Found 104 hits with Last Name = 'chin' and Initial = 'yw' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM24567
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1 | PDB
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| Article
PubMed
| 260 | -39.1 | 1.24E+3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50103521
(Actos | CHEBI:8228 | Duetact | Pioglitazone | US10...)Show InChI InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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PDB
UniChem
Similars
| DrugBank
PDB
| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246486
(3,3',5-Trihydroxy-2'-methoxybibenzyl (3))Show InChI InChI=1S/C15H16O4/c1-19-15-11(3-2-4-14(15)18)6-5-10-7-12(16)9-13(17)8-10/h2-4,7-9,16-18H,5-6H2,1H3 | PDB
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UniChem
| Article
PubMed
| 1.82E+3 | -34.1 | 8.77E+3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246500
((4E,6E)-1,7-bis(4-hydroxyphenyl)-4,6-heptadien-3-o...)Show InChI InChI=1S/C19H18O3/c20-17(10-7-16-8-13-19(22)14-9-16)4-2-1-3-15-5-11-18(21)12-6-15/h1-6,8-9,11-14,21-22H,7,10H2/b3-1+,4-2+ | PDB
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| 1.92E+3 | -33.9 | 9.12E+3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246501
((4E,6E)-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxy...)Show InChI InChI=1S/C20H20O4/c1-24-20-14-16(9-13-19(20)23)4-2-3-5-17(21)10-6-15-7-11-18(22)12-8-15/h2-5,7-9,11-14,22-23H,6,10H2,1H3/b4-2+,5-3+ | PDB
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UniChem
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PubMed
| 2.17E+3 | -33.6 | 1.11E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246493
(3,5-Dimethoxy-2,7-phenanthrenediol (11))Show InChI InChI=1S/C16H14O4/c1-19-14-8-12-9(6-13(14)18)3-4-10-5-11(17)7-15(20-2)16(10)12/h3-8,17-18H,1-2H3 | PDB
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| 2.67E+3 | -33.1 | 1.27E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246485
(Tristin (1))Show InChI InChI=1S/C15H16O4/c1-19-15-8-10(4-5-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h4-9,16-18H,2-3H2,1H3 | PDB
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PubMed
| 2.75E+3 | -33.0 | 1.35E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50421798
(CHEMBL5268127)Show InChI InChI=1S/C16H23N5/c1-9-5-10(7-12(13(9)17)16(2,3)4)6-11-8-20-15(19)21-14(11)18/h5,7-8H,6,17H2,1-4H3,(H4,18,19,20,21) | PDB
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| | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246499
((1E,4E,6E)-1,7-bis(4-hydroxyphenyl)-1,4,6-heptatri...)Show InChI InChI=1S/C19H16O3/c20-17(10-7-16-8-13-19(22)14-9-16)4-2-1-3-15-5-11-18(21)12-6-15/h1-14,21-22H/b3-1+,4-2+,10-7+ | PDB
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| 3.34E+3 | -32.5 | 1.64E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246496
(2,5-Dihydroxy-7-methoxy-9,10-dihydrophenanthrene (...)Show InChI InChI=1S/C15H14O3/c1-18-12-7-10-3-2-9-6-11(16)4-5-13(9)15(10)14(17)8-12/h4-8,16-17H,2-3H2,1H3 | PDB
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| 4.96E+3 | -31.5 | 2.51E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246488
(2',4-Dihydroxy-3,5-dihydroxy-4-methoxybibenzyl...)Show InChI InChI=1S/C15H16O3/c1-18-15-13(16)9-12(10-14(15)17)8-7-11-5-3-2-4-6-11/h2-6,9-10,16-17H,7-8H2,1H3 | PDB
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| 5.06E+3 | -31.4 | 2.54E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM50211956
(2-(3-hydroxy-5-methoxyphenethyl)phenol | Batatasin...)Show InChI InChI=1S/C15H16O3/c1-18-14-9-11(8-13(16)10-14)6-7-12-4-2-3-5-15(12)17/h2-5,8-10,16-17H,6-7H2,1H3 | PDB
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| 6.28E+3 | -30.9 | 3.01E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM64584
(2',3,5-Trihydroxybibenzyl (2))Show InChI InChI=1S/C14H14O3/c15-12-7-10(8-13(16)9-12)5-6-11-3-1-2-4-14(11)17/h1-4,7-9,15-17H,5-6H2 | PDB
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| 6.45E+3 | -30.8 | 2.92E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246487
(Batatasin III (4))Show InChI InChI=1S/C15H16O3/c1-18-15-9-12(8-14(17)10-15)6-5-11-3-2-4-13(16)7-11/h2-4,7-10,16-17H,5-6H2,1H3 | PDB
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| 6.79E+3 | -30.7 | 3.23E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM50131679
(CHEMBL3628211 | p-Hydroxyphenylethyl p-coumarate (...)Show InChI InChI=1S/C17H16O4/c18-15-6-1-13(2-7-15)5-10-17(20)21-12-11-14-3-8-16(19)9-4-14/h1-10,18-19H,11-12H2/b10-5+ | PDB
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PC cid
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UniChem
Similars
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PubMed
| 7.49E+3 | -30.4 | 3.48E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246495
(Hircinol (13))Show InChI InChI=1S/C15H14O3/c1-18-13-8-11(16)7-10-6-5-9-3-2-4-12(17)14(9)15(10)13/h2-4,7-8,16-17H,5-6H2,1H3 | PDB
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| 8.57E+3 | -30.1 | 4.06E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246489
(3,5-Dimethoxy-2'hydroxybibenzyl (7))Show InChI InChI=1S/C16H18O3/c1-18-14-9-12(10-15(11-14)19-2)7-8-13-5-3-4-6-16(13)17/h3-6,9-11,17H,7-8H2,1-2H3 | PDB
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PC sid
UniChem
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PubMed
| 9.28E+3 | -29.9 | 4.41E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Sus scrofa (Pig)) | BDBM246492
(Batatasin V (10))Show InChI InChI=1S/C17H20O4/c1-19-15-10-12(11-16(20-2)17(15)21-3)8-9-13-6-4-5-7-14(13)18/h4-7,10-11,18H,8-9H2,1-3H3 | PDB
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| 9.66E+3 | -29.8 | 4.57E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Seoul National University
| Assay Description
Various concentrations of test compound (5, 10, 25, 50 and 100 mM) were dissolved in DMSO (final culture concentration 0.1%) and 4-MU oleate and lipa... |
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Article DOI: 10.3109/14756366.2012.742517
BindingDB Entry DOI: 10.7270/Q2DJ5DKB |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50490819
(CHEMBL2346913)Show SMILES [#6]-[#8]-c1cc2ccc(=O)oc2cc1-[#8]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6] Show InChI InChI=1S/C20H24O4/c1-14(2)6-5-7-15(3)10-11-23-19-13-17-16(12-18(19)22-4)8-9-20(21)24-17/h6,8-10,12-13H,5,7,11H2,1-4H3/b15-10+ | PDB
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| | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50423773
(A-1544750 | CEP-701 | KT-5555 | LESTAURTINIB | SP9...)Show SMILES C[C@]12O[C@@H](C[C@@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18?,25-,26+/m0/s1 | PDB
NCI pathway
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UniChem
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| Article
PubMed
| n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM17638
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1 Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23) | PDB
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| PDB
Article
PubMed
| n/a | n/a | 558 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by colorimetric assay |
Bioorg Med Chem 17: 2689-94 (2009)
Article DOI: 10.1016/j.bmc.2009.02.057
BindingDB Entry DOI: 10.7270/Q2RF5XTR |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM7460
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H | PDB
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PC cid
PC sid
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UniChem
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| Article
PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM17638
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1 Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23) | PDB
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| n/a | n/a | 754 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX1 by colorimetric assay |
Bioorg Med Chem 17: 2689-94 (2009)
Article DOI: 10.1016/j.bmc.2009.02.057
BindingDB Entry DOI: 10.7270/Q2RF5XTR |
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM234389
(Mangiferin)Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc2oc3cc(O)c(O)cc3c(=O)c2c1O |r| Show InChI InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19?/m1/s1 | PDB
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| Article
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| n/a | n/a | 810 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Gyeongsang National University
| Assay Description
Inhibition of kinase activity against a variety of recombinant kinases [FLT3, FLT3 D835Y, anaplastic lymphoma kinase (ALK), insulin receptor, and epi... |
J Enzyme Inhib Med Chem 26: 445-8 (2011)
Article DOI: 10.3109/14756366.2010.515215
BindingDB Entry DOI: 10.7270/Q2S46QTV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM7459
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)Show InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H | PDB
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PubMed
| n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM7458
(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H | PDB
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PubMed
| n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50430091
(OROXYLIN A)Show InChI InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3 | PDB
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| n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM15236
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H | PDB
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| n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM7462
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H | PDB
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| n/a | n/a | 2.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM246486
(3,3',5-Trihydroxy-2'-methoxybibenzyl (3))Show InChI InChI=1S/C15H16O4/c1-19-15-11(3-2-4-14(15)18)6-5-10-7-12(16)9-13(17)8-10/h2-4,7-9,16-18H,5-6H2,1H3 | PDB
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| n/a | n/a | 6.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by colorimetric assay |
Bioorg Med Chem 17: 2689-94 (2009)
Article DOI: 10.1016/j.bmc.2009.02.057
BindingDB Entry DOI: 10.7270/Q2RF5XTR |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM246493
(3,5-Dimethoxy-2,7-phenanthrenediol (11))Show InChI InChI=1S/C16H14O4/c1-19-14-8-12-9(6-13(14)18)3-4-10-5-11(17)7-15(20-2)16(10)12/h3-8,17-18H,1-2H3 | PDB
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| n/a | n/a | 9.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by colorimetric assay |
Bioorg Med Chem 17: 2689-94 (2009)
Article DOI: 10.1016/j.bmc.2009.02.057
BindingDB Entry DOI: 10.7270/Q2RF5XTR |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM23419
((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro...)Show SMILES Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 |r| Show InChI InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50325671
((2S)-2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-2,3-DIH...)Show SMILES Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccc(O)c(O)c1 |r| Show InChI InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2/t13-/m0/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50240348
((+)-dihydrokaempferol | (2R,3R)-3,5,7-trihydroxy-2...)Show SMILES O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1ccc(O)cc1 |r| Show InChI InChI=1S/C15H12O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,14-18,20H/t14-,15+/m0/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50049400
((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)Show InChI InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,13,15-20H | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50009001
(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)Show InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM23411
(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50241354
(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-(3,4,5-tr...)Show SMILES OC[C@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-25,27-30H,6H2/t13-,15-,17+,18-,21+/m1/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50241367
(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...)Show SMILES OC[C@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-25,27-30H,6H2/t13-,15+,17+,18-,21+/m1/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50430090
(CHEMBL2337336)Show SMILES OC[C@H]1OC(Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-25,27-30H,6H2/t13-,15-,17+,18+,21?/m1/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM234389
(Mangiferin)Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc2oc3cc(O)c(O)cc3c(=O)c2c1O |r| Show InChI InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19?/m1/s1 | PDB
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Gyeongsang National University
| Assay Description
Inhibition of kinase activity against a variety of recombinant kinases [FLT3, FLT3 D835Y, anaplastic lymphoma kinase (ALK), insulin receptor, and epi... |
J Enzyme Inhib Med Chem 26: 445-8 (2011)
Article DOI: 10.3109/14756366.2010.515215
BindingDB Entry DOI: 10.7270/Q2S46QTV |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM234389
(Mangiferin)Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc2oc3cc(O)c(O)cc3c(=O)c2c1O |r| Show InChI InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19?/m1/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Gyeongsang National University
| Assay Description
Inhibition of kinase activity against a variety of recombinant kinases [FLT3, FLT3 D835Y, anaplastic lymphoma kinase (ALK), insulin receptor, and epi... |
J Enzyme Inhib Med Chem 26: 445-8 (2011)
Article DOI: 10.3109/14756366.2010.515215
BindingDB Entry DOI: 10.7270/Q2S46QTV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM7461
(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)Show InChI InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H | PDB
NCI pathway
Reactome pathway
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| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50049391
(3,5,7-Trihydroxyflavone | 3,5,7-triOH-flavone | 3,...)Show InChI InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H | PDB
NCI pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay |
Bioorg Med Chem Lett 23: 1768-70 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.049
BindingDB Entry DOI: 10.7270/Q2H70H54 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM246499
((1E,4E,6E)-1,7-bis(4-hydroxyphenyl)-1,4,6-heptatri...)Show InChI InChI=1S/C19H16O3/c20-17(10-7-16-8-13-19(22)14-9-16)4-2-1-3-15-5-11-18(21)12-6-15/h1-14,21-22H/b3-1+,4-2+,10-7+ | PDB
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| n/a | n/a | 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by colorimetric assay |
Bioorg Med Chem 17: 2689-94 (2009)
Article DOI: 10.1016/j.bmc.2009.02.057
BindingDB Entry DOI: 10.7270/Q2RF5XTR |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM246493
(3,5-Dimethoxy-2,7-phenanthrenediol (11))Show InChI InChI=1S/C16H14O4/c1-19-14-8-12-9(6-13(14)18)3-4-10-5-11(17)7-15(20-2)16(10)12/h3-8,17-18H,1-2H3 | PDB
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UniChem
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| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX1 by colorimetric assay |
Bioorg Med Chem 17: 2689-94 (2009)
Article DOI: 10.1016/j.bmc.2009.02.057
BindingDB Entry DOI: 10.7270/Q2RF5XTR |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM246500
((4E,6E)-1,7-bis(4-hydroxyphenyl)-4,6-heptadien-3-o...)Show InChI InChI=1S/C19H18O3/c20-17(10-7-16-8-13-19(22)14-9-16)4-2-1-3-15-5-11-18(21)12-6-15/h1-6,8-9,11-14,21-22H,7,10H2/b3-1+,4-2+ | PDB
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| n/a | n/a | 1.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by colorimetric assay |
Bioorg Med Chem 17: 2689-94 (2009)
Article DOI: 10.1016/j.bmc.2009.02.057
BindingDB Entry DOI: 10.7270/Q2RF5XTR |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM246485
(Tristin (1))Show InChI InChI=1S/C15H16O4/c1-19-15-8-10(4-5-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h4-9,16-18H,2-3H2,1H3 | PDB
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| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX1 by colorimetric assay |
Bioorg Med Chem 17: 2689-94 (2009)
Article DOI: 10.1016/j.bmc.2009.02.057
BindingDB Entry DOI: 10.7270/Q2RF5XTR |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM246485
(Tristin (1))Show InChI InChI=1S/C15H16O4/c1-19-15-8-10(4-5-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h4-9,16-18H,2-3H2,1H3 | PDB
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UniChem
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| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by colorimetric assay |
Bioorg Med Chem 17: 2689-94 (2009)
Article DOI: 10.1016/j.bmc.2009.02.057
BindingDB Entry DOI: 10.7270/Q2RF5XTR |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM246499
((1E,4E,6E)-1,7-bis(4-hydroxyphenyl)-1,4,6-heptatri...)Show InChI InChI=1S/C19H16O3/c20-17(10-7-16-8-13-19(22)14-9-16)4-2-1-3-15-5-11-18(21)12-6-15/h1-14,21-22H/b3-1+,4-2+,10-7+ | PDB
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| n/a | n/a | 1.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX1 by colorimetric assay |
Bioorg Med Chem 17: 2689-94 (2009)
Article DOI: 10.1016/j.bmc.2009.02.057
BindingDB Entry DOI: 10.7270/Q2RF5XTR |
More data for this
Ligand-Target Pair | |
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