Found 54 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273022
(1-(2,3-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)Show SMILES Cc1cccc(N2CCC(CC2)C(=O)Nc2ccc3OCC(=O)Nc3c2)c1C Show InChI InChI=1S/C22H25N3O3/c1-14-4-3-5-19(15(14)2)25-10-8-16(9-11-25)22(27)23-17-6-7-20-18(12-17)24-21(26)13-28-20/h3-7,12,16H,8-11,13H2,1-2H3,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273058
(CHEMBL457186 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES Fc1cc(cc(F)c1F)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H18F3N3O3/c21-14-8-13(9-15(22)19(14)23)26-5-3-11(4-6-26)20(28)24-12-1-2-17-16(7-12)25-18(27)10-29-17/h1-2,7-9,11H,3-6,10H2,(H,24,28)(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273024
(1-(3,4-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)Show SMILES Fc1ccc(cc1F)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H19F2N3O3/c21-15-3-2-14(10-16(15)22)25-7-5-12(6-8-25)20(27)23-13-1-4-18-17(9-13)24-19(26)11-28-18/h1-4,9-10,12H,5-8,11H2,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272980
(CHEMBL455958 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES Cc1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H23N3O3/c1-14-4-2-3-5-18(14)24-10-8-15(9-11-24)21(26)22-16-6-7-19-17(12-16)23-20(25)13-27-19/h2-7,12,15H,8-11,13H2,1H3,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272856
(CHEMBL497485 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES FC(F)(F)c1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H20F3N3O3/c22-21(23,24)14-2-1-3-16(10-14)27-8-6-13(7-9-27)20(29)25-15-4-5-18-17(11-15)26-19(28)12-30-18/h1-5,10-11,13H,6-9,12H2,(H,25,29)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272979
(CHEMBL509968 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES FC(F)(F)c1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H20F3N3O3/c22-21(23,24)15-3-1-2-4-17(15)27-9-7-13(8-10-27)20(29)25-14-5-6-18-16(11-14)26-19(28)12-30-18/h1-6,11,13H,7-10,12H2,(H,25,29)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272900
(1-(2-bromophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)Show SMILES Brc1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20BrN3O3/c21-15-3-1-2-4-17(15)24-9-7-13(8-10-24)20(26)22-14-5-6-18-16(11-14)23-19(25)12-27-18/h1-6,11,13H,7-10,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272982
(1-(2-isopropylphenyl)-N-(3-oxo-3,4-dihydro-2H-benz...)Show SMILES CC(C)c1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C23H27N3O3/c1-15(2)18-5-3-4-6-20(18)26-11-9-16(10-12-26)23(28)24-17-7-8-21-19(13-17)25-22(27)14-29-21/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,24,28)(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272983
(1-(2-bromo-3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H...)Show SMILES Fc1cccc(N2CCC(CC2)C(=O)Nc2ccc3OCC(=O)Nc3c2)c1Br Show InChI InChI=1S/C20H19BrFN3O3/c21-19-14(22)2-1-3-16(19)25-8-6-12(7-9-25)20(27)23-13-4-5-17-15(10-13)24-18(26)11-28-17/h1-5,10,12H,6-9,11H2,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272858
(1-(3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)Show SMILES Fc1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20FN3O3/c21-14-2-1-3-16(10-14)24-8-6-13(7-9-24)20(26)22-15-4-5-18-17(11-15)23-19(25)12-27-18/h1-5,10-11,13H,6-9,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272899
(1-(2-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)Show SMILES Clc1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20ClN3O3/c21-15-3-1-2-4-17(15)24-9-7-13(8-10-24)20(26)22-14-5-6-18-16(11-14)23-19(25)12-27-18/h1-6,11,13H,7-10,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272859
(1-(3-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)Show SMILES Clc1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20ClN3O3/c21-14-2-1-3-16(10-14)24-8-6-13(7-9-24)20(26)22-15-4-5-18-17(11-15)23-19(25)12-27-18/h1-5,10-11,13H,6-9,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 97 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273021
(1-(3-chloro-2-methylphenyl)-N-(3-oxo-3,4-dihydro-2...)Show SMILES Cc1c(Cl)cccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-16(22)3-2-4-18(13)25-9-7-14(8-10-25)21(27)23-15-5-6-19-17(11-15)24-20(26)12-28-19/h2-6,11,14H,7-10,12H2,1H3,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272981
(1-(2-ethylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)Show SMILES CCc1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C22H25N3O3/c1-2-15-5-3-4-6-19(15)25-11-9-16(10-12-25)22(27)23-17-7-8-20-18(13-17)24-21(26)14-28-20/h3-8,13,16H,2,9-12,14H2,1H3,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273057
(1-(3,5-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)Show SMILES Fc1cc(F)cc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H19F2N3O3/c21-13-7-14(22)9-16(8-13)25-5-3-12(4-6-25)20(27)23-15-1-2-18-17(10-15)24-19(26)11-28-18/h1-2,7-10,12H,3-6,11H2,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 137 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273023
(1-(4-tert-butylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)Show SMILES CC(C)(C)c1ccc(cc1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C24H29N3O3/c1-24(2,3)17-4-7-19(8-5-17)27-12-10-16(11-13-27)23(29)25-18-6-9-21-20(14-18)26-22(28)15-30-21/h4-9,14,16H,10-13,15H2,1-3H3,(H,25,29)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 142 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272897
(CHEMBL455926 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES Cc1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H23N3O3/c1-14-3-2-4-17(11-14)24-9-7-15(8-10-24)21(26)22-16-5-6-19-18(12-16)23-20(25)13-27-19/h2-6,11-12,15H,7-10,13H2,1H3,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 225 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273025
(1-(3,4-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)Show SMILES Cc1ccc(cc1C)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C22H25N3O3/c1-14-3-5-18(11-15(14)2)25-9-7-16(8-10-25)22(27)23-17-4-6-20-19(12-17)24-21(26)13-28-20/h3-6,11-12,16H,7-10,13H2,1-2H3,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 314 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272898
(1-(2-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)Show SMILES Fc1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20FN3O3/c21-15-3-1-2-4-17(15)24-9-7-13(8-10-24)20(26)22-14-5-6-18-16(11-14)23-19(25)12-27-18/h1-6,11,13H,7-10,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membrane |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273175
(CHEMBL446545 | N-(2-(2-hydroxyethyl)-3-oxo-3,4-dih...)Show SMILES OCCC1Oc2ccc(NC(=O)C3CCN(CC3)c3cc(F)c(F)c(F)c3)cc2NC1=O Show InChI InChI=1S/C22H22F3N3O4/c23-15-10-14(11-16(24)20(15)25)28-6-3-12(4-7-28)21(30)26-13-1-2-18-17(9-13)27-22(31)19(32-18)5-8-29/h1-2,9-12,19,29H,3-8H2,(H,26,30)(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273058
(CHEMBL457186 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES Fc1cc(cc(F)c1F)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H18F3N3O3/c21-14-8-13(9-15(22)19(14)23)26-5-3-11(4-6-26)20(28)24-12-1-2-17-16(7-12)25-18(27)10-29-17/h1-2,7-9,11H,3-6,10H2,(H,24,28)(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273022
(1-(2,3-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)Show SMILES Cc1cccc(N2CCC(CC2)C(=O)Nc2ccc3OCC(=O)Nc3c2)c1C Show InChI InChI=1S/C22H25N3O3/c1-14-4-3-5-19(15(14)2)25-10-8-16(9-11-25)22(27)23-17-6-7-20-18(12-17)24-21(26)13-28-20/h3-7,12,16H,8-11,13H2,1-2H3,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273023
(1-(4-tert-butylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)Show SMILES CC(C)(C)c1ccc(cc1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C24H29N3O3/c1-24(2,3)17-4-7-19(8-5-17)27-12-10-16(11-13-27)23(29)25-18-6-9-21-20(14-18)26-22(28)15-30-21/h4-9,14,16H,10-13,15H2,1-3H3,(H,25,29)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273021
(1-(3-chloro-2-methylphenyl)-N-(3-oxo-3,4-dihydro-2...)Show SMILES Cc1c(Cl)cccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H22ClN3O3/c1-13-16(22)3-2-4-18(13)25-9-7-14(8-10-25)21(27)23-15-5-6-19-17(11-15)24-20(26)12-28-19/h2-6,11,14H,7-10,12H2,1H3,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272983
(1-(2-bromo-3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H...)Show SMILES Fc1cccc(N2CCC(CC2)C(=O)Nc2ccc3OCC(=O)Nc3c2)c1Br Show InChI InChI=1S/C20H19BrFN3O3/c21-19-14(22)2-1-3-16(19)25-8-6-12(7-9-25)20(27)23-13-4-5-17-15(10-13)24-18(26)11-28-17/h1-5,10,12H,6-9,11H2,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272980
(CHEMBL455958 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES Cc1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H23N3O3/c1-14-4-2-3-5-18(14)24-10-8-15(9-11-24)21(26)22-16-6-7-19-17(12-16)23-20(25)13-27-19/h2-7,12,15H,8-11,13H2,1H3,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272981
(1-(2-ethylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)Show SMILES CCc1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C22H25N3O3/c1-2-15-5-3-4-6-19(15)25-11-9-16(10-12-25)22(27)23-17-7-8-20-18(13-17)24-21(26)14-28-20/h3-8,13,16H,2,9-12,14H2,1H3,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272900
(1-(2-bromophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)Show SMILES Brc1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20BrN3O3/c21-15-3-1-2-4-17(15)24-9-7-13(8-10-24)20(26)22-14-5-6-18-16(11-14)23-19(25)12-27-18/h1-6,11,13H,7-10,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272856
(CHEMBL497485 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES FC(F)(F)c1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H20F3N3O3/c22-21(23,24)14-2-1-3-16(10-14)27-8-6-13(7-9-27)20(29)25-15-4-5-18-17(11-15)26-19(28)12-30-18/h1-5,10-11,13H,6-9,12H2,(H,25,29)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272982
(1-(2-isopropylphenyl)-N-(3-oxo-3,4-dihydro-2H-benz...)Show SMILES CC(C)c1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C23H27N3O3/c1-15(2)18-5-3-4-6-20(18)26-11-9-16(10-12-26)23(28)24-17-7-8-21-19(13-17)25-22(27)14-29-21/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,24,28)(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272859
(1-(3-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)Show SMILES Clc1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20ClN3O3/c21-14-2-1-3-16(10-14)24-8-6-13(7-9-24)20(26)22-15-4-5-18-17(11-15)23-19(25)12-27-18/h1-5,10-11,13H,6-9,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272899
(1-(2-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)Show SMILES Clc1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20ClN3O3/c21-15-3-1-2-4-17(15)24-9-7-13(8-10-24)20(26)22-14-5-6-18-16(11-14)23-19(25)12-27-18/h1-6,11,13H,7-10,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272820
(CHEMBL498664 | N-(1H-indol-4-yl)-1-(3-(trifluorome...)Show SMILES FC(F)(F)c1cccc(c1)N1CCC(CC1)C(=O)Nc1cccc2[nH]ccc12 Show InChI InChI=1S/C21H20F3N3O/c22-21(23,24)15-3-1-4-16(13-15)27-11-8-14(9-12-27)20(28)26-19-6-2-5-18-17(19)7-10-25-18/h1-7,10,13-14,25H,8-9,11-12H2,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272860
(1-(3-bromophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)Show SMILES Brc1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20BrN3O3/c21-14-2-1-3-16(10-14)24-8-6-13(7-9-24)20(26)22-15-4-5-18-17(11-15)23-19(25)12-27-18/h1-5,10-11,13H,6-9,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273057
(1-(3,5-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)Show SMILES Fc1cc(F)cc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H19F2N3O3/c21-13-7-14(22)9-16(8-13)25-5-3-12(4-6-25)20(27)23-15-1-2-18-17(10-15)24-19(26)11-28-18/h1-2,7-10,12H,3-6,11H2,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273025
(1-(3,4-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)Show SMILES Cc1ccc(cc1C)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C22H25N3O3/c1-14-3-5-18(11-15(14)2)25-9-7-16(8-10-25)22(27)23-17-4-6-20-19(12-17)24-21(26)13-28-20/h3-6,11-12,16H,7-10,13H2,1-2H3,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272979
(CHEMBL509968 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES FC(F)(F)c1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H20F3N3O3/c22-21(23,24)15-3-1-2-4-17(15)27-9-7-13(8-10-27)20(29)25-14-5-6-18-16(11-14)26-19(28)12-30-18/h1-6,11,13H,7-10,12H2,(H,25,29)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272897
(CHEMBL455926 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES Cc1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H23N3O3/c1-14-3-2-4-17(11-14)24-9-7-15(8-10-24)21(26)22-16-5-6-19-18(12-16)23-20(25)13-27-19/h2-6,11-12,15H,7-10,13H2,1H3,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272858
(1-(3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)Show SMILES Fc1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20FN3O3/c21-14-2-1-3-16(10-14)24-8-6-13(7-9-24)20(26)22-15-4-5-18-17(11-15)23-19(25)12-27-18/h1-5,10-11,13H,6-9,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272784
(CHEMBL498653 | N-(quinolin-3-yl)-1-(3-(trifluorome...)Show SMILES FC(F)(F)c1cccc(c1)N1CCC(CC1)C(=O)Nc1cnc2ccccc2c1 Show InChI InChI=1S/C22H20F3N3O/c23-22(24,25)17-5-3-6-19(13-17)28-10-8-15(9-11-28)21(29)27-18-12-16-4-1-2-7-20(16)26-14-18/h1-7,12-15H,8-11H2,(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272898
(1-(2-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)Show SMILES Fc1ccccc1N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H20FN3O3/c21-15-3-1-2-4-17(15)24-9-7-13(8-10-24)20(26)22-14-5-6-18-16(11-14)23-19(25)12-27-18/h1-6,11,13H,7-10,12H2,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272818
(CHEMBL497648 | N-(1-acetylindolin-6-yl)-1-(3-(trif...)Show SMILES CC(=O)N1CCc2ccc(NC(=O)C3CCN(CC3)c3cccc(c3)C(F)(F)F)cc12 Show InChI InChI=1S/C23H24F3N3O2/c1-15(30)29-12-9-16-5-6-19(14-21(16)29)27-22(31)17-7-10-28(11-8-17)20-4-2-3-18(13-20)23(24,25)26/h2-6,13-14,17H,7-12H2,1H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273024
(1-(3,4-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)Show SMILES Fc1ccc(cc1F)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C20H19F2N3O3/c21-15-3-2-14(10-16(15)22)25-7-5-12(6-8-25)20(27)23-13-1-4-18-17(9-13)24-19(26)11-28-18/h1-4,9-10,12H,5-8,11H2,(H,23,27)(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273093
(CHEMBL457196 | ethyl 2-methyl-3-oxo-6-(1-(3,4,5-tr...)Show SMILES CCOC(=O)C1(C)Oc2ccc(NC(=O)C3CCN(CC3)c3cc(F)c(F)c(F)c3)cc2NC1=O Show InChI InChI=1S/C24H24F3N3O5/c1-3-34-23(33)24(2)22(32)29-18-10-14(4-5-19(18)35-24)28-21(31)13-6-8-30(9-7-13)15-11-16(25)20(27)17(26)12-15/h4-5,10-13H,3,6-9H2,1-2H3,(H,28,31)(H,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273129
(CHEMBL514249 | methyl 2-(3-oxo-6-(1-(3,4,5-trifluo...)Show SMILES COC(=O)CC1Oc2ccc(NC(=O)C3CCN(CC3)c3cc(F)cc(F)c3)cc2NC1=O Show InChI InChI=1S/C23H23F2N3O5/c1-32-21(29)12-20-23(31)27-18-11-16(2-3-19(18)33-20)26-22(30)13-4-6-28(7-5-13)17-9-14(24)8-15(25)10-17/h2-3,8-11,13,20H,4-7,12H2,1H3,(H,26,30)(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272821
(CHEMBL498665 | N-(1H-indol-5-yl)-1-(3-(trifluorome...)Show SMILES FC(F)(F)c1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2[nH]ccc2c1 Show InChI InChI=1S/C21H20F3N3O/c22-21(23,24)16-2-1-3-18(13-16)27-10-7-14(8-11-27)20(28)26-17-4-5-19-15(12-17)6-9-25-19/h1-6,9,12-14,25H,7-8,10-11H2,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272896
(1-(3-methoxyphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[...)Show SMILES COc1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C21H23N3O4/c1-27-17-4-2-3-16(12-17)24-9-7-14(8-10-24)21(26)22-15-5-6-19-18(11-15)23-20(25)13-28-19/h2-6,11-12,14H,7-10,13H2,1H3,(H,22,26)(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272857
(CHEMBL497486 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show InChI InChI=1S/C20H21N3O3/c24-19-13-26-18-7-6-15(12-17(18)22-19)21-20(25)14-8-10-23(11-9-14)16-4-2-1-3-5-16/h1-7,12,14H,8-11,13H2,(H,21,25)(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50273092
(CHEMBL457195 | N-(3-oxo-3,4-dihydro-2H-benzo[b][1,...)Show SMILES Fc1cc(cc(F)c1F)N1CCC(CC1)C(=O)Nc1ccc2SCC(=O)Nc2c1 Show InChI InChI=1S/C20H18F3N3O2S/c21-14-8-13(9-15(22)19(14)23)26-5-3-11(4-6-26)20(28)24-12-1-2-17-16(7-12)25-18(27)10-29-17/h1-2,7-9,11H,3-6,10H2,(H,24,28)(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 1.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50273175
(CHEMBL446545 | N-(2-(2-hydroxyethyl)-3-oxo-3,4-dih...)Show SMILES OCCC1Oc2ccc(NC(=O)C3CCN(CC3)c3cc(F)c(F)c(F)c3)cc2NC1=O Show InChI InChI=1S/C22H22F3N3O4/c23-15-10-14(11-16(24)20(15)25)28-6-3-12(4-7-28)21(30)26-13-1-2-18-17(9-13)27-22(31)19(32-18)5-8-29/h1-2,9-12,19,29H,3-8H2,(H,26,30)(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of recombinant CYP3A4 |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272785
(CHEMBL498654 | N-(1-acetylindolin-7-yl)-1-(3-(trif...)Show SMILES CC(=O)N1CCc2cccc(NC(=O)C3CCN(CC3)c3cccc(c3)C(F)(F)F)c12 Show InChI InChI=1S/C23H24F3N3O2/c1-15(30)29-13-10-16-4-2-7-20(21(16)29)27-22(31)17-8-11-28(12-9-17)19-6-3-5-18(14-19)23(24,25)26/h2-7,14,17H,8-13H2,1H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272822
(CHEMBL526109 | N-(1H-indol-6-yl)-1-(3-(trifluorome...)Show SMILES FC(F)(F)c1cccc(c1)N1CCC(CC1)C(=O)Nc1ccc2cc[nH]c2c1 Show InChI InChI=1S/C21H20F3N3O/c22-21(23,24)16-2-1-3-18(12-16)27-10-7-15(8-11-27)20(28)26-17-5-4-14-6-9-25-19(14)13-17/h1-6,9,12-13,15,25H,7-8,10-11H2,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50272819
(CHEMBL498492 | N-(1-acetylindolin-5-yl)-1-(3-(trif...)Show SMILES CC(=O)N1CCc2cc(NC(=O)C3CCN(CC3)c3cccc(c3)C(F)(F)F)ccc12 Show InChI InChI=1S/C23H24F3N3O2/c1-15(30)29-12-9-17-13-19(5-6-21(17)29)27-22(31)16-7-10-28(11-8-16)20-4-2-3-18(14-20)23(24,25)26/h2-6,13-14,16H,7-12H2,1H3,(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPR |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50273175
(CHEMBL446545 | N-(2-(2-hydroxyethyl)-3-oxo-3,4-dih...)Show SMILES OCCC1Oc2ccc(NC(=O)C3CCN(CC3)c3cc(F)c(F)c(F)c3)cc2NC1=O Show InChI InChI=1S/C22H22F3N3O4/c23-15-10-14(11-16(24)20(15)25)28-6-3-12(4-7-28)21(30)26-13-1-2-18-17(9-13)27-22(31)19(32-18)5-8-29/h1-2,9-12,19,29H,3-8H2,(H,26,30)(H,27,31) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of recombinant CYP2D6 |
Bioorg Med Chem Lett 18: 4569-72 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.035
BindingDB Entry DOI: 10.7270/Q2154GV5 |
More data for this
Ligand-Target Pair | |
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