Compile Data Set for Download or QSAR

Found 1572 hits with Last Name = 'hägebarth' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139736 (US8895549, 11) Show SMILES COc1c(OC[C@H](O)CN(C)C)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12 |r,c:31,t:15| Show InChI InChI=1S/C22H26N6O4/c1-27(2)12-15(29)13-32-17-7-6-16-18(19(17)31-3)25-22(28-10-9-24-20(16)28)26-21(30)14-5-4-8-23-11-14/h4-8,11,15,29H,9-10,12-13H2,1-3H3,(H,25,26,30)/t15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139746 (US8895549, 24) Show SMILES COc1c(OC[C@H](O)CN2CCCC2)ccc2C3=NCCN3C(NC(=O)c3cncnc3)=Nc12 |r,c:34,t:18| Show InChI InChI=1S/C23H27N7O4/c1-33-20-18(34-13-16(31)12-29-7-2-3-8-29)5-4-17-19(20)27-23(30-9-6-26-21(17)30)28-22(32)15-10-24-14-25-11-15/h4-5,10-11,14,16,31H,2-3,6-9,12-13H2,1H3,(H,27,28,32)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.99	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139750 (US8895549, 9) Show SMILES COc1c(OC[C@H](O)CN2CCCCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12 |r,c:35,t:19| Show InChI InChI=1S/C25H30N6O4/c1-34-22-20(35-16-18(32)15-30-11-3-2-4-12-30)8-7-19-21(22)28-25(31-13-10-27-23(19)31)29-24(33)17-6-5-9-26-14-17/h5-9,14,18,32H,2-4,10-13,15-16H2,1H3,(H,28,29,33)/t18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.02	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139741 (US8895549, 7) Show SMILES COc1c(OC[C@H](O)CN2CCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12 |r,c:33,t:17| Show InChI InChI=1S/C23H26N6O4/c1-32-20-18(33-14-16(30)13-28-9-3-10-28)6-5-17-19(20)26-23(29-11-8-25-21(17)29)27-22(31)15-4-2-7-24-12-15/h2,4-7,12,16,30H,3,8-11,13-14H2,1H3,(H,26,27,31)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.22	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312567 (1-[4-(6-Methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b...) Show SMILES COc1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1 Show InChI InChI=1S/C25H26N4O/c1-16-17(2)24(30-3)28-29-22(19-8-5-4-6-9-19)21(27-23(16)29)18-10-12-20(13-11-18)25(26)14-7-15-25/h4-6,8-13H,7,14-15,26H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312579 (US9604989, Example 65) Show SMILES CNC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1 Show InChI InChI=1S/C27H25N7O/c1-29-26(35)22-16-20(21-12-15-30-32-21)25-31-23(24(34(25)33-22)18-6-3-2-4-7-18)17-8-10-19(11-9-17)27(28)13-5-14-27/h2-4,6-12,15-16H,5,13-14,28H2,1H3,(H,29,35)(H,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312522 (2-[4-(1-Aminocyclobutyl)phenyl]-8-methoxy-3-phenyl...) Show SMILES COc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(C)=O Show InChI InChI=1S/C25H24N4O2/c1-16(30)20-15-21(31-2)24-27-22(23(29(24)28-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139743 (US8895549, 8) Show SMILES COc1c(OC[C@H](O)CN2CCCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12 |r,c:34,t:18| Show InChI InChI=1S/C24H28N6O4/c1-33-21-19(34-15-17(31)14-29-10-2-3-11-29)7-6-18-20(21)27-24(30-12-9-26-22(18)30)28-23(32)16-5-4-8-25-13-16/h4-8,13,17,31H,2-3,9-12,14-15H2,1H3,(H,27,28,32)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.62	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139754 (US8895549, 19) Show SMILES COc1c(OC[C@H](O)CN2CCCCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3C)=Nc12 |r,c:36,t:19| Show InChI InChI=1S/C26H32N6O4/c1-17-19(7-6-10-27-17)25(34)30-26-29-22-20(24-28-11-14-32(24)26)8-9-21(23(22)35-2)36-16-18(33)15-31-12-4-3-5-13-31/h6-10,18,33H,3-5,11-16H2,1-2H3,(H,29,30,34)/t18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.78	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139717 (US8895549, 2 | US9675616, 2 N-(8-{[(2R)-2-hydroxy-...) Show SMILES COc1c(OC[C@H](O)CN2CCOCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12 |r,c:35,t:19| Show InChI InChI=1S/C24H28N6O5/c1-33-21-19(35-15-17(31)14-29-9-11-34-12-10-29)5-4-18-20(21)27-24(30-8-7-26-22(18)30)28-23(32)16-3-2-6-25-13-16/h2-6,13,17,31H,7-12,14-15H2,1H3,(H,27,28,32)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.98	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139763 (US8895549, 37) Show SMILES COc1c(OC[C@H](O)CN2CCCCC2)ccc2C3=NCCN3C(NC(=O)c3cncs3)=Nc12 |r,c:34,t:19| Show InChI InChI=1S/C23H28N6O4S/c1-32-20-17(33-13-15(30)12-28-8-3-2-4-9-28)6-5-16-19(20)26-23(29-10-7-25-21(16)29)27-22(31)18-11-24-14-34-18/h5-6,11,14-15,30H,2-4,7-10,12-13H2,1H3,(H,26,27,31)/t15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.98	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337242 ((5S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...) Show SMILES OC[C@@H]1CCC(=O)N1c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r| Show InChI InChI=1S/C19H16N4O3/c24-11-13-5-8-19(25)22(13)18-7-6-17-20-10-14(23(17)21-18)16-9-12-3-1-2-4-15(12)26-16/h1-4,6-7,9-10,13,24H,5,8,11H2/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337246 ((2R)-2-hydroxy-N-[3-(4-methoxyfuro[3,2-c]pyridin-2...) Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(NC(=O)[C@@H](C)O)nn12 |r| Show InChI InChI=1S/C17H15N5O4/c1-9(23)16(24)20-14-3-4-15-19-8-11(22(15)21-14)13-7-10-12(26-13)5-6-18-17(10)25-2/h3-9,23H,1-2H3,(H,20,21,24)/t9-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337240 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES O=C(CCc1cccnc1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 Show InChI InChI=1S/C22H17N5O2/c28-22(10-7-15-4-3-11-23-13-15)25-20-8-9-21-24-14-17(27(21)26-20)19-12-16-5-1-2-6-18(16)29-19/h1-6,8-9,11-14H,7,10H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337234 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cccnc1 |w:1.0| Show InChI InChI=1S/C21H15N5O3/c27-20(14-5-3-9-22-11-14)21(28)24-18-7-8-19-23-12-15(26(19)25-18)17-10-13-4-1-2-6-16(13)29-17/h1-12,20,27H,(H,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337246 ((2R)-2-hydroxy-N-[3-(4-methoxyfuro[3,2-c]pyridin-2...) Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(NC(=O)[C@@H](C)O)nn12 |r| Show InChI InChI=1S/C17H15N5O4/c1-9(23)16(24)20-14-3-4-15-19-8-11(22(15)21-14)13-7-10-12(26-13)5-6-18-17(10)25-2/h3-9,23H,1-2H3,(H,20,21,24)/t9-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337242 ((5S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...) Show SMILES OC[C@@H]1CCC(=O)N1c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r| Show InChI InChI=1S/C19H16N4O3/c24-11-13-5-8-19(25)22(13)18-7-6-17-20-10-14(23(17)21-18)16-9-12-3-1-2-4-15(12)26-16/h1-4,6-7,9-10,13,24H,5,8,11H2/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337240 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES O=C(CCc1cccnc1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 Show InChI InChI=1S/C22H17N5O2/c28-22(10-7-15-4-3-11-23-13-15)25-20-8-9-21-24-14-17(27(21)26-20)19-12-16-5-1-2-6-18(16)29-19/h1-6,8-9,11-14H,7,10H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337234 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cccnc1 |w:1.0| Show InChI InChI=1S/C21H15N5O3/c27-20(14-5-3-9-22-11-14)21(28)24-18-7-8-19-23-12-15(26(19)25-18)17-10-13-4-1-2-6-16(13)29-17/h1-12,20,27H,(H,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139749 (US8895549, 40) Show SMILES COc1c(OC[C@H](O)CN2CCCC2)ccc2C3=NCCN3C(NC(=O)c3cnco3)=Nc12 |r,c:33,t:18| Show InChI InChI=1S/C22H26N6O5/c1-31-19-16(32-12-14(29)11-27-7-2-3-8-27)5-4-15-18(19)25-22(28-9-6-24-20(15)28)26-21(30)17-10-23-13-33-17/h4-5,10,13-14,29H,2-3,6-9,11-12H2,1H3,(H,25,26,30)/t14-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.09	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139752 (US8895549, 14) Show SMILES COc1c(OC[C@H](O)CN2CCOCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3C)=Nc12 |r,c:36,t:19| Show InChI InChI=1S/C25H30N6O5/c1-16-18(4-3-7-26-16)24(33)29-25-28-21-19(23-27-8-9-31(23)25)5-6-20(22(21)34-2)36-15-17(32)14-30-10-12-35-13-11-30/h3-7,17,32H,8-15H2,1-2H3,(H,28,29,33)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.09	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312579 (US9604989, Example 65) Show SMILES CNC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1 Show InChI InChI=1S/C27H25N7O/c1-29-26(35)22-16-20(21-12-15-30-32-21)25-31-23(24(34(25)33-22)18-6-3-2-4-7-18)17-8-10-19(11-9-17)27(28)13-5-14-27/h2-4,6-12,15-16H,5,13-14,28H2,1H3,(H,29,35)(H,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139747 (US8895549, 36) Show SMILES COc1c(OC[C@H](O)CN2CCCC2)ccc2C3=NCCN3C(NC(=O)c3cncs3)=Nc12 |r,c:33,t:18| Show InChI InChI=1S/C22H26N6O4S/c1-31-19-16(32-12-14(29)11-27-7-2-3-8-27)5-4-15-18(19)25-22(28-9-6-24-20(15)28)26-21(30)17-10-23-13-33-17/h4-5,10,13-14,29H,2-3,6-9,11-12H2,1H3,(H,25,26,30)/t14-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.41	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139727 (US8895549, 5) Show SMILES COc1c(OC[C@H](O)CN2CC3CCC(C2)O3)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12 |r,c:38,t:22| Show InChI InChI=1S/C26H30N6O5/c1-35-23-21(36-15-17(33)12-31-13-18-4-5-19(14-31)37-18)7-6-20-22(23)29-26(32-10-9-28-24(20)32)30-25(34)16-3-2-8-27-11-16/h2-3,6-8,11,17-19,33H,4-5,9-10,12-15H2,1H3,(H,29,30,34)/t17-,18?,19?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.68	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312575 (US9604989, Example 61) Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(N)=O Show InChI InChI=1S/C25H25N5O2/c1-2-32-20-15-19(23(26)31)29-30-22(17-7-4-3-5-8-17)21(28-24(20)30)16-9-11-18(12-10-16)25(27)13-6-14-25/h3-5,7-12,15H,2,6,13-14,27H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312548 (US9604989, Example 34) Show SMILES NC(=O)c1cc(C(N)=O)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1 Show InChI InChI=1S/C24H22N6O2/c25-21(31)17-13-18(22(26)32)29-30-20(15-5-2-1-3-6-15)19(28-23(17)30)14-7-9-16(10-8-14)24(27)11-4-12-24/h1-3,5-10,13H,4,11-12,27H2,(H2,25,31)(H2,26,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139745 (US8895549, 18) Show SMILES COc1c(OC[C@H](O)CN2CCCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3C)=Nc12 |r,c:35,t:18| Show InChI InChI=1S/C25H30N6O4/c1-16-18(6-5-9-26-16)24(33)29-25-28-21-19(23-27-10-13-31(23)25)7-8-20(22(21)34-2)35-15-17(32)14-30-11-3-4-12-30/h5-9,17,32H,3-4,10-15H2,1-2H3,(H,28,29,33)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312521 (1-[4-(6,8-Dimethyloxy-3-phenylimidazo[1,2-b]pyrida...) Show SMILES COc1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1 Show InChI InChI=1S/C24H24N4O2/c1-29-19-15-20(30-2)27-28-22(17-7-4-3-5-8-17)21(26-23(19)28)16-9-11-18(12-10-16)24(25)13-6-14-24/h3-5,7-12,15H,6,13-14,25H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139729 (US8895549, 16) Show SMILES COc1c(OC[C@H](O)CN2CCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3C)=Nc12 |r,c:34,t:17| Show InChI InChI=1S/C24H28N6O4/c1-15-17(5-3-8-25-15)23(32)28-24-27-20-18(22-26-9-12-30(22)24)6-7-19(21(20)33-2)34-14-16(31)13-29-10-4-11-29/h3,5-8,16,31H,4,9-14H2,1-2H3,(H,27,28,32)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.94	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM343673 (3-(1-Benzofuran-2-yl)-6-[2-(morpholin-2-yl)ethoxy]...) Show SMILES C(CC1CNCCO1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1 Show InChI InChI=1S/C20H20N4O3/c1-2-4-17-14(3-1)11-18(27-17)16-13-22-19-5-6-20(23-24(16)19)26-9-7-15-12-21-8-10-25-15/h1-6,11,13,15,21H,7-10,12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...				US Patent US9777004 (2017) BindingDB Entry DOI: 10.7270/Q2B27XDM
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM343674 (6-Chloro-3-(4-methoxy-1-benzofuran-2-yl)imidazo[1,...) Show SMILES C(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CNCCO1 Show InChI InChI=1S/C19H18N4O3/c1-2-4-16-13(3-1)9-17(26-16)15-11-21-18-5-6-19(22-23(15)18)25-12-14-10-20-7-8-24-14/h1-6,9,11,14,20H,7-8,10,12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...				US Patent US9777004 (2017) BindingDB Entry DOI: 10.7270/Q2B27XDM
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM343675 (6-Chloro-3-(5-methoxy-1-benzofuran-2-yl)imidazo[1,...) Show SMILES CC(C)(C)CNCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1 Show InChI InChI=1S/C22H26N4O2/c1-22(2,3)15-23-11-6-12-27-21-10-9-20-24-14-17(26(20)25-21)19-13-16-7-4-5-8-18(16)28-19/h4-5,7-10,13-14,23H,6,11-12,15H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description For the assay 50 nL of a 100fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384well microtiter plate (Gr...				US Patent US9777004 (2017) BindingDB Entry DOI: 10.7270/Q2B27XDM
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337244 ((2R)¿N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...) Show SMILES C[C@@H](O)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r| Show InChI InChI=1S/C17H14N4O3/c1-10(22)17(23)19-15-6-7-16-18-9-12(21(16)20-15)14-8-11-4-2-3-5-13(11)24-14/h2-10,22H,1H3,(H,19,20,23)/t10-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM151095 (US8987273, 4-2) Show SMILES COC(=O)c1cccc(c1)-c1cnc2cc(-c3ccccc3)c(nn12)-c1ccc(cc1)C1(N)CCC1 Show InChI InChI=1S/C30H26N4O2/c1-36-29(35)23-10-5-9-22(17-23)26-19-32-27-18-25(20-7-3-2-4-8-20)28(33-34(26)27)21-11-13-24(14-12-21)30(31)15-6-16-30/h2-5,7-14,17-19H,6,15-16,31H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	22
Bayer Intellectual Property GmbH US Patent					Assay Description Akt1 inhibitory activity of compounds of the present invention was quantified employing the Akt1 TR-FRET assay as described in the following paragrap...				US Patent US8987273 (2015) BindingDB Entry DOI: 10.7270/Q2CZ35WJ
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337236 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES OC(C1CCOCC1)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 |w:1.0| Show InChI InChI=1S/C21H20N4O4/c26-20(13-7-9-28-10-8-13)21(27)23-18-5-6-19-22-12-15(25(19)24-18)17-11-14-3-1-2-4-16(14)29-17/h1-6,11-13,20,26H,7-10H2,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337244 ((2R)¿N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...) Show SMILES C[C@@H](O)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r| Show InChI InChI=1S/C17H14N4O3/c1-10(22)17(23)19-15-6-7-16-18-9-12(21(16)20-15)14-8-11-4-2-3-5-13(11)24-14/h2-10,22H,1H3,(H,19,20,23)/t10-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337248 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES CC(C)CC(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 Show InChI InChI=1S/C19H18N4O2/c1-12(2)9-19(24)21-17-7-8-18-20-11-14(23(18)22-17)16-10-13-5-3-4-6-15(13)25-16/h3-8,10-12H,9H2,1-2H3,(H,21,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337236 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES OC(C1CCOCC1)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 |w:1.0| Show InChI InChI=1S/C21H20N4O4/c26-20(13-7-9-28-10-8-13)21(27)23-18-5-6-19-22-12-15(25(19)24-18)17-11-14-3-1-2-4-16(14)29-17/h1-6,11-13,20,26H,7-10H2,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337248 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES CC(C)CC(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 Show InChI InChI=1S/C19H18N4O2/c1-12(2)9-19(24)21-17-7-8-18-20-11-14(23(18)22-17)16-10-13-5-3-4-6-15(13)25-16/h3-8,10-12H,9H2,1-2H3,(H,21,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312522 (2-[4-(1-Aminocyclobutyl)phenyl]-8-methoxy-3-phenyl...) Show SMILES COc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(C)=O Show InChI InChI=1S/C25H24N4O2/c1-16(30)20-15-21(31-2)24-27-22(23(29(24)28-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312575 (US9604989, Example 61) Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(N)=O Show InChI InChI=1S/C25H25N5O2/c1-2-32-20-15-19(23(26)31)29-30-22(17-7-4-3-5-8-17)21(28-24(20)30)16-9-11-18(12-10-16)25(27)13-6-14-25/h3-5,7-12,15H,2,6,13-14,27H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139738 (US8895549, 20) Show SMILES COc1c(OC[C@H](O)CN(C(C)C)C(C)C)ccc2C3=NCCN3C(NC(=O)c3cccnc3C)=Nc12 |r,c:36,t:19| Show InChI InChI=1S/C27H36N6O4/c1-16(2)33(17(3)4)14-19(34)15-37-22-10-9-21-23(24(22)36-6)30-27(32-13-12-29-25(21)32)31-26(35)20-8-7-11-28-18(20)5/h7-11,16-17,19,34H,12-15H2,1-6H3,(H,30,31,35)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312518 (1-[4-(6-Methyloxy-3-phenylimidazo[1,2-b]pyridazin-...) Show SMILES COc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1 Show InChI InChI=1S/C23H22N4O/c1-28-20-13-12-19-25-21(22(27(19)26-20)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312587 (1-{4-[6-Methoxy-3-phenyl-8-(1H-pyrazol-3-yl)imidaz...) Show SMILES COc1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1 Show InChI InChI=1S/C26H24N6O/c1-33-22-16-20(21-12-15-28-30-21)25-29-23(24(32(25)31-22)18-6-3-2-4-7-18)17-8-10-19(11-9-17)26(27)13-5-14-26/h2-4,6-12,15-16H,5,13-14,27H2,1H3,(H,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312527 (US9604989, Example 15) Show SMILES COc1cc(-c2cn[nH]c2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1 Show InChI InChI=1S/C26H24N6O/c1-33-22-14-21(19-15-28-29-16-19)25-30-23(24(32(25)31-22)18-6-3-2-4-7-18)17-8-10-20(11-9-17)26(27)12-5-13-26/h2-4,6-11,14-16H,5,12-13,27H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139731 (US8895549, 28) Show SMILES COc1c(OC[C@H](O)CN2CC3CCC(C2)O3)ccc2C3=NCCN3C(NC(=O)c3cnc(N)nc3)=Nc12 |r,c:39,t:22| Show InChI InChI=1S/C25H30N8O5/c1-36-21-19(37-13-15(34)10-32-11-16-2-3-17(12-32)38-16)5-4-18-20(21)30-25(33-7-6-27-22(18)33)31-23(35)14-8-28-24(26)29-9-14/h4-5,8-9,15-17,34H,2-3,6-7,10-13H2,1H3,(H2,26,28,29)(H,30,31,35)/t15-,16?,17?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.71	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139737 (US8895549, 12) Show SMILES COc1c(OC[C@H](O)CN(C(C)C)C(C)C)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12 |r,c:35,t:19| Show InChI InChI=1S/C26H34N6O4/c1-16(2)32(17(3)4)14-19(33)15-36-21-9-8-20-22(23(21)35-5)29-26(31-12-11-28-24(20)31)30-25(34)18-7-6-10-27-13-18/h6-10,13,16-17,19,33H,11-12,14-15H2,1-5H3,(H,29,30,34)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.74	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM312578 (US9604989, Example 64) Show SMILES CNC(=O)c1cc(OCC2CC2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1 Show InChI InChI=1S/C28H29N5O2/c1-30-27(34)22-16-23(35-17-18-8-9-18)26-31-24(25(33(26)32-22)20-6-3-2-4-7-20)19-10-12-21(13-11-19)28(29)14-5-15-28/h2-4,6-7,10-13,16,18H,5,8-9,14-15,17,29H2,1H3,(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9604989 (2017) BindingDB Entry DOI: 10.7270/Q22N54BT
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139724 (US8895549, 4 | US9675616, 4 N-[8-({(2R)-3-[(2R,6S)...) Show SMILES COc1c(OC[C@H](O)CN2C[C@H](C)O[C@H](C)C2)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12 |r,c:37,t:21| Show InChI InChI=1S/C26H32N6O5/c1-16-12-31(13-17(2)37-16)14-19(33)15-36-21-7-6-20-22(23(21)35-3)29-26(32-10-9-28-24(20)32)30-25(34)18-5-4-8-27-11-18/h4-8,11,16-17,19,33H,9-10,12-15H2,1-3H3,(H,29,30,34)/t16-,17+,19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.85	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] (Homo sapiens (Human))	BDBM337243 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES OC(C1CC1)C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 |w:0.0| Show InChI InChI=1S/C19H16N4O3/c24-18(11-5-6-11)19(25)21-16-7-8-17-20-10-13(23(17)22-16)15-9-12-3-1-2-4-14(12)26-15/h1-4,7-11,18,24H,5-6H2,(H,21,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair

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