Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13324
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid [6-Cyano-1-(...)
Show SMILES Cc1ccccc1CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C27H29N7O2S/c1-20-6-4-5-7-22(20)14-34(37(35,36)27-17-31(2)19-30-27)24-11-23-10-21(12-28)8-9-26(23)33(15-24)16-25-13-29-18-32(25)3/h4-10,13,17-19,24H,11,14-16H2,1-3H3
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University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13331
PNG
(N-tert-butyl-2-({6-isocyano-1-[(1-methyl-1H-imidaz...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)[N+]#[C-])N(CC(=O)NC(C)(C)C)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)30-24(34)17-33(37(35,36)25-8-6-7-11-29-25)21-13-19-12-20(27-4)9-10-23(19)32(15-21)16-22-14-28-18-31(22)5/h6-12,14,18,21H,13,15-17H2,1-3,5H3,(H,30,34)
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Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13327
PNG
(N-{6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1ccccn1)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C26H25N7O2S/c1-31-19-28-15-24(31)18-32-17-23(13-21-12-20(14-27)8-9-25(21)32)33(16-22-6-2-4-10-29-22)36(34,35)26-7-3-5-11-30-26/h2-12,15,19,23H,13,16-18H2,1H3
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n/an/a 2.80n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13328
PNG
(N-{6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1...)
Show SMILES Cc1onc(c1CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1ccccn1)-c1ccccc1
Show InChI InChI=1S/C31H29N7O3S/c1-22-28(31(35-41-22)24-8-4-3-5-9-24)20-38(42(39,40)30-10-6-7-13-34-30)26-15-25-14-23(16-32)11-12-29(25)37(18-26)19-27-17-33-21-36(27)2/h3-14,17,21,26H,15,18-20H2,1-2H3
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University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13325
PNG
(4-{[[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC1CCN(CC1)C(=O)OC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C30H40N8O4S/c1-30(2,3)42-29(39)36-10-8-22(9-11-36)16-38(43(40,41)28-19-34(4)21-33-28)25-13-24-12-23(14-31)6-7-27(24)37(17-25)18-26-15-32-20-35(26)5/h6-7,12,15,19-22,25H,8-11,13,16-18H2,1-5H3
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n/an/a 3.20n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13324
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid [6-Cyano-1-(...)
Show SMILES Cc1ccccc1CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C27H29N7O2S/c1-20-6-4-5-7-22(20)14-34(37(35,36)27-17-31(2)19-30-27)24-11-23-10-21(12-28)8-9-26(23)33(15-24)16-25-13-29-18-32(25)3/h4-10,13,17-19,24H,11,14-16H2,1-3H3
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n/an/a 3.40n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13327
PNG
(N-{6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1ccccn1)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C26H25N7O2S/c1-31-19-28-15-24(31)18-32-17-23(13-21-12-20(14-27)8-9-25(21)32)33(16-22-6-2-4-10-29-22)36(34,35)26-7-3-5-11-30-26/h2-12,15,19,23H,13,16-18H2,1H3
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n/an/a 3.80n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM16180
PNG
((2S)-2-{[4-({[(2S)-1-cyclohexyl-3-(ethylsulfanyl)p...)
Show SMILES CCSC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C(O)=O)c(c1)-c1ccccc1C |r|
Show InChI InChI=1S/C31H44N2O3S2/c1-4-38-21-25(18-23-11-6-5-7-12-23)32-20-24-14-15-27(28(19-24)26-13-9-8-10-22(26)2)30(34)33-29(31(35)36)16-17-37-3/h8-10,13-15,19,23,25,29,32H,4-7,11-12,16-18,20-21H2,1-3H3,(H,33,34)(H,35,36)/t25-,29-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13335
PNG
(N-tert-Butyl-2-[[6-cyano-1-(3-methyl-3H-imidazol-4...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(CC(=O)NC(C)(C)C)S(=O)(=O)c1nccn1C
Show InChI InChI=1S/C25H32N8O3S/c1-25(2,3)29-23(34)16-33(37(35,36)24-28-8-9-30(24)4)20-11-19-10-18(12-26)6-7-22(19)32(14-20)15-21-13-27-17-31(21)5/h6-10,13,17,20H,11,14-16H2,1-5H3,(H,29,34)
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n/an/a 5n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13332
PNG
(N-tert-Butyl-2-[[6-isocyano-1-(3-methyl-3H-imidazo...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)[N+]#[C-])N(CC(=O)NC(C)(C)C)S(=O)(=O)c1cccnc1
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)30-25(34)17-33(37(35,36)23-7-6-10-28-14-23)21-12-19-11-20(27-4)8-9-24(19)32(15-21)16-22-13-29-18-31(22)5/h6-11,13-14,18,21H,12,15-17H2,1-3,5H3,(H,30,34)
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n/an/a 6n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13334
PNG
(N-tert-Butyl-2-[[6-cyano-1-(3-methyl-3H-imidazol-4...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(CC(=O)NC(C)(C)C)S(=O)(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C28H33FN6O3S/c1-28(2,3)32-27(36)17-35(39(37,38)18-20-5-8-23(29)9-6-20)24-12-22-11-21(13-30)7-10-26(22)34(15-24)16-25-14-31-19-33(25)4/h5-11,14,19,24H,12,15-18H2,1-4H3,(H,32,36)
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n/an/a 7.60n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13335
PNG
(N-tert-Butyl-2-[[6-cyano-1-(3-methyl-3H-imidazol-4...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(CC(=O)NC(C)(C)C)S(=O)(=O)c1nccn1C
Show InChI InChI=1S/C25H32N8O3S/c1-25(2,3)29-23(34)16-33(37(35,36)24-28-8-9-30(24)4)20-11-19-10-18(12-26)6-7-22(19)32(14-20)15-21-13-27-17-31(21)5/h6-10,13,17,20H,11,14-16H2,1-5H3,(H,29,34)
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n/an/a 8n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM16178
PNG
(3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-(thiophen-2-...)
Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1)C#N)c1cccs1
Show InChI InChI=1S/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11,14,18,23H,12,15-17H2,(H,27,28)
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n/an/a 8n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM16181
PNG
(1-[2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imid...)
Show SMILES Cn1cncc1C(O)(CN1CCC(C#N)=C(C1)c1cccc2ccccc12)c1ccc(cc1)C#N |c:15|
Show InChI InChI=1S/C29H25N5O/c1-33-20-32-17-28(33)29(35,24-11-9-21(15-30)10-12-24)19-34-14-13-23(16-31)27(18-34)26-8-4-6-22-5-2-3-7-25(22)26/h2-12,17,20,35H,13-14,18-19H2,1H3
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n/an/a 9n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13330
PNG
(N-[(6-chloro-2,1,3-benzothiadiazol-5-yl)methyl]-N-...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1cc2nsnc2cc1Cl)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C27H23ClN8O2S2/c1-34-17-30-13-22(34)16-35-15-21(9-19-8-18(12-29)5-6-26(19)35)36(40(37,38)27-4-2-3-7-31-27)14-20-10-24-25(11-23(20)28)33-39-32-24/h2-8,10-11,13,17,21H,9,14-16H2,1H3
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n/an/a 10n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM16182
PNG
((2S)-2-[(4-{[(1H-imidazol-4-ylmethyl)amino]methyl}...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C)C(O)=O |r|
Show InChI InChI=1S/C24H28N4O3S/c1-16-5-3-4-6-19(16)21-11-17(12-25-13-18-14-26-15-27-18)7-8-20(21)23(29)28-22(24(30)31)9-10-32-2/h3-8,11,14-15,22,25H,9-10,12-13H2,1-2H3,(H,26,27)(H,28,29)(H,30,31)/t22-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM14434
PNG
(6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...)
Show SMILES Cn1cncc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3
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n/an/a 17n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13332
PNG
(N-tert-Butyl-2-[[6-isocyano-1-(3-methyl-3H-imidazo...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)[N+]#[C-])N(CC(=O)NC(C)(C)C)S(=O)(=O)c1cccnc1
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)30-25(34)17-33(37(35,36)23-7-6-10-28-14-23)21-12-19-11-20(27-4)8-9-24(19)32(15-21)16-22-13-29-18-31(22)5/h6-11,13-14,18,21H,12,15-17H2,1-3,5H3,(H,30,34)
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n/an/a 25n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13326
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid (1-Bromonaph...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(Cc1ccc2ccccc2c1Br)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C30H28BrN7O2S/c1-35-18-29(34-20-35)41(39,40)38(15-23-9-8-22-5-3-4-6-27(22)30(23)31)25-12-24-11-21(13-32)7-10-28(24)37(16-25)17-26-14-33-19-36(26)2/h3-11,14,18-20,25H,12,15-17H2,1-2H3
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n/an/a 28n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13334
PNG
(N-tert-Butyl-2-[[6-cyano-1-(3-methyl-3H-imidazol-4...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(CC(=O)NC(C)(C)C)S(=O)(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C28H33FN6O3S/c1-28(2,3)32-27(36)17-35(39(37,38)18-20-5-8-23(29)9-6-20)24-12-22-11-21(13-30)7-10-26(22)34(15-24)16-25-14-31-19-33(25)4/h5-11,14,19,24H,12,15-18H2,1-4H3,(H,32,36)
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n/an/a 42n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13330
PNG
(N-[(6-chloro-2,1,3-benzothiadiazol-5-yl)methyl]-N-...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1cc2nsnc2cc1Cl)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C27H23ClN8O2S2/c1-34-17-30-13-22(34)16-35-15-21(9-19-8-18(12-29)5-6-26(19)35)36(40(37,38)27-4-2-3-7-31-27)14-20-10-24-25(11-23(20)28)33-39-32-24/h2-8,10-11,13,17,21H,9,14-16H2,1H3
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n/an/a 55n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM16179
PNG
(4-{[5-({[(3S)-1-(3-chlorobenzyl)-2-oxopyrrolidin-3...)
Show SMILES Clc1cccc(CN2CC[C@H](NCc3cncn3Cc3ccc(cc3)C#N)C2=O)c1 |r|
Show InChI InChI=1S/C23H22ClN5O/c24-20-3-1-2-19(10-20)15-28-9-8-22(23(28)30)27-13-21-12-26-16-29(21)14-18-6-4-17(11-25)5-7-18/h1-7,10,12,16,22,27H,8-9,13-15H2/t22-/m0/s1
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University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13333
PNG
(N-tert-Butyl-2-[[6-isocyano-1-(3-methyl-3H-imidazo...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)[N+]#[C-])N(CC(=O)NC(C)(C)C)S(=O)(=O)c1ccncc1
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)30-25(34)17-33(37(35,36)23-8-10-28-11-9-23)21-13-19-12-20(27-4)6-7-24(19)32(15-21)16-22-14-29-18-31(22)5/h6-12,14,18,21H,13,15-17H2,1-3,5H3,(H,30,34)
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n/an/a 160n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13329
PNG
(N-[(1-bromonaphthalen-2-yl)methyl]-N-{6-cyano-1-[(...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1ccc2ccccc2c1Br)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C31H27BrN6O2S/c1-36-21-34-17-27(36)20-37-19-26(15-25-14-22(16-33)9-12-29(25)37)38(41(39,40)30-8-4-5-13-35-30)18-24-11-10-23-6-2-3-7-28(23)31(24)32/h2-14,17,21,26H,15,18-20H2,1H3
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n/an/a 165n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM14459
PNG
((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |r|
Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
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n/an/a>250n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13329
PNG
(N-[(1-bromonaphthalen-2-yl)methyl]-N-{6-cyano-1-[(...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1ccc2ccccc2c1Br)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C31H27BrN6O2S/c1-36-21-34-17-27(36)20-37-19-26(15-25-14-22(16-33)9-12-29(25)37)38(41(39,40)30-8-4-5-13-35-30)18-24-11-10-23-6-2-3-7-28(23)31(24)32/h2-14,17,21,26H,15,18-20H2,1H3
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n/an/a 440n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM13333
PNG
(N-tert-Butyl-2-[[6-isocyano-1-(3-methyl-3H-imidazo...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)[N+]#[C-])N(CC(=O)NC(C)(C)C)S(=O)(=O)c1ccncc1
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)30-25(34)17-33(37(35,36)23-8-10-28-11-9-23)21-13-19-12-20(27-4)6-7-24(19)32(15-21)16-22-14-29-18-31(22)5/h6-12,14,18,21H,13,15-17H2,1-3,5H3,(H,30,34)
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n/an/a 1.00E+3n/an/an/an/a7.537



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
ATP-dependent RNA helicase RhlE


(Plasmodium falciparum (malaria parasite P. falcipa...)		BDBM16183
PNG
(Hamilton/Sebti Compound 10b | benzyl (2S)-2-[(4-{[...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C31H34N4O3S/c1-22-8-6-7-11-26(22)28-16-24(17-32-18-25-19-33-21-34-25)12-13-27(28)30(36)35-29(14-15-39-2)31(37)38-20-23-9-4-3-5-10-23/h3-13,16,19,21,29,32H,14-15,17-18,20H2,1-2H3,(H,33,34)(H,35,36)/t29-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus (rat))		BDBM13326
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid (1-Bromonaph...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(Cc1ccc2ccccc2c1Br)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C30H28BrN7O2S/c1-35-18-29(34-20-35)41(39,40)38(15-23-9-8-22-5-3-4-6-27(22)30(23)31)25-12-24-11-21(13-32)7-10-28(24)37(16-25)17-26-14-33-19-36(26)2/h3-11,14,18-20,25H,12,15-17H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...

J Med Chem 48: 3704-13 (2005)


Article DOI: 10.1021/jm0491039
BindingDB Entry DOI: 10.7270/Q2BC3WSQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%