Compile Data Set for Download or QSAR

Found 460 hits with Last Name = 'okun' and Initial = 'im'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318625 (CHEMBL1083654 | N-Methyl-(3-phenylsulfonyl)-7,8-di...) Show SMILES CNc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C16H16N4O2S/c1-17-15-14(23(21,22)12-7-3-2-4-8-12)16-18-10-11-6-5-9-13(11)20(16)19-15/h2-4,7-8,10H,5-6,9H2,1H3,(H,17,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.0880	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318626 (CHEMBL1082763 | N-Methyl-(3-phenylsulfonyl)-6,7,8,...) Show SMILES CNc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-11-12-7-5-6-10-14(12)21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.112	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50358778 (CHEMBL1922616) Show SMILES CNc1nn2c(N)c(Cl)c(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C14H14ClN5O2S/c1-8-10(15)12(16)20-14(18-8)11(13(17-2)19-20)23(21,22)9-6-4-3-5-7-9/h3-7H,16H2,1-2H3,(H,17,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation				J Med Chem 54: 8161-73 (2011) Article DOI: 10.1021/jm201079g BindingDB Entry DOI: 10.7270/Q2X067F0
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318627 (CHEMBL1083075 | N,5-Dimethyl-3-(phenylsulfonyl)-7,...) Show SMILES CNc1nn2c3CCCc3c(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H18N4O2S/c1-11-13-9-6-10-14(13)21-17(19-11)15(16(18-2)20-21)24(22,23)12-7-4-3-5-8-12/h3-5,7-8H,6,9-10H2,1-2H3,(H,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.202	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318633 (3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...) Show SMILES O=S(=O)(c1ccccc1)c1cnc2c(cccc2c1)N1CCNCC1 Show InChI InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.234	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to 5HT6 receptor				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318624 (CHEMBL1082762 | N,9-Dimethyl-3-(phenylsulfonyl)-5,...) Show SMILES CNc1nn2c(C)c3CCCCc3nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C18H20N4O2S/c1-12-14-10-6-7-11-15(14)20-18-16(17(19-2)21-22(12)18)25(23,24)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3,(H,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.256	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318626 (CHEMBL1082763 | N-Methyl-(3-phenylsulfonyl)-6,7,8,...) Show SMILES CNc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-11-12-7-5-6-10-14(12)21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.259	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50340725 (CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...) Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation				J Med Chem 54: 8161-73 (2011) Article DOI: 10.1021/jm201079g BindingDB Entry DOI: 10.7270/Q2X067F0
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318625 (CHEMBL1083654 | N-Methyl-(3-phenylsulfonyl)-7,8-di...) Show SMILES CNc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C16H16N4O2S/c1-17-15-14(23(21,22)12-7-3-2-4-8-12)16-18-10-11-6-5-9-13(11)20(16)19-15/h2-4,7-8,10H,5-6,9H2,1H3,(H,17,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.375	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318627 (CHEMBL1083075 | N,5-Dimethyl-3-(phenylsulfonyl)-7,...) Show SMILES CNc1nn2c3CCCc3c(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H18N4O2S/c1-11-13-9-6-10-14(13)21-17(19-11)15(16(18-2)20-21)24(22,23)12-7-4-3-5-8-12/h3-5,7-8H,6,9-10H2,1-2H3,(H,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.413	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50314762 (5-methyl-2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9...) Show SMILES CSc1nn2c3CCCCc3c(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C18H19N3O2S2/c1-12-14-10-6-7-11-15(14)21-17(19-12)16(18(20-21)24-2)25(22,23)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.440	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins				Bioorg Med Chem Lett 20: 2133-6 (2010) Article DOI: 10.1016/j.bmcl.2010.02.046 BindingDB Entry DOI: 10.7270/Q2V40VBK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50314759 (2-(methylthio)-3-(phenylsulfonyl)-7,8-dihydro-6H-c...) Show SMILES CSc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C16H15N3O2S2/c1-22-16-14(23(20,21)12-7-3-2-4-8-12)15-17-10-11-6-5-9-13(11)19(15)18-16/h2-4,7-8,10H,5-6,9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.458	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins				Bioorg Med Chem Lett 20: 2133-6 (2010) Article DOI: 10.1016/j.bmcl.2010.02.046 BindingDB Entry DOI: 10.7270/Q2V40VBK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318628 (CHEMBL1083076 | N,5-Dimethyl-3-(phenylsulfonyl)-6,...) Show SMILES CNc1nn2c3CCCCc3c(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C18H20N4O2S/c1-12-14-10-6-7-11-15(14)22-18(20-12)16(17(19-2)21-22)25(23,24)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3,(H,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318623 (CHEMBL1082761 | N-Methyl-3-(phenylsulfonyl)-5,6,7,...) Show SMILES CNc1nn2cc3CCCCc3nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-14-10-6-5-7-12(14)11-21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.499	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cells				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318623 (CHEMBL1082761 | N-Methyl-3-(phenylsulfonyl)-5,6,7,...) Show SMILES CNc1nn2cc3CCCCc3nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H18N4O2S/c1-18-16-15(24(22,23)13-8-3-2-4-9-13)17-19-14-10-6-5-7-12(14)11-21(17)20-16/h2-4,8-9,11H,5-7,10H2,1H3,(H,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.542	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50314760 (2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9-tetrahyd...) Show SMILES CSc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H17N3O2S2/c1-23-17-15(24(21,22)13-8-3-2-4-9-13)16-18-11-12-7-5-6-10-14(12)20(16)19-17/h2-4,8-9,11H,5-7,10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.549	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins				Bioorg Med Chem Lett 20: 2133-6 (2010) Article DOI: 10.1016/j.bmcl.2010.02.046 BindingDB Entry DOI: 10.7270/Q2V40VBK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50314763 (9-methyl-2-(methylthio)-3-(phenylsulfonyl)-5,6,7,8...) Show SMILES CSc1nn2c(C)c3CCCCc3nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C18H19N3O2S2/c1-12-14-10-6-7-11-15(14)19-17-16(18(24-2)20-21(12)17)25(22,23)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins				Bioorg Med Chem Lett 20: 2133-6 (2010) Article DOI: 10.1016/j.bmcl.2010.02.046 BindingDB Entry DOI: 10.7270/Q2V40VBK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50358774 (CHEMBL1642114 | Ro-657674) Show SMILES CSc1nn2c(N3CCNCC3)c3CCCc3nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C20H23N5O2S2/c1-28-19-17(29(26,27)14-6-3-2-4-7-14)18-22-16-9-5-8-15(16)20(25(18)23-19)24-12-10-21-11-13-24/h2-4,6-7,21H,5,8-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation				J Med Chem 54: 8161-73 (2011) Article DOI: 10.1021/jm201079g BindingDB Entry DOI: 10.7270/Q2X067F0
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318634 (CHEMBL1084244 | N-methyl-3-(phenylsulfonyl)-8-(pip...) Show SMILES O=S(=O)(c1cnn2c(N3CCNCC3)c3CCCc3nc12)c1ccccc1 Show InChI InChI=1S/C19H21N5O2S/c25-27(26,14-5-2-1-3-6-14)17-13-21-24-18(17)22-16-8-4-7-15(16)19(24)23-11-9-20-10-12-23/h1-3,5-6,13,20H,4,7-12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to 5HT6 receptor				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50358776 (CHEMBL1922716) Show SMILES CNc1cc(ccc1S(=O)(=O)c1cccc(F)c1)N1CCCNCC1 Show InChI InChI=1S/C18H22FN3O2S/c1-20-17-13-15(22-10-3-8-21-9-11-22)6-7-18(17)25(23,24)16-5-2-4-14(19)12-16/h2,4-7,12-13,20-21H,3,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation				J Med Chem 54: 8161-73 (2011) Article DOI: 10.1021/jm201079g BindingDB Entry DOI: 10.7270/Q2X067F0
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322093 (3-(phenylsulfonyl)-N-(thiophen-2-ylmethyl)thieno[2...) Show SMILES O=S(=O)(c1nnn2c3ccsc3c(NCc3cccs3)nc12)c1ccccc1 Show InChI InChI=1S/C18H13N5O2S3/c24-28(25,13-6-2-1-3-7-13)18-17-20-16(19-11-12-5-4-9-26-12)15-14(8-10-27-15)23(17)22-21-18/h1-10H,11H2,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50316295 (CHEMBL1099284 | N-(3-Fluorophenyl)-2-methyl-2,3,4,...) Show SMILES CN1CCc2[nH]c3ccc(cc3c2C1)S(=O)(=O)Nc1cccc(F)c1 Show InChI InChI=1S/C18H18FN3O2S/c1-22-8-7-18-16(11-22)15-10-14(5-6-17(15)20-18)25(23,24)21-13-4-2-3-12(19)9-13/h2-6,9-10,20-21H,7-8,11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor by radioligand displacement assay				Eur J Med Chem 45: 782-9 (2010) Article DOI: 10.1016/j.ejmech.2009.10.035 BindingDB Entry DOI: 10.7270/Q2542NR1
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322162 (CHEMBL1169707 | N-Benzyl-N-methyl-3-(phenylsulfony...) Show SMILES CN(Cc1ccccc1)c1nc2c(nnn2c2ccsc12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C21H17N5O2S2/c1-25(14-15-8-4-2-5-9-15)19-18-17(12-13-29-18)26-20(22-19)21(23-24-26)30(27,28)16-10-6-3-7-11-16/h2-13H,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50358775 (CHEMBL1922641) Show SMILES CCNc1cc(ccc1S(=O)(=O)c1ccccc1)N1CCNCC1 Show InChI InChI=1S/C18H23N3O2S/c1-2-20-17-14-15(21-12-10-19-11-13-21)8-9-18(17)24(22,23)16-6-4-3-5-7-16/h3-9,14,19-20H,2,10-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation				J Med Chem 54: 8161-73 (2011) Article DOI: 10.1021/jm201079g BindingDB Entry DOI: 10.7270/Q2X067F0
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322092 (CHEMBL1172725 | N-(furan-2-yl)-3-(phenylsulfonyl)t...) Show SMILES O=S(=O)(c1nnn2c3ccsc3c(NCc3ccco3)nc12)c1ccccc1 Show InChI InChI=1S/C18H13N5O3S2/c24-28(25,13-6-2-1-3-7-13)18-17-20-16(19-11-12-5-4-9-26-12)15-14(8-10-27-15)23(17)22-21-18/h1-10H,11H2,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM93394 (PSTQ Analog, 3{1,27}) Show SMILES CC1CCCCC1Nc1nc2c(nnn2c2ccccc12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C22H23N5O2S/c1-15-9-5-7-13-18(15)23-20-17-12-6-8-14-19(17)27-21(24-20)22(25-26-27)30(28,29)16-10-3-2-4-11-16/h2-4,6,8,10-12,14-15,18H,5,7,9,13H2,1H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	2.86	n/a	6.17	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute					Assay Description Radioligand binding assay using 5-HT6R.				J Comb Chem 12: 445-52 (2010) Article DOI: 10.1021/cc1000049 BindingDB Entry DOI: 10.7270/Q2KH0KX6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322112 (CHEMBL1170673 | N-Cyclohexyl-3-(phenylsulfonyl)thi...) Show SMILES O=S(=O)(c1nnn2c3ccsc3c(NC3CCCCC3)nc12)c1ccccc1 Show InChI InChI=1S/C19H19N5O2S2/c25-28(26,14-9-5-2-6-10-14)19-18-21-17(20-13-7-3-1-4-8-13)16-15(11-12-27-16)24(18)23-22-19/h2,5-6,9-13H,1,3-4,7-8H2,(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322159 (CHEMBL1173578 | N-benzyl-N-methyl-3-(phenylsulfony...) Show SMILES CN(Cc1ccccc1)c1nc2c(nnn2c2ccsc12)S(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C21H16ClN5O2S2/c1-26(13-14-6-3-2-4-7-14)19-18-17(10-11-30-18)27-20(23-19)21(24-25-27)31(28,29)16-9-5-8-15(22)12-16/h2-12H,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM93364 (PSTQ Analog, 3{1,22}) Show SMILES O=S(=O)(c1nnn2c1nc(NCc1ccco1)c1ccccc21)c1ccccc1 Show InChI InChI=1S/C20H15N5O3S/c26-29(27,15-8-2-1-3-9-15)20-19-22-18(21-13-14-7-6-12-28-14)16-10-4-5-11-17(16)25(19)24-23-20/h1-12H,13H2,(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	3.54	n/a	7.62	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute					Assay Description Radioligand binding assay using 5-HT6R.				J Comb Chem 12: 445-52 (2010) Article DOI: 10.1021/cc1000049 BindingDB Entry DOI: 10.7270/Q2KH0KX6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM93393 (PSTQ Analog, 3{1,26}) Show SMILES O=S(=O)(c1nnn2c1nc(NC1CCCCC1)c1ccccc21)c1ccccc1 Show InChI InChI=1S/C21H21N5O2S/c27-29(28,16-11-5-2-6-12-16)21-20-23-19(22-15-9-3-1-4-10-15)17-13-7-8-14-18(17)26(20)25-24-21/h2,5-8,11-15H,1,3-4,9-10H2,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	5.01	n/a	10.8	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute					Assay Description Radioligand binding assay using 5-HT6R.				J Comb Chem 12: 445-52 (2010) Article DOI: 10.1021/cc1000049 BindingDB Entry DOI: 10.7270/Q2KH0KX6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322111 (CHEMBL1170672 | N-Cyclopentyl-3-(phenylsulfonyl)th...) Show SMILES O=S(=O)(c1nnn2c3ccsc3c(NC3CCCC3)nc12)c1ccccc1 Show InChI InChI=1S/C18H17N5O2S2/c24-27(25,13-8-2-1-3-9-13)18-17-20-16(19-12-6-4-5-7-12)15-14(10-11-26-15)23(17)22-21-18/h1-3,8-12H,4-7H2,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50316296 (2,5-Dimethyl-8-(phenylsulfonyl)-2,3,4,5-tetrahydro...) Show SMILES CN1CCc2c(C1)c1cc(ccc1n2C)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C19H20N2O2S/c1-20-11-10-19-17(13-20)16-12-15(8-9-18(16)21(19)2)24(22,23)14-6-4-3-5-7-14/h3-9,12H,10-11,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor by radioligand displacement assay				Eur J Med Chem 45: 782-9 (2010) Article DOI: 10.1016/j.ejmech.2009.10.035 BindingDB Entry DOI: 10.7270/Q2542NR1
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50316295 (CHEMBL1099284 | N-(3-Fluorophenyl)-2-methyl-2,3,4,...) Show SMILES CN1CCc2[nH]c3ccc(cc3c2C1)S(=O)(=O)Nc1cccc(F)c1 Show InChI InChI=1S/C18H18FN3O2S/c1-22-8-7-18-16(11-22)15-10-14(5-6-17(15)20-18)25(23,24)21-13-4-2-3-12(19)9-13/h2-6,9-10,20-21H,7-8,11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to 5HT1A receptor by radioligand displacement assay				Eur J Med Chem 45: 782-9 (2010) Article DOI: 10.1016/j.ejmech.2009.10.035 BindingDB Entry DOI: 10.7270/Q2542NR1
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM93392 (PSTQ Analog, 3{1,4}) Show SMILES CCC(C)Nc1nc2c(nnn2c2ccccc12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C19H19N5O2S/c1-3-13(2)20-17-15-11-7-8-12-16(15)24-18(21-17)19(22-23-24)27(25,26)14-9-5-4-6-10-14/h4-13H,3H2,1-2H3,(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	7.04	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute					Assay Description Radioligand binding assay using 5-HT6R.				J Comb Chem 12: 445-52 (2010) Article DOI: 10.1021/cc1000049 BindingDB Entry DOI: 10.7270/Q2KH0KX6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM93385 (PSTQ Analog, 3{1,43}) Show SMILES CN(Cc1ccccc1)c1nc2c(nnn2c2ccccc12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C23H19N5O2S/c1-27(16-17-10-4-2-5-11-17)21-19-14-8-9-15-20(19)28-22(24-21)23(25-26-28)31(29,30)18-12-6-3-7-13-18/h2-15H,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	7.65	n/a	16.5	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute					Assay Description Radioligand binding assay using 5-HT6R.				J Comb Chem 12: 445-52 (2010) Article DOI: 10.1021/cc1000049 BindingDB Entry DOI: 10.7270/Q2KH0KX6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50314761 (2-Methylsulfanyl-3-phenylsulfonyl-5,6,7,8-tetrahyd...) Show SMILES CSc1nn2cc3CCCCc3nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H17N3O2S2/c1-23-17-15(24(21,22)13-8-3-2-4-9-13)16-18-14-10-6-5-7-12(14)11-20(16)19-17/h2-4,8-9,11H,5-7,10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7.97	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5HT6 receptor in humanHeLa cells after 120 mins				Bioorg Med Chem Lett 20: 2133-6 (2010) Article DOI: 10.1016/j.bmcl.2010.02.046 BindingDB Entry DOI: 10.7270/Q2V40VBK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50305261 (CHEMBL589390 | Dimebolin) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1 Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to 5HT7 receptor by radioligand displacement assay				Eur J Med Chem 45: 782-9 (2010) Article DOI: 10.1016/j.ejmech.2009.10.035 BindingDB Entry DOI: 10.7270/Q2542NR1
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322091 (3-(phenylsulfonyl)-N-((tetrahydrofuran-2-yl)methyl...) Show SMILES O=S(=O)(c1nnn2c3ccsc3c(NCC3CCCO3)nc12)c1ccccc1 Show InChI InChI=1S/C18H17N5O3S2/c24-28(25,13-6-2-1-3-7-13)18-17-20-16(19-11-12-5-4-9-26-12)15-14(8-10-27-15)23(17)22-21-18/h1-3,6-8,10,12H,4-5,9,11H2,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM93376 (PSTQ Analog, 3{1,25}) Show SMILES O=S(=O)(c1nnn2c1nc(NC1CCCC1)c1ccccc21)c1ccccc1 Show InChI InChI=1S/C20H19N5O2S/c26-28(27,15-10-2-1-3-11-15)20-19-22-18(21-14-8-4-5-9-14)16-12-6-7-13-17(16)25(19)24-23-20/h1-3,6-7,10-14H,4-5,8-9H2,(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	12.9	n/a	27.8	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute					Assay Description Radioligand binding assay using 5-HT6R.				J Comb Chem 12: 445-52 (2010) Article DOI: 10.1021/cc1000049 BindingDB Entry DOI: 10.7270/Q2KH0KX6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM93363 (PSTQ Analog, 3{1,21}) Show SMILES O=S(=O)(c1nnn2c1nc(NCC1CCCO1)c1ccccc21)c1ccccc1 Show InChI InChI=1S/C20H19N5O3S/c26-29(27,15-8-2-1-3-9-15)20-19-22-18(21-13-14-7-6-12-28-14)16-10-4-5-11-17(16)25(19)24-23-20/h1-5,8-11,14H,6-7,12-13H2,(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	13.2	n/a	28.4	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute					Assay Description Radioligand binding assay using 5-HT6R.				J Comb Chem 12: 445-52 (2010) Article DOI: 10.1021/cc1000049 BindingDB Entry DOI: 10.7270/Q2KH0KX6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322102 (3-(3-chlorophenylsulfonyl)-N-(pyridin-3-ylmethyl)t...) Show SMILES Clc1cccc(c1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3cccnc3)nc12 Show InChI InChI=1S/C19H13ClN6O2S2/c20-13-4-1-5-14(9-13)30(27,28)19-18-23-17(22-11-12-3-2-7-21-10-12)16-15(6-8-29-16)26(18)25-24-19/h1-10H,11H2,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322161 (3-(4-bromophenylsulfonyl)-N-isopentylthieno[2,3-e]...) Show SMILES CC(C)CCNc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C18H18BrN5O2S2/c1-11(2)7-9-20-16-15-14(8-10-27-15)24-17(21-16)18(22-23-24)28(25,26)13-5-3-12(19)4-6-13/h3-6,8,10-11H,7,9H2,1-2H3,(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM93400 (PSTQ Analog, 3{8,4}) Show SMILES CCC(C)Nc1nc2c(nnn2c2ccccc12)S(=O)(=O)c1cc(C)ccc1C Show InChI InChI=1S/C21H23N5O2S/c1-5-15(4)22-19-16-8-6-7-9-17(16)26-20(23-19)21(24-25-26)29(27,28)18-12-13(2)10-11-14(18)3/h6-12,15H,5H2,1-4H3,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	16.7	n/a	35.9	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute					Assay Description Radioligand binding assay using 5-HT6R.				J Comb Chem 12: 445-52 (2010) Article DOI: 10.1021/cc1000049 BindingDB Entry DOI: 10.7270/Q2KH0KX6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM93399 (PSTQ Analog, 3{1,49}) Show SMILES CC1CCCCN1c1nc2c(nnn2c2ccccc12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C21H21N5O2S/c1-15-9-7-8-14-25(15)19-17-12-5-6-13-18(17)26-20(22-19)21(23-24-26)29(27,28)16-10-3-2-4-11-16/h2-6,10-13,15H,7-9,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	19.5	n/a	42.1	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute					Assay Description Radioligand binding assay using 5-HT6R.				J Comb Chem 12: 445-52 (2010) Article DOI: 10.1021/cc1000049 BindingDB Entry DOI: 10.7270/Q2KH0KX6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318630 (CHEMBL1083078 | N,N,5-Trimethyl-3-(phenylsulfonyl)...) Show SMILES CN(C)c1nn2c3CCCc3c(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C18H20N4O2S/c1-12-14-10-7-11-15(14)22-17(19-12)16(18(20-22)21(2)3)25(23,24)13-8-5-4-6-9-13/h4-6,8-9H,7,10-11H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	25.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50305261 (CHEMBL589390 | Dimebolin) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1 Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor				Eur J Med Chem 45: 782-9 (2010) Article DOI: 10.1016/j.ejmech.2009.10.035 BindingDB Entry DOI: 10.7270/Q2542NR1
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322163 (10-(benzenesulfonyl)-N-(3,5-dimethyladamantan-1- y...) Show SMILES CC12CC3CC(C)(C1)CC(C3)(C2)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1ccccc1 |TLB:4:3:11:7.5.8,4:5:2.3.10:11,12:9:2:7.4.5,THB:8:5:2:10.9.11,8:9:2:7.4.5,6:5:2:10.9.11,6:5:2.3.10:11| Show InChI InChI=1S/C25H27N5O2S2/c1-23-10-16-11-24(2,13-23)15-25(12-16,14-23)27-20-19-18(8-9-33-19)30-21(26-20)22(28-29-30)34(31,32)17-6-4-3-5-7-17/h3-9,16H,10-15H2,1-2H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	26.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM93395 (PSTQ Analog, 3{1,28}) Show SMILES CC1CCC(CC1)Nc1nc2c(nnn2c2ccccc12)S(=O)(=O)c1ccccc1 |(-7.58,11.61,;-6.24,10.84,;-4.91,11.61,;-3.58,10.84,;-3.58,9.3,;-4.91,8.53,;-6.24,9.3,;-2.24,8.53,;-2.24,6.99,;-.91,6.22,;-.91,4.62,;.24,3.59,;-.39,2.18,;-1.92,2.34,;-2.24,3.85,;-3.58,4.68,;-4.91,3.91,;-6.24,4.68,;-6.24,6.22,;-4.91,6.99,;-3.58,6.22,;1.74,3.91,;1.43,5.42,;2.13,2.42,;3.23,4.31,;3.63,5.8,;5.12,6.19,;6.21,5.11,;5.81,3.62,;4.32,3.22,)| Show InChI InChI=1S/C22H23N5O2S/c1-15-11-13-16(14-12-15)23-20-18-9-5-6-10-19(18)27-21(24-20)22(25-26-27)30(28,29)17-7-3-2-4-8-17/h2-10,15-16H,11-14H2,1H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	27.6	n/a	59.5	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute					Assay Description Radioligand binding assay using 5-HT6R.				J Comb Chem 12: 445-52 (2010) Article DOI: 10.1021/cc1000049 BindingDB Entry DOI: 10.7270/Q2KH0KX6
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50318629 (CHEMBL1083077 | N,N-Dimethyl-3-(phenylsulfonyl)-7,...) Show SMILES CN(C)c1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H18N4O2S/c1-20(2)17-15(24(22,23)13-8-4-3-5-9-13)16-18-11-12-7-6-10-14(12)21(16)19-17/h3-5,8-9,11H,6-7,10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	28.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP release				J Med Chem 53: 5186-96 (2010) Article DOI: 10.1021/jm100350r BindingDB Entry DOI: 10.7270/Q26T0NMP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50322165 (CHEMBL1173579 | N-(benzo[d][1,3]dioxol-5-ylmethyl)...) Show SMILES Brc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(NCc3ccc4OCOc4c3)nc12 Show InChI InChI=1S/C21H14BrN5O4S2/c22-13-2-4-14(5-3-13)33(28,29)21-20-24-19(18-15(7-8-32-18)27(20)26-25-21)23-10-12-1-6-16-17(9-12)31-11-30-16/h1-9H,10-11H2,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	28.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assay				Bioorg Med Chem 18: 5282-90 (2010) Article DOI: 10.1016/j.bmc.2010.05.051 BindingDB Entry DOI: 10.7270/Q2F190QT
					More data for this Ligand-Target Pair

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