Found 4524 hits with Last Name = 'xie' and Initial = 'y' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM50035105
(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccccc32)c2ccccc12 Show InChI InChI=1S/C30H31FN2O/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30/h1-4,8-15,21H,5-7,16-20,22H2 | UniProtKB/SwissProt
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PC sid
UniChem
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| Article
PubMed
| 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Guangdong Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to sigma-2 receptor (unknown origin) |
Eur J Med Chem 147: 227-237 (2018)
Article DOI: 10.1016/j.ejmech.2017.11.016
BindingDB Entry DOI: 10.7270/Q2SQ92XB |
More data for this
Ligand-Target Pair | |
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM50216056
((N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-...)Show SMILES COc1cc2CCN(CCCCNC(=O)c3cc(I)cc(OC)c3OCCF)Cc2cc1OC Show InChI InChI=1S/C25H32FIN2O5/c1-31-21-12-17-6-10-29(16-18(17)13-22(21)32-2)9-5-4-8-28-25(30)20-14-19(27)15-23(33-3)24(20)34-11-7-26/h12-15H,4-11,16H2,1-3H3,(H,28,30) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Guangdong Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to sigma-2 receptor (unknown origin) |
Eur J Med Chem 147: 227-237 (2018)
Article DOI: 10.1016/j.ejmech.2017.11.016
BindingDB Entry DOI: 10.7270/Q2SQ92XB |
More data for this
Ligand-Target Pair | |
Androgen receptor
(Rattus norvegicus (Rat)) | BDBM50099679
(3-Bromo-2-hydroxy-2-methyl-N-(4-nitro-3-trifluorom...)Show SMILES C[C@@](O)(CBr)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O Show InChI InChI=1S/C11H10BrF3N2O4/c1-10(19,5-12)9(18)16-6-2-3-8(17(20)21)7(4-6)11(13,14)15/h2-4,19H,5H2,1H3,(H,16,18)/t10-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114119
BindingDB Entry DOI: 10.7270/Q2P55SHP |
More data for this
Ligand-Target Pair | |
Sigma intracellular receptor 2
(Homo sapiens (Human)) | BDBM50048866
(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)Show InChI InChI=1S/C24H38N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3 | UniProtKB/SwissProt
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PubMed
| 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Guangdong Medical University
Curated by ChEMBL
| Assay Description
Binding affinity to sigma-2 receptor (unknown origin) |
Eur J Med Chem 147: 227-237 (2018)
Article DOI: 10.1016/j.ejmech.2017.11.016
BindingDB Entry DOI: 10.7270/Q2SQ92XB |
More data for this
Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50562182
(CHEMBL4744466)Show SMILES COc1cc2CCN(CCCCCC(=O)c3c(C)c(OC)c(OC)c(OC)c3OC)Cc2cc1OC | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting method |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112906
BindingDB Entry DOI: 10.7270/Q23T9MXS |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50132965
(CHEMBL115389 | Cyclopropylmethyl-[8-(2,4-dichloro-...)Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(cccc12)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C23H24Cl2N2/c1-3-11-27(14-16-7-8-16)22-12-15(2)26-23-19(5-4-6-20(22)23)18-10-9-17(24)13-21(18)25/h4-6,9-10,12-13,16H,3,7-8,11,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand |
Bioorg Med Chem Lett 13: 3375-9 (2003)
BindingDB Entry DOI: 10.7270/Q2WM1CS4 |
More data for this
Ligand-Target Pair | |
Androgen receptor
(Homo sapiens (Human)) | BDBM50594916
(CHEMBL469759)Show SMILES C[C@@](O)(COc1ccc(cc1)C#N)C(=O)Nc1ccc(C#N)c(I)c1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114119
BindingDB Entry DOI: 10.7270/Q2P55SHP |
More data for this
Ligand-Target Pair | |
Androgen receptor
(Homo sapiens (Human)) | BDBM50594922
(CHEMBL5170697)Show SMILES CCc1c(C)c2c(ccc3[nH]c(=O)cc(Cl)c23)n1CC(F)(F)F | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114119
BindingDB Entry DOI: 10.7270/Q2P55SHP |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50132951
(8-(2,4-dichlorophenyl)-2-methyl-N,N-dipropylquinol...)Show SMILES CCCN(CCC)c1cc(C)nc2c(cccc12)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C22H24Cl2N2/c1-4-11-26(12-5-2)21-13-15(3)25-22-18(7-6-8-19(21)22)17-10-9-16(23)14-20(17)24/h6-10,13-14H,4-5,11-12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human CRF1 receptor expressed in CHO cells using [125I]-o-CRF as the radioligand |
Bioorg Med Chem Lett 13: 3375-9 (2003)
BindingDB Entry DOI: 10.7270/Q2WM1CS4 |
More data for this
Ligand-Target Pair | |
Androgen receptor
(Homo sapiens (Human)) | BDBM18524
(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)Show SMILES FC(F)(F)CN(CC(F)(F)F)c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F Show InChI InChI=1S/C14H9F9N2O/c15-12(16,17)5-25(6-13(18,19)20)7-1-2-10-8(3-7)9(14(21,22)23)4-11(26)24-10/h1-4H,5-6H2,(H,24,26) | PDB
MMDB
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Reactome pathway
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PC cid
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| MMDB
PDB
Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114119
BindingDB Entry DOI: 10.7270/Q2P55SHP |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
C-C chemokine receptor type 5
(Homo sapiens (Human)) | BDBM50088301
((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)Show SMILES Cc1ccc(cc1)-c1ccc2CCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCOCC2)cc1 |c:15| Show InChI InChI=1S/C33H38N2O2/c1-24-7-11-27(12-8-24)28-14-13-26-5-4-6-29(22-30(26)21-28)33(36)34-31-15-9-25(10-16-31)23-35(2,3)32-17-19-37-20-18-32/h7-16,21-22,32H,4-6,17-20,23H2,1-3H3/p+1 | PDB
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Similars
| | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152188
((4-Chloro-benzyl)-[3-(6-dimethylamino-4-methyl-pyr...)Show SMILES CCN(Cc1ccc(Cl)cc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.7,1.45,;4.67,.3,;3.17,.61,;2.68,2.07,;3.69,3.22,;3.2,4.68,;4.21,5.83,;5.75,5.52,;6.77,6.67,;6.23,4.05,;5.21,2.91,;2.15,-.54,;2.61,-1.99,;1.59,-3.15,;2.08,-4.6,;.1,-2.83,;-.39,-1.38,;-1.8,-.75,;-1.65,.79,;-2.8,1.8,;-.14,1.11,;.63,-.23,;-3.13,-1.52,;-3.13,-3.08,;-4.45,-3.85,;-5.79,-3.08,;-5.79,-1.54,;-4.45,-.75,;-4.46,.79,;-7.13,-3.85,;-8.46,-3.08,;-7.13,-5.39,)| Show InChI InChI=1S/C25H29ClN6/c1-7-31(15-19-8-10-20(26)11-9-19)23-13-17(3)28-25-24(18(4)29-32(23)25)21-14-27-22(30(5)6)12-16(21)2/h8-14H,7,15H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50562185
(CHEMBL4746910)Show SMILES COc1cc2CCN(CCCCCCC(=O)c3c(C)c(OC)c(OC)c(OC)c3OC)Cc2cc1OC | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting method |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112906
BindingDB Entry DOI: 10.7270/Q23T9MXS |
More data for this
Ligand-Target Pair | |
Androgen receptor
(Homo sapiens (Human)) | BDBM50594913
(CHEMBL5184779)Show SMILES Cc1c(Cl)c(ccc1N1C(=O)C2[C@H](O)CCN2C1=O)C#N |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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PC cid
PC sid
UniChem
| Article
PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114119
BindingDB Entry DOI: 10.7270/Q2P55SHP |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50531908
(Btrx-335140 | CYM-53093 | US10676469, Compound 142...)Show SMILES CCc1cc(F)c2nc(N3CCC(CC3)NC3CCOCC3)c(-c3nc(C)no3)c(C)c2c1 Show InChI InChI=1S/C25H32FN5O2/c1-4-17-13-20-15(2)22(25-27-16(3)30-33-25)24(29-23(20)21(26)14-17)31-9-5-18(6-10-31)28-19-7-11-32-12-8-19/h13-14,18-19,28H,4-12H2,1-3H3 | PDB
Reactome pathway
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MCE
PC cid
PC sid
UniChem
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human KOR |
J Med Chem 62: 1761-1780 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01679
BindingDB Entry DOI: 10.7270/Q2CV4N6Q |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50071235
(CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...)Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl |(17.18,-6.55,;17.15,-8.09,;15.79,-8.82,;15.75,-10.36,;17.06,-11.17,;17.01,-12.71,;18.31,-13.5,;15.65,-13.44,;14.4,-11.1,;14.35,-12.63,;12.98,-13.38,;12.93,-14.91,;11.67,-12.57,;11.72,-11.01,;10.61,-9.94,;11.28,-8.56,;10.55,-7.21,;12.81,-8.78,;13.09,-10.29,;9.11,-10.22,;8.1,-9.04,;6.59,-9.31,;6.08,-10.76,;4.57,-11.03,;7.07,-11.93,;8.59,-11.67,;9.57,-12.83,)| Show InChI InChI=1S/C21H24Cl2N4/c1-4-9-26(12-15-5-6-15)19-10-13(2)24-21-20(14(3)25-27(19)21)17-8-7-16(22)11-18(17)23/h7-8,10-11,15H,4-6,9,12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50054245
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses |
J Med Chem 39: 4358-60 (1996)
Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50054252
(5-Bromo-N-cyclopropylmethyl-2-methyl-N-propyl-N'-(...)Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Br Show InChI InChI=1S/C18H20BrCl3N4/c1-3-6-26(9-11-4-5-11)18-15(19)17(23-10(2)24-18)25-16-13(21)7-12(20)8-14(16)22/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses |
J Med Chem 39: 4358-60 (1996)
Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50132973
(CHEMBL114596 | Cyclopropylmethyl-[2-methyl-8-(2,4,...)Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(cccc12)-c1c(C)cc(C)cc1C |(9.34,3.42,;9.34,1.88,;8.01,1.11,;8.01,-.43,;9.36,-1.2,;9.36,-2.74,;8.03,-3.51,;10.69,-3.51,;6.68,-1.22,;6.68,-2.75,;5.34,-3.53,;5.34,-5.07,;4.01,-2.76,;4.01,-1.22,;2.68,-.45,;2.68,1.1,;4.01,1.87,;5.35,1.1,;5.35,-.45,;1.35,-1.22,;.01,-.44,;.02,1.1,;-1.32,-1.21,;-1.32,-2.75,;-2.65,-3.52,;.02,-3.52,;1.35,-2.75,;2.69,-3.52,)| Show InChI InChI=1S/C26H32N2/c1-6-12-28(16-21-10-11-21)24-15-20(5)27-26-22(24)8-7-9-23(26)25-18(3)13-17(2)14-19(25)4/h7-9,13-15,21H,6,10-12,16H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand |
Bioorg Med Chem Lett 13: 3375-9 (2003)
BindingDB Entry DOI: 10.7270/Q2WM1CS4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152164
(CHEMBL366155 | [3-(6-Dimethylamino-2-methyl-pyridi...)Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(nc1C)N(C)C |(3.88,5.71,;4.35,4.24,;3.34,3.1,;3.81,1.63,;5.33,1.32,;6.35,2.47,;7.85,2.16,;2.78,.48,;3.27,-.98,;2.25,-2.13,;2.73,-3.59,;.75,-1.8,;.26,-.36,;-1.14,.27,;-1,1.81,;-2.14,2.82,;.52,2.12,;1.29,.79,;-2.47,-.52,;-3.8,.26,;-5.13,-.52,;-5.13,-2.06,;-3.8,-2.83,;-2.47,-2.06,;-1.14,-2.83,;-6.48,-2.83,;-6.48,-4.37,;-7.81,-2.06,)| Show InChI InChI=1S/C22H32N6/c1-8-12-27(13-9-2)20-14-15(3)23-22-21(17(5)25-28(20)22)18-10-11-19(26(6)7)24-16(18)4/h10-11,14H,8-9,12-13H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50054250
(CHEMBL306482 | N-Cyclopropylmethyl-2,5-dimethyl-N-...)Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C Show InChI InChI=1S/C19H23Cl3N4/c1-4-7-26(10-13-5-6-13)19-11(2)18(23-12(3)24-19)25-17-15(21)8-14(20)9-16(17)22/h8-9,13H,4-7,10H2,1-3H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses |
J Med Chem 39: 4358-60 (1996)
Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152183
(CHEMBL186033 | [3-(6-Dimethylamino-4-methyl-pyridi...)Show SMILES CCN(Cc1ccc(C)cc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.7,1.45,;4.67,.3,;3.17,.61,;2.68,2.07,;3.69,3.22,;3.2,4.68,;4.21,5.83,;5.75,5.52,;6.77,6.67,;6.23,4.05,;5.21,2.91,;2.15,-.54,;2.61,-1.99,;1.59,-3.15,;2.08,-4.6,;.1,-2.83,;-.39,-1.38,;-1.8,-.75,;-1.65,.79,;-2.8,1.8,;-.14,1.11,;.63,-.23,;-3.13,-1.52,;-3.13,-3.08,;-4.45,-3.85,;-5.79,-3.08,;-5.79,-1.54,;-4.45,-.75,;-4.46,.79,;-7.13,-3.85,;-8.46,-3.08,;-7.13,-5.39,)| Show InChI InChI=1S/C26H32N6/c1-8-31(16-21-11-9-17(2)10-12-21)24-14-19(4)28-26-25(20(5)29-32(24)26)22-15-27-23(30(6)7)13-18(22)3/h9-15H,8,16H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50132961
(Butyl-ethyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-q...)Show SMILES CCCCN(CC)c1cc(C)nc2c(cccc12)-c1c(C)cc(C)cc1C |(10.69,-5.05,;10.69,-3.51,;9.36,-2.74,;9.36,-1.2,;8.01,-.43,;8.01,1.11,;9.34,1.88,;6.68,-1.22,;6.68,-2.75,;5.34,-3.53,;5.34,-5.07,;4.01,-2.76,;4.01,-1.22,;2.68,-.45,;2.68,1.1,;4.01,1.87,;5.35,1.1,;5.35,-.45,;1.35,-1.22,;.01,-.44,;.02,1.1,;-1.32,-1.21,;-1.32,-2.75,;-2.65,-3.52,;.02,-3.52,;1.35,-2.75,;2.69,-3.52,)| Show InChI InChI=1S/C25H32N2/c1-7-9-13-27(8-2)23-16-20(6)26-25-21(23)11-10-12-22(25)24-18(4)14-17(3)15-19(24)5/h10-12,14-16H,7-9,13H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand |
Bioorg Med Chem Lett 13: 3375-9 (2003)
BindingDB Entry DOI: 10.7270/Q2WM1CS4 |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Homo sapiens (Human)) | BDBM35723
(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)Show SMILES Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1 Show InChI InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00567
BindingDB Entry DOI: 10.7270/Q2RR2392 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152179
(CHEMBL185705 | [3-(6-Dimethylamino-4-methyl-pyridi...)Show SMILES CCN(Cc1cccc(C)c1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.79,1.42,;4.77,.27,;3.27,.6,;2.79,2.06,;3.81,3.22,;5.3,2.89,;6.34,4.04,;5.85,5.5,;4.33,5.81,;3.84,7.28,;3.32,4.67,;2.24,-.56,;2.72,-2.02,;1.68,-3.18,;2.18,-4.63,;.19,-2.86,;-.3,-1.4,;-1.7,-.78,;-1.54,.76,;-2.7,1.78,;-.04,1.09,;.73,-.26,;-3.03,-1.55,;-3.03,-3.09,;-4.36,-3.88,;-5.69,-3.09,;-5.69,-1.56,;-4.36,-.78,;-4.38,.76,;-7.03,-3.88,;-7.03,-5.42,;-8.36,-3.09,)| Show InChI InChI=1S/C26H32N6/c1-8-31(16-21-11-9-10-17(2)12-21)24-14-19(4)28-26-25(20(5)29-32(24)26)22-15-27-23(30(6)7)13-18(22)3/h9-15H,8,16H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152178
(CHEMBL361509 | [3-(6-Dimethylamino-4-methyl-pyridi...)Show SMILES CCN(Cc1ccccc1C)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.86,1.5,;4.84,.34,;3.33,.67,;2.85,2.13,;3.86,3.29,;5.37,2.96,;6.4,4.13,;5.91,5.58,;4.39,5.89,;3.37,4.74,;1.87,5.06,;2.3,-.49,;2.78,-1.94,;1.75,-3.09,;2.24,-4.56,;.26,-2.78,;-.23,-1.32,;-1.64,-.71,;-1.49,.84,;-2.64,1.86,;.02,1.16,;.79,-.17,;-2.97,-1.47,;-2.97,-3.02,;-4.3,-3.81,;-5.63,-3.02,;-5.63,-1.5,;-4.3,-.71,;-4.31,.84,;-6.98,-3.81,;-8.31,-3.02,;-6.98,-5.33,)| Show InChI InChI=1S/C26H32N6/c1-8-31(16-21-12-10-9-11-17(21)2)24-14-19(4)28-26-25(20(5)29-32(24)26)22-15-27-23(30(6)7)13-18(22)3/h9-15H,8,16H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152176
((3,4-Dichloro-benzyl)-[3-(6-dimethylamino-4-methyl...)Show SMILES CCN(Cc1ccc(Cl)c(Cl)c1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.58,1.23,;4.56,.09,;3.06,.39,;2.57,1.84,;3.59,3,;5.09,2.7,;6.12,3.84,;5.63,5.31,;6.66,6.46,;4.11,5.6,;3.62,7.06,;3.1,4.47,;2.03,-.77,;2.5,-2.2,;1.48,-3.37,;1.97,-4.81,;-.02,-3.06,;-.51,-1.59,;-1.91,-.96,;-1.75,.56,;-2.91,1.58,;-.25,.9,;.52,-.45,;-3.24,-1.75,;-3.24,-3.3,;-4.57,-4.07,;-5.9,-3.3,;-5.9,-1.76,;-4.57,-.96,;-4.57,.56,;-7.23,-4.07,;-8.58,-3.3,;-7.23,-5.61,)| Show InChI InChI=1S/C25H28Cl2N6/c1-7-32(14-18-8-9-20(26)21(27)12-18)23-11-16(3)29-25-24(17(4)30-33(23)25)19-13-28-22(31(5)6)10-15(19)2/h8-13H,7,14H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50054248
(2,5-Dimethyl-N,N-dipropyl-N'-(2,4,6-trichloro-phen...)Show InChI InChI=1S/C18H23Cl3N4/c1-5-7-25(8-6-2)18-11(3)17(22-12(4)23-18)24-16-14(20)9-13(19)10-15(16)21/h9-10H,5-8H2,1-4H3,(H,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses |
J Med Chem 39: 4358-60 (1996)
Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50132966
(CHEMBL114422 | Cyclopropylmethyl-[8-(2,4-dichloro-...)Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)ccc12)-c1ccc(Cl)cc1Cl |(10.69,1.11,;9.34,1.88,;8.01,1.11,;8.01,-.43,;9.36,-1.2,;9.36,-2.74,;8.03,-3.51,;10.69,-3.51,;6.68,-1.22,;6.68,-2.75,;5.34,-3.53,;5.34,-5.07,;4.01,-2.76,;4.01,-1.22,;2.68,-.45,;2.68,1.1,;1.35,1.86,;4.01,1.87,;5.35,1.1,;5.35,-.45,;1.35,-1.22,;1.35,-2.75,;.02,-3.52,;-1.32,-2.75,;-2.65,-3.52,;-1.32,-1.21,;.01,-.44,;.02,1.1,)| Show InChI InChI=1S/C24H26Cl2N2/c1-4-11-28(14-17-6-7-17)22-12-16(3)27-24-20(22)9-5-15(2)23(24)19-10-8-18(25)13-21(19)26/h5,8-10,12-13,17H,4,6-7,11,14H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand |
Bioorg Med Chem Lett 13: 3375-9 (2003)
BindingDB Entry DOI: 10.7270/Q2WM1CS4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152173
(Butyl-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-2...)Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.11,6.53,;4.07,5.37,;4.56,3.91,;3.55,2.75,;4.02,1.3,;5.51,.97,;6.56,2.14,;2.99,.14,;3.46,-1.31,;2.45,-2.46,;2.94,-3.93,;.96,-2.15,;.45,-.68,;-.93,-.05,;-.79,1.46,;-1.95,2.49,;.71,1.79,;1.49,.46,;-2.28,-.85,;-2.28,-2.39,;-3.59,-3.16,;-4.94,-2.39,;-4.94,-.85,;-3.59,-.08,;-3.61,1.46,;-6.27,-3.16,;-6.27,-4.7,;-7.6,-2.39,)| Show InChI InChI=1S/C22H32N6/c1-8-10-11-27(9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152169
(CHEMBL189821 | Cyclopropylmethyl-[3-(6-dimethylami...)Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(3.74,5.38,;4.2,3.92,;3.2,2.77,;3.69,1.31,;5.18,.99,;6.21,2.14,;6.51,3.65,;7.67,2.61,;2.66,.16,;3.13,-1.31,;2.11,-2.46,;2.6,-3.92,;.61,-2.13,;.12,-.68,;-1.27,-.05,;-1.12,1.46,;-2.28,2.49,;.38,1.8,;1.15,.47,;-2.6,-.84,;-2.6,-2.39,;-3.93,-3.15,;-5.26,-2.39,;-5.26,-.84,;-3.93,-.05,;-3.94,1.46,;-6.6,-3.15,;-7.93,-2.39,;-6.6,-4.69,)| Show InChI InChI=1S/C23H32N6/c1-7-10-28(14-18-8-9-18)21-12-16(3)25-23-22(17(4)26-29(21)23)19-13-24-20(27(5)6)11-15(19)2/h11-13,18H,7-10,14H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152170
(Benzyl-butyl-[3-(6-dimethylamino-4-methyl-pyridin-...)Show SMILES CCCCN(Cc1ccccc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(6.96,-2.52,;6.47,-1.06,;4.96,-.75,;4.48,.72,;2.97,1.03,;2.48,2.49,;3.51,3.66,;5.02,3.33,;6.03,4.47,;5.55,5.92,;4.04,6.25,;3.02,5.09,;1.95,-.12,;2.43,-1.59,;1.4,-2.73,;1.88,-4.2,;-.11,-2.41,;-.58,-.96,;-1.98,-.33,;-1.84,1.19,;-2.99,2.22,;-.33,1.52,;.44,.19,;-3.33,-1.12,;-3.33,-2.66,;-4.66,-3.43,;-5.99,-2.66,;-5.99,-1.12,;-4.66,-.35,;-4.66,1.19,;-7.32,-3.43,;-8.65,-2.66,;-7.32,-4.97,)| Show InChI InChI=1S/C27H34N6/c1-7-8-14-32(18-22-12-10-9-11-13-22)25-16-20(3)29-27-26(21(4)30-33(25)27)23-17-28-24(31(5)6)15-19(23)2/h9-13,15-17H,7-8,14,18H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50132969
(CHEMBL431076 | [2-Methyl-8-(2,4,6-trimethyl-phenyl...)Show SMILES CCCN(CCC)c1cc(C)nc2c(cccc12)-c1c(C)cc(C)cc1C |(10.69,-3.51,;9.36,-2.74,;9.36,-1.2,;8.01,-.43,;8.01,1.11,;9.34,1.88,;9.34,3.42,;6.68,-1.22,;6.68,-2.75,;5.34,-3.53,;5.34,-5.07,;4.01,-2.76,;4.01,-1.22,;2.68,-.45,;2.68,1.1,;4.01,1.87,;5.35,1.1,;5.35,-.45,;1.35,-1.22,;.01,-.44,;.02,1.1,;-1.32,-1.21,;-1.32,-2.75,;-2.65,-3.52,;.02,-3.52,;1.35,-2.75,;2.69,-3.52,)| Show InChI InChI=1S/C25H32N2/c1-7-12-27(13-8-2)23-16-20(6)26-25-21(23)10-9-11-22(25)24-18(4)14-17(3)15-19(24)5/h9-11,14-16H,7-8,12-13H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Corticotropin releasing factor receptor 1-stimulated cAMP production |
Bioorg Med Chem Lett 13: 3375-9 (2003)
BindingDB Entry DOI: 10.7270/Q2WM1CS4 |
More data for this
Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50562179
(CHEMBL4739972)Show SMILES COc1cc2CCN(CCCCC(=O)c3c(C)c(OC)c(OC)c(OC)c3OC)Cc2cc1OC | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting method |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112906
BindingDB Entry DOI: 10.7270/Q23T9MXS |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50132971
(Butyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-quinoli...)Show SMILES CCCCN(CCC)c1cc(C)nc2c(cccc12)-c1c(C)cc(C)cc1C |(12.02,-2.74,;10.69,-3.51,;9.36,-2.74,;9.36,-1.2,;8.01,-.43,;8.01,1.11,;9.34,1.88,;9.34,3.42,;6.68,-1.22,;6.68,-2.75,;5.34,-3.53,;5.34,-5.07,;4.01,-2.76,;4.01,-1.22,;2.68,-.45,;2.68,1.1,;4.01,1.87,;5.35,1.1,;5.35,-.45,;1.35,-1.22,;.01,-.44,;.02,1.1,;-1.32,-1.21,;-1.32,-2.75,;-2.65,-3.52,;.02,-3.52,;1.35,-2.75,;2.69,-3.52,)| Show InChI InChI=1S/C26H34N2/c1-7-9-14-28(13-8-2)24-17-21(6)27-26-22(24)11-10-12-23(26)25-19(4)15-18(3)16-20(25)5/h10-12,15-17H,7-9,13-14H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand |
Bioorg Med Chem Lett 13: 3375-9 (2003)
BindingDB Entry DOI: 10.7270/Q2WM1CS4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50132964
(Benzyl-[2-methyl-8-(2,4,6-trimethyl-phenyl)-quinol...)Show SMILES CCCN(Cc1ccccc1)c1cc(C)nc2c(cccc12)-c1c(C)cc(C)cc1C |(9.34,3.42,;9.34,1.88,;8.01,1.11,;8.01,-.43,;9.36,-1.2,;9.36,-2.74,;10.69,-3.5,;10.69,-5.04,;9.36,-5.82,;8.03,-5.05,;8.01,-3.51,;6.68,-1.22,;6.68,-2.75,;5.34,-3.53,;5.34,-5.07,;4.01,-2.76,;4.01,-1.22,;2.68,-.45,;2.68,1.1,;4.01,1.87,;5.35,1.1,;5.35,-.45,;1.35,-1.22,;.01,-.44,;.02,1.1,;-1.32,-1.21,;-1.32,-2.75,;-2.65,-3.52,;.02,-3.52,;1.35,-2.75,;2.69,-3.52,)| Show InChI InChI=1S/C29H32N2/c1-6-15-31(19-24-11-8-7-9-12-24)27-18-23(5)30-29-25(27)13-10-14-26(29)28-21(3)16-20(2)17-22(28)4/h7-14,16-18H,6,15,19H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand |
Bioorg Med Chem Lett 13: 3375-9 (2003)
BindingDB Entry DOI: 10.7270/Q2WM1CS4 |
More data for this
Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig)) | BDBM21398
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by microbeta scintillation counting method |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112906
BindingDB Entry DOI: 10.7270/Q23T9MXS |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50148889
(CHEMBL121896 | [3-(2,4-Dimethoxy-phenyl)-2,5-dimet...)Show SMILES CCCN(CCOC)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC |(12.65,-5.99,;12.6,-7.53,;13.92,-8.34,;13.89,-9.88,;15.19,-10.68,;15.15,-12.22,;16.47,-13.03,;16.45,-14.57,;12.53,-10.61,;12.48,-12.15,;11.11,-12.9,;11.06,-14.42,;9.8,-12.09,;9.85,-10.53,;8.75,-9.45,;9.41,-8.08,;8.68,-6.72,;10.95,-8.29,;11.22,-9.8,;7.23,-9.73,;6.72,-11.18,;5.21,-11.45,;4.21,-10.28,;2.69,-10.55,;2.18,-11.99,;4.72,-8.83,;6.24,-8.55,;6.77,-7.1,;5.79,-5.93,)| Show InChI InChI=1S/C22H30N4O3/c1-7-10-25(11-12-27-4)20-13-15(2)23-22-21(16(3)24-26(20)22)18-9-8-17(28-5)14-19(18)29-6/h8-9,13-14H,7,10-12H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152160
(CHEMBL186592 | [3-(6-Dimethylamino-4-methyl-pyridi...)Show SMILES CCN(Cc1ccccc1F)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.85,1.49,;4.82,.34,;3.32,.67,;2.84,2.12,;3.85,3.28,;5.36,2.95,;6.38,4.12,;5.9,5.56,;4.38,5.87,;3.36,4.73,;1.86,5.05,;2.29,-.49,;2.77,-1.93,;1.75,-3.08,;2.24,-4.54,;.26,-2.77,;-.23,-1.31,;-1.63,-.71,;-1.48,.84,;-2.63,1.86,;.02,1.16,;.79,-.17,;-2.96,-1.47,;-2.96,-3.01,;-4.29,-3.8,;-5.62,-3.01,;-5.62,-1.49,;-4.29,-.71,;-4.3,.84,;-6.96,-3.8,;-6.96,-5.32,;-8.29,-3.01,)| Show InChI InChI=1S/C25H29FN6/c1-7-31(15-19-10-8-9-11-21(19)26)23-13-17(3)28-25-24(18(4)29-32(23)25)20-14-27-22(30(5)6)12-16(20)2/h8-14H,7,15H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50116105
(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(-1.91,-13.39,;-3.24,-14.16,;-4.58,-13.4,;-5.91,-14.18,;-7.24,-13.41,;-8.57,-14.19,;-9.91,-13.42,;-5.9,-15.72,;-7.22,-16.49,;-7.23,-18.03,;-8.56,-18.8,;-5.9,-18.8,;-4.55,-18.03,;-3.07,-18.5,;-2.16,-17.24,;-.62,-17.23,;-3.09,-15.99,;-4.56,-16.48,;-2.58,-19.96,;-3.61,-21.11,;-3.13,-22.57,;-1.62,-22.88,;-.59,-21.72,;-1.08,-20.27,;-.06,-19.11,;-1.13,-24.34,;.38,-24.65,;-2.15,-25.5,)| Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50132953
(Benzyl-[8-(2,4-dichloro-phenyl)-2-methyl-quinolin-...)Show SMILES CCCN(Cc1ccccc1)c1cc(C)nc2c(cccc12)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C26H24Cl2N2/c1-3-14-30(17-19-8-5-4-6-9-19)25-15-18(2)29-26-22(10-7-11-23(25)26)21-13-12-20(27)16-24(21)28/h4-13,15-16H,3,14,17H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand |
Bioorg Med Chem Lett 13: 3375-9 (2003)
BindingDB Entry DOI: 10.7270/Q2WM1CS4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50054253
(CHEMBL77716 | N-Cyclopropylmethyl-5-ethyl-2-methyl...)Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1CC Show InChI InChI=1S/C20H25Cl3N4/c1-4-8-27(11-13-6-7-13)20-15(5-2)19(24-12(3)25-20)26-18-16(22)9-14(21)10-17(18)23/h9-10,13H,4-8,11H2,1-3H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses |
J Med Chem 39: 4358-60 (1996)
Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6 |
More data for this
Ligand-Target Pair | |
Androgen receptor
(Homo sapiens (Human)) | BDBM50594917
(CHEMBL511130)Show SMILES CC(=O)Nc1ccc(OC[C@@](C)(O)C(=O)Nc2ccc(c(c2)C(F)(F)F)[N+]([O-])=O)cc1 |r| | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114119
BindingDB Entry DOI: 10.7270/Q2P55SHP |
More data for this
Ligand-Target Pair | |
Androgen receptor
(Homo sapiens (Human)) | BDBM50594918
(CHEMBL4754501)Show SMILES C[C@@](O)(COc1ccc(cc1)C#N)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114119
BindingDB Entry DOI: 10.7270/Q2P55SHP |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152185
(CHEMBL360851 | Dibutyl-[3-(6-dimethylamino-4-methy...)Show SMILES CCCCN(CCCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(8.52,2.82,;7.49,1.66,;5.98,1.98,;4.95,.83,;3.45,1.14,;2.97,2.59,;3.97,3.75,;3.51,5.2,;4.53,6.39,;2.43,-.02,;2.9,-1.47,;1.87,-2.62,;2.36,-4.08,;.38,-2.31,;-.11,-.85,;-1.51,-.23,;-1.35,1.31,;-2.51,2.33,;.15,1.63,;.92,.3,;-2.84,-1,;-2.84,-2.55,;-4.17,-3.32,;-5.5,-2.55,;-5.5,-1.01,;-4.17,-.23,;-4.18,1.31,;-6.84,-3.32,;-6.84,-4.86,;-8.17,-2.55,)| Show InChI InChI=1S/C24H36N6/c1-8-10-12-29(13-11-9-2)22-15-18(4)26-24-23(19(5)27-30(22)24)20-16-25-21(28(6)7)14-17(20)3/h14-16H,8-13H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152162
(CHEMBL188844 | CHEMBL2165204 | [3-(6-Dimethylamino...)Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(nc1)N(C)C Show InChI InChI=1S/C21H30N6/c1-7-11-26(12-8-2)19-13-15(3)23-21-20(16(4)24-27(19)21)17-9-10-18(22-14-17)25(5)6/h9-10,13-14H,7-8,11-12H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Vasopressin V2 receptor
(Homo sapiens (Human)) | BDBM50600600
(CHEMBL5207885)Show SMILES O=C(Nc1ccc(cc1)C(=O)N1CCCN(CCCN2CCOCC2)c2ccccc12)c1ccccc1-c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00567
BindingDB Entry DOI: 10.7270/Q2RR2392 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50132967
(CHEMBL432607 | [8-(2,4-Dichloro-phenyl)-2,7-dimeth...)Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)ccc12)-c1ccc(Cl)cc1Cl |(10.69,1.11,;9.34,1.88,;8.01,1.11,;8.01,-.43,;9.36,-1.2,;9.36,-2.74,;10.69,-3.51,;6.68,-1.22,;6.68,-2.75,;5.34,-3.53,;5.34,-5.07,;4.01,-2.76,;4.01,-1.22,;2.68,-.45,;2.68,1.1,;1.35,1.86,;4.01,1.87,;5.35,1.1,;5.35,-.45,;1.35,-1.22,;1.35,-2.75,;.02,-3.52,;-1.32,-2.75,;-2.65,-3.52,;-1.32,-1.21,;.01,-.44,;.02,1.1,)| Show InChI InChI=1S/C23H26Cl2N2/c1-5-11-27(12-6-2)21-13-16(4)26-23-19(21)9-7-15(3)22(23)18-10-8-17(24)14-20(18)25/h7-10,13-14H,5-6,11-12H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards cloned human Corticotropin releasing factor receptor 1 expressed in CHO cells using [125I]-o-CRF as the radioligand |
Bioorg Med Chem Lett 13: 3375-9 (2003)
BindingDB Entry DOI: 10.7270/Q2WM1CS4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50152186
(CHEMBL188609 | [3-(6-Dimethylamino-4-methyl-pyridi...)Show SMILES CCCC(CCC)Nc1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(7.26,4.55,;6.23,3.41,;4.72,3.73,;3.7,2.56,;2.18,2.87,;1.69,4.34,;.19,4.67,;4.19,1.09,;3.16,-.05,;3.63,-1.5,;2.6,-2.67,;3.09,-4.12,;1.11,-2.35,;.62,-.9,;-.79,-.27,;-.63,1.28,;-1.79,2.28,;.87,1.61,;1.64,.25,;-2.12,-1.04,;-2.12,-2.6,;-3.45,-3.37,;-4.79,-2.6,;-4.79,-1.06,;-3.45,-.27,;-3.45,1.28,;-6.13,-3.37,;-7.47,-2.6,;-6.13,-4.92,)| Show InChI InChI=1S/C23H34N6/c1-8-10-18(11-9-2)26-21-13-16(4)25-23-22(17(5)27-29(21)23)19-14-24-20(28(6)7)12-15(19)3/h12-14,18,26H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor |
J Med Chem 47: 4787-98 (2004)
Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR |
More data for this
Ligand-Target Pair | |
Oxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha
(Homo sapiens (Human)) | BDBM50204085
(CHEMBL3960606)Show SMILES CC(C)(O)c1cn(c(Cc2ccccc2Cl)n1)-c1ccc(cc1)-c1ccc(CO)c(c1)S(C)(=O)=O Show InChI InChI=1S/C27H27ClN2O4S/c1-27(2,32)25-16-30(26(29-25)15-20-6-4-5-7-23(20)28)22-12-10-18(11-13-22)19-8-9-21(17-31)24(14-19)35(3,33)34/h4-14,16,31-32H,15,17H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Displacement of [3H]-24,25-epoxycholesterol from human LXRbeta/RXRalpha expressed in baculovirus infected Sf9 cells by scintillation proximity analys... |
ACS Med Chem Lett 7: 1207-1212 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00234
BindingDB Entry DOI: 10.7270/Q2V98B13 |
More data for this
Ligand-Target Pair | |
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