Compile Data Set for Download or QSAR

Found 1812 hits with Last Name = 'miao' and Initial = 'z'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50446130 (AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...) Show SMILES CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23 Show InChI InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50300121 ((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...) Show SMILES CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2)[C@@]11C(=O)Nc2cc(Cl)c(F)cc12)C(=O)NCC[C@H](O)CO |r| Show InChI InChI=1S/C27H32Cl2FN3O4/c1-26(2,3)12-21-27(17-10-19(30)18(29)11-20(17)32-25(27)37)22(14-5-4-6-15(28)9-14)23(33-21)24(36)31-8-7-16(35)13-34/h4-6,9-11,16,21-23,33-35H,7-8,12-13H2,1-3H3,(H,31,36)(H,32,37)/t16-,21+,22-,23+,27-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to MDM2				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM97563 (US8470825, 4i) Show SMILES OC1CCN(Cc2ccc3oc4cccc5c4c(n[nH]c5=O)c3c2)CC1 Show InChI InChI=1S/C20H19N3O3/c24-13-6-8-23(9-7-13)11-12-4-5-16-15(10-12)19-18-14(20(25)22-21-19)2-1-3-17(18)26-16/h1-5,10,13,24H,6-9,11H2,(H,22,25)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449913 (CHEMBL4170056) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCC(CC1)C(=O)NO)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C34H38Cl2N4O4/c1-5-44-28-20-24(34(2,3)4)10-15-27(28)31-37-29(21-6-11-25(35)12-7-21)30(22-8-13-26(36)14-9-22)40(31)33(42)39-18-16-23(17-19-39)32(41)38-43/h6-15,20,23,29-30,43H,5,16-19H2,1-4H3,(H,38,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449907 (CHEMBL4163675) Show SMILES CCOc1cc(ccc1C1=N[C@H]([C@H](N1C(=O)N1CCN(CCCCCCC(=O)NO)CC1)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |r,t:10| Show InChI InChI=1S/C39H49Cl2N5O4/c1-5-50-33-26-29(39(2,3)4)15-20-32(33)37-42-35(27-11-16-30(40)17-12-27)36(28-13-18-31(41)19-14-28)46(37)38(48)45-24-22-44(23-25-45)21-9-7-6-8-10-34(47)43-49/h11-20,26,35-36,49H,5-10,21-25H2,1-4H3,(H,43,47)/t35-,36+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449901 (CHEMBL4160754) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCN(CC(=O)NO)CC1)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C34H39Cl2N5O4/c1-5-45-28-20-24(34(2,3)4)10-15-27(28)32-37-30(22-6-11-25(35)12-7-22)31(23-8-13-26(36)14-9-23)41(32)33(43)40-18-16-39(17-19-40)21-29(42)38-44/h6-15,20,30-31,44H,5,16-19,21H2,1-4H3,(H,38,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
5'-nucleotidase (Homo sapiens (Human))	BDBM18136 (ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C11H17N5O9P2/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	88	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116672 BindingDB Entry DOI: 10.7270/Q2833X2B
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50420273 (CHEMBL2089208) Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2ccc(F)cc2C1=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H17Cl2FN2O3S/c1-32-24(31)21(14-4-8-16(26)9-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-11-10-17(27)12-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	89	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018543 (CHEMBL3290677) Show SMILES CC(C)Oc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(N[C@H](C)c2ccccc2)C1=O)c1ccc(Br)cc1)C(F)(F)F |r,t:23| Show InChI InChI=1S/C36H32BrF3N2O3/c1-22(2)45-30-20-28(36(38,39)40)17-14-27(30)21-42-33(25-15-18-29(37)19-16-25)31(34(43)26-12-8-5-9-13-26)32(35(42)44)41-23(3)24-10-6-4-7-11-24/h4-20,22-23,33,41H,21H2,1-3H3/t23-,33?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50229787 ((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...) Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1 |t:6| Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50404376 (CHEMBL5273773) Show SMILES COc1cc2ccc(cc2cc1OC)S(=O)(=O)NC(CCCNC(N)=N)C(=O)N1CCC(CC1)C(O)=O Show InChI InChI=1S/C24H33N5O7S/c1-35-20-13-16-5-6-18(12-17(16)14-21(20)36-2)37(33,34)28-19(4-3-9-27-24(25)26)22(30)29-10-7-15(8-11-29)23(31)32/h5-6,12-15,19,28H,3-4,7-11H2,1-2H3,(H,31,32)(H4,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.				Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018554 (CHEMBL3290682) Show SMILES C[C@@H](NC1=C(C(N(Cc2cccnc2)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1)c1ccccc1 |r,t:3| Show InChI InChI=1S/C31H26BrN3O2/c1-21(23-10-4-2-5-11-23)34-28-27(30(36)25-12-6-3-7-13-25)29(24-14-16-26(32)17-15-24)35(31(28)37)20-22-9-8-18-33-19-22/h2-19,21,29,34H,20H2,1H3/t21-,29?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50420268 (CHEMBL2089203) Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(ccc2C1=O)C(F)(F)F)c1ccc(Cl)cc1 Show InChI InChI=1S/C25H17Cl2F3N2O3S/c1-35-24(34)21(14-4-9-17(27)10-5-14)32-20(13-2-7-16(26)8-3-13)22(36)31-19-12-15(25(28,29)30)6-11-18(19)23(32)33/h2-12,20-21H,1H3,(H,31,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	91	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase (Homo sapiens (Human))	BDBM50139421 (CHEMBL3764451) Show SMILES Cc1ccc(cc1)C(=O)Nc1sc(Nc2ccccc2)nc1C(N)=O Show InChI InChI=1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged human TNIK kinase domain (1 to 314 residues) expressed in baculovirus-infected Sf21 cells using FITC-epsilon-aminocaproic ac...				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127749 BindingDB Entry DOI: 10.7270/Q2639TBB
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449900 (CHEMBL4174805) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCN(CCCCCCC(=O)NO)CC1)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C39H49Cl2N5O4/c1-5-50-33-26-29(39(2,3)4)15-20-32(33)37-42-35(27-11-16-30(40)17-12-27)36(28-13-18-31(41)19-14-28)46(37)38(48)45-24-22-44(23-25-45)21-9-7-6-8-10-34(47)43-49/h11-20,26,35-36,49H,5-10,21-25H2,1-4H3,(H,43,47)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50229787 ((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...) Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1 |t:6| Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	121	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50229787 ((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...) Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1 |t:6| Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018555 (CHEMBL3290683) Show SMILES C[C@@H](NC1=C(C(N(CCCn2ccnc2)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1)c1ccccc1 |r,t:3| Show InChI InChI=1S/C31H29BrN4O2/c1-22(23-9-4-2-5-10-23)34-28-27(30(37)25-11-6-3-7-12-25)29(24-13-15-26(32)16-14-24)36(31(28)38)19-8-18-35-20-17-33-21-35/h2-7,9-17,20-22,29,34H,8,18-19H2,1H3/t22-,29?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50229787 ((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...) Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1 |t:6| Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.				Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449896 (CHEMBL4164148) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCN(CCCCCC(=O)NO)CC1)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C38H47Cl2N5O4/c1-5-49-32-25-28(38(2,3)4)14-19-31(32)36-41-34(26-10-15-29(39)16-11-26)35(27-12-17-30(40)18-13-27)45(36)37(47)44-23-21-43(22-24-44)20-8-6-7-9-33(46)42-48/h10-19,25,34-35,48H,5-9,20-24H2,1-4H3,(H,42,46)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449924 (CHEMBL4171353) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCN(CCCCC(=O)NO)CC1)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C37H45Cl2N5O4/c1-5-48-31-24-27(37(2,3)4)13-18-30(31)35-40-33(25-9-14-28(38)15-10-25)34(26-11-16-29(39)17-12-26)44(35)36(46)43-22-20-42(21-23-43)19-7-6-8-32(45)41-47/h9-18,24,33-34,47H,5-8,19-23H2,1-4H3,(H,41,45)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449923 (CHEMBL4163017) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCN(Cc2ccc(cc2)C(=O)NO)CC1)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C40H43Cl2N5O4/c1-5-51-34-24-30(40(2,3)4)14-19-33(34)37-43-35(27-10-15-31(41)16-11-27)36(28-12-17-32(42)18-13-28)47(37)39(49)46-22-20-45(21-23-46)25-26-6-8-29(9-7-26)38(48)44-50/h6-19,24,35-36,50H,5,20-23,25H2,1-4H3,(H,44,48)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018541 (CHEMBL2180122) Show SMILES CC(C)OC1=C(C(N(CCCn2ccnc2)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1 |t:4| Show InChI InChI=1S/C26H26BrN3O3/c1-18(2)33-25-22(24(31)20-7-4-3-5-8-20)23(19-9-11-21(27)12-10-19)30(26(25)32)15-6-14-29-16-13-28-17-29/h3-5,7-13,16-18,23H,6,14-15H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449903 (CHEMBL4170573) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)NCCCCCC(=O)NO)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C34H40Cl2N4O4/c1-5-44-28-21-24(34(2,3)4)14-19-27(28)32-38-30(22-10-15-25(35)16-11-22)31(23-12-17-26(36)18-13-23)40(32)33(42)37-20-8-6-7-9-29(41)39-43/h10-19,21,30-31,43H,5-9,20H2,1-4H3,(H,37,42)(H,39,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449895 (CHEMBL4173404) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCN(CCCCCCCC(=O)NO)CC1)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C40H51Cl2N5O4/c1-5-51-34-27-30(40(2,3)4)16-21-33(34)38-43-36(28-12-17-31(41)18-13-28)37(29-14-19-32(42)20-15-29)47(38)39(49)46-25-23-45(24-26-46)22-10-8-6-7-9-11-35(48)44-50/h12-21,27,36-37,50H,5-11,22-26H2,1-4H3,(H,44,48)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50420266 (CHEMBL2089201) Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2ccc(Cl)cc2C1=O)c1ccc(F)cc1 Show InChI InChI=1S/C24H17Cl2FN2O3S/c1-32-24(31)21(14-4-9-17(27)10-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-11-8-16(26)12-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	315	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018540 (CHEMBL3290675) Show SMILES CC(C)OC1=C(C(N(Cc2cccnc2)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1 |t:4| Show InChI InChI=1S/C26H23BrN2O3/c1-17(2)32-25-22(24(30)20-8-4-3-5-9-20)23(19-10-12-21(27)13-11-19)29(26(25)31)16-18-7-6-14-28-15-18/h3-15,17,23H,16H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449925 (CHEMBL4159921) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)NCCCCCCC(=O)NO)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C35H42Cl2N4O4/c1-5-45-29-22-25(35(2,3)4)15-20-28(29)33-39-31(23-11-16-26(36)17-12-23)32(24-13-18-27(37)19-14-24)41(33)34(43)38-21-9-7-6-8-10-30(42)40-44/h11-20,22,31-32,44H,5-10,21H2,1-4H3,(H,38,43)(H,40,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449898 (CHEMBL4166471) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)NCCCCC(=O)NO)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C33H38Cl2N4O4/c1-5-43-27-20-23(33(2,3)4)13-18-26(27)31-37-29(21-9-14-24(34)15-10-21)30(22-11-16-25(35)17-12-22)39(31)32(41)36-19-7-6-8-28(40)38-42/h9-18,20,29-30,42H,5-8,19H2,1-4H3,(H,36,41)(H,38,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449897 (CHEMBL4163120) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)NCCCCCCCC(=O)NO)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C36H44Cl2N4O4/c1-5-46-30-23-26(36(2,3)4)16-21-29(30)34-40-32(24-12-17-27(37)18-13-24)33(25-14-19-28(38)20-15-25)42(34)35(44)39-22-10-8-6-7-9-11-31(43)41-45/h12-21,23,32-33,45H,5-11,22H2,1-4H3,(H,39,44)(H,41,43)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449894 (CHEMBL4163059) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCC(CC1)Nc1ncc(cn1)C(=O)NO)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C38H41Cl2N7O4/c1-5-51-31-20-26(38(2,3)4)10-15-30(31)34-44-32(23-6-11-27(39)12-7-23)33(24-8-13-28(40)14-9-24)47(34)37(49)46-18-16-29(17-19-46)43-36-41-21-25(22-42-36)35(48)45-50/h6-15,20-22,29,32-33,50H,5,16-19H2,1-4H3,(H,45,48)(H,41,42,43)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	460	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50420276 (CHEMBL2089211) Show SMILES COC(=O)C(N1C(c2ccc(cc2)C(F)(F)F)C(=S)Nc2cc(Cl)ccc2C1=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C25H17Cl2F3N2O3S/c1-35-24(34)21(14-4-8-16(26)9-5-14)32-20(13-2-6-15(7-3-13)25(28,29)30)22(36)31-19-12-17(27)10-11-18(19)23(32)33/h2-12,20-21H,1H3,(H,31,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	518	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449902 (CHEMBL4173507) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)NCc1ccc(cc1)C(=O)NO)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C36H36Cl2N4O4/c1-5-46-30-20-26(36(2,3)4)14-19-29(30)33-40-31(23-10-15-27(37)16-11-23)32(24-12-17-28(38)18-13-24)42(33)35(44)39-21-22-6-8-25(9-7-22)34(43)41-45/h6-20,31-32,45H,5,21H2,1-4H3,(H,39,44)(H,41,43)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	580	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449905 (CHEMBL4171605) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)NCCCCCCC(=O)Nc1ccccc1N)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C41H47Cl2N5O3/c1-5-51-35-26-29(41(2,3)4)19-24-32(35)39-47-37(27-15-20-30(42)21-16-27)38(28-17-22-31(43)23-18-28)48(39)40(50)45-25-11-7-6-8-14-36(49)46-34-13-10-9-12-33(34)44/h9-10,12-13,15-24,26,37-38H,5-8,11,14,25,44H2,1-4H3,(H,45,50)(H,46,49)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50420263 (CHEMBL2089152) Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(F)ccc2C1=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H17Cl2FN2O3S/c1-32-24(31)21(14-4-8-16(26)9-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-12-17(27)10-11-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	707	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018537 (CHEMBL3290672) Show SMILES COc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(OC(C)C)C1=O)c1ccc(Br)cc1)C(F)(F)F |t:21| Show InChI InChI=1S/C29H25BrF3NO4/c1-17(2)38-27-24(26(35)19-7-5-4-6-8-19)25(18-10-13-22(30)14-11-18)34(28(27)36)16-20-9-12-21(29(31,32)33)15-23(20)37-3/h4-15,17,25H,16H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	710	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018536 (CHEMBL3290671) Show SMILES CCOc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(OC(C)C)C1=O)c1ccc(Br)cc1)C(F)(F)F |t:22| Show InChI InChI=1S/C30H27BrF3NO4/c1-4-38-24-16-22(30(32,33)34)13-10-21(24)17-35-26(19-11-14-23(31)15-12-19)25(28(29(35)37)39-18(2)3)27(36)20-8-6-5-7-9-20/h5-16,18,26H,4,17H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	720	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50420262 (CHEMBL2089151) Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2ccc(Cl)cc2C1=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H17Cl3N2O3S/c1-32-24(31)21(14-4-8-16(26)9-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-11-10-17(27)12-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	721	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449899 (CHEMBL4175049) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)NCCCCC(=O)Nc1ccccc1N)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C39H43Cl2N5O3/c1-5-49-33-24-27(39(2,3)4)17-22-30(33)37-45-35(25-13-18-28(40)19-14-25)36(26-15-20-29(41)21-16-26)46(37)38(48)43-23-9-8-12-34(47)44-32-11-7-6-10-31(32)42/h6-7,10-11,13-22,24,35-36H,5,8-9,12,23,42H2,1-4H3,(H,43,48)(H,44,47)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	960	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449904 (CHEMBL4174687) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)NCCCCCCCC(=O)Nc1ccccc1N)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C42H49Cl2N5O3/c1-5-52-36-27-30(42(2,3)4)20-25-33(36)40-48-38(28-16-21-31(43)22-17-28)39(29-18-23-32(44)24-19-29)49(40)41(51)46-26-12-8-6-7-9-15-37(50)47-35-14-11-10-13-34(35)45/h10-11,13-14,16-25,27,38-39H,5-9,12,15,26,45H2,1-4H3,(H,46,51)(H,47,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50420274 (CHEMBL2089209) Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(F)ccc2C1=O)c1ccc(F)cc1 Show InChI InChI=1S/C24H17ClF2N2O3S/c1-32-24(31)21(14-4-8-16(26)9-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-12-17(27)10-11-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449922 (CHEMBL4170975) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCN(CC1)c1ncc(cn1)C(=O)NO)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C37H39Cl2N7O4/c1-5-50-30-20-26(37(2,3)4)10-15-29(30)33-42-31(23-6-11-27(38)12-7-23)32(24-8-13-28(39)14-9-24)46(33)36(48)45-18-16-44(17-19-45)35-40-21-25(22-41-35)34(47)43-49/h6-15,20-22,31-32,49H,5,16-19H2,1-4H3,(H,43,47)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50420280 (CHEMBL2089149) Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(Cl)ccc2C1=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H17Cl3N2O3S/c1-32-24(31)21(14-4-8-16(26)9-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-12-17(27)10-11-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.37E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018534 (CHEMBL3290670) Show SMILES CC(C)OC1=C(C(N(Cc2ccc(cc2OC(C)(C)C)C(F)(F)F)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1 |t:4| Show InChI InChI=1S/C32H31BrF3NO4/c1-19(2)40-29-26(28(38)21-9-7-6-8-10-21)27(20-12-15-24(33)16-13-20)37(30(29)39)18-22-11-14-23(32(34,35)36)17-25(22)41-31(3,4)5/h6-17,19,27H,18H2,1-5H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.37E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449906 (CHEMBL4163726) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)NCCCCCC(=O)Nc1ccccc1N)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C40H45Cl2N5O3/c1-5-50-34-25-28(40(2,3)4)18-23-31(34)38-46-36(26-14-19-29(41)20-15-26)37(27-16-21-30(42)22-17-27)47(38)39(49)44-24-10-6-7-13-35(48)45-33-12-9-8-11-32(33)43/h8-9,11-12,14-23,25,36-37H,5-7,10,13,24,43H2,1-4H3,(H,44,49)(H,45,48)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.43E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50420265 (CHEMBL2089200) Show SMILES COC(=O)C(N1C(c2ccc(F)cc2)C(=S)Nc2cc(Cl)ccc2C1=O)c1ccc(F)cc1 Show InChI InChI=1S/C24H17ClF2N2O3S/c1-32-24(31)21(14-4-9-17(27)10-5-14)29-20(13-2-7-16(26)8-3-13)22(33)28-19-12-15(25)6-11-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.72E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018539 (CHEMBL3290674) Show SMILES CC(C)OC1=C(C(N(Cc2ccc(cc2)C(F)(F)F)C1=O)c1ccc(Br)cc1)C(=O)c1ccccc1 |t:4| Show InChI InChI=1S/C28H23BrF3NO3/c1-17(2)36-26-23(25(34)20-6-4-3-5-7-20)24(19-10-14-22(29)15-11-19)33(27(26)35)16-18-8-12-21(13-9-18)28(30,31)32/h3-15,17,24H,16H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.72E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50449921 (CHEMBL4161826) Show SMILES CCOc1cc(ccc1C1=NC(C(N1C(=O)N1CCC(CC1)C(=O)Nc1ccc(\C=C\C(=O)NO)cc1)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(C)(C)C |t:10| Show InChI InChI=1S/C43H45Cl2N5O5/c1-5-55-36-26-31(43(2,3)4)13-20-35(36)40-47-38(28-9-14-32(44)15-10-28)39(29-11-16-33(45)17-12-29)50(40)42(53)49-24-22-30(23-25-49)41(52)46-34-18-6-27(7-19-34)8-21-37(51)48-54/h6-21,26,30,38-39,54H,5,22-25H2,1-4H3,(H,46,52)(H,48,51)/b21-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.65E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) preincubated for 30 mins by fluorescence polarization assay				J Med Chem 61: 7245-7260 (2018) Article DOI: 10.1021/acs.jmedchem.8b00664 BindingDB Entry DOI: 10.7270/Q2R213Z9
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50018547 (CHEMBL3290678) Show SMILES CCOc1cc(ccc1CN1C(C(C(=O)c2ccccc2)=C(N[C@H](C)c2ccccc2)C1=O)c1ccc(Br)cc1)C(F)(F)F |r,t:22| Show InChI InChI=1S/C35H30BrF3N2O3/c1-3-44-29-20-27(35(37,38)39)17-14-26(29)21-41-32(24-15-18-28(36)19-16-24)30(33(42)25-12-8-5-9-13-25)31(34(41)43)40-22(2)23-10-6-4-7-11-23/h4-20,22,32,40H,3,21H2,1-2H3/t22-,32?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.02E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Second Military Medical University Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by fluorescence polarization binding assay				Bioorg Med Chem Lett 24: 2648-50 (2014) Article DOI: 10.1016/j.bmcl.2014.04.063 BindingDB Entry DOI: 10.7270/Q2QV3P22
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50420269 (CHEMBL2089204) Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(ccc2C1=O)C(F)(F)F)c1ccc(F)cc1 Show InChI InChI=1S/C25H17ClF4N2O3S/c1-35-24(34)21(14-4-9-17(27)10-5-14)32-20(13-2-7-16(26)8-3-13)22(36)31-19-12-15(25(28,29)30)6-11-18(19)23(32)33/h2-12,20-21H,1H3,(H,31,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.02E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay				Eur J Med Chem 56: 10-16 (2012) Article DOI: 10.1016/j.ejmech.2012.08.003 BindingDB Entry DOI: 10.7270/Q2K938SR
					More data for this Ligand-Target Pair

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