Affinity Data by PubMed id=26730808

PubMed code 26730808

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM7814 (Maleimide-Related Compound 13 \| pyrrolidine-2,5-di...) Show SMILES O=C1CCC(=O)N1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by Cheng-Prusoff equation analysis				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50070114 ((+/-)-thalidomide \| 2-(2,6-Dioxo-piperidin-3-yl)-i...) Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by Cheng-Prusoff equation analysis				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM50070114 ((+/-)-thalidomide \| 2-(2,6-Dioxo-piperidin-3-yl)-i...) Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.27E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysis				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM7814 (Maleimide-Related Compound 13 \| pyrrolidine-2,5-di...) Show SMILES O=C1CCC(=O)N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	2.62E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysis				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50146597 (CHEMBL3763941) Show SMILES O=C1CCCC(=O)N1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	2.78E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by Cheng-Prusoff equation analysis				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM50146597 (CHEMBL3763941) Show SMILES O=C1CCCC(=O)N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	1.03E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysis				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50026473 (CHEMBL25028 \| Sulfonylbismethane \| dimethyl sulfon...) Show SMILES CS(C)(=O)=O Show InChI InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	5.69E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by Cheng-Prusoff equation analysis				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Protein cereblon (Homo sapiens (Human))	BDBM50026473 (CHEMBL25028 \| Sulfonylbismethane \| dimethyl sulfon...) Show SMILES CS(C)(=O)=O Show InChI InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.37E+8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysis				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM7814 (Maleimide-Related Compound 13 \| pyrrolidine-2,5-di...) Show SMILES O=C1CCC(=O)N1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assay				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50070114 ((+/-)-thalidomide \| 2-(2,6-Dioxo-piperidin-3-yl)-i...) Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assay				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM50070114 ((+/-)-thalidomide \| 2-(2,6-Dioxo-piperidin-3-yl)-i...) Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.99E+4	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assay				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM7814 (Maleimide-Related Compound 13 \| pyrrolidine-2,5-di...) Show SMILES O=C1CCC(=O)N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assay				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50146597 (CHEMBL3763941) Show SMILES O=C1CCCC(=O)N1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.89E+4	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assay				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM50146597 (CHEMBL3763941) Show SMILES O=C1CCCC(=O)N1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assay				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50026473 (CHEMBL25028 \| Sulfonylbismethane \| dimethyl sulfon...) Show SMILES CS(C)(=O)=O Show InChI InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+7	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assay				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Protein cereblon (Homo sapiens (Human))	BDBM50026473 (CHEMBL25028 \| Sulfonylbismethane \| dimethyl sulfon...) Show SMILES CS(C)(=O)=O Show InChI InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.81E+8	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assay				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50146598 (CHEMBL3764647) Show SMILES CNc1ccccc1C(=O)NCCn1ccc(=O)[nH]c1=O Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Binding affinity to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assay				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair
Protein cereblon (Homo sapiens (Human))	BDBM50146598 (CHEMBL3764647) Show SMILES CNc1ccccc1C(=O)NCCn1ccc(=O)[nH]c1=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Binding affinity to human CRBN (delta 1 to 315) by FRET assay				J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF
					More data for this Ligand-Target Pair

* indicates data uncertainty>20%