165 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
25470070	81	Probing the carboxyester side chain in controlled deactivation (-)-d(8)-tetrahydrocannabinols.	Northeastern University
1732519	15	Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor.	Sterling Research Group
1317925	6	A novel probe for the cannabinoid receptor.	Hebrew University
1659638	8	Synthesis and pharmacological evaluation of ether and related analogues of delta 8-, delta 9-, and delta 9,11-tetrahydrocannabinol.	Virginia Commonwealth University
27096053	4	Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability.	Kannalife Sciences
26890113	41	Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties.	Universit£
26275680	68	Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist.	University of Tennessee Health Science Center
25935384	26	New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.	University of Pisa
25760146	49	3'-functionalized adamantyl cannabinoid receptor probes.	University of Hawaii At Manoa
25703248	3	Cannabidiol (CBD) and its analogs: a review of their effects on inflammation.	University of Massachusetts Medical School
25701254	48	Novel tail and head group prostamide probes.	Northeastern University
23902803	9	Peripherally restricted CB1 receptor blockers.	Jenrin Discovery
25575658	83	Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model.	Boehringer Ingelheim Pharmaceuticals
25488844	154	Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.	Arena Pharmaceuticals
24900848	11	C-ring cannabinoid lactones: a novel cannabinergic chemotype.	Northeastern University
23865723	169	Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.	Arena Pharmaceuticals
23621789	69	Novel adamantyl cannabinoids as CB1 receptor probes.	Northeastern University
23350768	196	Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.	Universit£
19249138	142	Development of CoMFA and CoMSIA models of affinity and selectivity for indole ligands of cannabinoid CB1 and CB2 receptors.	Universidade Federal Do Rio De Janeiro
15149681	3	Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives.	University of Kuopio
23147076	163	Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action.	Nycomed Pharma
23083016	20	Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.	Northeastern University
22738638	59	Assay and inhibition of diacylglycerol lipase activity.	Northeastern University
22738271	250	7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2) cannabinoid receptor ligands: structural investigations around a novel class of full agonists.	Universit£
22796181	51	C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor.	University of Hawaii At Manoa
22370265	63	Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB2 receptor agonists for pain management.	Abbott Laboratories
20943404	24	1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-¿(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor.	Clemson University
19278853	67	Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists.	University of Bonn
18680277	198	Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists.	Amgen
18448340	27	Aminopyrazine CB1 receptor inverse agonists.	Neurogen
17919913	55	Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940.	Clemson University
18337096	37	Tetrazole-biarylpyrazole derivatives as cannabinoid CB1 receptor antagonists.	Reen Cross
17630726	32	Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.	Novartis Institutes For Biomedical Research
16451075	6	New cannabidiol derivatives: synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity.	Ben-Gurion University of The Negev
16451053	37	Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists.	Universit£
16190764	24	Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.	Northeastern University
16078824	48	The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.	Universit£
15139773	3	Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif.	Instituto De Qu£Mica M£Dica
12672252	104	Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.	Universidad Complutense
11741470	40	Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.	Universidad Complutense
9057852	74	Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.	Hebrew University
8809166	10	Unsaturated side chain beta-11-hydroxyhexahydrocannabinol analogs.	University of Hawaii
22284817	82	¿-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration.	Astrazeneca R&D Montreal
21962575	8	Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.	Bristol-Myers Squibb
21880487	21	Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands.	Northeastern University
21885167	3	Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: design, synthesis, structure-activity relationships, physicochemical properties and biological activity.	Abbott Healthcare Products
21741835	41	Structure-activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists.	Dr. Reddy'S Laboratories
21420857	115	Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia.	Merck Research Laboratories
21420860	34	Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.	Merck Research Laboratories
20845959	94	Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor.	Research Triangle Institute
20925434	43	Novel 1',1'-chain substituted hexahydrocannabinols: 9ß-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist.	Northeastern University
20673729	60	Discovery of 2-(4-((1H-1,2,4-triazol-1-yl)methyl)-5-(4-bromophenyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)-5-tert-butyl-1,3,4-thiadiazole (GCC2680) as a potent, selective and orally efficacious cannabinoid-1 receptor antagonist.	Green Cross
20621488	13	Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.	Clemson University
20593789	47	Heteroadamantyl cannabinoids.	University of Hawaii At Manoa
20584609	13	Rational design of a novel peripherally-restricted, orally active CB(1) cannabinoid antagonist containing a 2,3-diarylpyrrole motif.	Sanofi-Aventis R&D
20423086	93	Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.	Merck Research Laboratories
20045337	117	Synthesis and structure-activity relationship of 1,2,4-triazole-containing diarylpyrazolyl carboxamide as CB1 cannabinoid receptor-ligand.	Green Cross
19921781	220	Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.	Abbott Laboratories
19850473	30	Pentacycle derivatives as cannabinoid CB1 receptor ligands.	Green Cross
19683918	36	Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles.	Pfizer
19762126	16	Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide.	Instituto De Qu£Mica M£Dica
19596576	60	Substituted pyrimidines as cannabinoid CB1 receptor ligands.	Green Cross
19527048	19	Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists.	Gedeon Richter
	4	Synthesis of (+)- and (−)-2-methylarachidonyl-2′-fluoroethylamide (O-689)	TBA
	11	Morpholinoalkylindenes as antinociceptive agents: Novel cannabinoid receptor agonists	TBA
19457667	17	Hit-to-lead optimization of pyrrolo[1,2-a]quinoxalines as novel cannabinoid type 1 receptor antagonists.	Gedeon Richter
19331413	54	New resorcinol-anandamide"hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo.	Universita Degli Studi Di Siena
19328001	49	Synthesis and structure-activity relationship of novel diarylpyrazole imide analogues as CB1 cannabinoid receptor ligands.	Green Cross
19320488	171	1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.	Merck Research Laboratories
19269817	28	Oxadiazole-diarylpyrazole 4-carboxamides as cannabinoid CB1 receptor ligands.	Green Cross
19128970	18	Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice.	University of California
19097888	11	Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles.	University of New Orleans
19022666	71	Diarylimidazolyl oxadiazole and thiadiazole derivatives as cannabinoid CB1 receptor antagonists.	Green Cross
18954042	117	Biarylpyrazolyl oxadiazole as potent, selective, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity.	Green Cross
18826296	12	Bornyl- and isobornyl-Delta8-tetrahydrocannabinols: a novel class of cannabinergic ligands.	Northeastern University
18723350	37	Development of novel tail-modified anandamide analogs.	Northeastern University
18243711	76	Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands.	Central Research Institute
18077343	2	Hemopressin is an inverse agonist of CB1 cannabinoid receptors.	Proteimax Biotechnology
17582659	22	Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor.	Monash University (Parkville Campus)
14575438	4	Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena.	Oregon State University
18038967	12	Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity.	Northeastern University
17826996	5	Conformationally constrained analogues of 2-arachidonoylglycerol.	Northeastern University
17672444	22	C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.	National Hellenic Research Foundation
17513109	32	Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.	Pharmaceutical Research Institute
17293109	69	Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists.	Merck Research Laboratories
16889960	56	1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.	Clemson University
16387492	26	Structural modifications of the cannabinoid side chain towards C3-aryl and 1',1'-cycloalkyl-1'-cyano cannabinoids.	National Hellenic Research Foundation
16134948	15	Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography.	National Institute On Drug Abuse
16005223	64	1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles.	Clemson University
15999995	12	Adamantyl cannabinoids: a novel class of cannabinergic ligands.	Northeastern University
12951114	18	Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.	University of California
12852753	17	Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.	National Hellenic Research Foundation
12781177	7	Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues.	Umr Cnrs 5074
12570386	15	Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.	National Institute On Drug Abuse
12467613	15	Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors.	Discaff
12443781	22	Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols.	National Hellenic Research Foundation
12166944	48	Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase.	Utrecht University
12061874	60	Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716).	Research Triangle Institute
11906286	34	Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor.	University of South Carolina
32551012	18	P2Y	Saint Louis University School of Medicine
11229744	7	Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine.	Institute of Bioorganic Chemistry Ras
27482723	73	Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain.	Research Triangle Institute
27624523	33	Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB	Universit£
27367336	78	Novel C-Ring-Hydroxy-Substituted Controlled Deactivation Cannabinergic Analogues.	Northeastern University
30816712	78	Plant-Based Modulators of Endocannabinoid Signaling.	Concordia University Wisconsin
10465529	9	Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.	University of Connecticut
10354405	31	Unique analogues of anandamide: arachidonyl ethers and carbamates and norarachidonyl carbamates and ureas.	Organix
10072686	25	Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.	University of Connecticut
10052983	40	Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.	University of Connecticut
31756109	108	Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.	Northeastern University
9876105	75	Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.	University of Connecticut
9873517	4	Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC.	Clemson University
31220675	88	Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.	Biological Research Centre of The Hungarian Academy of Sciences
9784095	4	Derivation of a pharmacophore model for anandamide using constrained conformational searching and comparative molecular field analysis.	Saint Louis University School of Medicine
9733485	16	Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues.	University of Hawaii
9544219	12	Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols.	National Hellenic Research Foundation
9379452	8	Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs.	Kennesaw State University
9379442	61	Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.	Institute of Science
8893848	21	Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.	University of Connecticut
8831752	9	Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.	Clemson University
8642555	11	(Aminoalkyl)indole isothiocyanates as potential electrophilic affinity ligands for the brain cannabinoid receptor.	National Institute of Diabetes and Digestive and Kidney Diseases
8411007	392	Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands.	Mayo Foundation
24445310	25	Design, synthesis, biological evaluation, and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists.	Zhejiang University
24518874	61	1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.	Universit£
24286207	30	Controlled-deactivation cannabinergic ligands.	Northeastern University
23795771	94	Selective cannabinoid receptor type 2 (CB2) agonists: optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain.	Lilly Research Laboratories
24125850	89	Mastering tricyclic ring systems for desirable functional cannabinoid activity.	The University of Montana
23807113	6	Discovery of novel tetrahydro-pyrazolo [4,3-c] pyridines for the treatment of neuropathic pain: synthesis and neuropharmacology.	Birla Institute of Technology & Science - Pilani
23697626	167	Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists.	Universit£
7636873	62	Aminoalkylindoles: structure-activity relationships of novel cannabinoid mimetics.	Sanofi Research Division
21215643	20	Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists.	University of Eastern Finland
16466915	4	Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability.	University of Kuopio
16420041	24	3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.	University of Kuopio
16190768	6	High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor.	Northeastern University
11448223	70	Volume learning algorithm artificial neural networks for 3D QSAR studies.	Institute of Bioorganic & Petroleum Chemistry
9804691	84	Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis.	Sanofi Research Division
9357529	20	Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide.	Research Triangle Institute
7966145	2	(-)-11-Hydroxy-7'-isothiocyanato-1',1'-dimethylheptyl-delta 8-THC: a novel, high-affinity irreversible probe for the cannabinoid receptor in the brain.	University of Connecticut
8021930	10	(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.	University of Connecticut
30122284	70	Oximes short-acting CB1 receptor agonists.	Northeastern University
30196704	90	( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.	Northeastern University
29259753	70	Discovery of APD371: Identification of a Highly Potent and Selective CB	Arena Pharmaceuticals
28792219	61	Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution.	Research Triangle Institute
28726401	55	Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis.	East China Normal University
26808391	6	A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition.	Jawaharlal Nehru Centre For Advanced Scientific Research
26833890	18	Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.	Yogi Vemana University
26575582	15	Development of 2-(Substituted Benzylamino)-4-Methyl-1, 3-Thiazole-5-Carboxylic Acid Derivatives as Xanthine Oxidase Inhibitors and Free Radical Scavengers.	Jamia Hamdard
26469307	7	Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.	University of Leipzig
8022403	113	A binding site model and structure-activity relationships for the rat A3 adenosine receptor.	National Institute of Diabetes, Digestive and Kidney Diseases