Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase B-raf |
---|
Ligand | BDBM88120 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2047188 (CHEMBL4701887) |
---|
IC50 | 78±n/a nM |
---|
Citation | LaMarche, MJ; Acker, M; Argintaru, A; Bauer, D; Boisclair, J; Chan, H; Chen, CH; Chen, YN; Chen, Z; Deng, Z; Dore, M; Dunstan, D; Fan, J; Fekkes, P; Firestone, B; Fodor, M; Garcia-Fortanet, J; Fortin, PD; Fridrich, C; Giraldes, J; Glick, M; Grunenfelder, D; Hao, HX; Hentemann, M; Ho, S; Jouk, A; Kang, ZB; Karki, R; Kato, M; Keen, N; Koenig, R; LaBonte, LR; Larrow, J; Liu, G; Liu, S; Majumdar, D; Mathieu, S; Meyer, MJ; Mohseni, M; Ntaganda, R; Palermo, M; Perez, L; Pu, M; Ramsey, T; Reilly, J; Sarver, P; Sellers, WR; Sendzik, M; Shultz, MD; Slisz, J; Slocum, K; Smith, T; Spence, S; Stams, T; Straub, C; Tamez, V; Toure, BB; Towler, C; Wang, P; Wang, H; Williams, SL; Yang, F; Yu, B; Zhang, JH; Zhu, S Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. J Med Chem63:13578-13594 (2020) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase B-raf |
---|
Name: | Serine/threonine-protein kinase B-raf |
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 84446.00 |
Organism: | Homo sapiens (Human) |
Description: | P15056 |
Residue: | 766 |
Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
|
|
|
BDBM88120 |
---|
n/a |
---|
Name | BDBM88120 |
Synonyms: | US10245267, Example 1156 | US10709712, Example 1156 | US9694016, 1156 |
Type | Small organic molecule |
Emp. Form. | C25H25F3N4O4 |
Mol. Mass. | 502.4856 |
SMILES | Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(OCCO)nc(c1)N1CCOCC1 |
Structure |
|