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USPatent US9669035

Compile data set for download or QSAR
Found 66 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50444038
PNG
(CHEMBL3092563 | US9669035, B-5)
Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1c(F)cccc1Cl |(32.38,-11.31,;31.04,-12.08,;29.71,-11.31,;28.38,-12.08,;27.05,-11.3,;25.72,-12.08,;25.72,-13.62,;24.39,-14.39,;23.06,-13.63,;23.06,-12.09,;21.73,-11.32,;20.39,-12.09,;20.39,-13.63,;21.73,-14.4,;27.05,-14.38,;28.38,-13.62,;29.71,-14.39,;30.03,-15.9,;31.56,-16.06,;32.19,-14.65,;31.04,-13.62,;28.92,-16.96,;27.44,-16.51,;27.08,-15.02,;26.32,-17.57,;26.68,-19.07,;28.16,-19.51,;29.28,-18.45,;30.75,-18.88,)|
Show InChI InChI=1S/C21H19ClFN5O/c1-13-20-25-26-21(19-15(22)3-2-4-16(19)23)28(20)18-11-14(5-6-17(18)24-13)12-27-7-9-29-10-8-27/h2-6,11H,7-10,12H2,1H3
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n/an/a 1.40n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50425123
PNG
(CHEMBL2313234 | US9669035, B-3)
Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl
Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3
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n/an/a 2.30n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50026827
PNG
(CHEMBL3331516 | US9669035, B-6)
Show SMILES CC(C)Oc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H26ClN5O2/c1-15(2)32-18-5-6-20(25)19(13-18)24-28-27-23-16(3)26-21-7-4-17(12-22(21)30(23)24)14-29-8-10-31-11-9-29/h4-7,12-13,15H,8-11,14H2,1-3H3
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n/an/a 4.80n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50026829
PNG
(CHEMBL3331514 | US9669035, B-7)
Show SMILES CCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C23H24ClN5O2/c1-3-31-17-5-6-19(24)18(13-17)23-27-26-22-15(2)25-20-7-4-16(12-21(20)29(22)23)14-28-8-10-30-11-9-28/h4-7,12-13H,3,8-11,14H2,1-2H3
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n/an/a 6.20n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50026828
PNG
(CHEMBL3331515 | US9669035, B-8)
Show SMILES CCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H26ClN5O2/c1-3-10-32-18-5-6-20(25)19(14-18)24-28-27-23-16(2)26-21-7-4-17(13-22(21)30(23)24)15-29-8-11-31-12-9-29/h4-7,13-14H,3,8-12,15H2,1-2H3
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n/an/a 6.5n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50026821
PNG
(CHEMBL3331521 | US11419874, Example 10 | US9669035...)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H28N6O2/c1-3-4-9-32-20-13-19(14-25-15-20)24-28-27-23-17(2)26-21-6-5-18(12-22(21)30(23)24)16-29-7-10-31-11-8-29/h5-6,12-15H,3-4,7-11,16H2,1-2H3
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n/an/a 7.40n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50026826
PNG
(CHEMBL3331517 | US11419874, Example 9 | US9669035,...)
Show SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C25H28ClN5O2/c1-3-4-11-33-19-6-7-21(26)20(15-19)25-29-28-24-17(2)27-22-8-5-18(14-23(22)31(24)25)16-30-9-12-32-13-10-30/h5-8,14-15H,3-4,9-13,16H2,1-2H3
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n/an/a 7.80n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM179970
PNG
(US9669035, B-9)
Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1cc(F)ccc1Cl
Show InChI InChI=1S/C21H19ClFN5O/c1-13-20-25-26-21(16-11-15(23)3-4-17(16)22)28(20)19-10-14(2-5-18(19)24-13)12-27-6-8-29-9-7-27/h2-5,10-11H,6-9,12H2,1H3
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n/an/a 9.5n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50026820
PNG
(CHEMBL3331513 | US9669035, B-10)
Show SMILES COc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C22H22ClN5O2/c1-14-21-25-26-22(17-12-16(29-2)4-5-18(17)23)28(21)20-11-15(3-6-19(20)24-14)13-27-7-9-30-10-8-27/h3-6,11-12H,7-10,13H2,1-2H3
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n/an/a 10n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM179972
PNG
(US9669035, B-11)
Show SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
Show InChI InChI=1S/C23H26ClN5O/c1-5-6-11-30-17-8-9-19(24)18(13-17)23-27-26-22-15(2)25-20-10-7-16(14-28(3)4)12-21(20)29(22)23/h7-10,12-13H,5-6,11,14H2,1-4H3
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n/an/a 11n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50026825
PNG
(CHEMBL3331518 | US9669035, B-12)
Show SMILES COc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C21H22N6O2/c1-14-20-24-25-21(16-10-17(28-2)12-22-11-16)27(20)19-9-15(3-4-18(19)23-14)13-26-5-7-29-8-6-26/h3-4,9-12H,5-8,13H2,1-2H3
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n/an/a 12n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50026821
PNG
(CHEMBL3331521 | US11419874, Example 10 | US9669035...)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H28N6O2/c1-3-4-9-32-20-13-19(14-25-15-20)24-28-27-23-17(2)26-21-6-5-18(12-22(21)30(23)24)16-29-7-10-31-11-8-29/h5-6,12-15H,3-4,7-11,16H2,1-2H3
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n/an/a 13n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50444038
PNG
(CHEMBL3092563 | US9669035, B-5)
Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1c(F)cccc1Cl |(32.38,-11.31,;31.04,-12.08,;29.71,-11.31,;28.38,-12.08,;27.05,-11.3,;25.72,-12.08,;25.72,-13.62,;24.39,-14.39,;23.06,-13.63,;23.06,-12.09,;21.73,-11.32,;20.39,-12.09,;20.39,-13.63,;21.73,-14.4,;27.05,-14.38,;28.38,-13.62,;29.71,-14.39,;30.03,-15.9,;31.56,-16.06,;32.19,-14.65,;31.04,-13.62,;28.92,-16.96,;27.44,-16.51,;27.08,-15.02,;26.32,-17.57,;26.68,-19.07,;28.16,-19.51,;29.28,-18.45,;30.75,-18.88,)|
Show InChI InChI=1S/C21H19ClFN5O/c1-13-20-25-26-21(19-15(22)3-2-4-16(19)23)28(20)18-11-14(5-6-17(18)24-13)12-27-7-9-29-10-8-27/h2-6,11H,7-10,12H2,1H3
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n/an/a 14n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM181755
PNG
(US9669035, B-25)
Show SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CNC)cc3n12
Show InChI InChI=1S/C22H24ClN5O/c1-4-5-10-29-16-7-8-18(23)17(12-16)22-27-26-21-14(2)25-19-9-6-15(13-24-3)11-20(19)28(21)22/h6-9,11-12,24H,4-5,10,13H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50425124
PNG
(CHEMBL2313233 | US9669035, B-13)
Show SMILES CN(C)Cc1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1
Show InChI InChI=1S/C19H18ClN5/c1-12-18-22-23-19(14-6-4-5-7-15(14)20)25(18)17-10-13(11-24(2)3)8-9-16(17)21-12/h4-10H,11H2,1-3H3
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n/an/a 20n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50425125
PNG
(CHEMBL2313232 | US9669035, B-4)
Show SMILES CCNCc1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1
Show InChI InChI=1S/C19H18ClN5/c1-3-21-11-13-8-9-16-17(10-13)25-18(12(2)22-16)23-24-19(25)14-6-4-5-7-15(14)20/h4-10,21H,3,11H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM179977
PNG
(US9669035, B-14)
Show SMILES CCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CNCC)cc3n12
Show InChI InChI=1S/C22H24ClN5O/c1-4-10-29-16-7-8-18(23)17(12-16)22-27-26-21-14(3)25-19-9-6-15(13-24-5-2)11-20(19)28(21)22/h6-9,11-12,24H,4-5,10,13H2,1-3H3
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n/an/a 21n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM179978
PNG
(US9669035, B-15)
Show SMILES CCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
Show InChI InChI=1S/C22H24ClN5O/c1-5-10-29-16-7-8-18(23)17(12-16)22-26-25-21-14(2)24-19-9-6-15(13-27(3)4)11-20(19)28(21)22/h6-9,11-12H,5,10,13H2,1-4H3
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n/an/a 22n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM181763
PNG
(US9669035, B-26)
Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1cncc(OCC2CC2)c1
Show InChI InChI=1S/C24H26N6O2/c1-16-23-27-28-24(19-11-20(13-25-12-19)32-15-17-2-3-17)30(23)22-10-18(4-5-21(22)26-16)14-29-6-8-31-9-7-29/h4-5,10-13,17H,2-3,6-9,14-15H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50026824
PNG
(CHEMBL3331519 | US9669035, B-16)
Show SMILES CCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C23H26N6O2/c1-3-8-31-19-12-18(13-24-14-19)23-27-26-22-16(2)25-20-5-4-17(11-21(20)29(22)23)15-28-6-9-30-10-7-28/h4-5,11-14H,3,6-10,15H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50425123
PNG
(CHEMBL2313234 | US9669035, B-3)
Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl
Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM179980
PNG
(US9669035, B-17)
Show SMILES CC(C)Oc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
Show InChI InChI=1S/C22H24ClN5O/c1-13(2)29-16-7-8-18(23)17(11-16)22-26-25-21-14(3)24-19-9-6-15(12-27(4)5)10-20(19)28(21)22/h6-11,13H,12H2,1-5H3
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n/an/a 35n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM179981
PNG
(US9669035, B-18)
Show SMILES CCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
Show InChI InChI=1S/C21H22ClN5O/c1-5-28-15-7-8-17(22)16(11-15)21-25-24-20-13(2)23-18-9-6-14(12-26(3)4)10-19(18)27(20)21/h6-11H,5,12H2,1-4H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM181676
PNG
(US9669035, B-22a)
Show SMILES CCNCc1ccc2nc(C)c3nnc(-c4cc(OCC)ccc4Cl)n3c2c1
Show InChI InChI=1S/C21H22ClN5O/c1-4-23-12-14-6-9-18-19(10-14)27-20(13(3)24-18)25-26-21(27)16-11-15(28-5-2)7-8-17(16)22/h6-11,23H,4-5,12H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM179983
PNG
(US9669035, B-20)
Show SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CNC(C)C)cc3n12
Show InChI InChI=1S/C24H28ClN5O/c1-5-6-11-31-18-8-9-20(25)19(13-18)24-29-28-23-16(4)27-21-10-7-17(14-26-15(2)3)12-22(21)30(23)24/h7-10,12-13,15,26H,5-6,11,14H2,1-4H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM179982
PNG
(US9669035, B-19)
Show SMILES CCNCc1ccc2nc(C)c3nnc(-c4cc(OC(C)C)ccc4Cl)n3c2c1
Show InChI InChI=1S/C22H24ClN5O/c1-5-24-12-15-6-9-19-20(10-15)28-21(14(4)25-19)26-27-22(28)17-11-16(29-13(2)3)7-8-18(17)23/h6-11,13,24H,5,12H2,1-4H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM181673
PNG
(US9669035, B-21)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNCC)cc3n12
Show InChI InChI=1S/C22H26N6O/c1-4-6-9-29-18-11-17(13-24-14-18)22-27-26-21-15(3)25-19-8-7-16(12-23-5-2)10-20(19)28(21)22/h7-8,10-11,13-14,23H,4-6,9,12H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM181678
PNG
(US9669035, B-23)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNC(C)C)cc3n12
Show InChI InChI=1S/C23H28N6O/c1-5-6-9-30-19-11-18(13-24-14-19)23-28-27-22-16(4)26-20-8-7-17(12-25-15(2)3)10-21(20)29(22)23/h7-8,10-11,13-15,25H,5-6,9,12H2,1-4H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM182096
PNG
(US9669035, B-27)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
Show InChI InChI=1S/C22H26N6O/c1-5-6-9-29-18-11-17(12-23-13-18)22-26-25-21-15(2)24-19-8-7-16(14-27(3)4)10-20(19)28(21)22/h7-8,10-13H,5-6,9,14H2,1-4H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM179970
PNG
(US9669035, B-9)
Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1cc(F)ccc1Cl
Show InChI InChI=1S/C21H19ClFN5O/c1-13-20-25-26-21(16-11-15(23)3-4-17(16)22)28(20)19-10-14(2-5-18(19)24-13)12-27-6-8-29-9-7-27/h2-5,10-11H,6-9,12H2,1H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM182226
PNG
(US9669035, B-28)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNC)cc3n12
Show InChI InChI=1S/C21H24N6O/c1-4-5-8-28-17-10-16(12-23-13-17)21-26-25-20-14(2)24-18-7-6-15(11-22-3)9-19(18)27(20)21/h6-7,9-10,12-13,22H,4-5,8,11H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50026820
PNG
(CHEMBL3331513 | US9669035, B-10)
Show SMILES COc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C22H22ClN5O2/c1-14-21-25-26-22(17-12-16(29-2)4-5-18(17)23)28(21)20-11-15(3-6-19(20)24-14)13-27-7-9-30-10-8-27/h3-6,11-12H,7-10,13H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50425124
PNG
(CHEMBL2313233 | US9669035, B-13)
Show SMILES CN(C)Cc1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1
Show InChI InChI=1S/C19H18ClN5/c1-12-18-22-23-19(14-6-4-5-7-15(14)20)25(18)17-10-13(11-24(2)3)8-9-16(17)21-12/h4-10H,11H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM182234
PNG
(US9669035, B-29)
Show SMILES CCCCOc1cc(cnc1Cl)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H27ClN6O2/c1-3-4-9-33-21-13-18(14-26-22(21)25)24-29-28-23-16(2)27-19-6-5-17(12-20(19)31(23)24)15-30-7-10-32-11-8-30/h5-6,12-14H,3-4,7-11,15H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM182294
PNG
(US9669035, B-30)
Show SMILES CN(C)Cc1ccc2nc(C)c3nnc(-c4cncc(OCC5CC5)c4)n3c2c1
Show InChI InChI=1S/C22H24N6O/c1-14-21-25-26-22(17-9-18(11-23-10-17)29-13-15-4-5-15)28(21)20-8-16(12-27(2)3)6-7-19(20)24-14/h6-11,15H,4-5,12-13H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50425125
PNG
(CHEMBL2313232 | US9669035, B-4)
Show SMILES CCNCc1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1
Show InChI InChI=1S/C19H18ClN5/c1-3-21-11-13-8-9-16-17(10-13)25-18(12(2)22-16)23-24-19(25)14-6-4-5-7-15(14)20/h4-10,21H,3,11H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM181713
PNG
(US9669035, B-24)
Show SMILES CCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNCC)cc3n12
Show InChI InChI=1S/C21H24N6O/c1-4-8-28-17-10-16(12-23-13-17)21-26-25-20-14(3)24-18-7-6-15(11-22-5-2)9-19(18)27(20)21/h6-7,9-10,12-13,22H,4-5,8,11H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50026829
PNG
(CHEMBL3331514 | US9669035, B-7)
Show SMILES CCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C23H24ClN5O2/c1-3-31-17-5-6-19(24)18(13-17)23-27-26-22-15(2)25-20-7-4-16(12-21(20)29(22)23)14-28-8-10-30-11-9-28/h4-7,12-13H,3,8-11,14H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50026825
PNG
(CHEMBL3331518 | US9669035, B-12)
Show SMILES COc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C21H22N6O2/c1-14-20-24-25-21(16-10-17(28-2)12-22-11-16)27(20)19-9-15(3-4-18(19)23-14)13-26-5-7-29-8-6-26/h3-4,9-12H,5-8,13H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM179981
PNG
(US9669035, B-18)
Show SMILES CCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
Show InChI InChI=1S/C21H22ClN5O/c1-5-28-15-7-8-17(22)16(11-15)21-25-24-20-13(2)23-18-9-6-14(12-26(3)4)10-19(18)27(20)21/h6-11H,5,12H2,1-4H3
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n/an/a 320n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50026828
PNG
(CHEMBL3331515 | US9669035, B-8)
Show SMILES CCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H26ClN5O2/c1-3-10-32-18-5-6-20(25)19(14-18)24-28-27-23-16(2)26-21-7-4-17(13-22(21)30(23)24)15-29-8-11-31-12-9-29/h4-7,13-14H,3,8-12,15H2,1-2H3
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n/an/a 320n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM182857
PNG
(US9669035, B-31)
Show SMILES CC(C)NCc1ccc2nc(C)c3nnc(-c4cncc(OCC5CC5)c4)n3c2c1
Show InChI InChI=1S/C23H26N6O/c1-14(2)25-10-17-6-7-20-21(8-17)29-22(15(3)26-20)27-28-23(29)18-9-19(12-24-11-18)30-13-16-4-5-16/h6-9,11-12,14,16,25H,4-5,10,13H2,1-3H3
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n/an/a 330n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM182858
PNG
(US9669035, B-32)
Show SMILES CCNCc1ccc2nc(C)c3nnc(-c4cncc(OCC5CC5)c4)n3c2c1
Show InChI InChI=1S/C22H24N6O/c1-3-23-10-16-6-7-19-20(8-16)28-21(14(2)25-19)26-27-22(28)17-9-18(12-24-11-17)29-13-15-4-5-15/h6-9,11-12,15,23H,3-5,10,13H2,1-2H3
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n/an/a 350n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM181676
PNG
(US9669035, B-22a)
Show SMILES CCNCc1ccc2nc(C)c3nnc(-c4cc(OCC)ccc4Cl)n3c2c1
Show InChI InChI=1S/C21H22ClN5O/c1-4-23-12-14-6-9-18-19(10-14)27-20(13(3)24-18)25-26-21(27)16-11-15(28-5-2)7-8-17(16)22/h6-11,23H,4-5,12H2,1-3H3
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n/an/a 910n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM182857
PNG
(US9669035, B-31)
Show SMILES CC(C)NCc1ccc2nc(C)c3nnc(-c4cncc(OCC5CC5)c4)n3c2c1
Show InChI InChI=1S/C23H26N6O/c1-14(2)25-10-17-6-7-20-21(8-17)29-22(15(3)26-20)27-28-23(29)18-9-19(12-24-11-18)30-13-16-4-5-16/h6-9,11-12,14,16,25H,4-5,10,13H2,1-3H3
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n/an/a 1.40E+3n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM179978
PNG
(US9669035, B-15)
Show SMILES CCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
Show InChI InChI=1S/C22H24ClN5O/c1-5-10-29-16-7-8-18(23)17(12-16)22-26-25-21-14(2)24-19-9-6-15(13-27(3)4)11-20(19)28(21)22/h6-9,11-12H,5,10,13H2,1-4H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM179980
PNG
(US9669035, B-17)
Show SMILES CC(C)Oc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
Show InChI InChI=1S/C22H24ClN5O/c1-13(2)29-16-7-8-18(23)17(11-16)22-26-25-21-14(3)24-19-9-6-15(12-27(4)5)10-20(19)28(21)22/h6-11,13H,12H2,1-5H3
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n/an/a 1.60E+3n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50026826
PNG
(CHEMBL3331517 | US11419874, Example 9 | US9669035,...)
Show SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C25H28ClN5O2/c1-3-4-11-33-19-6-7-21(26)20(15-19)25-29-28-24-17(2)27-22-8-5-18(14-23(22)31(24)25)16-30-9-12-32-13-10-30/h5-8,14-15H,3-4,9-13,16H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM179977
PNG
(US9669035, B-14)
Show SMILES CCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CNCC)cc3n12
Show InChI InChI=1S/C22H24ClN5O/c1-4-10-29-16-7-8-18(23)17(12-16)22-27-26-21-14(3)25-19-9-6-15(13-24-5-2)11-20(19)28(21)22/h6-9,11-12,24H,4-5,10,13H2,1-3H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50026827
PNG
(CHEMBL3331516 | US9669035, B-6)
Show SMILES CC(C)Oc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H26ClN5O2/c1-15(2)32-18-5-6-20(25)19(13-18)24-28-27-23-16(3)26-21-7-4-17(12-22(21)30(23)24)14-29-8-10-31-11-9-29/h4-7,12-13,15H,8-11,14H2,1-3H3
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n/an/a 1.90E+3n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM179972
PNG
(US9669035, B-11)
Show SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
Show InChI InChI=1S/C23H26ClN5O/c1-5-6-11-30-17-8-9-19(24)18(13-17)23-27-26-22-15(2)25-20-10-7-16(14-28(3)4)12-21(20)29(22)23/h7-10,12-13H,5-6,11,14H2,1-4H3
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n/an/a 2.10E+3n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM181763
PNG
(US9669035, B-26)
Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1cncc(OCC2CC2)c1
Show InChI InChI=1S/C24H26N6O2/c1-16-23-27-28-24(19-11-20(13-25-12-19)32-15-17-2-3-17)30(23)22-10-18(4-5-21(22)26-16)14-29-6-8-31-9-7-29/h4-5,10-13,17H,2-3,6-9,14-15H2,1H3
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n/an/a 3.60E+3n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50026821
PNG
(CHEMBL3331521 | US11419874, Example 10 | US9669035...)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H28N6O2/c1-3-4-9-32-20-13-19(14-25-15-20)24-28-27-23-17(2)26-21-6-5-18(12-22(21)30(23)24)16-29-7-10-31-11-8-29/h5-6,12-15H,3-4,7-11,16H2,1-2H3
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n/an/a 4.10E+3n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM179983
PNG
(US9669035, B-20)
Show SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CNC(C)C)cc3n12
Show InChI InChI=1S/C24H28ClN5O/c1-5-6-11-31-18-8-9-20(25)19(13-18)24-29-28-23-16(4)27-21-10-7-17(14-26-15(2)3)12-22(21)30(23)24/h7-10,12-13,15,26H,5-6,11,14H2,1-4H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50026821
PNG
(CHEMBL3331521 | US11419874, Example 10 | US9669035...)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H28N6O2/c1-3-4-9-32-20-13-19(14-25-15-20)24-28-27-23-17(2)26-21-6-5-18(12-22(21)30(23)24)16-29-7-10-31-11-8-29/h5-6,12-15H,3-4,7-11,16H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50026824
PNG
(CHEMBL3331519 | US9669035, B-16)
Show SMILES CCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C23H26N6O2/c1-3-8-31-19-12-18(13-24-14-19)23-27-26-22-16(2)25-20-5-4-17(11-21(20)29(22)23)15-28-6-9-30-10-7-28/h4-5,11-14H,3,6-10,15H2,1-2H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM179982
PNG
(US9669035, B-19)
Show SMILES CCNCc1ccc2nc(C)c3nnc(-c4cc(OC(C)C)ccc4Cl)n3c2c1
Show InChI InChI=1S/C22H24ClN5O/c1-5-24-12-15-6-9-19-20(10-15)28-21(14(4)25-19)26-27-22(28)17-11-16(29-13(2)3)7-8-18(17)23/h6-11,13,24H,5,12H2,1-4H3
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JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM181755
PNG
(US9669035, B-25)
Show SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccc(CNC)cc3n12
Show InChI InChI=1S/C22H24ClN5O/c1-4-5-10-29-16-7-8-18(23)17(12-16)22-27-26-21-14(2)25-19-9-6-15(13-24-3)11-20(19)28(21)22/h6-9,11-12,24H,4-5,10,13H2,1-3H3
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n/an/a 9.10E+3n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM182096
PNG
(US9669035, B-27)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN(C)C)cc3n12
Show InChI InChI=1S/C22H26N6O/c1-5-6-9-29-18-11-17(12-23-13-18)22-26-25-21-15(2)24-19-8-7-16(14-27(3)4)10-20(19)28(21)22/h7-8,10-13H,5-6,9,14H2,1-4H3
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n/an/a 9.30E+3n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM182858
PNG
(US9669035, B-32)
Show SMILES CCNCc1ccc2nc(C)c3nnc(-c4cncc(OCC5CC5)c4)n3c2c1
Show InChI InChI=1S/C22H24N6O/c1-3-23-10-16-6-7-19-20(8-16)28-21(14(2)25-19)26-27-22(28)17-9-18(12-24-11-17)29-13-15-4-5-15/h6-9,11-12,15,23H,3-5,10,13H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM182294
PNG
(US9669035, B-30)
Show SMILES CN(C)Cc1ccc2nc(C)c3nnc(-c4cncc(OCC5CC5)c4)n3c2c1
Show InChI InChI=1S/C22H24N6O/c1-14-21-25-26-22(17-9-18(11-23-10-17)29-13-15-4-5-15)28(21)20-8-16(12-27(2)3)6-7-19(20)24-14/h6-11,15H,4-5,12-13H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM181673
PNG
(US9669035, B-21)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNCC)cc3n12
Show InChI InChI=1S/C22H26N6O/c1-4-6-9-29-18-11-17(13-24-14-18)22-27-26-21-15(3)25-19-8-7-16(12-23-5-2)10-20(19)28(21)22/h7-8,10-11,13-14,23H,4-6,9,12H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM182234
PNG
(US9669035, B-29)
Show SMILES CCCCOc1cc(cnc1Cl)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12
Show InChI InChI=1S/C24H27ClN6O2/c1-3-4-9-33-21-13-18(14-26-22(21)25)24-29-28-23-16(2)27-19-6-5-17(12-20(19)31(23)24)15-30-7-10-32-11-8-30/h5-6,12-14H,3-4,7-11,15H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM182226
PNG
(US9669035, B-28)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNC)cc3n12
Show InChI InChI=1S/C21H24N6O/c1-4-5-8-28-17-10-16(12-23-13-17)21-26-25-20-14(2)24-18-7-6-15(11-22-3)9-19(18)27(20)21/h6-7,9-10,12-13,22H,4-5,8,11H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM181678
PNG
(US9669035, B-23)
Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNC(C)C)cc3n12
Show InChI InChI=1S/C23H28N6O/c1-5-6-9-30-19-11-18(13-24-14-19)23-28-27-22-16(4)26-20-8-7-17(12-25-15(2)3)10-21(20)29(22)23/h7-8,10-11,13-15,25H,5-6,9,12H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM181713
PNG
(US9669035, B-24)
Show SMILES CCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CNCC)cc3n12
Show InChI InChI=1S/C21H24N6O/c1-4-8-28-17-10-16(12-23-13-17)21-26-25-20-14(3)24-18-7-6-15(11-22-5-2)9-19(18)27(20)21/h6-7,9-10,12-13,22H,4-5,8,11H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/a7.825



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...

US Patent US9669035 (2017)


BindingDB Entry DOI: 10.7270/Q2Z60M6H
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%