The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 8258822 |
102 |
Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods. |
University of Georgia |
| 8515429 |
16 |
(+/-) 3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analogue of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor. |
Smithkline Beecham Pharmaceuticals |
| 1992127 |
6 |
2,3-Dihydrobenzofuran analogues of hallucinogenic phenethylamines. |
Purdue University |
| 2342076 |
34 |
Syntheses and platelet aggregation inhibitory and antithrombotic properties of [2-[(omega-aminoalkoxy)phenyl]ethyl]benzenes. |
Mitsubishi Kasei |
| 2308135 |
28 |
A structure-affinity study of the binding of 4-substituted analogues of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors. |
Virginia Commonwealth University |
| 2457705 |
14 |
6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists. |
Eli Lilly |
| 2456389 |
40 |
Ergolines as selective 5-HT1 agonists. |
Eli Lilly |
| 3385733 |
28 |
Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors. |
Purdue University |
| 3572981 |
12 |
N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane. |
TBA |
| 3701781 |
14 |
Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. |
TBA |
| 3950904 |
26 |
5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. |
TBA |
| 3783602 |
22 |
2,3-Dialkyl(dimethylamino)indoles: interaction with 5HT1, 5HT2, and rat stomach fundal serotonin receptors. |
TBA |
| 3783595 |
14 |
5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. |
TBA |
| 12467617 |
17 |
New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. |
Meiji Seika Kaisha |
| 3373482 |
50 |
Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor. |
Merrell Dow Research Institute |
| 8496922 |
92 |
Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors. |
Merck Sharp and Dohme Research Laboratories |
| 8246241 |
34 |
18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. |
University of Pennsylvania |
| 8410990 |
141 |
Stereospecific and selective 5-HT2 antagonism in a series of 5-substituted trans-1-piperazino-3-phenylindans. |
H. Lundbeck |
| 1573641 |
60 |
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype. |
Searle Research and Development |
| 1542100 |
67 |
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity. |
Virginia Commonwealth University |
| 1346653 |
168 |
Pyrrole mannich bases as potential antipsychotic agents. |
R. W. Johnson Pharmaceutical Research Institute |
| 1479590 |
73 |
Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. |
Virginia Commonwealth University |
| 1361578 |
99 |
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. |
Bristol-Myers Squibb |
| 1908521 |
106 |
Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists. |
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer |
| 1672156 |
81 |
Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents. |
Hoechst-Roussel Pharmaceuticals |
| 1995885 |
15 |
Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds. |
Dainippon Pharmaceutical |
| 1833546 |
47 |
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands. |
Abbott Laboratories |
| 1671416 |
15 |
Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones. |
Warner-Lambert |
| 2258903 |
23 |
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors. |
Eli Lilly |
| 2542551 |
89 |
The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity. |
Bristol-Myers |
| 2903929 |
143 |
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity. |
H. Lundbeck |
| 3039136 |
328 |
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships. |
TBA |
| 2889830 |
26 |
2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1. |
Duphar Research Laboratories |
| 2888898 |
41 |
Antipsychotic activity of substituted gamma-carbolines. |
Wyeth Laboratories |
| 3543362 |
184 |
Central serotonin receptors as targets for drug research. |
TBA |
| 2874226 |
27 |
Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives. |
TBA |
| 2869146 |
72 |
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents. |
TBA |
| 11078200 |
61 |
N-[1-(2-Phenylethyl)pyrrolidin-3-yl]-1-adamantanecarboxamides as novel 5-HT2 receptor antagonists. |
Welfide |
| | 52 |
Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity. |
TBA |
| | 58 |
Synthesis and serotonin receptor binding properties of 5-substituted 3-(1′,2′,5′,6′-tetrahydropyridin-3′-yl) indoles |
TBA |
| 12482441 |
45 |
Development of a presynaptic 5-HT1A antagonist. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 10743959 |
48 |
N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists. |
Yoshitomi Pharmaceutical Industries |
| 9873609 |
15 |
NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists. |
Neurogen |
| 9871719 |
144 |
Serotonergic ergoline derivatives. |
Pharmacia & Upjohn |
| 9871525 |
56 |
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors. |
R. W. Johnson Pharmaceutical Research Institute |
| 8558529 |
195 |
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease. |
Hoechst-Roussel Pharmaceuticals |
| 8496920 |
14 |
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. |
Wyeth Research (Uk) |
| 8355253 |
74 |
Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. |
Virginia Commonwealth University |
| 8246239 |
84 |
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. |
Solvay Duphar |
| 8101877 |
80 |
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study. |
University of LièGe |
| 7901415 |
36 |
Examination of the D2/5-HT2 affinity ratios of resolved 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: an enantioselective approach toward the design of potential atypical antipsychotics. |
Scios Nova |
| 12014957 |
86 |
2a-[4-(Tetrahydropyridoindol-2-yl)butyl]tetrahydrobenzindole derivatives: new selective antagonists of the 5-hydroxytryptamine7 receptor. |
Meiji Seika Kaisha |
| 10052959 |
20 |
Tetrahydrobenzindoles: selective antagonists of the 5-HT7 receptor. |
Meiji Seika Kaisha |
| 10514291 |
51 |
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors. |
University of Bologna |
| 7658446 |
4 |
Effect of a chiral 4-alkyl substituent in hallucinogenic amphetamines. |
Purdue University |
| 3746815 |
15 |
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin. |
TBA |
| 2965244 |
32 |
N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin. |
Virginia Commonwealth University |
| 2902227 |
10 |
Serotonergic properties of spiroxatrine enantiomers. |
University of Arizona |
| 2902226 |
39 |
2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 2. |
Duphar Research Laboratories |
| 2892936 |
21 |
Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
Warner-Lambert |
| 2875184 |
57 |
(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents. |
TBA |
| 2565400 |
132 |
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. |
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide |
| 2537429 |
61 |
2H-[1]benzopyrano[3,4-b]pyridines: synthesis and activity at central monoamine receptors. |
Ciba-Geigy |
| 2374139 |
50 |
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole. |
Pfizer |
| 2299641 |
24 |
5-HT1 and 5-HT2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin. |
Virginia Commonwealth University |
| 2213830 |
30 |
Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. |
Virginia Commonwealth University |
| 1676758 |
12 |
Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists. |
H. Lundbeck |
| 1652026 |
43 |
Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity. |
Virginia Commonwealth University |
| 1652023 |
179 |
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
Abbott Laboratories |
| 1534585 |
8 |
Benzofuran bioisosteres of hallucinogenic tryptamines. |
Purdue University |
| 1531364 |
42 |
Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. |
University of Pennsylvania |
| 1447752 |
28 |
Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. |
Pfizer |
| 1433172 |
30 |
1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. |
Pfizer |
| 1353116 |
10 |
3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia. |
Hoechst-Roussel Pharmaceuticals |
| 1348090 |
64 |
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles. |
H. Lundbeck |
| 1336054 |
63 |
Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles. |
H. Lundbeck |
| 1336053 |
86 |
Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles. |
H. Lundbeck |
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