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PubMed code 15999992

Compile data set for download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a 3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CDK5/p35


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
CDK2/Cyclin A/Cyclin A1


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a 7n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against CDK2/cyclin A


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a 21n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of cyclin dependent kinase CDK1


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a 21n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50169895
PNG
(3-{5-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cncc(c1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(8-13)23-17-22-11-21-16(24-17)12-7-15(10-19-9-12)20-5-2-6-25/h1,3-4,7-11,20,25H,2,5-6H2,(H,21,22,23,24)
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n/an/a 60n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of cyclin dependent kinase (CDK1)


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a 126n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin H


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a 308n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CDK4/cyclin D1


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50169896
PNG
(3-{5-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-ylamino)-[...)
Show SMILES OCCCNc1cncc(c1)-c1ncnc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C19H20N6O3/c26-5-1-4-21-15-8-13(10-20-11-15)18-22-12-23-19(25-18)24-14-2-3-16-17(9-14)28-7-6-27-16/h2-3,8-12,21,26H,1,4-7H2,(H,22,23,24,25)
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n/an/a 344n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of cyclin dependent kinase (CDK1)


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
CDK6/G1/S-specific cyclin D3


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a 356n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of CDK6/cyclin D3


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50169894
PNG
(3-{6-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cncc(n1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C16H16ClN7O/c17-11-3-1-4-12(7-11)22-16-21-10-20-15(24-16)13-8-18-9-14(23-13)19-5-2-6-25/h1,3-4,7-10,25H,2,5-6H2,(H,19,23)(H,20,21,22,24)
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n/an/a 971n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of cyclin dependent kinase (CDK1)


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50169897
PNG
(3-{4-[4-Amino-6-(3-chloro-phenylamino)-[1,3,5]tria...)
Show SMILES Nc1nc(Nc2cccc(Cl)c2)nc(n1)-c1ccnc(NCCCO)c1
Show InChI InChI=1S/C17H18ClN7O/c18-12-3-1-4-13(10-12)22-17-24-15(23-16(19)25-17)11-5-7-21-14(9-11)20-6-2-8-26/h1,3-5,7,9-10,26H,2,6,8H2,(H,20,21)(H3,19,22,23,24,25)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50169897
PNG
(3-{4-[4-Amino-6-(3-chloro-phenylamino)-[1,3,5]tria...)
Show SMILES Nc1nc(Nc2cccc(Cl)c2)nc(n1)-c1ccnc(NCCCO)c1
Show InChI InChI=1S/C17H18ClN7O/c18-12-3-1-4-13(10-12)22-17-24-15(23-16(19)25-17)11-5-7-21-14(9-11)20-6-2-8-26/h1,3-5,7,9-10,26H,2,6,8H2,(H,20,21)(H3,19,22,23,24,25)
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n/an/a 1.11E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of cyclin dependent kinase (CDK1)


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50169893
PNG
(3-{5-[4-(4-Morpholin-4-yl-phenylamino)-[1,3,5]tria...)
Show SMILES OCCCNc1cncc(c1)-c1ncnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C21H25N7O2/c29-9-1-6-23-18-12-16(13-22-14-18)20-24-15-25-21(27-20)26-17-2-4-19(5-3-17)28-7-10-30-11-8-28/h2-5,12-15,23,29H,1,6-11H2,(H,24,25,26,27)
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n/an/a 1.24E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of cyclin dependent kinase (CDK1)


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50169895
PNG
(3-{5-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cncc(c1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(8-13)23-17-22-11-21-16(24-17)12-7-15(10-19-9-12)20-5-2-6-25/h1,3-4,7-11,20,25H,2,5-6H2,(H,21,22,23,24)
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n/an/a 2.01E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a 3.05E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Casein kinase I


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50169896
PNG
(3-{5-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-ylamino)-[...)
Show SMILES OCCCNc1cncc(c1)-c1ncnc(Nc2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C19H20N6O3/c26-5-1-4-21-15-8-13(10-20-11-15)18-22-12-23-19(25-18)24-14-2-3-16-17(9-14)28-7-6-27-16/h2-3,8-12,21,26H,1,4-7H2,(H,22,23,24,25)
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n/an/a 4.14E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50169893
PNG
(3-{5-[4-(4-Morpholin-4-yl-phenylamino)-[1,3,5]tria...)
Show SMILES OCCCNc1cncc(c1)-c1ncnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C21H25N7O2/c29-9-1-6-23-18-12-16(13-22-14-18)20-24-15-25-21(27-20)26-17-2-4-19(5-3-17)28-7-10-30-11-8-28/h2-5,12-15,23,29H,1,6-11H2,(H,24,25,26,27)
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n/an/a 5.03E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor 1


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3/cAMP-dependent protein kinase alpha-catalytic subunit


(Homo sapiens (Human)-Oryctolagus cuniculus (Rabbit...)
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 1-cyclin B


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Platelet derived growth factor receptor


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of ERK 2


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PKB beta


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50169892
PNG
(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24)
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Fibroblast growth factor receptor 2


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50169894
PNG
(3-{6-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Show SMILES OCCCNc1cncc(n1)-c1ncnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C16H16ClN7O/c17-11-3-1-4-12(7-11)22-16-21-10-20-15(24-16)13-8-18-9-14(23-13)19-5-2-6-25/h1,3-4,7-10,25H,2,5-6H2,(H,19,23)(H,20,21,22,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 4535-46 (2005)


Article DOI: 10.1021/jm040214h
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%