264 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27105029	37	2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4.	University Of Lille
27092410	26	The design of 8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors.	Glaxosmithkline
26509831	29	Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends.	Shandong University
25629256	56	Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.	Universit£
25522204	178	Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.	University Of Minnesota
25618597	12	Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors.	Beijing University Of Technology
25019478	13	Flavones: an important scaffold for medicinal chemistry.	Punjabi University
24908608	37	Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.	Glaxosmithkline
25529736	30	Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.	Bristol-Myers Squibb Research And Development
25462257	3	A review on recent developments of indole-containing antiviral agents.	Central China Normal University
25150089	42	Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase.	Shandong University
24997293	16	Pyridopyrimidinone inhibitors of HIV-1 RNase H.	Glaxosmithkline
24944749	21	Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.	Boehringer Ingelheim (Canada)
24901667	50	4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.	National Institutes Of Health
24794743	85	Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.	South China Normal University
24793360	29	Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.	University Of Lille
24900852	22	Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.	Boehringer Ingelheim (Canada)
24618511	6	A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.	Universit£
24684270	34	Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.	Sapienza University Of Rome
14711310	154	Application of CoMFA and CoMSIA 3D-QSAR and docking studies in optimization of mercaptobenzenesulfonamides as HIV-1 integrase inhibitors.	University Of Southern California
11831895	47	CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.	University Of Tennessee Health Science Center
16546383	25	Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.	Bristol-Myers Squibb
12109903	50	Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.	National Cancer Institute/Nih
11063607	1	Active site binding modes of HIV-1 integrase inhibitors.	University Of California
10841789	48	Developing a dynamic pharmacophore model for HIV-1 integrase.	University Of California
10821707	26	Modeling of the inhibition of retroviral integrases by styrylquinoline derivatives.	Cnrs Umr 8532
9986720	24	Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication.	University Of California
9767632	27	Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.	Sapienza University Of Rome
9083483	172	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.	National Cancer Institute-Bethesda
9083480	125	HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.	National Cancer Institute-Bethesda
9301668	18	Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.	National Cancer Institute-Bethesda
8691444	105	Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.	National Cancer Institute-Bethesda
7699704	30	Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.	National Cancer Institute-Bethesda
15006380	40	HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.	University Of Houston
12127545	4	Binding modes of two novel dinucleotide inhibitors of HIV-1 integrase.	The University Of Iowa
10969990	12	Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides.	Institute Of Science And Technology
17074494	36	Ring substituent effects on biological activity of vinyl sulfones as inhibitors of HIV-1.	University Of California
16879966	40	Inhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome.	University Of Southern California
16854053	108	Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.	Graduate School Of The Chinese Academy Of Sciences
16821784	10	From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.	Università
16723226	8	Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring.	Gilead Sciences
16723225	13	Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.	Gilead Sciences
16716589	15	Effect of substitution on novel tricyclic HIV-1 integrase inhibitors.	Gilead Sciences
16554152	12	A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.	Merck Research Laboratories
16539381	20	Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.	Sapienza University Of Rome
16509584	44	Dynamic pharmacophore model optimization: identification of novel HIV-1 integrase inhibitors.	University Of Houston
16509568	8	Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.	Central Pharmaceutical Research Institute
16439124	8	Beta-diketo acids with purine nucleobase scaffolds: novel, selective inhibitors of the strand transfer step of HIV integrase.	University Of Georgia
16420027	8	HIV integrase inhibitors with nucleobase scaffolds: discovery of a highly potent anti-HIV agent.	University Of Georgia
16335925	68	Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase.	University Of Southern California
16289813	4	Intermolecular interactions in the crystal structures of potential HIV-1 integrase inhibitors.	Jagiellonian University
16250669	72	Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.	Università
16183277	3	Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis.	Université
16102965	5	A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.	Merck Research Laboratories
15999991	22	Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors.	University Of California
15771437	42	Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.	Tibotec
15743192	45	Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors.	University Of Houston
15743172	2	New approaches toward anti-HIV chemotherapy.	Katholieke Universiteit Leuven
15482931	20	Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.	National Cancer Institute-Frederick
15481971	32	HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.	Italy. Vinc
15456274	34	Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.	Università
15115398	22	Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase.	Institute Of Materia Medica
15109635	20	Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.	Cnrs Umr 8076
15026063	26	6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays.	Sapienza University Of Rome
14980666	12	Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes.	Nci-Frederick
14643320	6	Catechol-substituted L-chicoric acid analogues as HIV integrase inhibitors.	Institute Of Science & Technology
12951093	12	Design and synthesis of dimeric HIV-1 integrase inhibitory peptides.	Nih
12643946	32	Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.	National Cancer Institute-Bethesda
12643937	7	Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.	Purdue University
12639565	19	Four novel bis-(naphtho-gamma-pyrones) isolated from Fusarium species as inhibitors of HIV-1 integrase.	Merck Research Laboratories
12570367	9	Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.	Merck Research Laboratories
12477350	47	Metal-dependent inhibition of HIV-1 integrase.	University Of Southern California
11720868	14	Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives.	Université
32089391	8	DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n).	Russian Academy Of Sciences
31952962	1	Synthesis and biological evaluation of bis-N	Rhodes University
11378371	2	Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase.	The University Of Iowa
32435387	43	Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase.	"Sapienza" Universit£
32435383	17	5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein.	Irbm
11150161	19	4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.	Merck Research Laboratories
31761656	3	Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.	Bristol-Myers Squibb Research & Development
31753802	6	Design, synthesis and biological evaluation of imidazole and oxazole fragments as HIV-1 integrase-LEDGF/p75 disruptors and inhibitors of microbial pathogens.	University Of The Witwatersrand
27283261	44	3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.	University Of Minnesota
27568085	13	Indole-based allosteric inhibitors of HIV-1 integrase.	The Ohio State University
27658796	6	Advances in rationally designed dual inhibitors of HIV-1 reverse transcriptase and integrase.	Wuhan Institute Of Technology
26927866	250	3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.	University Of Minnesota
10780910	44	Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.	Université
10698443	19	Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity.	Merck Research Laboratories
32081010	18	Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.	Bristol-Myers Squibb Research And Development
31401538	11	Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review.	Wuhan University Of Technology
30739822	69	Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.	University Of Minnesota
10464020	62	Thiazolothiazepine inhibitors of HIV-1 integrase.	National Cancer Institute-Bethesda
10354398	12	Lamellarin alpha 20-sulfate, an inhibitor of HIV-1 integrase active against HIV-1 virus in cell culture.	Institute Of Chemical Technology
31324562	24	Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.	Shandong University
10212126	54	Chicoric acid analogues as HIV-1 integrase inhibitors.	National Cancer Institute-Bethesda
9873453	5	Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases.	University Of Iowa
31442684	43	Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.	University Of Cagliari
31285097	14	Biological evaluation of molecules of the azaBINOL class as antiviral agents: Inhibition of HIV-1 RNase H activity by 7-isopropoxy-8-(naphth-1-yl)quinoline.	Oregon State University
9703465	98	Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.	National Cancer Institute-Bethesda
9667973	35	Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.	Paris-Sud University
30783506	22	An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.	The Ohio State University
9111292	38	Arylamide inhibitors of HIV-1 integrase.	National Cancer Institute-Bethesda
9083482	40	Hydrazide-containing inhibitors of HIV-1 integrase.	National Cancer Institute-Bethesda
9083481	38	Discovery of HIV-1 integrase inhibitors by pharmacophore searching.	National Cancer Institute-Bethesda
9003523	71	Coumarin-based inhibitors of HIV integrase.	National Cancer Institute-Bethesda
26230724	10	New Frontiers in Druggability.	Stony Brook University
8568830	2	(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.	Freie UniversitäT Berlin
26487913	39	Design, Synthesis, and Biological Evaluation of 1,2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors.	University Of Delhi
26451771	41	Synthesis of dihydropyrimidine ?,?-diketobutanoic acid derivatives targeting HIV integrase.	Univ. Orl£Ans Et Cnrs
26150289	9	Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.	"Sapienza" Universit£
26048795	7	Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.	Universit£
25999203	7	Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors.	Universit£
25907370	11	Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action.	Fudan University
25961960	118	N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.	"Sapienza" Universit£
24471816	28	Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.	National Cancer Institute-Frederick
24025027	5	Inhibiting the HIV integration process: past, present, and the future.	"Sapienza" Universit£
24378711	50	Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives.	Lomonosov Moscow State University
24291042	4	Synthesis, anti-HIV activity, integrase enzyme inhibition and molecular modeling of catechol, hydroquinone and quinol labdane analogs.	Mumbai University
24124919	101	6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.	"Sapienza" Universit£
24091080	22	Synthesis, docking, and biological studies of phenanthrene ?-diketo acids as novel HIV-1 integrase inhibitors.	University Of Tennessee Health Science Center
24084160	42	Design and synthesis of novel pyrimidone analogues as HIV-1 integrase inhibitors.	Shandong University
23985689	32	Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.	University Of Southern California
24900718	52	4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.	Universit£
23845180	3	Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).	Glaxosmithkline Research & Development
23746474	1	Notable difference in anti-HIV activity of integrase inhibitors as a consequence of geometric and enantiomeric configurations.	University Of Georgia
23758584	40	Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.	Shanghai Institute Of Materia Medica
23165001	16	Inhibition of HIV-1 integrase dimerization and activity with crosslinked interfacial peptides.	Purdue University
23742639	2	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?	Universit£
7853337	12	Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.	Purdue University
23445471	82	Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.	University Of Southern California
23306052	76	Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.	University Of Southern California
23245515	42	Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.	Glaxosmithkline Research & Development
7473544	32	Hydroxylated aromatic inhibitors of HIV-1 integrase.	National Cancer Institute-Bethesda
23149229	48	6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.	Frederick National Laboratory For Cancer Research
23098137	40	Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.	Chinese Academy Of Sciences
23046280	21	Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays.	East China University Of Science And Technology
22963135	7	Carbamoyl pyridone HIV-1 integrase inhibitors. 1. Molecular design and establishment of an advanced two-metal binding pharmacophore.	Shionogi
22845329	2	Thiazoline peptides and a tris-phenethyl urea from Didemnum molle with anti-HIV activity.	University Of Utah
22607675	28	Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.	University Of Lille
22483582	3	Discovery of small molecule HIV-1 integrase dimerization inhibitors.	University Of Siena
24900345	28	Structure-Activity Relationship Studies of HIV-1 Integrase Oligonucleotide Inhibitors.	Lomonosov Moscow State University
22154762	15	Design and synthesis of novel ?-diketo derivatives as HIV-1 integrase inhibitors.	Beijing University Of Technology
22071527	2	Synthesis, structure-activity relationships, and mechanism of action of anti-HIV-1 lamellarin ? 20-sulfate analogues.	Nagasaki University
21945283	22	Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors.	Glaxosmithkline Research & Development
21996518	16	Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase.	Fudan University
21778063	84	Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.	Chinese Academy Of Sciences
21767953	13	Ethyl malonate amides: a diketo acid offspring fragment for HIV integrase inhibition.	University Of Silesia
17452064	35	Exploring molecular shape analysis of styrylquinoline derivatives as HIV-1 integrase inhibitors.	Jadavpur University
21493066	39	Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.	National Cancer Institute-Frederick
21446745	29	Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.	Pfizer
21385662	10	Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: new structural insight into the HIV-1 integrase inhibition.	Facult£S Universitaires Notre-Dame De La Paix (Fundp)
21392991	23	6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase.	University Of Minnesota
21115794	3	In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.	Shionogi
21371895	165	Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors.	University Of Tennessee Health Science Center
18541726	30	Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.	Katholieke Universiteit Leuven
21227704	7	Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5.	National Institute Of Pharmaceutical Education And Research
21227550	14	HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.	University Of Messina
21185110	28	2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.	University Of Lille
19104010	4	Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.	Gilead Sciences
18316517	2	Inhibitors of strand transfer that prevent integration and inhibit human T-cell leukemia virus type 1 early replication.	Universit£
20869872	16	Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold.	Merck And
20864343	64	Development of the next generation of HIV-1 integrase inhibitors: pyrazolone as a novel inhibitor scaffold.	University Of Southern California
18160521	10	The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.	Glaxosmithkline
20727753	15	Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators.	Avexa
20727748	32	Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: selection of the scaffold.	Avexa
20708407	52	Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.	Tokyo Medical And Dental University
20598780	5	Tricyclononene carboxamide derivatives as novel anti-HIV-1 agents.	Beijing Institute Of Biotechnology
20709544	12	Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.	Beijing University Of Technology
20685126	24	Antiviral agents 2. Synthesis of trimeric naphthoquinone analogues of conocurvone and their antiviral evaluation against HIV.	Monash University (Parkville Campus)
20674351	15	Development of 2-pyrrolidinyl-N-methyl pyrimidones as potent and orally bioavailable HIV integrase inhibitors.	Irbm-Mrl
20630765	58	New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.	Universit£
20488589	48	CoMFA and CoMSIA 3D-QSAR studies on quionolone caroxylic acid derivatives inhibitors of HIV-1 integrase.	Lanzhou University
20541944	15	New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent.	Universit£
20586421	12	Peptide HIV-1 integrase inhibitors from HIV-1 gene products.	Tokyo Medical And Dental University
19796851	29	Synthesis and anti-HIV-1 integrase activity of modified dinucleotides.	Affiliated With The University Of Orl£Ans And With Inserm Rue Charles Sadron
19813754	9	Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum.	University Of Toyama
19327872	33	Multivariate QSAR study of 4,5-dihydroxypyrimidine carboxamides as HIV-1 integrase inhibitors.	Universidade Estadual Do Oeste Do Paran£
19850483	4	Peptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds.	The Hebrew University Of Jerusalem
19527935	48	Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.	National Cancer Institute-Frederick
19873974	32	Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors.	Pfizer
19450984	45	Analysis of binding parameters of HIV-1 integrase inhibitors: correlates of drug inhibition and resistance.	University Of Cyprus
19616948	29	Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center.	Irbm-Merck Research Laboratories Rome
19556126	6	Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitor.	Facult£S Universitaires Notre-Dame De La Paix
19625188	44	Design and synthesis of novel nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors from caffeic acid phenethyl ester.	Shandong University
19523819	49	N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors.	Irbm-Mrl
19364649	110	Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.	National Cancer Institute-Frederick
17967911	28	Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.	National Cancer Institute
19719237	52	Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors.	Jt
11430019	8	Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.	National Cancer Institute
19447621	49	Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.	Universit£
18394758	114	Synthesis and anti-HIV-1 integrase activities of 3-aroyl-2,3-dihydro-1,1-dioxo-1,4,2-benzodithiazines.	Medical University Of Gda?Sk
18243421	4	The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.	Universit£
19269185	34	Amide-containing diketoacids as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity.	Shandong University
19269170	24	3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors.	Merck Research Laboratories Rome
19026554	22	Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors.	Universit£
18952420	40	Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.	Zhejiang University
19105658	46	Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions.	Universita Di Messina
19053754	34	Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.	Universit£
18805696	44	Discovery of 3-acetyl-4-hydroxy-2-pyranone derivatives and their difluoridoborate complexes as a novel class of HIV-1 integrase inhibitors.	University Of Southern California
18774711	8	Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.	Merck Research Laboratories
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11975488	2	Synthesis and structure-activity relationship study of lamellarin derivatives.	Nagasaki University
17949860	54	Synthesis, anti-HIV-1 integrase, and cytotoxic activities of 4-chloro-N-(4-oxopyrimidin-2-yl)-2-mercaptobenzenesulfonamide derivatives.	Medical University Of Gdansk
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18665580	54	Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.	Universita Degli Studi Di Siena
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18646746	72	Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.	Fondazione Cenci Bolognettiuniversit£
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18595690	9	4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors.	Irbm-Mrl Rome
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16643034	13	Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.	Korea Institute Of Science And Technology
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11473415	21	The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.	Merck Research Laboratories
15165153	1	Isolation, structure, absolute stereochemistry, and HIV-1 integrase inhibitory activity of integrasone, a novel fungal polyketide.	Merck Research Laboratories
18417342	26	A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.	Universit£
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17488811	3	Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium.	Hebrew University Of Jerusalem
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18095643	112	2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors.	National Cancer Institute-Frederick
17420131	3	Calculation of binding energy using BLYP/MM for the HIV-1 integrase complexed with the S-1360 and two analogues.	Universidade Federal Do Par£
17367896	14	Development of integrase inhibitors for treatment of AIDS: an overview.	K.L.E.S. College Of Pharmacy
17950601	34	Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.	University Of Southern California
17502148	166	Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore.	University Of Southern California
17376679	18	Newer tetracycline derivatives: synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase.	Birla Institute Of Technology And Science
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17931865	16	8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.	Merck Research Laboratories
17911021	40	Substituted 2-pyrrolinone inhibitors of HIV-1 integrase.	University Of Southern California
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17719223	26	Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA.	National Cancer Institute
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17158051	80	Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.	University Of Tennessee Health Science Center
30031978	95	6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H.	University Of Minnesota
30031976	140	6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.	University Of Minnesota
30344908	27	Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors.	University Of Southern Mississippi
29602675	1	DNA sequence-specific ligands. XVII. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric bisbenzimidazoles DBA(n).	Engelhardt Institute Of Molecular Biology Russian Academy Of Sciences
29482943	9	Synthesis and evaluation of substituted 4-arylimino-3-hydroxybutanoic acids as potential HIV-1 integrase inhibitors.	Rhodes University
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29779976	55	The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.	Bristol-Myers Squibb Research And Development