Found 362 hits with Last Name = 'geck' and Initial = 'm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Genome polyprotein
(Hepacivirus C) | BDBM50495950
(Danoprevir | R-05190591 | R05190591 | RO-5190591 |...)Show SMILES [H][C@@]12C[C@]1(NC(=O)[C@]1([H])C[C@H](CN1C(=O)[C@H](CCCCC\C=C/2)NC(=O)OC(C)(C)C)OC(=O)N1Cc2cccc(F)c2C1)C(=O)NS(=O)(=O)C1CC1 |c:23| Show InChI InChI=1S/C35H46FN5O9S/c1-34(2,3)50-32(45)37-27-13-8-6-4-5-7-11-22-17-35(22,31(44)39-51(47,48)24-14-15-24)38-29(42)28-16-23(19-41(28)30(27)43)49-33(46)40-18-21-10-9-12-26(36)25(21)20-40/h7,9-12,22-24,27-28H,4-6,8,13-20H2,1-3H3,(H,37,45)(H,38,42)(H,39,44)/b11-7-/t22-,23-,27+,28+,35-/m1/s1 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of Hepatitis C virus genotype 1a NS3/4A protease A156T mutant expressed in Escherichia coli BL21 (DE3) cells assessed as substrate cleavag... |
J Med Chem 57: 1753-69 (2014)
Article DOI: 10.1021/jm400164c BindingDB Entry DOI: 10.7270/Q2T72MD2 |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170292
((S)-2-{4'-[(5-Methanesulfonylamino-benzofuran-2-ca...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(NS(C)(=O)=O)ccc3o2)cc1)C(O)=O Show InChI InChI=1S/C27H27N3O8S2/c1-16(2)25(27(32)33)30-40(36,37)22-11-6-18(7-12-22)17-4-8-20(9-5-17)28-26(31)24-15-19-14-21(29-39(3,34)35)10-13-23(19)38-24/h4-16,25,29-30H,1-3H3,(H,28,31)(H,32,33)/t25-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170302
((S)-2-{4'-[(5-Chloro-benzofuran-2-carbonyl)-amino]...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(Cl)ccc3o2)cc1)C(O)=O Show InChI InChI=1S/C26H23ClN2O6S/c1-15(2)24(26(31)32)29-36(33,34)21-10-5-17(6-11-21)16-3-8-20(9-4-16)28-25(30)23-14-18-13-19(27)7-12-22(18)35-23/h3-15,24,29H,1-2H3,(H,28,30)(H,31,32)/t24-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170287
((S)-2-{4'-[(5-Methoxy-benzofuran-2-carbonyl)-amino...)Show SMILES COc1ccc2oc(cc2c1)C(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C27H26N2O7S/c1-16(2)25(27(31)32)29-37(33,34)22-11-6-18(7-12-22)17-4-8-20(9-5-17)28-26(30)24-15-19-14-21(35-3)10-13-23(19)36-24/h4-16,25,29H,1-3H3,(H,28,30)(H,31,32)/t25-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170300
((S)-3-Methyl-2-{4'-[(5-nitro-benzofuran-2-carbonyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(ccc3o2)[N+]([O-])=O)cc1)C(O)=O Show InChI InChI=1S/C26H23N3O8S/c1-15(2)24(26(31)32)28-38(35,36)21-10-5-17(6-11-21)16-3-7-19(8-4-16)27-25(30)23-14-18-13-20(29(33)34)9-12-22(18)37-23/h3-15,24,28H,1-2H3,(H,27,30)(H,31,32)/t24-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170294
((S)-2-{4'-[(5-Acetylamino-benzofuran-2-carbonyl)-a...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(NC(C)=O)ccc3o2)cc1)C(O)=O Show InChI InChI=1S/C28H27N3O7S/c1-16(2)26(28(34)35)31-39(36,37)23-11-6-19(7-12-23)18-4-8-21(9-5-18)30-27(33)25-15-20-14-22(29-17(3)32)10-13-24(20)38-25/h4-16,26,31H,1-3H3,(H,29,32)(H,30,33)(H,34,35)/t26-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM28485
((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3o2)cc1)C(O)=O |r| Show InChI InChI=1S/C26H24N2O6S/c1-16(2)24(26(30)31)28-35(32,33)21-13-9-18(10-14-21)17-7-11-20(12-8-17)27-25(29)23-15-19-5-3-4-6-22(19)34-23/h3-16,24,28H,1-2H3,(H,27,29)(H,30,31)/t24-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Collagenase 3
(Bos taurus) | BDBM50170304
((S)-2-{4'-[(5-Amino-benzofuran-2-carbonyl)-amino]-...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(N)ccc3o2)cc1)C(O)=O Show InChI InChI=1S/C26H25N3O6S/c1-15(2)24(26(31)32)29-36(33,34)21-10-5-17(6-11-21)16-3-8-20(9-4-16)28-25(30)23-14-18-13-19(27)7-12-22(18)35-23/h3-15,24,29H,27H2,1-2H3,(H,28,30)(H,31,32)/t24-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-14
(Homo sapiens (Human)) | BDBM50170287
((S)-2-{4'-[(5-Methoxy-benzofuran-2-carbonyl)-amino...)Show SMILES COc1ccc2oc(cc2c1)C(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C27H26N2O7S/c1-16(2)25(27(31)32)29-37(33,34)22-11-6-18(7-12-22)17-4-8-20(9-5-17)28-26(30)24-15-19-14-21(35-3)10-13-23(19)36-24/h4-16,25,29H,1-3H3,(H,28,30)(H,31,32)/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-14 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170287
((S)-2-{4'-[(5-Methoxy-benzofuran-2-carbonyl)-amino...)Show SMILES COc1ccc2oc(cc2c1)C(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C27H26N2O7S/c1-16(2)25(27(31)32)29-37(33,34)22-11-6-18(7-12-22)17-4-8-20(9-5-17)28-26(30)24-15-19-14-21(35-3)10-13-23(19)36-24/h4-16,25,29H,1-3H3,(H,28,30)(H,31,32)/t25-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170300
((S)-3-Methyl-2-{4'-[(5-nitro-benzofuran-2-carbonyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(ccc3o2)[N+]([O-])=O)cc1)C(O)=O Show InChI InChI=1S/C26H23N3O8S/c1-15(2)24(26(31)32)28-38(35,36)21-10-5-17(6-11-21)16-3-7-19(8-4-16)27-25(30)23-14-18-13-20(29(33)34)9-12-22(18)37-23/h3-15,24,28H,1-2H3,(H,27,30)(H,31,32)/t24-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170299
((S)-3-Methyl-2-{4'-[([1,2,3]thiadiazole-4-carbonyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2csnn2)cc1)C(O)=O Show InChI InChI=1S/C20H20N4O5S2/c1-12(2)18(20(26)27)23-31(28,29)16-9-5-14(6-10-16)13-3-7-15(8-4-13)21-19(25)17-11-30-24-22-17/h3-12,18,23H,1-2H3,(H,21,25)(H,26,27)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170289
((S)-2-{4'-[(Benzofuran-2-carbonyl)-amino]-biphenyl...)Show SMILES CC(C)C[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3o2)cc1)C(O)=O Show InChI InChI=1S/C27H26N2O6S/c1-17(2)15-23(27(31)32)29-36(33,34)22-13-9-19(10-14-22)18-7-11-21(12-8-18)28-26(30)25-16-20-5-3-4-6-24(20)35-25/h3-14,16-17,23,29H,15H2,1-2H3,(H,28,30)(H,31,32)/t23-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170298
((S)-2-{4'-[(4-Methoxy-benzofuran-2-carbonyl)-amino...)Show SMILES COc1cccc2oc(cc12)C(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C27H26N2O7S/c1-16(2)25(27(31)32)29-37(33,34)20-13-9-18(10-14-20)17-7-11-19(12-8-17)28-26(30)24-15-21-22(35-3)5-4-6-23(21)36-24/h4-16,25,29H,1-3H3,(H,28,30)(H,31,32)/t25-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170295
((S)-2-{4'-[(Benzofuran-2-carbonyl)-amino]-biphenyl...)Show SMILES NC(=O)C[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3o2)cc1)C(O)=O Show InChI InChI=1S/C25H21N3O7S/c26-23(29)14-20(25(31)32)28-36(33,34)19-11-7-16(8-12-19)15-5-9-18(10-6-15)27-24(30)22-13-17-3-1-2-4-21(17)35-22/h1-13,20,28H,14H2,(H2,26,29)(H,27,30)(H,31,32)/t20-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170302
((S)-2-{4'-[(5-Chloro-benzofuran-2-carbonyl)-amino]...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(Cl)ccc3o2)cc1)C(O)=O Show InChI InChI=1S/C26H23ClN2O6S/c1-15(2)24(26(31)32)29-36(33,34)21-10-5-17(6-11-21)16-3-8-20(9-4-16)28-25(30)23-14-18-13-19(27)7-12-22(18)35-23/h3-15,24,29H,1-2H3,(H,28,30)(H,31,32)/t24-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170288
((S)-2-{4'-[(5-Benzenesulfonylamino-benzofuran-2-ca...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(NS(=O)(=O)c4ccccc4)ccc3o2)cc1)C(O)=O Show InChI InChI=1S/C32H29N3O8S2/c1-20(2)30(32(37)38)35-45(41,42)27-15-10-22(11-16-27)21-8-12-24(13-9-21)33-31(36)29-19-23-18-25(14-17-28(23)43-29)34-44(39,40)26-6-4-3-5-7-26/h3-20,30,34-35H,1-2H3,(H,33,36)(H,37,38)/t30-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170296
((S)-2-{4'-[(4-Benzyloxy-benzofuran-2-carbonyl)-ami...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3c(OCc4ccccc4)cccc3o2)cc1)C(O)=O Show InChI InChI=1S/C33H30N2O7S/c1-21(2)31(33(37)38)35-43(39,40)26-17-13-24(14-18-26)23-11-15-25(16-12-23)34-32(36)30-19-27-28(9-6-10-29(27)42-30)41-20-22-7-4-3-5-8-22/h3-19,21,31,35H,20H2,1-2H3,(H,34,36)(H,37,38)/t31-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170292
((S)-2-{4'-[(5-Methanesulfonylamino-benzofuran-2-ca...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(NS(C)(=O)=O)ccc3o2)cc1)C(O)=O Show InChI InChI=1S/C27H27N3O8S2/c1-16(2)25(27(32)33)30-40(36,37)22-11-6-18(7-12-22)17-4-8-20(9-5-17)28-26(31)24-15-19-14-21(29-39(3,34)35)10-13-23(19)38-24/h4-16,25,29-30H,1-3H3,(H,28,31)(H,32,33)/t25-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170294
((S)-2-{4'-[(5-Acetylamino-benzofuran-2-carbonyl)-a...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(NC(C)=O)ccc3o2)cc1)C(O)=O Show InChI InChI=1S/C28H27N3O7S/c1-16(2)26(28(34)35)31-39(36,37)23-11-6-19(7-12-23)18-4-8-21(9-5-18)30-27(33)25-15-20-14-22(29-17(3)32)10-13-24(20)38-25/h4-16,26,31H,1-3H3,(H,29,32)(H,30,33)(H,34,35)/t26-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170286
((S)-2-{4'-[(Benzofuran-2-carbonyl)-amino]-biphenyl...)Show SMILES OC[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3o2)cc1)C(O)=O Show InChI InChI=1S/C24H20N2O7S/c27-14-20(24(29)30)26-34(31,32)19-11-7-16(8-12-19)15-5-9-18(10-6-15)25-23(28)22-13-17-3-1-2-4-21(17)33-22/h1-13,20,26-27H,14H2,(H,25,28)(H,29,30)/t20-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170301
((S)-2-{4'-[(Benzofuran-2-ylmethyl)-amino]-biphenyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NCc2cc3ccccc3o2)cc1)C(O)=O Show InChI InChI=1S/C26H26N2O5S/c1-17(2)25(26(29)30)28-34(31,32)23-13-9-19(10-14-23)18-7-11-21(12-8-18)27-16-22-15-20-5-3-4-6-24(20)33-22/h3-15,17,25,27-28H,16H2,1-2H3,(H,29,30)/t25-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM28485
((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3o2)cc1)C(O)=O |r| Show InChI InChI=1S/C26H24N2O6S/c1-16(2)24(26(30)31)28-35(32,33)21-13-9-18(10-14-21)17-7-11-20(12-8-17)27-25(29)23-15-19-5-3-4-6-22(19)34-23/h3-16,24,28H,1-2H3,(H,27,29)(H,30,31)/t24-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM50033406
(CHEMBL3357658)Show SMILES [H][C@]12OCCC[C@]1(C)Oc1ccc(cc1[C@]21N=C(N)N(C)C1=O)-c1cccnc1F |r,t:19| Show InChI InChI=1S/C21H21FN4O3/c1-20-8-4-10-28-17(20)21(18(27)26(2)19(23)25-21)14-11-12(6-7-15(14)29-20)13-5-3-9-24-16(13)22/h3,5-7,9,11,17H,4,8,10H2,1-2H3,(H2,23,25)/t17-,20-,21-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assay |
J Med Chem 57: 10112-29 (2014)
Article DOI: 10.1021/jm5015132 BindingDB Entry DOI: 10.7270/Q2348N0T |
More data for this Ligand-Target Pair | |
Transcription intermediary factor 1-alpha
(Homo sapiens (Human)) | BDBM50150818
(CHEMBL3774575)Show SMILES CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)c1 Show InChI InChI=1S/C32H42N4O8S/c1-8-14-42-22-16-23(43-15-10-9-13-34(2)3)18-24(17-22)44-30-21-28-27(35(4)32(37)36(28)5)20-26(30)33-45(38,39)25-11-12-29(40-6)31(19-25)41-7/h11-12,16-21,33H,8-10,13-15H2,1-7H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ... |
J Med Chem 59: 1440-54 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00405 BindingDB Entry DOI: 10.7270/Q26975F4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription intermediary factor 1-alpha
(Homo sapiens (Human)) | BDBM50150821
(CHEMBL3775251)Show SMILES CCCOc1cc(OCCCCN)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cn(C)cn2)c1 Show InChI InChI=1S/C26H34N6O6S/c1-5-9-36-18-11-19(37-10-7-6-8-27)13-20(12-18)38-24-15-23-22(31(3)26(33)32(23)4)14-21(24)29-39(34,35)25-16-30(2)17-28-25/h11-17,29H,5-10,27H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ... |
J Med Chem 59: 1440-54 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00405 BindingDB Entry DOI: 10.7270/Q26975F4 |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170305
((S)-2-{4'-[(Benzofuran-2-carbonyl)-amino]-biphenyl...)Show SMILES OC(=O)[C@H](Cc1cnc[nH]1)NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3o2)cc1 Show InChI InChI=1S/C27H22N4O6S/c32-26(25-13-19-3-1-2-4-24(19)37-25)30-20-9-5-17(6-10-20)18-7-11-22(12-8-18)38(35,36)31-23(27(33)34)14-21-15-28-16-29-21/h1-13,15-16,23,31H,14H2,(H,28,29)(H,30,32)(H,33,34)/t23-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Transcription intermediary factor 1-alpha
(Homo sapiens (Human)) | BDBM50150820
(CHEMBL3774933)Show SMILES CCCOc1cc(OCCCCN)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)c1 Show InChI InChI=1S/C30H38N4O8S/c1-6-12-40-20-14-21(41-13-8-7-11-31)16-22(15-20)42-28-19-26-25(33(2)30(35)34(26)3)18-24(28)32-43(36,37)23-9-10-27(38-4)29(17-23)39-5/h9-10,14-19,32H,6-8,11-13,31H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ... |
J Med Chem 59: 1440-54 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00405 BindingDB Entry DOI: 10.7270/Q26975F4 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170289
((S)-2-{4'-[(Benzofuran-2-carbonyl)-amino]-biphenyl...)Show SMILES CC(C)C[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3o2)cc1)C(O)=O Show InChI InChI=1S/C27H26N2O6S/c1-17(2)15-23(27(31)32)29-36(33,34)22-13-9-19(10-14-22)18-7-11-21(12-8-18)28-26(30)25-16-20-5-3-4-6-24(20)35-25/h3-14,16-17,23,29H,15H2,1-2H3,(H,28,30)(H,31,32)/t23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM50448549
(CHEMBL3127106)Show SMILES CN1C(N)=N[C@@]2([C@H]3COCC[C@@H]3Oc3ccc(cc23)-c2cccnc2F)C1=O |r,c:3| Show InChI InChI=1S/C20H19FN4O3/c1-25-18(26)20(24-19(25)22)13-9-11(12-3-2-7-23-17(12)21)4-5-15(13)28-16-6-8-27-10-14(16)20/h2-5,7,9,14,16H,6,8,10H2,1H3,(H2,22,24)/t14-,16-,20-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assay |
J Med Chem 57: 10112-29 (2014)
Article DOI: 10.1021/jm5015132 BindingDB Entry DOI: 10.7270/Q2348N0T |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription intermediary factor 1-alpha
(Homo sapiens (Human)) | BDBM50150758
(CHEMBL3775901)Show SMILES CCCOc1cc(OCCCCCCN)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cn(C)cn2)c1 Show InChI InChI=1S/C28H38N6O6S/c1-5-11-38-20-13-21(39-12-9-7-6-8-10-29)15-22(14-20)40-26-17-25-24(33(3)28(35)34(25)4)16-23(26)31-41(36,37)27-18-32(2)19-30-27/h13-19,31H,5-12,29H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins... |
J Med Chem 59: 1440-54 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00405 BindingDB Entry DOI: 10.7270/Q26975F4 |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM50432537
(CHEMBL2349506)Show SMILES CC#Cc1cncc(c1)-c1ccc2OC(C)(C)CC3(N=C(N)N(C)C3=O)c2c1 |t:20| Show InChI InChI=1S/C22H22N4O2/c1-5-6-14-9-16(12-24-11-14)15-7-8-18-17(10-15)22(13-21(2,3)28-18)19(27)26(4)20(23)25-22/h7-12H,13H2,1-4H3,(H2,23,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly... |
J Med Chem 56: 3379-403 (2013)
Article DOI: 10.1021/jm4002154 BindingDB Entry DOI: 10.7270/Q2JD4Z52 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170295
((S)-2-{4'-[(Benzofuran-2-carbonyl)-amino]-biphenyl...)Show SMILES NC(=O)C[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3o2)cc1)C(O)=O Show InChI InChI=1S/C25H21N3O7S/c26-23(29)14-20(25(31)32)28-36(33,34)19-11-7-16(8-12-19)15-5-9-18(10-6-15)27-24(30)22-13-17-3-1-2-4-21(17)35-22/h1-13,20,28H,14H2,(H2,26,29)(H,27,30)(H,31,32)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170299
((S)-3-Methyl-2-{4'-[([1,2,3]thiadiazole-4-carbonyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2csnn2)cc1)C(O)=O Show InChI InChI=1S/C20H20N4O5S2/c1-12(2)18(20(26)27)23-31(28,29)16-9-5-14(6-10-16)13-3-7-15(8-4-13)21-19(25)17-11-30-24-22-17/h3-12,18,23H,1-2H3,(H,21,25)(H,26,27)/t18-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Transcription intermediary factor 1-alpha
(Homo sapiens (Human)) | BDBM50150822
(CHEMBL3775348)Show SMILES CCCOc1cc(OCCCCCN)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2cn(C)cn2)c1 Show InChI InChI=1S/C27H36N6O6S/c1-5-10-37-19-12-20(38-11-8-6-7-9-28)14-21(13-19)39-25-16-24-23(32(3)27(34)33(24)4)15-22(25)30-40(35,36)26-17-31(2)18-29-26/h12-18,30H,5-11,28H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins... |
J Med Chem 59: 1440-54 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00405 BindingDB Entry DOI: 10.7270/Q26975F4 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170291
((S)-2-{4'-[(7-Methoxy-benzofuran-2-carbonyl)-amino...)Show SMILES COc1cccc2cc(oc12)C(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C27H26N2O7S/c1-16(2)24(27(31)32)29-37(33,34)21-13-9-18(10-14-21)17-7-11-20(12-8-17)28-26(30)23-15-19-5-4-6-22(35-3)25(19)36-23/h4-16,24,29H,1-3H3,(H,28,30)(H,31,32)/t24-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM50033408
(CHEMBL3357656)Show SMILES [H][C@]12CCCO[C@]1([H])[C@@]1(N=C(N)N(C)C1=O)c1cc(ccc1O2)-c1cccnc1F |r,t:10| Show InChI InChI=1S/C20H19FN4O3/c1-25-18(26)20(24-19(25)22)13-10-11(12-4-2-8-23-17(12)21)6-7-14(13)28-15-5-3-9-27-16(15)20/h2,4,6-8,10,15-16H,3,5,9H2,1H3,(H2,22,24)/t15-,16-,20-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assay |
J Med Chem 57: 10112-29 (2014)
Article DOI: 10.1021/jm5015132 BindingDB Entry DOI: 10.7270/Q2348N0T |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM50033406
(CHEMBL3357658)Show SMILES [H][C@]12OCCC[C@]1(C)Oc1ccc(cc1[C@]21N=C(N)N(C)C1=O)-c1cccnc1F |r,t:19| Show InChI InChI=1S/C21H21FN4O3/c1-20-8-4-10-28-17(20)21(18(27)26(2)19(23)25-21)14-11-12(6-7-15(14)29-20)13-5-3-9-24-16(13)22/h3,5-7,9,11,17H,4,8,10H2,1-2H3,(H2,23,25)/t17-,20-,21-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assay |
J Med Chem 57: 10112-29 (2014)
Article DOI: 10.1021/jm5015132 BindingDB Entry DOI: 10.7270/Q2348N0T |
More data for this Ligand-Target Pair | |
Transcription intermediary factor 1-alpha
(Homo sapiens (Human)) | BDBM50150756
(CHEMBL3774766)Show SMILES CCCOc1cc(OCCCCCCN)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)c1 Show InChI InChI=1S/C32H42N4O8S/c1-6-14-42-22-16-23(43-15-10-8-7-9-13-33)18-24(17-22)44-30-21-28-27(35(2)32(37)36(28)3)20-26(30)34-45(38,39)25-11-12-29(40-4)31(19-25)41-5/h11-12,16-21,34H,6-10,13-15,33H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins... |
J Med Chem 59: 1440-54 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00405 BindingDB Entry DOI: 10.7270/Q26975F4 |
More data for this Ligand-Target Pair | |
Transcription intermediary factor 1-alpha
(Homo sapiens (Human)) | BDBM50150819
(CHEMBL3774542)Show SMILES CCCOc1cc(OCCCN)cc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)c1 Show InChI InChI=1S/C29H36N4O8S/c1-6-11-39-19-13-20(40-12-7-10-30)15-21(14-19)41-27-18-25-24(32(2)29(34)33(25)3)17-23(27)31-42(35,36)22-8-9-26(37-4)28(16-22)38-5/h8-9,13-18,31H,6-7,10-12,30H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas MD Anderson Cancer Center
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ... |
J Med Chem 59: 1440-54 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00405 BindingDB Entry DOI: 10.7270/Q26975F4 |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170303
((S)-2-[4'-(3-Methoxy-benzoylamino)-biphenyl-4-sulf...)Show SMILES COc1cccc(c1)C(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C25H26N2O6S/c1-16(2)23(25(29)30)27-34(31,32)22-13-9-18(10-14-22)17-7-11-20(12-8-17)26-24(28)19-5-4-6-21(15-19)33-3/h4-16,23,27H,1-3H3,(H,26,28)(H,29,30)/t23-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170303
((S)-2-[4'-(3-Methoxy-benzoylamino)-biphenyl-4-sulf...)Show SMILES COc1cccc(c1)C(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C25H26N2O6S/c1-16(2)23(25(29)30)27-34(31,32)22-13-9-18(10-14-22)17-7-11-20(12-8-17)26-24(28)19-5-4-6-21(15-19)33-3/h4-16,23,27H,1-3H3,(H,26,28)(H,29,30)/t23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170293
((S)-2-(4'-{[4-(1-Carboxy-ethoxy)-benzofuran-2-carb...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3c(OC(C)C(O)=O)cccc3o2)cc1)C(O)=O Show InChI InChI=1S/C29H28N2O9S/c1-16(2)26(29(35)36)31-41(37,38)21-13-9-19(10-14-21)18-7-11-20(12-8-18)30-27(32)25-15-22-23(39-17(3)28(33)34)5-4-6-24(22)40-25/h4-17,26,31H,1-3H3,(H,30,32)(H,33,34)(H,35,36)/t17?,26-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170298
((S)-2-{4'-[(4-Methoxy-benzofuran-2-carbonyl)-amino...)Show SMILES COc1cccc2oc(cc12)C(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C27H26N2O7S/c1-16(2)25(27(31)32)29-37(33,34)20-13-9-18(10-14-20)17-7-11-19(12-8-17)28-26(30)24-15-21-22(35-3)5-4-6-23(21)36-24/h4-16,25,29H,1-3H3,(H,28,30)(H,31,32)/t25-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM50432512
(CHEMBL2349468)Show SMILES CN1C(N)=N[C@@]2(CC(C)(C)Cc3ccc(cc23)-c2cccc(c2)C#N)C1=O |r,c:3| Show InChI InChI=1S/C22H22N4O/c1-21(2)11-17-8-7-16(15-6-4-5-14(9-15)12-23)10-18(17)22(13-21)19(27)26(3)20(24)25-22/h4-10H,11,13H2,1-3H3,(H2,24,25)/t22-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly... |
J Med Chem 56: 3379-403 (2013)
Article DOI: 10.1021/jm4002154 BindingDB Entry DOI: 10.7270/Q2JD4Z52 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170297
((S)-2-{4'-[(1H-Indole-2-carbonyl)-amino]-biphenyl-...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3[nH]2)cc1)C(O)=O Show InChI InChI=1S/C26H25N3O5S/c1-16(2)24(26(31)32)29-35(33,34)21-13-9-18(10-14-21)17-7-11-20(12-8-17)27-25(30)23-15-19-5-3-4-6-22(19)28-23/h3-16,24,28-29H,1-2H3,(H,27,30)(H,31,32)/t24-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50170288
((S)-2-{4'-[(5-Benzenesulfonylamino-benzofuran-2-ca...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3cc(NS(=O)(=O)c4ccccc4)ccc3o2)cc1)C(O)=O Show InChI InChI=1S/C32H29N3O8S2/c1-20(2)30(32(37)38)35-45(41,42)27-15-10-22(11-16-27)21-8-12-24(13-9-21)33-31(36)29-19-23-18-25(14-17-28(23)43-29)34-44(39,40)26-6-4-3-5-7-26/h3-20,30,34-35H,1-2H3,(H,33,36)(H,37,38)/t30-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-2 |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM50432513
(CHEMBL2349467)Show SMILES CN1C(N)=N[C@@]2(CC(C)(C)Oc3ccc(cc23)-c2cncc(Cl)c2)C1=O |r,c:3| Show InChI InChI=1S/C19H19ClN4O2/c1-18(2)10-19(16(25)24(3)17(21)23-19)14-7-11(4-5-15(14)26-18)12-6-13(20)9-22-8-12/h4-9H,10H2,1-3H3,(H2,21,23)/t19-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma
Curated by ChEMBL
| Assay Description Inhibition of human recombinant BACE1 expressed in CHO cells using biotin-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly... |
J Med Chem 56: 3379-403 (2013)
Article DOI: 10.1021/jm4002154 BindingDB Entry DOI: 10.7270/Q2JD4Z52 |
More data for this Ligand-Target Pair | |
Collagenase 3
(Bos taurus) | BDBM50170291
((S)-2-{4'-[(7-Methoxy-benzofuran-2-carbonyl)-amino...)Show SMILES COc1cccc2cc(oc12)C(=O)Nc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C27H26N2O7S/c1-16(2)24(27(31)32)29-37(33,34)21-13-9-18(10-14-21)17-7-11-20(12-8-17)28-26(30)23-15-19-5-4-6-22(35-3)25(19)36-23/h4-16,24,29H,1-3H3,(H,28,30)(H,31,32)/t24-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory concentration against MMP-13 of bovine articular cartilage explants |
Bioorg Med Chem Lett 15: 4105-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.019 BindingDB Entry DOI: 10.7270/Q2TX3DXK |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM50015538
(CHEMBL3265330)Show SMILES [H][C@@]12COCC[C@@]1([H])[C@]1(COC(N)=N1)c1cc(ccc1O2)-c1cncc(Cl)c1 |r,c:13| Show InChI InChI=1S/C19H18ClN3O3/c20-13-5-12(7-22-8-13)11-1-2-16-15(6-11)19(10-25-18(21)23-19)14-3-4-24-9-17(14)26-16/h1-2,5-8,14,17H,3-4,9-10H2,(H2,21,23)/t14-,17-,19-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc.
Curated by ChEMBL
| Assay Description Inhibition of BACE1 (unknown origin) assessed as amyloid beta production wild type APP expressing by cell based assay |
Bioorg Med Chem Lett 24: 2477-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.012 BindingDB Entry DOI: 10.7270/Q22J6DDC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |