Reaction Details |
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Target | Indoleamine 2,3-dioxygenase 1 |
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Ligand | BDBM50604017 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2246301 (CHEMBL5160511) |
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IC50 | 165±n/a nM |
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Citation | Li, D; Sloman, DL; Achab, A; Zhou, H; McGowan, MA; White, C; Gibeau, C; Zhang, H; Pu, Q; Bharathan, I; Hopkins, B; Liu, K; Ferguson, H; Fradera, X; Lesburg, CA; Martinot, TA; Qi, J; Song, ZJ; Yin, J; Zhang, H; Song, L; Wan, B; DAddio, S; Solban, N; Miller, JR; Zamlynny, B; Bass, A; Freeland, E; Ykoruk, B; Hilliard, C; Ferraro, J; Zhai, J; Knemeyer, I; Otte, KM; Vincent, S; Sciammetta, N; Pasternak, A; Bennett, DJ; Han, Y Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing. J Med Chem65:6001-6016 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Indoleamine 2,3-dioxygenase 1 |
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Name: | Indoleamine 2,3-dioxygenase 1 |
Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
Type: | Enzyme |
Mol. Mass.: | 45330.80 |
Organism: | Homo sapiens (Human) |
Description: | P14902 |
Residue: | 403 |
Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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BDBM50604017 |
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n/a |
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Name | BDBM50604017 |
Synonyms: | CHEMBL5208641 |
Type | Small organic molecule |
Emp. Form. | C22H26N2O |
Mol. Mass. | 334.4546 |
SMILES | CCCNC(=O)C1(CCC1)c1ccc(cc1)-c1ccc(nc1)C1CC1 |
Structure |
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