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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM50547848 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2019224 (CHEMBL4672802) | ||
| IC50 | 1.7±n/a nM | ||
| Citation |  Srivastava, AS; Ko, S; Watterson, SH; Pattoli, MA; Skala, S; Cheng, L; Obermeier, MT; Vickery, R; Discenza, LN; D'Arienzo, CJ; Gillooly, KM; Taylor, TL; Pulicicchio, C; McIntyre, KW; Yip, S; Li, P; Sun, D; Wu, DR; Dai, J; Wang, C; Zhang, Y; Wang, B; Pawluczyk, J; Kempson, J; Zhao, R; Hou, X; Rampulla, R; Mathur, A; Galella, MA; Salter-Cid, L; Barrish, JC; Carter, PH; Fura, A; Burke, JR; Tino, JA Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK. ACS Med Chem Lett11:2195-2203 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
| ||
| BDBM50547848 | |||
| n/a | |||
| Name | BDBM50547848 | ||
| Synonyms: | CHEMBL4741884 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H26N4O4 | ||
| Mol. Mass. | 518.5625 | ||
| SMILES | Cc1c(cccc1-n1c(=O)cc2ccccn2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(C)(C)O |(36.26,-27.65,;34.93,-28.42,;33.61,-27.65,;32.27,-28.43,;32.27,-29.97,;33.6,-30.73,;34.94,-29.96,;36.27,-30.72,;36.28,-32.26,;34.95,-33.04,;37.62,-33.03,;38.95,-32.25,;40.29,-33.02,;41.62,-32.24,;41.61,-30.69,;40.27,-29.94,;38.94,-30.71,;37.61,-29.95,;37.6,-28.41,;33.6,-26.12,;34.94,-25.35,;34.93,-23.8,;33.6,-23.03,;33.6,-21.49,;34.92,-20.72,;32.26,-20.73,;32.26,-23.81,;30.8,-23.34,;29.9,-24.59,;28.37,-24.76,;27.76,-26.16,;28.67,-27.4,;30.19,-27.23,;30.81,-25.83,;32.27,-25.35,;26.23,-26.34,;25.31,-25.1,;25.6,-27.74,;24.73,-26.73,)| | ||
| Structure | 
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