Compile Data Set for Download or QSAR

Found 151 hits with Last Name = 'tischler' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4560 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31i |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCC(O)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C26H28Cl2N4O4/c1-34-23-13-22(19(27)11-20(23)28)31-26-16(14-29)15-30-21-12-25(24(35-2)10-18(21)26)36-9-3-6-32-7-4-17(33)5-8-32/h10-13,15,17,33H,3-9H2,1-2H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4557 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31f |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCN(CCO)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H31Cl2N5O4/c1-36-24-15-23(20(28)13-21(24)29)32-27-18(16-30)17-31-22-14-26(25(37-2)12-19(22)27)38-11-3-4-33-5-7-34(8-6-33)9-10-35/h12-15,17,35H,3-11H2,1-2H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4553 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31b |...) Show SMILES CCN1CCN(CCCOc2cc3ncc(C#N)c(Nc4cc(OC)c(Cl)cc4Cl)c3cc2OC)CC1 Show InChI InChI=1S/C27H31Cl2N5O3/c1-4-33-7-9-34(10-8-33)6-5-11-37-26-14-22-19(12-25(26)36-3)27(18(16-30)17-31-22)32-23-15-24(35-2)21(29)13-20(23)28/h12-15,17H,4-11H2,1-3H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4543 (4-Phenylamino-3-quinolinecarbonitrile deriv. 2c | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C25H26Cl2N4O4/c1-32-22-13-21(18(26)11-19(22)27)30-25-16(14-28)15-29-20-12-24(23(33-2)10-17(20)25)35-7-3-4-31-5-8-34-9-6-31/h10-13,15H,3-9H2,1-2H3,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4544 (4-Phenylamino-3-quinolinecarbonitrile deriv. 2d | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c(Br)cc1Cl Show InChI InChI=1S/C25H26BrClN4O4/c1-32-22-13-21(18(26)11-19(22)27)30-25-16(14-28)15-29-20-12-24(23(33-2)10-17(20)25)35-7-3-4-31-5-8-34-9-6-31/h10-13,15H,3-9H2,1-2H3,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.950	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4547 (4-Phenylamino-3-quinolinecarbonitrile deriv. 2g | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1C Show InChI InChI=1S/C26H29ClN4O4/c1-17-11-20(27)22(14-23(17)32-2)30-26-18(15-28)16-29-21-13-25(24(33-3)12-19(21)26)35-8-4-5-31-6-9-34-10-7-31/h11-14,16H,4-10H2,1-3H3,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4556 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31e |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCNCC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C25H27Cl2N5O3/c1-33-22-13-21(18(26)11-19(22)27)31-25-16(14-28)15-30-20-12-24(23(34-2)10-17(20)25)35-9-3-6-32-7-4-29-5-8-32/h10-13,15,29H,3-9H2,1-2H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4555 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31d |...) Show SMILES CCCN1CCN(CCCOc2cc3ncc(C#N)c(Nc4cc(OC)c(Cl)cc4Cl)c3cc2OC)CC1 Show InChI InChI=1S/C28H33Cl2N5O3/c1-4-6-34-8-10-35(11-9-34)7-5-12-38-27-15-23-20(13-26(27)37-3)28(19(17-31)18-32-23)33-24-16-25(36-2)22(30)14-21(24)29/h13-16,18H,4-12H2,1-3H3,(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4552 (4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4559 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31h |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCCCC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C26H28Cl2N4O3/c1-33-23-14-22(19(27)12-20(23)28)31-26-17(15-29)16-30-21-13-25(24(34-2)11-18(21)26)35-10-6-9-32-7-4-3-5-8-32/h11-14,16H,3-10H2,1-2H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4545 (4-Phenylamino-3-quinolinecarbonitrile deriv. 2e | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c(C)cc1Cl Show InChI InChI=1S/C26H29ClN4O4/c1-17-11-20(27)23(32-2)13-21(17)30-26-18(15-28)16-29-22-14-25(24(33-3)12-19(22)26)35-8-4-5-31-6-9-34-10-7-31/h11-14,16H,4-10H2,1-3H3,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4550 (4-Phenylamino 3-quinolinecarbonitrile deriv. 27 | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C26H28Cl2N4O4/c1-33-23-14-22(19(27)12-20(23)28)31-26-17(15-29)16-30-21-13-25(24(34-2)11-18(21)26)36-8-4-3-5-32-6-9-35-10-7-32/h11-14,16H,3-10H2,1-2H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4554 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31c |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4C[C@H](C)N(C)[C@H](C)C4)c(OC)cc23)C#N)c(Cl)cc1Cl |r| Show InChI InChI=1S/C28H33Cl2N5O3/c1-17-15-35(16-18(2)34(17)3)7-6-8-38-27-11-23-20(9-26(27)37-5)28(19(13-31)14-32-23)33-24-12-25(36-4)22(30)10-21(24)29/h9-12,14,17-18H,6-8,15-16H2,1-5H3,(H,32,33)/t17-,18+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4558 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31g |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H31Cl2N5O3/c1-33-6-4-7-34(10-9-33)8-5-11-37-26-14-22-19(12-25(26)36-3)27(18(16-30)17-31-22)32-23-15-24(35-2)21(29)13-20(23)28/h12-15,17H,4-11H2,1-3H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4542 (4-Phenylamino-3-quinolinecarbonitrile deriv. 2b | ...) Show SMILES COc1ccc(Cl)c(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c1 Show InChI InChI=1S/C25H27ClN4O4/c1-31-18-4-5-20(26)22(12-18)29-25-17(15-27)16-28-21-14-24(23(32-2)13-19(21)25)34-9-3-6-30-7-10-33-11-8-30/h4-5,12-14,16H,3,6-11H2,1-2H3,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4546 (4-Phenylamino-3-quinolinecarbonitrile deriv. 2f | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)c(C)cc1C Show InChI InChI=1S/C27H32N4O4/c1-18-12-19(2)24(32-3)14-22(18)30-27-20(16-28)17-29-23-15-26(25(33-4)13-21(23)27)35-9-5-6-31-7-10-34-11-8-31/h12-15,17H,5-11H2,1-4H3,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4562 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31k |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCn4ccnn4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C23H20Cl2N6O3/c1-32-20-11-19(16(24)9-17(20)25)29-23-14(12-26)13-27-18-10-22(21(33-2)8-15(18)23)34-7-3-5-31-6-4-28-30-31/h4,6,8-11,13H,3,5,7H2,1-2H3,(H,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4563 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31l |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCn4ccnc4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C24H21Cl2N5O3/c1-32-21-11-20(17(25)9-18(21)26)30-24-15(12-27)13-29-19-10-23(22(33-2)8-16(19)24)34-7-3-5-31-6-4-28-14-31/h4,6,8-11,13-14H,3,5,7H2,1-2H3,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4549 (4-Phenylamino 3-quinolinecarbonitrile deriv. 26 | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C24H24Cl2N4O4/c1-31-21-12-20(17(25)10-18(21)26)29-24-15(13-27)14-28-19-11-23(22(32-2)9-16(19)24)34-8-5-30-3-6-33-7-4-30/h9-12,14H,3-8H2,1-2H3,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4565 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31n |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN(C)CCN(C)C)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C26H31Cl2N5O3/c1-32(2)8-9-33(3)7-6-10-36-25-13-21-18(11-24(25)35-5)26(17(15-29)16-30-21)31-22-14-23(34-4)20(28)12-19(22)27/h11-14,16H,6-10H2,1-5H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4551 (4-Phenylamino-3-quinolinecarbonitrile deriv. 28 | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H30Cl2N4O4/c1-34-24-15-23(20(28)13-21(24)29)32-27-18(16-30)17-31-22-14-26(25(35-2)12-19(22)27)37-9-5-3-4-6-33-7-10-36-11-8-33/h12-15,17H,3-11H2,1-2H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21034 ((1R,3R,5S,6S,18S)-6-hydroxy-18-(methoxymethyl)-1,5...) Show SMILES COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C2CC[C@H](O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O |r,t:16| Show InChI InChI=1S/C23H26O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-15,25H,5-7,9H2,1-4H3/t12?,13-,14+,15-,22+,23+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.5	22
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4534 (4-Phenylamino-3-quinolinecarbonitrile deriv. 1l | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)c(Cl)cc1C Show InChI InChI=1S/C20H18ClN3O3/c1-11-5-14(21)16(8-17(11)25-2)24-20-12(9-22)10-23-15-7-19(27-4)18(26-3)6-13(15)20/h5-8,10H,1-4H3,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4564 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31m |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCNCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H31Cl2N5O4/c1-35-24-15-23(20(28)13-21(24)29)33-27-18(16-30)17-32-22-14-26(25(36-2)12-19(22)27)38-9-3-4-31-5-6-34-7-10-37-11-8-34/h12-15,17,31H,3-11H2,1-2H3,(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4530 (4-Phenylamino-3-quinolinecarbonitrile deriv. 1h | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)c(Br)cc1Cl Show InChI InChI=1S/C19H15BrClN3O3/c1-25-16-7-15(12(20)5-13(16)21)24-19-10(8-22)9-23-14-6-18(27-3)17(26-2)4-11(14)19/h4-7,9H,1-3H3,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4520 (4-Phenylamino-3-quinolinecarbonitrile deriv. 25 | ...) Show SMILES COc1cc2c(Nc3ccc(Cl)cc3Cl)c(cnc2cc1OCCCN1CCOCC1)C#N Show InChI InChI=1S/C24H24Cl2N4O3/c1-31-22-12-18-21(13-23(22)33-8-2-5-30-6-9-32-10-7-30)28-15-16(14-27)24(18)29-20-4-3-17(25)11-19(20)26/h3-4,11-13,15H,2,5-10H2,1H3,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4531 (4-Phenylamino-3-quinolinecarbonitrile deriv. 1i | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)c(C)cc1Cl Show InChI InChI=1S/C20H18ClN3O3/c1-11-5-14(21)17(25-2)7-15(11)24-20-12(9-22)10-23-16-8-19(27-4)18(26-3)6-13(16)20/h5-8,10H,1-4H3,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4525 (4-Phenylamino-3-quinolinecarbonitrile deriv. 1c | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C19H15Cl2N3O3/c1-25-16-7-15(12(20)5-13(16)21)24-19-10(8-22)9-23-14-6-18(27-3)17(26-2)4-11(14)19/h4-7,9H,1-3H3,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4536 (4-Phenylamino-3-quinolinecarbonitrile deriv. 1n | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)c(C)cc1C Show InChI InChI=1S/C21H21N3O3/c1-12-6-13(2)18(25-3)8-16(12)24-21-14(10-22)11-23-17-9-20(27-5)19(26-4)7-15(17)21/h6-9,11H,1-5H3,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21042 ((2R,3S,6E,14S,15S,17R)-6-({[2-(dimethylamino)ethyl...) Show SMILES CCN(CCN(C)C)C=C1C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]2(C)[C@@H](COC)OC1=O |r,w:8.7,t:15| Show InChI InChI=1S/C29H42N2O8/c1-8-31(12-11-30(5)6)14-17-23-26(35)25(34)22-18-9-10-20(33)28(18,3)13-19(38-16(2)32)24(22)29(23,4)21(15-37-7)39-27(17)36/h14,18-21,23,33H,8-13,15H2,1-7H3/t18?,19-,20+,21-,23?,28+,29+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4515 (4-Phenylamino-3-quinolinecarbonitrile deriv. 1k | ...) Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(Cl)cc3I)c2cc1OC Show InChI InChI=1S/C18H13ClIN3O2/c1-24-16-6-12-15(7-17(16)25-2)22-9-10(8-21)18(12)23-14-4-3-11(19)5-13(14)20/h3-7,9H,1-2H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21036 ((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...) Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:22| Show InChI InChI=1S/C29H42N2O8/c1-16(32)38-19-13-28(2)18(9-10-20(28)33)22-24(19)29(3)21(15-37-7)39-27(36)17(23(29)26(35)25(22)34)14-31(6)12-8-11-30(4)5/h14,18-21,23,33H,8-13,15H2,1-7H3/t18?,19-,20+,21-,23?,28+,29+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	7.5	22
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5 (Homo sapiens (Human))	BDBM21036 ((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...) Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:22| Show InChI InChI=1S/C29H42N2O8/c1-16(32)38-19-13-28(2)18(9-10-20(28)33)22-24(19)29(3)21(15-37-7)39-27(36)17(23(29)26(35)25(22)34)14-31(6)12-8-11-30(4)5/h14,18-21,23,33H,8-13,15H2,1-7H3/t18?,19-,20+,21-,23?,28+,29+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	22
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21041 ((2R,3S,6E,14S,15S,17R)-6-({[2-(dimethylamino)ethyl...) Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCN(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:21| Show InChI InChI=1S/C28H40N2O8/c1-15(31)37-18-12-27(2)17(8-9-19(27)32)21-23(18)28(3)20(14-36-7)38-26(35)16(22(28)25(34)24(21)33)13-30(6)11-10-29(4)5/h13,17-20,22,32H,8-12,14H2,1-7H3/t17?,18-,19+,20-,22?,27+,28+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4561 (4-Phenylamino-3-quinolinecarbonitrile deriv. 31j |...) Show SMILES COc1cc(Nc2c(cnc3cc(OCCCn4nccn4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C23H20Cl2N6O3/c1-32-20-11-19(16(24)9-17(20)25)30-23-14(12-26)13-27-18-10-22(21(33-2)8-15(18)23)34-7-3-6-31-28-4-5-29-31/h4-5,8-11,13H,3,6-7H2,1-2H3,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21039 ((2R,3S,6Z,14S,15S,17R)-6-({tert-butyl[2-(dimethyla...) Show SMILES COC[C@H]1OC(=O)C(=CN(CCN(C)C)C(C)(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:24| Show InChI InChI=1S/C31H46N2O8/c1-17(34)40-20-14-30(5)19(10-11-21(30)35)23-25(20)31(6)22(16-39-9)41-28(38)18(24(31)27(37)26(23)36)15-33(29(2,3)4)13-12-32(7)8/h15,19-22,24,35H,10-14,16H2,1-9H3/t19?,20-,21+,22-,24?,30+,31+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	7.5	22
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21047 ((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...) Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN2CCN(C)CC2)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:27| Show InChI InChI=1S/C32H47N3O8/c1-19(36)42-22-16-31(2)21(8-9-23(31)37)25-27(22)32(3)24(18-41-6)43-30(40)20(26(32)29(39)28(25)38)17-34(5)10-7-11-35-14-12-33(4)13-15-35/h17,21-24,26,37H,7-16,18H2,1-6H3/t21?,22-,23+,24-,26?,31+,32+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4524 (4-Phenylamino-3-quinolinecarbonitrile deriv. 1b | ...) Show SMILES COc1ccc(Cl)c(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)c1 Show InChI InChI=1S/C19H16ClN3O3/c1-24-12-4-5-14(20)16(6-12)23-19-11(9-21)10-22-15-8-18(26-3)17(25-2)7-13(15)19/h4-8,10H,1-3H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM21036 ((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...) Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:22| Show InChI InChI=1S/C29H42N2O8/c1-16(32)38-19-13-28(2)18(9-10-20(28)33)22-24(19)29(3)21(15-37-7)39-27(36)17(23(29)26(35)25(22)34)14-31(6)12-8-11-30(4)5/h14,18-21,23,33H,8-13,15H2,1-7H3/t18?,19-,20+,21-,23?,28+,29+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	22
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21043 ((2R,3S,6E,14S,15S,17R)-6-({[3-(dimethylamino)propy...) Show SMILES CCN(CCCN(C)C)C=C1C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]2(C)[C@@H](COC)OC1=O |r,w:9.8,t:16| Show InChI InChI=1S/C30H44N2O8/c1-8-32(13-9-12-31(5)6)15-18-24-27(36)26(35)23-19-10-11-21(34)29(19,3)14-20(39-17(2)33)25(23)30(24,4)22(16-38-7)40-28(18)37/h15,19-22,24,34H,8-14,16H2,1-7H3/t19?,20-,21+,22-,24?,29+,30+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM21036 ((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...) Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:22| Show InChI InChI=1S/C29H42N2O8/c1-16(32)38-19-13-28(2)18(9-10-20(28)33)22-24(19)29(3)21(15-37-7)39-27(36)17(23(29)26(35)25(22)34)14-31(6)12-8-11-30(4)5/h14,18-21,23,33H,8-13,15H2,1-7H3/t18?,19-,20+,21-,23?,28+,29+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	22
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21049 ((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...) Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN2CCN(CC2)c2ccc(OC)cc2)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:35| Show InChI InChI=1S/C38H51N3O9/c1-23(42)49-28-20-37(2)27(12-13-29(37)43)31-33(28)38(3)30(22-47-5)50-36(46)26(32(38)35(45)34(31)44)21-39(4)14-7-15-40-16-18-41(19-17-40)24-8-10-25(48-6)11-9-24/h8-11,21,27-30,32,43H,7,12-20,22H2,1-6H3/t27?,28-,29+,30-,32?,37+,38+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21046 ((2R,3S,6E,14S,15S,17R)-6-({bis[3-(dimethylamino)pr...) Show SMILES COC[C@H]1OC(=O)C(=CN(CCCN(C)C)CCCN(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:27| Show InChI InChI=1S/C33H51N3O8/c1-20(37)43-23-17-32(2)22(11-12-24(32)38)26-28(23)33(3)25(19-42-8)44-31(41)21(27(33)30(40)29(26)39)18-36(15-9-13-34(4)5)16-10-14-35(6)7/h18,22-25,27,38H,9-17,19H2,1-8H3/t22?,23-,24+,25-,27?,32+,33+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21045 ((2R,3S,6E,14S,15S,17R)-6-({[2-(diethylamino)ethyl]...) Show SMILES CCN(CC)CCN(CC)C=C1C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]2(C)[C@@H](COC)OC1=O |r,w:10.9,t:17| Show InChI InChI=1S/C31H46N2O8/c1-8-32(9-2)13-14-33(10-3)16-19-25-28(37)27(36)24-20-11-12-22(35)30(20,5)15-21(40-18(4)34)26(24)31(25,6)23(17-39-7)41-29(19)38/h16,20-23,25,35H,8-15,17H2,1-7H3/t20?,21-,22+,23-,25?,30+,31+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21048 ((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...) Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN2CCOCC2)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:26| Show InChI InChI=1S/C31H44N2O9/c1-18(34)41-21-15-30(2)20(7-8-22(30)35)24-26(21)31(3)23(17-39-5)42-29(38)19(25(31)28(37)27(24)36)16-32(4)9-6-10-33-11-13-40-14-12-33/h16,20-23,25,35H,6-15,17H2,1-5H3/t20?,21-,22+,23-,25?,30+,31+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4548 (4-Phenylamino-3-quinolinecarbonitrile deriv. 18 | ...) Show SMILES COc1cc(Nc2c(cnc3cc(OC)c(OCCCN4CCOCC4)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C25H26Cl2N4O4/c1-32-22-13-21(18(26)11-19(22)27)30-25-16(14-28)15-29-20-12-23(33-2)24(10-17(20)25)35-7-3-4-31-5-8-34-9-6-31/h10-13,15H,3-9H2,1-2H3,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4492 (4-[(2,4-Dichlorophenyl)amino]-6,7-dimethoxy-3-quin...) Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(Cl)cc3Cl)c2cc1OC Show InChI InChI=1S/C18H13Cl2N3O2/c1-24-16-6-12-15(7-17(16)25-2)22-9-10(8-21)18(12)23-14-4-3-11(19)5-13(14)20/h3-7,9H,1-2H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	30
Wyeth-Ayerst Research					Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...				J Med Chem 44: 3965-77 (2001) Article DOI: 10.1021/jm0102250 BindingDB Entry DOI: 10.7270/Q2TD9VHP
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21065 (17-Hydroxywortmannin, S25 | methyl 1-{[(2R,3S,6E,1...) Show SMILES COC[C@H]1OC(=O)C(=CN2CCC(CC2)C(=O)OC)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:25| Show InChI InChI=1S/C30H39NO10/c1-15(32)40-19-12-29(2)18(6-7-20(29)33)22-24(19)30(3)21(14-38-4)41-28(37)17(23(30)26(35)25(22)34)13-31-10-8-16(9-11-31)27(36)39-5/h13,16,18-21,23,33H,6-12,14H2,1-5H3/t18?,19-,20+,21-,23?,29+,30+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21066 (1-{[(2R,3S,6E,14S,15S,17R)-17-(acetyloxy)-8,14-dih...) Show SMILES COC[C@H]1OC(=O)C(=CN2CCC(CC2)C(O)=O)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:24| Show InChI InChI=1S/C29H37NO10/c1-14(31)39-18-11-28(2)17(5-6-19(28)32)21-23(18)29(3)20(13-38-4)40-27(37)16(22(29)25(34)24(21)33)12-30-9-7-15(8-10-30)26(35)36/h12,15,17-20,22,32H,5-11,13H2,1-4H3,(H,35,36)/t17?,18-,19+,20-,22?,28+,29+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM21068 ((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...) Show SMILES COC[C@H]1OC(=O)C(=CN2CCOCC2)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C |r,w:8.8,t:21| Show InChI InChI=1S/C27H35NO9/c1-14(29)36-17-11-26(2)16(5-6-18(26)30)20-22(17)27(3)19(13-34-4)37-25(33)15(21(27)24(32)23(20)31)12-28-7-9-35-10-8-28/h12,16-19,21,30H,5-11,13H2,1-4H3/t16?,17-,18+,19-,21?,26+,27+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 51: 1319-23 (2008) Article DOI: 10.1021/jm7012858 BindingDB Entry DOI: 10.7270/Q2NP22QD
					More data for this Ligand-Target Pair

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