Compile Data Set for Download or QSAR

Found 595 hits with Last Name = 'berry' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM99582 (US8501936, 81) Show SMILES CN1CCN(CC1)c1ccc(Nc2nc3cccc(-c4ccc(cc4)S(C)(=O)=O)n3n2)cc1 Show InChI InChI=1S/C24H26N6O2S/c1-28-14-16-29(17-15-28)20-10-8-19(9-11-20)25-24-26-23-5-3-4-22(30(23)27-24)18-6-12-21(13-7-18)33(2,31)32/h3-13H,14-17H2,1-2H3,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438673 (CHEMBL2414535) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCOCC3)nc12 Show InChI InChI=1S/C24H23N5O4S/c1-34(31,32)20-10-6-17(7-11-20)21-3-2-12-29-22(21)26-24(27-29)25-19-8-4-18(5-9-19)23(30)28-13-15-33-16-14-28/h2-12H,13-16H2,1H3,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438670 (CHEMBL2414538) Show SMILES CC(C)Cn1cc(cn1)-c1cccn2nc(Nc3ccc(cc3)C(O)=O)nc12 Show InChI InChI=1S/C20H20N6O2/c1-13(2)11-25-12-15(10-21-25)17-4-3-9-26-18(17)23-20(24-26)22-16-7-5-14(6-8-16)19(27)28/h3-10,12-13H,11H2,1-2H3,(H,22,24)(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438667 (CHEMBL2414541) Show SMILES OC(=O)c1ccc(Nc2nc3c(cccn3n2)-c2cnn(c2)C2CCCCC2)cc1 Show InChI InChI=1S/C22H22N6O2/c29-21(30)15-8-10-17(11-9-15)24-22-25-20-19(7-4-12-27(20)26-22)16-13-23-28(14-16)18-5-2-1-3-6-18/h4,7-14,18H,1-3,5-6H2,(H,24,26)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438666 (CHEMBL2414542) Show SMILES CC(C)n1cc(cn1)-c1cccn2nc(Nc3ccc(cc3)C(O)=O)nc12 Show InChI InChI=1S/C19H18N6O2/c1-12(2)25-11-14(10-20-25)16-4-3-9-24-17(16)22-19(23-24)21-15-7-5-13(6-8-15)18(26)27/h3-12H,1-2H3,(H,21,23)(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438685 (CHEMBL2414549) Show SMILES CC(C)c1cccc(c1)-c1cccc2nc(Nc3ccnc(CO)c3)nn12 Show InChI InChI=1S/C21H21N5O/c1-14(2)15-5-3-6-16(11-15)19-7-4-8-20-24-21(25-26(19)20)23-17-9-10-22-18(12-17)13-27/h3-12,14,27H,13H2,1-2H3,(H,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438668 (CHEMBL2414540) Show SMILES OC(=O)c1ccc(Nc2nc3c(cccn3n2)-c2cnn(c2)C2CCCC2)cc1 Show InChI InChI=1S/C21H20N6O2/c28-20(29)14-7-9-16(10-8-14)23-21-24-19-18(6-3-11-26(19)25-21)15-12-22-27(13-15)17-4-1-2-5-17/h3,6-13,17H,1-2,4-5H2,(H,23,25)(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438688 (CHEMBL2414544) Show SMILES COc1ccc(cc1)-c1cccc2nc(Nc3ccc(cc3)N3CCN(C)CC3)nn12 Show InChI InChI=1S/C24H26N6O/c1-28-14-16-29(17-15-28)20-10-8-19(9-11-20)25-24-26-23-5-3-4-22(30(23)27-24)18-6-12-21(31-2)13-7-18/h3-13H,14-17H2,1-2H3,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438674 (CHEMBL2414534) Show SMILES CN(C)C(=O)c1ccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C22H21N5O3S/c1-26(2)21(28)16-6-10-17(11-7-16)23-22-24-20-19(5-4-14-27(20)25-22)15-8-12-18(13-9-15)31(3,29)30/h4-14H,1-3H3,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438671 (CHEMBL2414537) Show SMILES COc1ccc(cc1)-c1cccn2nc(Nc3cnn(c3)C3CCOCC3)nc12 Show InChI InChI=1S/C21H22N6O2/c1-28-18-6-4-15(5-7-18)19-3-2-10-26-20(19)24-21(25-26)23-16-13-22-27(14-16)17-8-11-29-12-9-17/h2-7,10,13-14,17H,8-9,11-12H2,1H3,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438687 (CHEMBL2414546) Show SMILES COc1cccc(c1)-c1cccc2nc(Nc3ccc(cc3)N3CCN(C)CC3)nn12 Show InChI InChI=1S/C24H26N6O/c1-28-13-15-29(16-14-28)20-11-9-19(10-12-20)25-24-26-23-8-4-7-22(30(23)27-24)18-5-3-6-21(17-18)31-2/h3-12,17H,13-16H2,1-2H3,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438669 (CHEMBL2414539) Show SMILES CC(C)c1cc(ccn1)-c1cccn2nc(Nc3ccc(cc3)C(O)=O)nc12 Show InChI InChI=1S/C21H19N5O2/c1-13(2)18-12-15(9-10-22-18)17-4-3-11-26-19(17)24-21(25-26)23-16-7-5-14(6-8-16)20(27)28/h3-13H,1-2H3,(H,23,25)(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438686 (CHEMBL2414548) Show SMILES CC(C)c1cccc(c1)-c1cccc2nc(Nc3ccnc(C)c3)nn12 Show InChI InChI=1S/C21H21N5/c1-14(2)16-6-4-7-17(13-16)19-8-5-9-20-24-21(25-26(19)20)23-18-10-11-22-15(3)12-18/h4-14H,1-3H3,(H,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438672 (CHEMBL2414536) Show SMILES COc1ccc(cc1)-c1cccn2nc(Nc3cnn(c3)[C@H](C)CO)nc12 |r| Show InChI InChI=1S/C19H20N6O2/c1-13(12-26)25-11-15(10-20-25)21-19-22-18-17(4-3-9-24(18)23-19)14-5-7-16(27-2)8-6-14/h3-11,13,26H,12H2,1-2H3,(H,21,23)/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438680 (CHEMBL2414554) Show SMILES COc1ccc(cc1)-c1cccc2nc(Nc3ccc(cc3)C(O)=O)nn12 Show InChI InChI=1S/C20H16N4O3/c1-27-16-11-7-13(8-12-16)17-3-2-4-18-22-20(23-24(17)18)21-15-9-5-14(6-10-15)19(25)26/h2-12H,1H3,(H,21,23)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438675 (CHEMBL2414533) Show SMILES COc1ccc(cc1)-c1cccn2nc(Nc3ccc(cc3)C(O)=O)nc12 Show InChI InChI=1S/C20H16N4O3/c1-27-16-10-6-13(7-11-16)17-3-2-12-24-18(17)22-20(23-24)21-15-8-4-14(5-9-15)19(25)26/h2-12H,1H3,(H,21,23)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM99583 (US8501936, 82) Show SMILES CN1CCN(CC1)c1ccc(Nc2nc3cccc(-c4cccc(c4)S(C)(=O)=O)n3n2)cc1 Show InChI InChI=1S/C24H26N6O2S/c1-28-13-15-29(16-14-28)20-11-9-19(10-12-20)25-24-26-23-8-4-7-22(30(23)27-24)18-5-3-6-21(17-18)33(2,31)32/h3-12,17H,13-16H2,1-2H3,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438676 (CHEMBL2414532) Show SMILES CC(C)Cn1cc(cn1)-c1cccc2nc(Nc3ccnc(C)c3)nn12 Show InChI InChI=1S/C19H21N7/c1-13(2)11-25-12-15(10-21-25)17-5-4-6-18-23-19(24-26(17)18)22-16-7-8-20-14(3)9-16/h4-10,12-13H,11H2,1-3H3,(H,20,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50358203 (CHEMBL1922093) Show SMILES Cc1c(CN2CCN(CC2)C(=O)CO)sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C22H28N8O3S/c1-14-16(12-28-2-4-29(5-3-28)17(32)13-31)34-19-18(14)26-20(15-10-24-22(23)25-11-15)27-21(19)30-6-8-33-9-7-30/h10-11,31H,2-9,12-13H2,1H3,(H2,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of PI3K subunit p110alpha assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...				J Med Chem 54: 7579-87 (2011) Article DOI: 10.1021/jm2009327 BindingDB Entry DOI: 10.7270/Q2SF2WMT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438677 (CHEMBL2414531) Show SMILES CCn1cc(cn1)-c1cccc2nc(Nc3ccnc(CO)c3)nn12 Show InChI InChI=1S/C17H17N7O/c1-2-23-10-12(9-19-23)15-4-3-5-16-21-17(22-24(15)16)20-13-6-7-18-14(8-13)11-25/h3-10,25H,2,11H2,1H3,(H,18,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315915 (5-(7-methyl-6-(3-(methylsulfonyl)phenyl)-4-morphol...) Show SMILES Cc1c(sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1)-c1cccc(c1)S(C)(=O)=O Show InChI InChI=1S/C22H22N6O3S2/c1-13-17-19(32-18(13)14-4-3-5-16(10-14)33(2,29)30)21(28-6-8-31-9-7-28)27-20(26-17)15-11-24-22(23)25-12-15/h3-5,10-12H,6-9H2,1-2H3,(H2,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315914 ((3-(2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin...) Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1sc2c(nc(nc2c1C)-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C27H30N8O2S/c1-17-21-23(25(34-10-12-37-13-11-34)32-24(31-21)20-15-29-27(28)30-16-20)38-22(17)18-4-3-5-19(14-18)26(36)35-8-6-33(2)7-9-35/h3-5,14-16H,6-13H2,1-2H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438678 (CHEMBL2414556) Show SMILES CCn1cc(cn1)-c1cccc2nc(Nc3ccnc(C)c3)nn12 Show InChI InChI=1S/C17H17N7/c1-3-23-11-13(10-19-23)15-5-4-6-16-21-17(22-24(15)16)20-14-7-8-18-12(2)9-14/h4-11H,3H2,1-2H3,(H,18,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315911 (5-(6-(3-(methylsulfonyl)phenyl)-4-morpholinothieno...) Show SMILES CS(=O)(=O)c1cccc(c1)-c1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1 Show InChI InChI=1S/C21H20N6O3S2/c1-32(28,29)15-4-2-3-13(9-15)17-10-16-18(31-17)20(27-5-7-30-8-6-27)26-19(25-16)14-11-23-21(22)24-12-14/h2-4,9-12H,5-8H2,1H3,(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438681 (CHEMBL2414553) Show SMILES COc1ccc(cc1)-c1cccc2nc(Nc3ccnc(C)c3)nn12 Show InChI InChI=1S/C19H17N5O/c1-13-12-15(10-11-20-13)21-19-22-18-5-3-4-17(24(18)23-19)14-6-8-16(25-2)9-7-14/h3-12H,1-2H3,(H,20,21,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50358206 (CHEMBL1922091) Show SMILES C[C@H](N)C(=O)N1CCN(Cc2sc3c(nc(nc3c2C)-c2cnc(N)nc2)N2CCOCC2)CC1 |r| Show InChI InChI=1S/C23H31N9O2S/c1-14-17(13-30-3-5-32(6-4-30)22(33)15(2)24)35-19-18(14)28-20(16-11-26-23(25)27-12-16)29-21(19)31-7-9-34-10-8-31/h11-12,15H,3-10,13,24H2,1-2H3,(H2,25,26,27)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...				J Med Chem 54: 7579-87 (2011) Article DOI: 10.1021/jm2009327 BindingDB Entry DOI: 10.7270/Q2SF2WMT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438693 (CHEMBL2414560) Show SMILES CC(C)c1cccc(c1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C19H20N4O/c1-12(2)14-5-3-6-15(11-14)16-7-4-8-17-20-19(22-23(16)17)21-18(24)13-9-10-13/h3-8,11-13H,9-10H2,1-2H3,(H,21,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438682 (CHEMBL2414552) Show SMILES CC(C)c1cccc(c1)-c1cccc2nc(Nc3cccc(C)c3)nn12 Show InChI InChI=1S/C22H22N4/c1-15(2)17-8-5-9-18(14-17)20-11-6-12-21-24-22(25-26(20)21)23-19-10-4-7-16(3)13-19/h4-15H,1-3H3,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315913 ((3-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3...) Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1 Show InChI InChI=1S/C26H28N8O2S/c1-32-5-7-34(8-6-32)25(35)18-4-2-3-17(13-18)21-14-20-22(37-21)24(33-9-11-36-12-10-33)31-23(30-20)19-15-28-26(27)29-16-19/h2-4,13-16H,5-12H2,1H3,(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315908 (CHEMBL1090598 | N-((2-(2-aminopyrimidin-5-yl)-4-mo...) Show SMILES CN(Cc1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1)S(C)(=O)=O Show InChI InChI=1S/C17H21N7O3S2/c1-23(29(2,25)26)10-12-7-13-14(28-12)16(24-3-5-27-6-4-24)22-15(21-13)11-8-19-17(18)20-9-11/h7-9H,3-6,10H2,1-2H3,(H2,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50358205 (CHEMBL1922090) Show SMILES Cc1c(CN2CCN(CC2)C(=O)CN)sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C22H29N9O2S/c1-14-16(13-29-2-4-30(5-3-29)17(32)10-23)34-19-18(14)27-20(15-11-25-22(24)26-12-15)28-21(19)31-6-8-33-9-7-31/h11-12H,2-10,13,23H2,1H3,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...				J Med Chem 54: 7579-87 (2011) Article DOI: 10.1021/jm2009327 BindingDB Entry DOI: 10.7270/Q2SF2WMT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50358207 (CHEMBL1922092) Show SMILES Cc1c(CN2CCN(CC2)C(=O)C(C)(C)N)sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C24H33N9O2S/c1-15-17(14-31-4-6-33(7-5-31)22(34)24(2,3)26)36-19-18(15)29-20(16-12-27-23(25)28-13-16)30-21(19)32-8-10-35-11-9-32/h12-13H,4-11,14,26H2,1-3H3,(H2,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...				J Med Chem 54: 7579-87 (2011) Article DOI: 10.1021/jm2009327 BindingDB Entry DOI: 10.7270/Q2SF2WMT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50358209 (CHEMBL1922095) Show SMILES Cc1c(CN2CCN(CC2)C(=O)C(C)(C)O)sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C24H32N8O3S/c1-15-17(14-30-4-6-32(7-5-30)22(33)24(2,3)34)36-19-18(15)28-20(16-12-26-23(25)27-13-16)29-21(19)31-8-10-35-11-9-31/h12-13,34H,4-11,14H2,1-3H3,(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...				J Med Chem 54: 7579-87 (2011) Article DOI: 10.1021/jm2009327 BindingDB Entry DOI: 10.7270/Q2SF2WMT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50358204 (CHEMBL1922094) Show SMILES C[C@H](O)C(=O)N1CCN(Cc2sc3c(nc(nc3c2C)-c2cnc(N)nc2)N2CCOCC2)CC1 |r| Show InChI InChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...				J Med Chem 54: 7579-87 (2011) Article DOI: 10.1021/jm2009327 BindingDB Entry DOI: 10.7270/Q2SF2WMT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438691 (CHEMBL2414562) Show SMILES COC(=O)Nc1nc2cccc(-c3cccc(c3)C(C)C)n2n1 Show InChI InChI=1S/C17H18N4O2/c1-11(2)12-6-4-7-13(10-12)14-8-5-9-15-18-16(20-21(14)15)19-17(22)23-3/h4-11H,1-3H3,(H,19,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438679 (CHEMBL2414555) Show SMILES Cc1cc(Nc2nc3cccc(-c4cccc(c4)S(C)(=O)=O)n3n2)ccn1 Show InChI InChI=1S/C19H17N5O2S/c1-13-11-15(9-10-20-13)21-19-22-18-8-4-7-17(24(18)23-19)14-5-3-6-16(12-14)27(2,25)26/h3-12H,1-2H3,(H,20,21,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315907 (5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...) Show SMILES Cc1c(CN2CCN(CC2)S(C)(=O)=O)sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C21H28N8O3S2/c1-14-16(13-27-3-5-29(6-4-27)34(2,30)31)33-18-17(14)25-19(15-11-23-21(22)24-12-15)26-20(18)28-7-9-32-10-8-28/h11-12H,3-10,13H2,1-2H3,(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315907 (5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...) Show SMILES Cc1c(CN2CCN(CC2)S(C)(=O)=O)sc2c(nc(nc12)-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C21H28N8O3S2/c1-14-16(13-27-3-5-29(6-4-27)34(2,30)31)33-18-17(14)25-19(15-11-23-21(22)24-12-15)26-20(18)28-7-9-32-10-8-28/h11-12H,3-10,13H2,1-2H3,(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...				J Med Chem 54: 7579-87 (2011) Article DOI: 10.1021/jm2009327 BindingDB Entry DOI: 10.7270/Q2SF2WMT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50312606 (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...) Show SMILES CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cnc(N)nc2)CC1 Show InChI InChI=1S/C20H26N8O3S2/c1-33(29,30)28-4-2-26(3-5-28)13-15-10-16-17(32-15)19(27-6-8-31-9-7-27)25-18(24-16)14-11-22-20(21)23-12-14/h10-12H,2-9,13H2,1H3,(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...				J Med Chem 54: 7579-87 (2011) Article DOI: 10.1021/jm2009327 BindingDB Entry DOI: 10.7270/Q2SF2WMT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50312606 (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...) Show SMILES CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cnc(N)nc2)CC1 Show InChI InChI=1S/C20H26N8O3S2/c1-33(29,30)28-4-2-26(3-5-28)13-15-10-16-17(32-15)19(27-6-8-31-9-7-27)25-18(24-16)14-11-22-20(21)23-12-14/h10-12H,2-9,13H2,1H3,(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315912 (CHEMBL1091979 | N-((2-(2-aminopyrimidin-5-yl)-7-me...) Show SMILES CN(Cc1sc2c(nc(nc2c1C)-c1cnc(N)nc1)N1CCOCC1)C(C)=O Show InChI InChI=1S/C19H23N7O2S/c1-11-14(10-25(3)12(2)27)29-16-15(11)23-17(13-8-21-19(20)22-9-13)24-18(16)26-4-6-28-7-5-26/h8-9H,4-7,10H2,1-3H3,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438684 (CHEMBL2414550) Show SMILES CC(C)c1cccc(c1)-c1cccc2nc(Nc3cc(C)ccn3)nn12 Show InChI InChI=1S/C21H21N5/c1-14(2)16-6-4-7-17(13-16)18-8-5-9-20-24-21(25-26(18)20)23-19-12-15(3)10-11-22-19/h4-14H,1-3H3,(H,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50304689 (5-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimid...) Show SMILES Nc1ncc(cn1)-c1nc(N2CCOCC2)c2sccc2n1 Show InChI InChI=1S/C14H14N6OS/c15-14-16-7-9(8-17-14)12-18-10-1-6-22-11(10)13(19-12)20-2-4-21-5-3-20/h1,6-8H,2-5H2,(H2,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315909 (CHEMBL1090599 | N-((2-(2-aminopyrimidin-5-yl)-4-mo...) Show SMILES CN(Cc1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1)C(C)=O Show InChI InChI=1S/C18H21N7O2S/c1-11(26)24(2)10-13-7-14-15(28-13)17(25-3-5-27-6-4-25)23-16(22-14)12-8-20-18(19)21-9-12/h7-9H,3-6,10H2,1-2H3,(H2,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50315910 (5-(6-(2-aminopropan-2-yl)-4-morpholinothieno[3,2-d...) Show SMILES CC(C)(N)c1cc2nc(nc(N3CCOCC3)c2s1)-c1cnc(N)nc1 Show InChI InChI=1S/C17H21N7OS/c1-17(2,19)12-7-11-13(26-12)15(24-3-5-25-6-4-24)23-14(22-11)10-8-20-16(18)21-9-10/h7-9H,3-6,19H2,1-2H3,(H2,18,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	59	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant mTOR assessed as reduction in GFP-4EBP1 phosphorylation after 30 mins by FRET assay				Bioorg Med Chem Lett 20: 2408-11 (2010) Article DOI: 10.1016/j.bmcl.2010.03.046 BindingDB Entry DOI: 10.7270/Q2GM87FX
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438695 (CHEMBL2414558) Show SMILES Clc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C16H13ClN4O/c17-12-8-6-10(7-9-12)13-2-1-3-14-18-16(20-21(13)14)19-15(22)11-4-5-11/h1-3,6-9,11H,4-5H2,(H,19,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	59	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438696 (CHEMBL2414557) Show SMILES Clc1cccc(c1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C16H13ClN4O/c17-12-4-1-3-11(9-12)13-5-2-6-14-18-16(20-21(13)14)19-15(22)10-7-8-10/h1-6,9-10H,7-8H2,(H,19,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438683 (CHEMBL2414551) Show SMILES CC(C)c1cccc(c1)-c1cccc2nc(Nc3cccc(C)n3)nn12 Show InChI InChI=1S/C21H21N5/c1-14(2)16-8-5-9-17(13-16)18-10-6-12-20-24-21(25-26(18)20)23-19-11-4-7-15(3)22-19/h4-14H,1-3H3,(H,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	71	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438694 (CHEMBL2414559) Show SMILES FC(F)(F)c1cccc(c1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C17H13F3N4O/c18-17(19,20)12-4-1-3-11(9-12)13-5-2-6-14-21-16(23-24(13)14)22-15(25)10-7-8-10/h1-6,9-10H,7-8H2,(H,22,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	83	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50438692 (CHEMBL2414561) Show SMILES COc1cccc(c1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C17H16N4O2/c1-23-13-5-2-4-12(10-13)14-6-3-7-15-18-17(20-21(14)15)19-16(22)11-8-9-11/h2-7,10-11H,8-9H2,1H3,(H,19,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	207	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 (unknown origin)				Bioorg Med Chem Lett 23: 5014-21 (2013) Article DOI: 10.1016/j.bmcl.2013.06.008 BindingDB Entry DOI: 10.7270/Q29S1SF2
					More data for this Ligand-Target Pair

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