Found 287 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336466
(US9744172, Compound UNC1265A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)NC1CCN(C)CC1 |r,wD:15.15,(-9.97,-6.6,;-8.64,-5.83,;-7.3,-6.6,;-5.97,-5.83,;-4.63,-6.6,;-3.3,-5.83,;-3.3,-4.29,;-1.97,-3.52,;-.63,-4.29,;.83,-3.81,;1.74,-5.06,;.83,-6.31,;1.23,-7.79,;2.72,-8.19,;3.12,-9.68,;2.03,-10.77,;2.43,-12.26,;.54,-10.37,;.14,-8.88,;-.63,-5.83,;-1.97,-6.6,;1.23,-2.33,;2.72,-1.93,;3.12,-.44,;2.03,.65,;.54,.25,;.14,-1.24,;2.43,2.14,;.94,2.53,;2.03,3.62,;3.91,2.53,;4.31,4.02,;5.8,4.42,;6.2,5.91,;5.11,7,;7.68,6.31,;8.08,7.79,;9.57,8.19,;9.97,9.68,;8.88,10.77,;9.28,12.26,;7.39,10.37,;6.99,8.88,)| Show InChI InChI=1S/C30H44N8O4S/c1-3-4-16-31-30-32-20-26-28(36-38(29(26)35-30)23-7-9-24(39)10-8-23)21-5-11-25(12-6-21)43(41,42)33-17-13-27(40)34-22-14-18-37(2)19-15-22/h5-6,11-12,20,22-24,33,39H,3-4,7-10,13-19H2,1-2H3,(H,34,40)(H,31,32,35)/t23?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336486
(US9744172, Compound UNC1314A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCOCC |r,wU:15.15,(-10.57,-7.54,;-9.23,-6.77,;-7.9,-7.54,;-6.57,-6.77,;-5.23,-7.54,;-3.9,-6.77,;-3.9,-5.23,;-2.57,-4.46,;-1.23,-5.23,;.23,-4.76,;1.14,-6,;.23,-7.25,;.63,-8.74,;-.46,-9.83,;-.06,-11.31,;1.43,-11.71,;1.83,-13.2,;2.52,-10.62,;2.12,-9.14,;-1.23,-6.77,;-2.57,-7.54,;.63,-3.27,;2.12,-2.87,;2.52,-1.38,;1.43,-.29,;-.06,-.69,;-.46,-2.18,;1.83,1.19,;.29,1.19,;1.06,2.53,;3.31,1.59,;4.4,.5,;3.71,3.08,;5.2,3.48,;5.6,4.96,;4.51,6.05,;3.02,5.66,;2.62,4.17,;4.91,7.54,;3.82,8.63,;6.4,7.94,;6.8,9.43,;8.28,9.83,;8.68,11.31,;10.17,11.71,;10.57,13.2,)| Show InChI InChI=1S/C33H43N7O5S/c1-4-6-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(3)25-11-7-24(8-12-25)32(42)34-20-21-45-5-2/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336487
(US9744172, Compound UNC1315A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N(C)c1ccc(cc1)C(=O)NCCCOC |r,wD:15.15,(-10.57,-7.54,;-9.23,-6.77,;-7.9,-7.54,;-6.57,-6.77,;-5.23,-7.54,;-3.9,-6.77,;-3.9,-5.23,;-2.57,-4.46,;-1.23,-5.23,;.23,-4.76,;1.14,-6,;.23,-7.25,;.63,-8.74,;2.12,-9.14,;2.52,-10.62,;1.43,-11.71,;1.83,-13.2,;-.06,-11.31,;-.46,-9.83,;-1.23,-6.77,;-2.57,-7.54,;.63,-3.27,;2.12,-2.87,;2.52,-1.38,;1.43,-.29,;-.06,-.69,;-.46,-2.18,;1.83,1.19,;.29,1.19,;1.06,2.53,;3.31,1.59,;4.4,.5,;3.71,3.08,;5.2,3.48,;5.6,4.96,;4.51,6.05,;3.02,5.66,;2.62,4.17,;4.91,7.54,;3.82,8.63,;6.4,7.94,;6.8,9.43,;8.28,9.83,;8.68,11.31,;10.17,11.71,;10.57,13.2,)| Show InChI InChI=1S/C33H43N7O5S/c1-4-5-19-35-33-36-22-29-30(38-40(31(29)37-33)26-13-15-27(41)16-14-26)23-9-17-28(18-10-23)46(43,44)39(2)25-11-7-24(8-12-25)32(42)34-20-6-21-45-3/h7-12,17-18,22,26-27,41H,4-6,13-16,19-21H2,1-3H3,(H,34,42)(H,35,36,37)/t26?,27- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336506
(US9744172, Compound UNC1350A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)Nc1ccc(F)cc1 |r,wU:30.33,wD:15.15,(-11.06,-4.57,;-9.72,-3.8,;-8.39,-4.57,;-7.06,-3.8,;-5.72,-4.57,;-4.39,-3.8,;-4.39,-2.26,;-3.06,-1.49,;-1.72,-2.26,;-.26,-1.78,;.65,-3.03,;-.26,-4.27,;.14,-5.76,;1.63,-6.16,;2.03,-7.65,;.94,-8.74,;1.34,-10.22,;-.55,-8.34,;-.95,-6.85,;-1.72,-3.8,;-3.06,-4.57,;.14,-.3,;1.63,.1,;2.03,1.59,;.94,2.68,;-.55,2.28,;-.95,.79,;1.34,4.17,;.25,5.26,;2.82,4.57,;3.22,6.05,;2.13,7.14,;.65,6.74,;2.53,8.63,;4.71,6.45,;5.8,5.36,;5.11,7.94,;6.6,8.34,;7.68,7.25,;9.17,7.65,;9.57,9.14,;11.06,9.53,;8.48,10.22,;6.99,9.83,)| Show InChI InChI=1S/C33H40FN7O3/c1-4-5-18-35-33-36-19-27-29(40-41(30(27)39-33)25-14-16-26(42)17-15-25)21-6-8-22(9-7-21)31(43)38-28(20(2)3)32(44)37-24-12-10-23(34)11-13-24/h6-13,19-20,25-26,28,42H,4-5,14-18H2,1-3H3,(H,37,44)(H,38,43)(H,35,36,39)/t25?,26-,28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336509
(US9744172, Compound UNC1227A)Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCO |r,wU:12.11,wD:15.15,(-6.94,-4.12,;-5.61,-3.35,;-4.27,-4.12,;-2.94,-3.35,;-1.61,-4.12,;-.27,-3.35,;-.27,-1.81,;1.06,-1.04,;2.39,-1.81,;3.86,-1.33,;4.76,-2.58,;3.86,-3.82,;4.26,-5.31,;5.75,-5.71,;6.14,-7.2,;5.05,-8.29,;5.45,-9.77,;3.57,-7.89,;3.17,-6.4,;2.39,-3.35,;1.06,-4.12,;4.26,.16,;5.75,.56,;6.14,2.04,;5.05,3.13,;3.57,2.73,;3.17,1.25,;5.45,4.62,;3.97,5.02,;6.94,4.22,;5.85,6.11,;4.76,7.2,;5.16,8.68,;4.07,9.77,)| Show InChI InChI=1S/C23H32N6O4S/c1-2-3-12-24-23-25-15-20-21(16-4-10-19(11-5-16)34(32,33)26-13-14-30)28-29(22(20)27-23)17-6-8-18(31)9-7-17/h4-5,10-11,15,17-18,26,30-31H,2-3,6-9,12-14H2,1H3,(H,24,25,27)/t17-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336263
(US9744172, Compound UNC582A)Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCOCC1 |r,wD:16.16,(-8.57,-4.12,;-7.24,-3.35,;-5.91,-4.12,;-4.57,-3.35,;-3.24,-4.12,;-1.91,-3.35,;-1.91,-1.81,;-.57,-1.04,;.76,-1.81,;2.23,-1.33,;3.13,-2.58,;2.23,-3.82,;2.62,-5.31,;4.11,-5.71,;5.2,-4.62,;6.69,-5.02,;7.09,-6.51,;8.57,-6.9,;6,-7.59,;4.51,-7.2,;.76,-3.35,;-.57,-4.12,;2.62,.16,;4.11,.56,;4.51,2.04,;3.42,3.13,;1.93,2.73,;1.54,1.25,;3.82,4.62,;5.31,5.02,;5.71,6.51,;4.62,7.59,;3.13,7.2,;2.73,5.71,)| Show InChI InChI=1S/C26H37N7O/c1-2-3-12-28-26-29-17-23-24(20-6-10-22(11-7-20)32-13-15-34-16-14-32)31-33(25(23)30-26)18-19-4-8-21(27)9-5-19/h6-7,10-11,17,19,21H,2-5,8-9,12-16,18,27H2,1H3,(H,28,29,30)/t19?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336372
(US9744172, Compound UNC983A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC |r,wD:15.15,(-7.34,-3.23,;-6.01,-2.46,;-4.67,-3.23,;-3.34,-2.46,;-2,-3.23,;-.67,-2.46,;-.67,-.92,;.66,-.15,;2,-.92,;3.46,-.44,;4.37,-1.69,;3.46,-2.93,;3.86,-4.42,;5.35,-4.82,;5.75,-6.31,;4.66,-7.4,;5.05,-8.88,;3.17,-7,;2.77,-5.51,;2,-2.46,;.66,-3.23,;3.86,1.05,;5.35,1.45,;5.75,2.93,;4.66,4.02,;3.17,3.62,;2.77,2.14,;5.05,5.51,;6.59,5.51,;3.72,6.28,;5.45,7,;6.94,7.4,;7.34,8.88,)| Show InChI InChI=1S/C23H32N6O3S/c1-3-5-14-24-23-25-15-20-21(16-6-12-19(13-7-16)33(31,32)26-4-2)28-29(22(20)27-23)17-8-10-18(30)11-9-17/h6-7,12-13,15,17-18,26,30H,3-5,8-11,14H2,1-2H3,(H,24,25,27)/t17?,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336383
(US9744172, Compound UNC1059A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC |r,wD:15.15,(-8.08,-3.43,;-6.75,-2.66,;-5.42,-3.43,;-4.08,-2.66,;-2.75,-3.43,;-1.42,-2.66,;-1.42,-1.12,;-.08,-.35,;1.25,-1.12,;2.72,-.64,;3.62,-1.89,;2.72,-3.13,;3.12,-4.62,;4.6,-5.02,;5,-6.51,;3.91,-7.59,;4.31,-9.08,;2.43,-7.2,;2.03,-5.71,;1.25,-2.66,;-.08,-3.43,;3.12,.85,;4.6,1.25,;5,2.73,;3.91,3.82,;2.43,3.42,;2.03,1.94,;4.31,5.31,;5.85,5.31,;2.98,6.08,;4.71,6.8,;6.2,7.2,;6.6,8.68,;8.08,9.08,)| Show InChI InChI=1S/C24H34N6O3S/c1-3-5-15-25-24-26-16-21-22(17-6-12-20(13-7-17)34(32,33)27-14-4-2)29-30(23(21)28-24)18-8-10-19(31)11-9-18/h6-7,12-13,16,18-19,27,31H,3-5,8-11,14-15H2,1-2H3,(H,25,26,28)/t18?,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336394
(US9744172, Compound UNC906A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC |r,wD:15.15,(-6.94,-2.83,;-5.61,-2.06,;-4.27,-2.83,;-2.94,-2.06,;-1.61,-2.83,;-.27,-2.06,;-.27,-.52,;1.06,.25,;2.39,-.52,;3.86,-.04,;4.76,-1.29,;3.86,-2.53,;4.26,-4.02,;5.75,-4.42,;6.14,-5.91,;5.05,-7,;5.45,-8.48,;3.57,-6.6,;3.17,-5.11,;2.39,-2.06,;1.06,-2.83,;4.26,1.45,;5.75,1.84,;6.14,3.33,;5.05,4.42,;3.57,4.02,;3.17,2.53,;5.45,5.91,;3.97,6.31,;6.94,5.51,;5.85,7.4,;4.76,8.48,)| Show InChI InChI=1S/C22H30N6O3S/c1-3-4-13-24-22-25-14-19-20(15-5-11-18(12-6-15)32(30,31)23-2)27-28(21(19)26-22)16-7-9-17(29)10-8-16/h5-6,11-12,14,16-17,23,29H,3-4,7-10,13H2,1-2H3,(H,24,25,26)/t16?,17- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336407
(US9744172, Compound UNC1084A)Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1 |r,wU:13.12,wD:16.16,(-8.57,-4.12,;-7.24,-3.35,;-5.91,-4.12,;-4.57,-3.35,;-3.24,-4.12,;-1.91,-3.35,;-1.91,-1.81,;-.57,-1.04,;.76,-1.81,;2.23,-1.33,;3.13,-2.58,;2.23,-3.82,;2.62,-5.31,;4.11,-5.71,;5.2,-4.62,;6.69,-5.02,;7.09,-6.51,;8.57,-6.9,;6,-7.59,;4.51,-7.2,;.76,-3.35,;-.57,-4.12,;2.62,.16,;1.54,1.25,;1.93,2.73,;3.42,3.13,;3.82,4.62,;5.31,5.02,;5.71,6.51,;4.62,7.59,;3.13,7.2,;2.73,5.71,;4.51,2.04,;6,2.44,;4.11,.56,)| Show InChI InChI=1S/C26H36FN7O/c1-2-3-10-29-26-30-16-21-24(19-6-9-23(22(27)15-19)33-11-13-35-14-12-33)32-34(25(21)31-26)17-18-4-7-20(28)8-5-18/h6,9,15-16,18,20H,2-5,7-8,10-14,17,28H2,1H3,(H,29,30,31)/t18-,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336410
(US9744172, Compound UNC1168A)Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(Br)cc1 |r,wU:13.12,wD:16.16,(-8.57,-2.63,;-7.24,-1.86,;-5.91,-2.63,;-4.57,-1.86,;-3.24,-2.63,;-1.91,-1.86,;-1.91,-.32,;-.57,.45,;.76,-.32,;2.23,.16,;3.13,-1.09,;2.23,-2.33,;2.62,-3.82,;4.11,-4.22,;5.2,-3.13,;6.69,-3.53,;7.09,-5.02,;8.57,-5.42,;6,-6.11,;4.51,-5.71,;.76,-1.86,;-.57,-2.63,;2.62,1.64,;4.11,2.04,;4.51,3.53,;3.42,4.62,;3.82,6.11,;1.93,4.22,;1.54,2.73,)| Show InChI InChI=1S/C22H29BrN6/c1-2-3-12-25-22-26-13-19-20(16-6-8-17(23)9-7-16)28-29(21(19)27-22)14-15-4-10-18(24)11-5-15/h6-9,13,15,18H,2-5,10-12,14,24H2,1H3,(H,25,26,27)/t15-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336417
(US9744172, Compound UNC1062A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 |r,wD:15.15,(-7.34,-3.77,;-6.01,-3,;-4.67,-3.77,;-3.34,-3,;-2,-3.77,;-.67,-3,;-.67,-1.46,;.66,-.69,;2,-1.46,;3.46,-.99,;4.37,-2.23,;3.46,-3.48,;3.86,-4.96,;5.35,-5.36,;5.75,-6.85,;4.66,-7.94,;5.05,-9.43,;3.17,-7.54,;2.77,-6.05,;2,-3,;.66,-3.77,;3.86,.5,;5.35,.9,;5.75,2.39,;4.66,3.48,;3.17,3.08,;2.77,1.59,;5.05,4.96,;3.57,5.36,;6.54,4.57,;5.45,6.45,;6.94,6.85,;7.34,8.34,;6.25,9.43,;4.76,9.03,;4.36,7.54,)| Show InChI InChI=1S/C25H34N6O4S/c1-2-3-12-26-25-27-17-22-23(29-31(24(22)28-25)19-6-8-20(32)9-7-19)18-4-10-21(11-5-18)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17,19-20,32H,2-3,6-9,12-16H2,1H3,(H,26,27,28)/t19?,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336421
(US9744172, Compound UNC1170A)Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCOCC1 |r,wD:16.16,(-8.68,-4.25,;-7.35,-3.48,;-6.01,-4.25,;-4.68,-3.48,;-3.34,-4.25,;-2.01,-3.48,;-2.01,-1.94,;-.68,-1.17,;.66,-1.94,;2.12,-1.46,;3.03,-2.71,;2.12,-3.95,;2.52,-5.44,;4.06,-5.44,;4.83,-4.11,;6.37,-4.11,;7.14,-5.44,;8.68,-5.44,;6.37,-6.77,;4.83,-6.77,;.66,-3.48,;-.68,-4.25,;2.52,.03,;4.01,.43,;4.41,1.91,;3.32,3,;1.83,2.6,;1.43,1.12,;3.72,4.49,;2.63,5.58,;5.2,4.89,;6.29,3.8,;7.78,4.2,;8.18,5.68,;7.09,6.77,;5.6,6.38,)| Show InChI InChI=1S/C27H37N7O2/c1-2-3-12-29-27-30-17-23-24(32-34(25(23)31-27)18-19-4-10-22(28)11-5-19)20-6-8-21(9-7-20)26(35)33-13-15-36-16-14-33/h6-9,17,19,22H,2-5,10-16,18,28H2,1H3,(H,29,30,31)/t19?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336422
(US9744172, Compound UNC1179A)Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)NC |r,wD:16.16,(-8.68,-3.65,;-7.35,-2.88,;-6.01,-3.65,;-4.68,-2.88,;-3.34,-3.65,;-2.01,-2.88,;-2.01,-1.34,;-.68,-.57,;.66,-1.34,;2.12,-.86,;3.03,-2.11,;2.12,-3.35,;2.52,-4.84,;4.06,-4.84,;4.83,-3.51,;6.37,-3.51,;7.14,-4.84,;8.68,-4.84,;6.37,-6.18,;4.83,-6.18,;.66,-2.88,;-.68,-3.65,;2.52,.62,;4.01,1.02,;4.41,2.51,;3.32,3.6,;1.83,3.2,;1.43,1.71,;3.72,5.09,;2.63,6.18,;5.2,5.49,;6.29,4.4,)| Show InChI InChI=1S/C24H33N7O/c1-3-4-13-27-24-28-14-20-21(17-7-9-18(10-8-17)23(32)26-2)30-31(22(20)29-24)15-16-5-11-19(25)12-6-16/h7-10,14,16,19H,3-6,11-13,15,25H2,1-2H3,(H,26,32)(H,27,28,29)/t16?,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336443
(US9744172, Compound UNC1185A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC(=O)NC1CCCC1 |r,wD:15.15,(-10.07,-4.36,;-8.74,-3.59,;-7.41,-4.36,;-6.07,-3.59,;-4.74,-4.36,;-3.4,-3.59,;-3.4,-2.05,;-2.07,-1.28,;-.74,-2.05,;.73,-1.57,;1.63,-2.82,;.73,-4.06,;1.13,-5.55,;2.61,-5.95,;3.01,-7.44,;1.92,-8.53,;2.32,-10.01,;.44,-8.13,;.04,-6.64,;-.74,-3.59,;-2.07,-4.36,;1.13,-.08,;2.61,.31,;3.01,1.8,;1.92,2.89,;.44,2.49,;.04,1,;2.32,4.38,;.83,4.78,;1.92,5.87,;3.81,4.78,;4.21,6.26,;5.7,6.66,;6.78,5.57,;6.09,8.15,;7.58,8.55,;8.06,10.01,;9.6,10.01,;10.07,8.55,;8.83,7.64,)| Show InChI InChI=1S/C28H39N7O4S/c1-2-3-16-29-28-30-17-24-26(34-35(27(24)33-28)21-10-12-22(36)13-11-21)19-8-14-23(15-9-19)40(38,39)31-18-25(37)32-20-6-4-5-7-20/h8-9,14-15,17,20-22,31,36H,2-7,10-13,16,18H2,1H3,(H,32,37)(H,29,30,33)/t21?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336452
(US9744172, Compound UNC1222A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)NC2CCCC2)cc1 |r,wD:15.15,(-9.13,-3.41,;-7.8,-2.64,;-6.46,-3.41,;-5.13,-2.64,;-3.8,-3.41,;-2.46,-2.64,;-2.46,-1.1,;-1.13,-.33,;.21,-1.1,;1.67,-.63,;2.58,-1.87,;1.67,-3.12,;2.07,-4.61,;3.56,-5.01,;3.96,-6.49,;2.87,-7.58,;3.26,-9.07,;1.38,-7.18,;.98,-5.7,;.21,-2.64,;-1.13,-3.41,;2.07,.86,;3.56,1.26,;3.96,2.74,;2.87,3.83,;3.26,5.32,;4.75,5.72,;5.84,4.63,;5.15,7.21,;6.64,7.61,;7.11,9.07,;8.65,9.07,;9.13,7.61,;7.88,6.7,;1.38,3.44,;.98,1.95,)| Show InChI InChI=1S/C27H37N7O2/c1-2-3-16-28-26-29-17-23-24(33-34(25(23)32-26)21-12-14-22(35)15-13-21)18-8-10-20(11-9-18)31-27(36)30-19-6-4-5-7-19/h8-11,17,19,21-22,35H,2-7,12-16H2,1H3,(H,28,29,32)(H2,30,31,36)/t21?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336461
(US9744172, Compound UNC1149A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1 |r,wD:15.15,(-7.29,-3.03,;-5.95,-2.26,;-4.62,-3.03,;-3.29,-2.26,;-1.95,-3.03,;-.62,-2.26,;-.62,-.72,;.72,.05,;2.05,-.72,;3.51,-.24,;4.42,-1.49,;3.51,-2.73,;3.91,-4.22,;5.4,-4.62,;5.8,-6.11,;4.71,-7.2,;5.11,-8.68,;3.22,-6.8,;2.82,-5.31,;2.05,-2.26,;.72,-3.03,;3.91,1.25,;2.82,2.33,;3.22,3.82,;4.71,4.22,;5.11,5.71,;6.6,6.11,;6.99,7.59,;5.91,8.68,;4.42,8.29,;4.02,6.8,;5.8,3.13,;7.29,3.53,;5.4,1.64,)| Show InChI InChI=1S/C25H33FN6O2/c1-2-3-10-27-25-28-16-20-23(30-32(24(20)29-25)18-5-7-19(33)8-6-18)17-4-9-22(21(26)15-17)31-11-13-34-14-12-31/h4,9,15-16,18-19,33H,2-3,5-8,10-14H2,1H3,(H,27,28,29)/t18?,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336470
(US9744172, Compound UNC1269A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)NC1CCCCC1 |r,wD:15.15,(-9.97,-5.86,;-8.64,-5.09,;-7.3,-5.86,;-5.97,-5.09,;-4.63,-5.86,;-3.3,-5.09,;-3.3,-3.55,;-1.97,-2.78,;-.63,-3.55,;.83,-3.07,;1.74,-4.32,;.83,-5.56,;1.23,-7.05,;2.72,-7.45,;3.12,-8.94,;2.03,-10.03,;2.43,-11.51,;.54,-9.63,;.14,-8.14,;-.63,-5.09,;-1.97,-5.86,;1.23,-1.58,;2.72,-1.18,;3.12,.3,;2.03,1.39,;.54,.99,;.14,-.49,;2.43,2.88,;.94,3.28,;2.03,4.37,;3.91,3.28,;4.31,4.77,;5.8,5.16,;6.2,6.65,;5.11,7.74,;7.68,7.05,;8.08,8.54,;9.57,8.94,;9.97,10.42,;8.88,11.51,;7.39,11.11,;6.99,9.63,)| Show InChI InChI=1S/C30H43N7O4S/c1-2-3-18-31-30-32-20-26-28(36-37(29(26)35-30)23-11-13-24(38)14-12-23)21-9-15-25(16-10-21)42(40,41)33-19-17-27(39)34-22-7-5-4-6-8-22/h9-10,15-16,20,22-24,33,38H,2-8,11-14,17-19H2,1H3,(H,34,39)(H,31,32,35)/t23?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336472
(US9744172, Compound UNC1234A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(N)cc1 |r,wD:15.15,(-6.54,-1.54,;-5.21,-.77,;-3.88,-1.54,;-2.54,-.77,;-1.21,-1.54,;.13,-.77,;.13,.77,;1.46,1.54,;2.79,.77,;4.26,1.25,;5.16,,;4.26,-1.25,;4.66,-2.73,;6.14,-3.13,;6.54,-4.62,;5.45,-5.71,;5.85,-7.2,;3.97,-5.31,;3.57,-3.82,;2.79,-.77,;1.46,-1.54,;4.66,2.73,;6.14,3.13,;6.54,4.62,;5.45,5.71,;5.85,7.2,;3.97,5.31,;3.57,3.82,)| Show InChI InChI=1S/C21H28N6O/c1-2-3-12-23-21-24-13-18-19(14-4-6-15(22)7-5-14)26-27(20(18)25-21)16-8-10-17(28)11-9-16/h4-7,13,16-17,28H,2-3,8-12,22H2,1H3,(H,23,24,25)/t16?,17- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336478
(US9744172, Compound UNC1284A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCCCC1 |r,wU:15.15,(-10.31,-4.57,;-8.98,-3.8,;-7.65,-4.57,;-6.31,-3.8,;-4.98,-4.57,;-3.65,-3.8,;-3.65,-2.26,;-2.31,-1.49,;-.98,-2.26,;.49,-1.78,;1.39,-3.03,;.49,-4.27,;.88,-5.76,;-.2,-6.85,;.19,-8.34,;1.68,-8.74,;2.08,-10.22,;2.77,-7.65,;2.37,-6.16,;-.98,-3.8,;-2.31,-4.57,;.88,-.3,;2.37,.1,;2.77,1.59,;1.68,2.68,;.19,2.28,;-.2,.79,;2.08,4.17,;.59,4.57,;1.68,5.66,;3.57,4.57,;3.97,6.05,;5.45,6.45,;5.85,7.94,;4.76,9.03,;7.34,8.34,;8.43,7.25,;9.92,7.65,;10.31,9.14,;9.23,10.22,;7.74,9.83,)| Show InChI InChI=1S/C29H41N7O4S/c1-2-3-16-30-29-31-20-25-27(34-36(28(25)33-29)22-9-11-23(37)12-10-22)21-7-13-24(14-8-21)41(39,40)32-17-15-26(38)35-18-5-4-6-19-35/h7-8,13-14,20,22-23,32,37H,2-6,9-12,15-19H2,1H3,(H,30,31,33)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336512
(US9744172, Compound UNC1285A)Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCN(CC)CC2)c(F)c1 |r,wU:12.11,wD:15.15,(-7.29,-4.32,;-5.95,-3.55,;-4.62,-4.32,;-3.29,-3.55,;-1.95,-4.32,;-.62,-3.55,;-.62,-2.01,;.72,-1.24,;2.05,-2.01,;3.51,-1.53,;4.42,-2.78,;3.51,-4.02,;3.91,-5.51,;5.4,-5.91,;5.8,-7.4,;4.71,-8.48,;5.11,-9.97,;3.22,-8.09,;2.82,-6.6,;2.05,-3.55,;.72,-4.32,;3.91,-.04,;2.82,1.05,;3.22,2.53,;4.71,2.93,;5.11,4.42,;6.6,4.82,;6.99,6.31,;5.91,7.4,;6.3,8.88,;5.22,9.97,;4.42,7,;4.02,5.51,;5.8,1.84,;7.29,2.24,;5.4,.36,)| Show InChI InChI=1S/C27H38FN7O/c1-3-5-12-29-27-30-18-22-25(32-35(26(22)31-27)20-7-9-21(36)10-8-20)19-6-11-24(23(28)17-19)34-15-13-33(4-2)14-16-34/h6,11,17-18,20-21,36H,3-5,7-10,12-16H2,1-2H3,(H,29,30,31)/t20-,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336260
(US9744172, Compound UNC00000569A)Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1 |r,wD:16.16,(-8.57,-2.63,;-7.24,-1.86,;-5.91,-2.63,;-4.57,-1.86,;-3.24,-2.63,;-1.91,-1.86,;-1.91,-.32,;-.57,.45,;.76,-.32,;2.23,.16,;3.13,-1.09,;2.23,-2.33,;2.62,-3.82,;4.11,-4.22,;5.2,-3.13,;6.69,-3.53,;7.09,-5.02,;8.57,-5.42,;6,-6.11,;4.51,-5.71,;.76,-1.86,;-.57,-2.63,;2.62,1.64,;4.11,2.04,;4.51,3.53,;3.42,4.62,;3.82,6.11,;1.93,4.22,;1.54,2.73,)| Show InChI InChI=1S/C22H29FN6/c1-2-3-12-25-22-26-13-19-20(16-6-8-17(23)9-7-16)28-29(21(19)27-22)14-15-4-10-18(24)11-5-15/h6-9,13,15,18H,2-5,10-12,14,24H2,1H3,(H,25,26,27)/t15?,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336262
(US9744172, Compound UNC583A)Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCNCC1 |r,wD:16.16,(-8.57,-4.12,;-7.24,-3.35,;-5.91,-4.12,;-4.57,-3.35,;-3.24,-4.12,;-1.91,-3.35,;-1.91,-1.81,;-.57,-1.04,;.76,-1.81,;2.23,-1.33,;3.13,-2.58,;2.23,-3.82,;2.62,-5.31,;4.11,-5.71,;5.2,-4.62,;6.69,-5.02,;7.09,-6.51,;8.57,-6.9,;6,-7.59,;4.51,-7.2,;.76,-3.35,;-.57,-4.12,;2.62,.16,;4.11,.56,;4.51,2.04,;3.42,3.13,;1.93,2.73,;1.54,1.25,;3.82,4.62,;5.31,5.02,;5.71,6.51,;4.62,7.59,;3.13,7.2,;2.73,5.71,)| Show InChI InChI=1S/C26H38N8/c1-2-3-12-29-26-30-17-23-24(20-6-10-22(11-7-20)33-15-13-28-14-16-33)32-34(25(23)31-26)18-19-4-8-21(27)9-5-19/h6-7,10-11,17,19,21,28H,2-5,8-9,12-16,18,27H2,1H3,(H,29,30,31)/t19?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336281
(US9744172, Compound UNC605A)Show SMILES O[C@H]1CC[C@H](Cn2nc(-c3ccc(cc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1 |r,wU:4.4,wD:1.0,(9.91,-6.9,;8.42,-6.51,;8.02,-5.02,;6.53,-4.62,;5.45,-5.71,;3.96,-5.31,;3.56,-3.82,;4.46,-2.58,;3.56,-1.33,;3.96,.16,;5.45,.56,;5.84,2.04,;4.76,3.13,;3.27,2.73,;2.87,1.25,;5.15,4.62,;6.64,5.02,;7.04,6.51,;5.95,7.59,;4.46,7.2,;4.06,5.71,;2.09,-1.81,;.76,-1.04,;-.57,-1.81,;-.57,-3.35,;-1.91,-4.12,;-3.24,-3.35,;-4.57,-4.12,;-5.91,-3.35,;-7.24,-4.12,;-8.57,-3.35,;-9.91,-4.12,;-9.91,-5.66,;-8.57,-6.43,;-7.24,-5.66,;.76,-4.12,;2.09,-3.35,;5.84,-7.2,;7.33,-7.59,)| Show InChI InChI=1S/C31H39N7O/c39-27-14-8-24(9-15-27)22-38-30-28(21-34-31(35-30)33-16-4-7-23-5-2-1-3-6-23)29(36-38)25-10-12-26(13-11-25)37-19-17-32-18-20-37/h1-3,5-6,10-13,21,24,27,32,39H,4,7-9,14-20,22H2,(H,33,34,35)/t24-,27- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336323
(US9744172, Compound UNC00000475A)Show SMILES CCCCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1 |(-9.91,-1.89,;-8.57,-1.12,;-7.24,-1.89,;-5.91,-1.12,;-4.57,-1.89,;-3.24,-1.12,;-1.91,-1.89,;-.57,-1.12,;-.57,.42,;.76,1.19,;2.09,.42,;3.56,.9,;4.46,-.35,;3.56,-1.59,;3.96,-3.08,;5.45,-3.48,;5.84,-4.96,;7.33,-5.36,;8.42,-4.27,;9.91,-4.67,;8.02,-2.79,;6.53,-2.39,;2.09,-1.12,;.76,-1.89,;3.96,2.39,;5.45,2.79,;5.84,4.27,;4.76,5.36,;3.27,4.96,;2.87,3.48,)| Show InChI InChI=1S/C24H34N6/c1-2-3-4-8-15-26-24-27-16-21-22(19-9-6-5-7-10-19)29-30(23(21)28-24)17-18-11-13-20(25)14-12-18/h5-7,9-10,16,18,20H,2-4,8,11-15,17,25H2,1H3,(H,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336366
(US9744172, Compound UNC973A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCCC |r,wD:15.15,(-8.28,-4.17,;-6.95,-3.4,;-5.62,-4.17,;-4.28,-3.4,;-2.95,-4.17,;-1.61,-3.4,;-1.61,-1.86,;-.28,-1.09,;1.05,-1.86,;2.52,-1.38,;3.42,-2.63,;2.52,-3.88,;2.92,-5.36,;4.4,-5.76,;4.8,-7.25,;3.71,-8.34,;4.11,-9.83,;2.23,-7.94,;1.83,-6.45,;1.05,-3.4,;-.28,-4.17,;2.92,.1,;4.4,.5,;4.8,1.99,;3.71,3.08,;2.23,2.68,;1.83,1.19,;4.11,4.57,;5.65,4.57,;2.78,5.34,;4.51,6.05,;6,6.45,;6.4,7.94,;7.88,8.34,;8.28,9.83,)| Show InChI InChI=1S/C25H36N6O3S/c1-3-5-15-26-25-27-17-22-23(30-31(24(22)29-25)19-9-11-20(32)12-10-19)18-7-13-21(14-8-18)35(33,34)28-16-6-4-2/h7-8,13-14,17,19-20,28,32H,3-6,9-12,15-16H2,1-2H3,(H,26,27,29)/t19?,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336408
(US9744172, Compound UNC1085A)Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(CN2CCOCC2)c(F)c1 |r,wU:13.12,wD:16.16,(-8.57,-4.46,;-7.24,-3.69,;-5.91,-4.46,;-4.57,-3.69,;-3.24,-4.46,;-1.91,-3.69,;-1.91,-2.15,;-.57,-1.38,;.76,-2.15,;2.23,-1.68,;3.13,-2.92,;2.23,-4.17,;2.62,-5.66,;4.11,-6.05,;5.2,-4.96,;6.69,-5.36,;7.09,-6.85,;8.57,-7.25,;6,-7.94,;4.51,-7.54,;.76,-3.69,;-.57,-4.46,;2.62,-.19,;1.54,.9,;1.93,2.39,;3.42,2.79,;3.82,4.27,;2.73,5.36,;3.13,6.85,;2.04,7.94,;.55,7.54,;.15,6.05,;1.24,4.96,;4.51,1.7,;6,2.1,;4.11,.21,)| Show InChI InChI=1S/C27H38FN7O/c1-2-3-10-30-27-31-16-23-25(33-35(26(23)32-27)17-19-4-8-22(29)9-5-19)20-6-7-21(24(28)15-20)18-34-11-13-36-14-12-34/h6-7,15-16,19,22H,2-5,8-14,17-18,29H2,1H3,(H,30,31,32)/t19-,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336430
(US9744172, Compound UNC1095A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCCN1CCOCC1 |r,wD:15.15,(-9.23,-5.66,;-7.89,-4.89,;-6.56,-5.66,;-5.22,-4.89,;-3.89,-5.66,;-2.56,-4.89,;-2.56,-3.35,;-1.22,-2.58,;.11,-3.35,;1.57,-2.87,;2.48,-4.12,;1.57,-5.36,;1.97,-6.85,;3.46,-7.25,;3.86,-8.74,;2.77,-9.83,;3.17,-11.31,;1.28,-9.43,;.88,-7.94,;.11,-4.89,;-1.22,-5.66,;1.97,-1.38,;3.46,-.99,;3.86,.5,;2.77,1.59,;1.28,1.19,;.88,-.3,;3.17,3.08,;4.71,3.08,;1.68,3.48,;3.57,4.57,;5.06,4.96,;5.45,6.45,;6.94,6.85,;7.34,8.34,;8.83,8.74,;9.23,10.22,;8.14,11.31,;6.65,10.91,;6.25,9.43,)| Show InChI InChI=1S/C28H41N7O4S/c1-2-3-13-29-28-30-20-25-26(33-35(27(25)32-28)22-7-9-23(36)10-8-22)21-5-11-24(12-6-21)40(37,38)31-14-4-15-34-16-18-39-19-17-34/h5-6,11-12,20,22-23,31,36H,2-4,7-10,13-19H2,1H3,(H,29,30,32)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336437
(US9744172, Compound UNC1174A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC1CCN(CC1)C(=O)OC(C)(C)C |r,wD:15.15,(-12.07,-4.02,;-10.74,-3.25,;-9.4,-4.02,;-8.07,-3.25,;-6.74,-4.02,;-5.4,-3.25,;-5.4,-1.71,;-4.07,-.94,;-2.73,-1.71,;-1.27,-1.24,;-.36,-2.48,;-1.27,-3.73,;-.87,-5.22,;.62,-5.62,;1.01,-7.1,;-.07,-8.19,;.32,-9.68,;-1.56,-7.79,;-1.96,-6.31,;-2.73,-3.25,;-4.07,-4.02,;-.87,.25,;.62,.65,;1.01,2.14,;-.07,3.22,;-1.56,2.83,;-1.96,1.34,;.32,4.71,;-.07,6.2,;-1.16,5.11,;1.81,5.11,;2.21,6.6,;3.7,7,;4.79,5.91,;6.27,6.31,;6.67,7.79,;5.58,8.88,;4.1,8.48,;8.16,8.19,;8.56,9.68,;9.25,7.1,;10.74,7.5,;11.51,8.84,;12.07,6.73,;11.14,6.01,)| Show InChI InChI=1S/C32H47N7O5S/c1-5-6-17-33-30-34-21-27-28(37-39(29(27)36-30)24-9-11-25(40)12-10-24)23-7-13-26(14-8-23)45(42,43)35-20-22-15-18-38(19-16-22)31(41)44-32(2,3)4/h7-8,13-14,21-22,24-25,35,40H,5-6,9-12,15-20H2,1-4H3,(H,33,34,36)/t24?,25- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336450
(US9744172, Compound UNC1192A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NC(=O)NCCC)cc1 |r,wD:15.15,(-8.83,-3.63,;-7.49,-2.86,;-6.16,-3.63,;-4.83,-2.86,;-3.49,-3.63,;-2.16,-2.86,;-2.16,-1.32,;-.83,-.55,;.51,-1.32,;1.97,-.84,;2.88,-2.09,;1.97,-3.33,;2.37,-4.82,;3.86,-5.22,;4.26,-6.7,;3.17,-7.79,;3.57,-9.28,;1.68,-7.4,;1.28,-5.91,;.51,-2.86,;-.83,-3.63,;2.37,.65,;3.86,1.05,;4.26,2.53,;3.17,3.62,;3.57,5.11,;5.05,5.51,;6.14,4.42,;5.45,7,;6.94,7.4,;7.34,8.88,;8.83,9.28,;1.68,3.22,;1.28,1.74,)| Show InChI InChI=1S/C25H35N7O2/c1-3-5-15-26-24-28-16-21-22(17-6-8-18(9-7-17)29-25(34)27-14-4-2)31-32(23(21)30-24)19-10-12-20(33)13-11-19/h6-9,16,19-20,33H,3-5,10-15H2,1-2H3,(H,26,28,30)(H2,27,29,34)/t19?,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336457
(US9744172, Compound UNC1145A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCOCC1 |r,wD:15.15,(-7.94,-6,;-6.6,-5.23,;-5.27,-6,;-3.94,-5.23,;-2.6,-6,;-1.27,-5.23,;-1.27,-3.69,;.06,-2.92,;1.4,-3.69,;2.86,-3.22,;3.77,-4.46,;2.86,-5.71,;3.26,-7.2,;4.75,-7.59,;5.15,-9.08,;4.06,-10.17,;4.46,-11.66,;2.57,-9.77,;2.17,-8.29,;1.4,-5.23,;.06,-6,;3.26,-1.73,;4.75,-1.33,;5.15,.16,;4.06,1.25,;2.57,.85,;2.17,-.64,;4.46,2.73,;2.97,3.13,;5.94,2.33,;4.86,4.22,;6.34,4.62,;6.74,6.11,;5.65,7.2,;4.17,6.8,;3.77,5.31,;6.05,8.68,;7.54,9.08,;7.94,10.57,;6.85,11.66,;5.36,11.26,;4.96,9.77,)| Show InChI InChI=1S/C30H43N7O4S/c1-2-3-14-31-30-32-21-27-28(34-37(29(27)33-30)24-6-8-25(38)9-7-24)22-4-10-26(11-5-22)42(39,40)36-15-12-23(13-16-36)35-17-19-41-20-18-35/h4-5,10-11,21,23-25,38H,2-3,6-9,12-20H2,1H3,(H,31,32,33)/t24?,25- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336477
(US9744172, Compound UNC1283A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCCCC1 |r,wD:15.15,(-10.31,-4.57,;-8.98,-3.8,;-7.65,-4.57,;-6.31,-3.8,;-4.98,-4.57,;-3.65,-3.8,;-3.65,-2.26,;-2.31,-1.49,;-.98,-2.26,;.49,-1.78,;1.39,-3.03,;.49,-4.27,;.88,-5.76,;2.37,-6.16,;2.77,-7.65,;1.68,-8.74,;2.08,-10.22,;.19,-8.34,;-.2,-6.85,;-.98,-3.8,;-2.31,-4.57,;.88,-.3,;2.37,.1,;2.77,1.59,;1.68,2.68,;.19,2.28,;-.2,.79,;2.08,4.17,;.59,4.57,;1.68,5.66,;3.57,4.57,;3.97,6.05,;5.45,6.45,;5.85,7.94,;4.76,9.03,;7.34,8.34,;8.43,7.25,;9.92,7.65,;10.31,9.14,;9.23,10.22,;7.74,9.83,)| Show InChI InChI=1S/C29H41N7O4S/c1-2-3-16-30-29-31-20-25-27(34-36(28(25)33-29)22-9-11-23(37)12-10-22)21-7-13-24(14-8-21)41(39,40)32-17-15-26(38)35-18-5-4-6-19-35/h7-8,13-14,20,22-23,32,37H,2-6,9-12,15-19H2,1H3,(H,30,31,33)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336500
(US9744172, Compound UNC1344A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(CC)=C1C(=O)OC |r,wD:15.15,c:38,(-7.88,-4.12,;-6.55,-3.35,;-5.22,-4.12,;-3.88,-3.35,;-2.55,-4.12,;-1.22,-3.35,;-1.22,-1.81,;.12,-1.04,;1.45,-1.81,;2.92,-1.33,;3.82,-2.58,;2.92,-3.82,;3.31,-5.31,;4.8,-5.71,;5.2,-7.2,;4.11,-8.29,;4.51,-9.77,;2.62,-7.89,;2.23,-6.4,;1.45,-3.35,;.12,-4.12,;3.31,.16,;4.8,.56,;5.2,2.04,;4.11,3.13,;2.62,2.73,;2.23,1.25,;4.51,4.62,;6,5.02,;6.4,6.51,;7.88,6.9,;5.31,7.59,;3.82,7.2,;2.73,8.29,;3.13,9.77,;3.42,5.71,;1.93,5.31,;1.54,3.82,;.85,6.4,;-.64,6,)| Show InChI InChI=1S/C29H37N7O4/c1-4-6-15-30-28-31-16-21-24(35-36(26(21)34-28)19-11-13-20(37)14-12-19)17-7-9-18(10-8-17)25-23(27(38)40-3)22(5-2)32-29(39)33-25/h7-10,16,19-20,25,37H,4-6,11-15H2,1-3H3,(H,30,31,34)(H2,32,33,39)/t19?,20-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336503
(US9744172, Compound UNC1347A)Show SMILES CCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)N(C)C(CC)=C1C(=O)OC |r,wU:14.14,c:38,(-7.22,-3.35,;-5.88,-4.12,;-4.55,-3.35,;-3.22,-4.12,;-1.88,-3.35,;-1.88,-1.81,;-.55,-1.04,;.78,-1.81,;2.25,-1.33,;3.15,-2.58,;2.25,-3.82,;2.65,-5.31,;1.56,-6.4,;1.96,-7.89,;3.45,-8.29,;3.84,-9.77,;4.53,-7.2,;4.14,-5.71,;.78,-3.35,;-.55,-4.12,;2.65,.16,;4.14,.56,;4.53,2.04,;3.45,3.13,;1.96,2.73,;1.56,1.25,;3.84,4.62,;5.33,5.02,;5.73,6.51,;7.22,6.9,;4.64,7.59,;5.04,9.08,;3.15,7.2,;2.06,8.29,;2.46,9.77,;2.75,5.71,;1.27,5.31,;.87,3.82,;.18,6.4,;-1.31,6,)| Show InChI InChI=1S/C29H37N7O4/c1-5-15-30-28-31-16-21-24(34-36(26(21)33-28)19-11-13-20(37)14-12-19)17-7-9-18(10-8-17)25-23(27(38)40-4)22(6-2)35(3)29(39)32-25/h7-10,16,19-20,25,37H,5-6,11-15H2,1-4H3,(H,32,39)(H,30,31,33)/t19?,20-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336505
(US9744172, Compound UNC1349A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(C)=C1C(=O)OC |r,wU:15.15,c:37,(-7.88,-3.37,;-6.55,-2.6,;-5.22,-3.37,;-3.88,-2.6,;-2.55,-3.37,;-1.22,-2.6,;-1.22,-1.06,;.12,-.29,;1.45,-1.06,;2.92,-.59,;3.82,-1.83,;2.92,-3.08,;3.31,-4.57,;2.23,-5.66,;2.62,-7.14,;4.11,-7.54,;4.51,-9.03,;5.2,-6.45,;4.8,-4.96,;1.45,-2.6,;.12,-3.37,;3.31,.9,;4.8,1.3,;5.2,2.79,;4.11,3.88,;2.62,3.48,;2.23,1.99,;4.51,5.36,;6,5.76,;6.4,7.25,;7.88,7.65,;5.31,8.34,;3.82,7.94,;2.73,9.03,;3.42,6.45,;1.93,6.05,;1.54,4.57,;.85,7.14,;-.64,6.74,)| Show InChI InChI=1S/C28H35N7O4/c1-4-5-14-29-27-30-15-21-23(34-35(25(21)33-27)19-10-12-20(36)13-11-19)17-6-8-18(9-7-17)24-22(26(37)39-3)16(2)31-28(38)32-24/h6-9,15,19-20,24,36H,4-5,10-14H2,1-3H3,(H,29,30,33)(H2,31,32,38)/t19?,20-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336511
(US9744172, Compound UNC1229A)Show SMILES CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC[C@@H](O)CO |r,wU:12.11,wD:15.15,32.36,(-6.94,-4.86,;-5.61,-4.09,;-4.27,-4.86,;-2.94,-4.09,;-1.61,-4.86,;-.27,-4.09,;-.27,-2.55,;1.06,-1.78,;2.39,-2.55,;3.86,-2.07,;4.76,-3.32,;3.86,-4.57,;4.26,-6.05,;5.75,-6.45,;6.14,-7.94,;5.05,-9.03,;5.45,-10.52,;3.57,-8.63,;3.17,-7.14,;2.39,-4.09,;1.06,-4.86,;4.26,-.59,;5.75,-.19,;6.14,1.3,;5.05,2.39,;3.57,1.99,;3.17,.5,;5.45,3.88,;3.97,4.27,;6.94,3.48,;5.85,5.36,;4.76,6.45,;5.16,7.94,;6.65,8.34,;4.07,9.03,;4.47,10.52,)| Show InChI InChI=1S/C24H34N6O5S/c1-2-3-12-25-24-26-14-21-22(29-30(23(21)28-24)17-6-8-18(32)9-7-17)16-4-10-20(11-5-16)36(34,35)27-13-19(33)15-31/h4-5,10-11,14,17-19,27,31-33H,2-3,6-9,12-13,15H2,1H3,(H,25,26,28)/t17-,18-,19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336265
(US9744172, Compound UNC580A)Show SMILES N[C@H]1CCC(Cn2nc(-c3ccc(F)cc3)c3cnc(NCCCc4ccccc4)nc23)CC1 |r,wD:1.0,(9.91,-5.42,;8.42,-5.02,;8.02,-3.53,;6.53,-3.13,;5.45,-4.22,;3.96,-3.82,;3.56,-2.33,;4.46,-1.09,;3.56,.16,;3.96,1.64,;5.45,2.04,;5.84,3.53,;4.76,4.62,;5.15,6.11,;3.27,4.22,;2.87,2.73,;2.09,-.32,;.76,.45,;-.57,-.32,;-.57,-1.86,;-1.91,-2.63,;-3.24,-1.86,;-4.57,-2.63,;-5.91,-1.86,;-7.24,-2.63,;-8.57,-1.86,;-9.91,-2.63,;-9.91,-4.17,;-8.57,-4.94,;-7.24,-4.17,;.76,-2.63,;2.09,-1.86,;5.84,-5.71,;7.33,-6.11,)| Show InChI InChI=1S/C27H31FN6/c28-22-12-10-21(11-13-22)25-24-17-31-27(30-16-4-7-19-5-2-1-3-6-19)32-26(24)34(33-25)18-20-8-14-23(29)15-9-20/h1-3,5-6,10-13,17,20,23H,4,7-9,14-16,18,29H2,(H,30,31,32)/t20?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336270
(US9744172, Compound UNC593A)Show SMILES CCCCNc1ncc2c(nn(C[C@@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCNCC1 |r,wU:13.12,16.16,(-8.57,-4.12,;-7.24,-3.35,;-5.91,-4.12,;-4.57,-3.35,;-3.24,-4.12,;-1.91,-3.35,;-1.91,-1.81,;-.57,-1.04,;.76,-1.81,;2.23,-1.33,;3.13,-2.58,;2.23,-3.82,;2.62,-5.31,;4.11,-5.71,;4.51,-7.2,;6,-7.59,;7.09,-6.51,;8.57,-6.9,;6.69,-5.02,;5.2,-4.62,;.76,-3.35,;-.57,-4.12,;2.62,.16,;4.11,.56,;4.51,2.04,;3.42,3.13,;1.93,2.73,;1.54,1.25,;3.82,4.62,;5.31,5.02,;5.71,6.51,;4.62,7.59,;3.13,7.2,;2.73,5.71,)| Show InChI InChI=1S/C26H37N7O/c1-2-3-12-28-26-29-17-23-24(20-6-8-21(9-7-20)32-15-13-27-14-16-32)31-33(25(23)30-26)18-19-4-10-22(34)11-5-19/h6-9,17,19,22,27,34H,2-5,10-16,18H2,1H3,(H,28,29,30)/t19-,22+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM50384602
(CHEMBL2036795 | US9744172, Compound UNC00000344A)Show SMILES CCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1 |(18.02,-41.5,;18.01,-43.04,;19.35,-43.81,;19.35,-45.35,;20.68,-46.13,;22.01,-45.36,;22.02,-43.81,;23.35,-43.04,;24.68,-43.81,;26.16,-43.33,;27.07,-44.58,;26.16,-45.84,;26.63,-47.3,;25.6,-48.44,;24.09,-48.11,;23.06,-49.25,;23.53,-50.72,;22.5,-51.86,;25.04,-51.04,;26.08,-49.9,;24.68,-45.36,;23.35,-46.13,;26.63,-41.86,;28.14,-41.54,;28.62,-40.08,;27.58,-38.94,;26.07,-39.26,;25.6,-40.73,)| Show InChI InChI=1S/C22H30N6/c1-2-3-13-24-22-25-14-19-20(17-7-5-4-6-8-17)27-28(21(19)26-22)15-16-9-11-18(23)12-10-16/h4-8,14,16,18H,2-3,9-13,15,23H2,1H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336364
(US9744172, Compound UNC971A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCCCC1 |r,wD:15.15,(-8.63,-3.43,;-7.29,-2.66,;-5.96,-3.43,;-4.63,-2.66,;-3.29,-3.43,;-1.96,-2.66,;-1.96,-1.12,;-.63,-.35,;.71,-1.12,;2.17,-.64,;3.08,-1.89,;2.17,-3.13,;2.57,-4.62,;4.06,-5.02,;4.46,-6.51,;3.37,-7.59,;3.77,-9.08,;1.88,-7.2,;1.48,-5.71,;.71,-2.66,;-.63,-3.43,;2.57,.85,;4.06,1.25,;4.46,2.73,;3.37,3.82,;1.88,3.42,;1.48,1.94,;3.77,5.31,;5.31,5.31,;2.43,6.08,;4.17,6.8,;5.65,7.2,;6.74,6.11,;8.23,6.51,;8.63,7.99,;7.54,9.08,;6.05,8.68,)| Show InChI InChI=1S/C27H38N6O3S/c1-2-3-17-28-27-29-18-24-25(31-33(26(24)30-27)21-11-13-22(34)14-12-21)19-9-15-23(16-10-19)37(35,36)32-20-7-5-4-6-8-20/h9-10,15-16,18,20-22,32,34H,2-8,11-14,17H2,1H3,(H,28,29,30)/t21?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336381
(US9744172, Compound UNC1036A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCCC1 |r,wU:15.15,(-8.39,-3.22,;-7.05,-2.45,;-5.72,-3.22,;-4.39,-2.45,;-3.05,-3.22,;-1.72,-2.45,;-1.72,-.91,;-.38,-.14,;.95,-.91,;2.41,-.43,;3.32,-1.68,;2.41,-2.92,;2.81,-4.41,;1.72,-5.5,;2.12,-6.99,;3.61,-7.38,;4.01,-8.87,;4.7,-6.29,;4.3,-4.81,;.95,-2.45,;-.38,-3.22,;2.81,1.06,;4.3,1.46,;4.7,2.94,;3.61,4.03,;2.12,3.63,;1.72,2.15,;4.01,5.52,;5.55,5.52,;2.67,6.29,;4.41,7.01,;5.89,7.41,;6.37,8.87,;7.91,8.87,;8.39,7.41,;7.14,6.5,)| Show InChI InChI=1S/C26H36N6O3S/c1-2-3-16-27-26-28-17-23-24(30-32(25(23)29-26)20-10-12-21(33)13-11-20)18-8-14-22(15-9-18)36(34,35)31-19-6-4-5-7-19/h8-9,14-15,17,19-21,31,33H,2-7,10-13,16H2,1H3,(H,27,28,29)/t20?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336401
(US9744172, Compound UNC913A)Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC |r,wU:13.12,wD:16.16,(-8.57,-3.92,;-7.24,-3.15,;-5.91,-3.92,;-4.57,-3.15,;-3.24,-3.92,;-1.91,-3.15,;-1.91,-1.61,;-.57,-.84,;.76,-1.61,;2.23,-1.13,;3.13,-2.38,;2.23,-3.62,;2.62,-5.11,;4.11,-5.51,;5.2,-4.42,;6.69,-4.82,;7.09,-6.31,;8.57,-6.7,;6,-7.4,;4.51,-7,;.76,-3.15,;-.57,-3.92,;2.62,.36,;4.11,.75,;4.51,2.24,;3.42,3.33,;1.93,2.93,;1.54,1.45,;3.82,4.82,;2.73,5.91,;5.31,5.22,;4.22,6.31,;3.13,7.4,)| Show InChI InChI=1S/C23H33N7O2S/c1-3-4-13-26-23-27-14-20-21(17-7-11-19(12-8-17)33(31,32)25-2)29-30(22(20)28-23)15-16-5-9-18(24)10-6-16/h7-8,11-12,14,16,18,25H,3-6,9-10,13,15,24H2,1-2H3,(H,26,27,28)/t16-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336423
(US9744172, Compound UNC1171A)Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCCC1 |r,wU:13.12,wD:16.16,(-8.68,-4.04,;-7.35,-3.27,;-6.01,-4.04,;-4.68,-3.27,;-3.34,-4.04,;-2.01,-3.27,;-2.01,-1.73,;-.68,-.96,;.66,-1.73,;2.12,-1.25,;3.03,-2.5,;2.12,-3.74,;2.52,-5.23,;4.06,-5.23,;4.83,-3.9,;6.37,-3.9,;7.14,-5.23,;8.68,-5.23,;6.37,-6.56,;4.83,-6.56,;.66,-3.27,;-.68,-4.04,;2.52,.24,;4.01,.64,;4.41,2.12,;3.32,3.21,;1.83,2.81,;1.43,1.33,;3.72,4.7,;2.63,5.79,;5.2,5.1,;5.68,6.56,;7.22,6.56,;7.69,5.1,;6.45,4.19,)| Show InChI InChI=1S/C27H37N7O/c1-2-3-14-29-27-30-17-23-24(20-8-10-21(11-9-20)26(35)33-15-4-5-16-33)32-34(25(23)31-27)18-19-6-12-22(28)13-7-19/h8-11,17,19,22H,2-7,12-16,18,28H2,1H3,(H,29,30,31)/t19-,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336434
(US9744172, Compound UNC1125A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCc1ccc(F)cc1 |r,wD:15.15,(-9.03,-5.66,;-7.69,-4.89,;-6.36,-5.66,;-5.03,-4.89,;-3.69,-5.66,;-2.36,-4.89,;-2.36,-3.35,;-1.02,-2.58,;.31,-3.35,;1.77,-2.87,;2.68,-4.12,;1.77,-5.36,;2.17,-6.85,;3.66,-7.25,;4.06,-8.74,;2.97,-9.83,;3.37,-11.31,;1.48,-9.43,;1.08,-7.94,;.31,-4.89,;-1.02,-5.66,;2.17,-1.38,;3.66,-.99,;4.06,.5,;2.97,1.59,;1.48,1.19,;1.08,-.3,;3.37,3.08,;2.97,4.57,;1.88,3.48,;4.86,3.48,;5.25,4.96,;6.74,5.36,;7.14,6.85,;8.63,7.25,;9.03,8.74,;7.94,9.83,;8.34,11.31,;6.45,9.43,;6.05,7.94,)| Show InChI InChI=1S/C29H35FN6O3S/c1-2-3-17-31-29-32-19-26-27(35-36(28(26)34-29)23-10-12-24(37)13-11-23)21-6-14-25(15-7-21)40(38,39)33-18-16-20-4-8-22(30)9-5-20/h4-9,14-15,19,23-24,33,37H,2-3,10-13,16-18H2,1H3,(H,31,32,34)/t23?,24- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336440
(US9744172, Compound UNC1177A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)C(O)=O |r,wD:15.15,(-9.72,-3.08,;-8.38,-2.31,;-7.05,-3.08,;-5.72,-2.31,;-4.38,-3.08,;-3.05,-2.31,;-3.05,-.77,;-1.71,-0,;-.38,-.77,;1.08,-.3,;1.99,-1.54,;1.08,-2.79,;1.48,-4.27,;2.97,-4.67,;3.37,-6.16,;2.28,-7.25,;2.68,-8.74,;.79,-6.85,;.39,-5.36,;-.38,-2.31,;-1.71,-3.08,;1.48,1.19,;2.97,1.59,;3.37,3.08,;2.28,4.17,;.79,3.77,;.39,2.28,;2.68,5.66,;2.28,7.14,;1.19,6.05,;4.17,6.05,;5.25,4.96,;6.74,5.36,;7.19,6.86,;6.05,7.94,;4.56,7.54,;8.68,7.26,;9.77,6.17,;9.08,8.75,)| Show InChI InChI=1S/C27H36N6O5S/c1-2-3-14-28-27-29-17-23-24(31-33(25(23)30-27)20-6-8-21(34)9-7-20)18-4-10-22(11-5-18)39(37,38)32-15-12-19(13-16-32)26(35)36/h4-5,10-11,17,19-21,34H,2-3,6-9,12-16H2,1H3,(H,35,36)(H,28,29,30)/t20?,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336441
(US9744172, Compound UNC1178A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)C(=O)OC |r,wD:15.15,(-10.46,-3.08,;-9.13,-2.31,;-7.79,-3.08,;-6.46,-2.31,;-5.13,-3.08,;-3.79,-2.31,;-3.79,-.77,;-2.46,-0,;-1.12,-.77,;.34,-.3,;1.24,-1.54,;.34,-2.79,;.74,-4.27,;2.23,-4.67,;2.62,-6.16,;1.54,-7.25,;1.93,-8.74,;.05,-6.85,;-.35,-5.36,;-1.12,-2.31,;-2.46,-3.08,;.74,1.19,;2.23,1.59,;2.62,3.08,;1.54,4.17,;.05,3.77,;-.35,2.28,;1.93,5.66,;1.54,7.14,;.45,6.05,;3.42,6.05,;4.51,4.96,;6,5.36,;6.45,6.86,;5.31,7.94,;3.82,7.54,;7.94,7.26,;8.34,8.75,;9.03,6.17,;8.63,4.69,)| Show InChI InChI=1S/C28H38N6O5S/c1-3-4-15-29-28-30-18-24-25(32-34(26(24)31-28)21-7-9-22(35)10-8-21)19-5-11-23(12-6-19)40(37,38)33-16-13-20(14-17-33)27(36)39-2/h5-6,11-12,18,20-22,35H,3-4,7-10,13-17H2,1-2H3,(H,29,30,31)/t21?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336445
(US9744172, Compound UNC1187A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)Nc1ccc(C)cc1 |r,wD:15.15,(-8.08,-4.71,;-6.75,-3.94,;-5.42,-4.71,;-4.08,-3.94,;-2.75,-4.71,;-1.42,-3.94,;-1.42,-2.4,;-.08,-1.63,;1.25,-2.4,;2.72,-1.93,;3.62,-3.17,;2.72,-4.42,;3.12,-5.91,;4.6,-6.31,;5,-7.79,;3.91,-8.88,;4.31,-10.37,;2.43,-8.48,;2.03,-7,;1.25,-3.94,;-.08,-4.71,;3.12,-.44,;4.6,-.04,;5,1.45,;3.91,2.53,;2.43,2.14,;2.03,.65,;4.31,4.02,;2.82,4.42,;3.91,5.51,;5.8,4.42,;6.2,5.91,;7.68,6.31,;8.08,7.79,;6.99,8.88,;7.39,10.37,;5.51,8.48,;5.11,7,)| Show InChI InChI=1S/C28H34N6O3S/c1-3-4-17-29-28-30-18-25-26(32-34(27(25)31-28)22-11-13-23(35)14-12-22)20-7-15-24(16-8-20)38(36,37)33-21-9-5-19(2)6-10-21/h5-10,15-16,18,22-23,33,35H,3-4,11-14,17H2,1-2H3,(H,29,30,31)/t22?,23- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336456
(US9744172, Compound UNC1144A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCCCC1 |r,wD:15.15,(-7.94,-6,;-6.6,-5.23,;-5.27,-6,;-3.94,-5.23,;-2.6,-6,;-1.27,-5.23,;-1.27,-3.69,;.06,-2.92,;1.4,-3.69,;2.86,-3.22,;3.77,-4.46,;2.86,-5.71,;3.26,-7.2,;4.75,-7.59,;5.15,-9.08,;4.06,-10.17,;4.46,-11.66,;2.57,-9.77,;2.17,-8.29,;1.4,-5.23,;.06,-6,;3.26,-1.73,;4.75,-1.33,;5.15,.16,;4.06,1.25,;2.57,.85,;2.17,-.64,;4.46,2.73,;2.97,3.13,;5.94,2.33,;4.86,4.22,;6.34,4.62,;6.74,6.11,;5.65,7.2,;4.17,6.8,;3.77,5.31,;6.05,8.68,;7.54,9.08,;7.94,10.57,;6.85,11.66,;5.36,11.26,;4.96,9.77,)| Show InChI InChI=1S/C31H45N7O3S/c1-2-3-17-32-31-33-22-28-29(35-38(30(28)34-31)25-9-11-26(39)12-10-25)23-7-13-27(14-8-23)42(40,41)37-20-15-24(16-21-37)36-18-5-4-6-19-36/h7-8,13-14,22,24-26,39H,2-6,9-12,15-21H2,1H3,(H,32,33,34)/t25?,26- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336475
(US9744172, Compound UNC1281A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCOCC1 |r,wD:15.15,(-10.31,-4.57,;-8.98,-3.8,;-7.65,-4.57,;-6.31,-3.8,;-4.98,-4.57,;-3.65,-3.8,;-3.65,-2.26,;-2.31,-1.49,;-.98,-2.26,;.49,-1.78,;1.39,-3.03,;.49,-4.27,;.88,-5.76,;2.37,-6.16,;2.77,-7.65,;1.68,-8.74,;2.08,-10.22,;.19,-8.34,;-.2,-6.85,;-.98,-3.8,;-2.31,-4.57,;.88,-.3,;2.37,.1,;2.77,1.59,;1.68,2.68,;.19,2.28,;-.2,.79,;2.08,4.17,;.59,4.57,;1.68,5.66,;3.57,4.57,;3.97,6.05,;5.45,6.45,;5.85,7.94,;4.76,9.03,;7.34,8.34,;8.43,7.25,;9.92,7.65,;10.31,9.14,;9.23,10.22,;7.74,9.83,)| Show InChI InChI=1S/C28H39N7O5S/c1-2-3-13-29-28-30-19-24-26(33-35(27(24)32-28)21-6-8-22(36)9-7-21)20-4-10-23(11-5-20)41(38,39)31-14-12-25(37)34-15-17-40-18-16-34/h4-5,10-11,19,21-22,31,36H,2-3,6-9,12-18H2,1H3,(H,29,30,32)/t21?,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM336498
(US9744172, Compound UNC1326A)Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1NC(=O)NC(C)=C1C(C)=O |r,wU:15.15,c:37,(-7.88,-3.37,;-6.55,-2.6,;-5.22,-3.37,;-3.88,-2.6,;-2.55,-3.37,;-1.22,-2.6,;-1.22,-1.06,;.12,-.29,;1.45,-1.06,;2.92,-.59,;3.82,-1.83,;2.92,-3.08,;3.31,-4.57,;2.23,-5.66,;2.62,-7.14,;4.11,-7.54,;4.51,-9.03,;5.2,-6.45,;4.8,-4.96,;1.45,-2.6,;.12,-3.37,;3.31,.9,;4.8,1.3,;5.2,2.79,;4.11,3.88,;2.62,3.48,;2.23,1.99,;4.51,5.36,;6,5.76,;6.4,7.25,;7.88,7.65,;5.31,8.34,;3.82,7.94,;2.73,9.03,;3.42,6.45,;1.93,6.05,;.85,7.14,;1.54,4.57,)| Show InChI InChI=1S/C28H35N7O3/c1-4-5-14-29-27-30-15-22-24(34-35(26(22)33-27)20-10-12-21(37)13-11-20)18-6-8-19(9-7-18)25-23(17(3)36)16(2)31-28(38)32-25/h6-9,15,20-21,25,37H,4-5,10-14H2,1-3H3,(H,29,30,33)(H2,31,32,38)/t20?,21-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi... |
US Patent US9744172 (2017)
BindingDB Entry DOI: 10.7270/Q2PR7Z30 |
More data for this
Ligand-Target Pair | |
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