The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 23458846 |
16 |
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers. |
Northwestern University |
| 21684157 |
68 |
Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights. |
Nycomed |
| 22840695 |
52 |
Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine. |
Neuraxon |
| 22335555 |
43 |
1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate. |
Neuraxon |
| 23123728 |
4 |
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: effect on inducible nitric oxide synthase. |
Universidade De S£O Paulo |
| 22758660 |
2 |
Saquayamycins G-K, cytotoxic angucyclines from Streptomyces sp. Including two analogues bearing the aminosugar rednose. |
University of Kentucky |
| 24900459 |
53 |
NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with µ-Opioid Agonist Activity. |
TBA |
| 22703704 |
3 |
New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714. |
Instituto Cajal (Csic) |
| 22420844 |
86 |
First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain. |
Neuraxon |
| 22370270 |
30 |
Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS). |
Neuraxon |
| 21923116 |
40 |
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. |
Neuraxon |
| 18357974 |
42 |
"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits. |
Novartis Institutes For Biomedical Research |
| 18083522 |
15 |
N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system. |
Christian-Albrechts-University of Kiel |
| 18077363 |
314 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
University of Oxford |
| 18220331 |
9 |
N(G)-aminoguanidines from primary amines and the preparation of nitric oxide synthase inhibitors. |
University of California |
| 18024030 |
110 |
Discovery of a series of aminopiperidines as novel iNOS inhibitors. |
Adolor |
| 17317165 |
77 |
Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors. |
Neuraxon |
| 15837296 |
6 |
Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action. |
Dartmouth College |
| 15993059 |
3 |
L-arginine analogs as alternate substrates for nitric oxide synthase. |
University of California |
| 15357988 |
87 |
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. |
Merck Research Laboratory |
| 14761191 |
19 |
5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors. |
Pfizer |
| 12620067 |
47 |
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. |
Astrazeneca R&D Charnwood |
| 11931623 |
6 |
Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor. |
Pfizer |
| 11931608 |
17 |
Inhibition of protein-protein association by small molecules: approaches and progress. |
Pfizer |
| 9554868 |
40 |
2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS). |
Pfizer |
| 9733492 |
54 |
2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase. |
Pfizer |
| 9667974 |
150 |
N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. |
Glaxo Wellcome Research and Development |
| 9191968 |
88 |
Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. |
Glaxo Wellcome Research and Development |
| 8576908 |
33 |
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. |
G. D. Searle Research and Development |
| 12781178 |
33 |
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors. |
Schering |
| 10741561 |
48 |
Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. |
Glaxo Wellcome Research and Development |
| 22318159 |
36 |
3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors. |
Neuraxon |
| 22175766 |
45 |
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities. |
Neuraxon |
| 22336385 |
4 |
1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence. |
Universidad De Granada |
| 22182498 |
71 |
Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors. |
Afraxis |
| 21699209 |
75 |
Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors. |
Neuraxon |
| 21986586 |
124 |
Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors. |
Kalypsys |
| 21824773 |
46 |
1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors. |
Neuraxon |
| 21813276 |
56 |
1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors. |
Neuraxon |
| 20931971 |
155 |
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNO |
Kalypsys |
| 21482467 |
28 |
Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor. |
Glaxosmithkline |
| 21410186 |
43 |
Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase. |
Northwestern University |
| 21398123 |
56 |
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS). |
Astrazeneca Charnwood |
| 20166671 |
85 |
Selectively nonselective kinase inhibition: striking the right balance. |
Schering-Plough |
| 19679481 |
29 |
Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation. |
Uned |
| 19203270 |
14 |
Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase. |
Universita G. D'Annunzio |
| | 44 |
Inhibition of nitric oxide synthase by benzoxazolones |
TBA |
| | 24 |
Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase |
TBA |
| | 10 |
1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidine |
TBA |
| 19323559 |
19 |
Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase. |
Washington University |
| 19230661 |
4 |
4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase. |
University of Utrecht |
| 17368901 |
6 |
1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation. |
Berlex Biosciences |
| 17336523 |
13 |
The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase. |
Berlex Biosciences |
| 17315988 |
80 |
Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors. |
Berlex Biosciences |
| 16033258 |
51 |
Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases. |
Sanofi-Aventis |
| 15911272 |
21 |
Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes. |
Nagoya City University |
| 15808455 |
39 |
Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase. |
Merck Research Laboratories |
| 15713387 |
18 |
Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives. |
Dainippon Pharmaceutical |
| 15501067 |
51 |
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. |
Merck Research Laboratories |
| 15163211 |
51 |
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. |
Astrazeneca R&D Charnwood |
| 14998342 |
73 |
Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure. |
Pfizer |
| 14741281 |
36 |
Fluorinated dihydroquinolines as potent n-NOS inhibitors. |
Schering |
| 12392746 |
18 |
3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor. |
Pharmacia |
| 12182860 |
72 |
Dihydroquinolines as novel n-NOS inhibitors. |
Schering |
| 12161118 |
28 |
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines. |
Fukui Research Institute |
| 11551770 |
40 |
Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. |
Pharmacia |
| 32676156 |
8 |
Antiglioma Activity of Aryl and Amido-Aryl Acetamidine Derivatives Targeting iNOS: Synthesis and Biological Evaluation. |
University "G. D'Annunzio" of Chieti-Pescara |
| 11327581 |
44 |
Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity. |
Astrazeneca R&D Charnwood |
| 11327580 |
73 |
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency. |
Astrazeneca R&D Charnwood |
| 10987430 |
86 |
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. |
Merck Research Laboratories |
| 31255927 |
34 |
Human disorders associated with inflammation and the evolving role of natural products to overcome. |
University of Delhi |
| 30802056 |
63 |
Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. |
Northwestern University |
| 9873583 |
4 |
Synthesis of boronic acid analogs of L-arginine as alternate substrates or inhibitors of nitric oxide synthase. |
Université |
| 32302123 |
114 |
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. |
Northwestern University |
| 9526553 |
6 |
Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase. |
Searle |
| 9438025 |
54 |
Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. |
G. D. Searle Research and Development |
| 8978842 |
9 |
Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracers. |
Washington University |
| 29626798 |
6 |
Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo. |
China Pharmaceutical University |
| 22380775 |
28 |
2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling. |
Sun Yat-Sen University |
| 24497639 |
38 |
Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1. |
Bayer Healthcare |
| 12784105 |
53 |
Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. |
Case Western Reserve University |
| 8863838 |
28 |
Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. |
Upr Centre |
| 7891350 |
9 |
Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist. |
Parke-Davis Pharmaceutical Research |
| 19413326 |
14 |
Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches. |
Pfizer |
| 15027867 |
10 |
Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
Emory University |
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