Found 181 hits with Last Name = 'harms' and Initial = 'cs' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50082930
(CHEMBL117662 | [6-(4-Carbamimidoyl-benzoylamino)-1...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2C(=O)C(CC(O)=O)CCc2c1 Show InChI InChI=1S/C20H19N3O4/c21-19(22)11-1-3-12(4-2-11)20(27)23-15-7-8-16-13(9-15)5-6-14(18(16)26)10-17(24)25/h1-4,7-9,14H,5-6,10H2,(H3,21,22)(H,23,27)(H,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin (GP IIb-IIIa) |
J Med Chem 42: 4875-89 (1999)
BindingDB Entry DOI: 10.7270/Q2NC60DZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50082930
(CHEMBL117662 | [6-(4-Carbamimidoyl-benzoylamino)-1...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2C(=O)C(CC(O)=O)CCc2c1 Show InChI InChI=1S/C20H19N3O4/c21-19(22)11-1-3-12(4-2-11)20(27)23-15-7-8-16-13(9-15)5-6-14(18(16)26)10-17(24)25/h1-4,7-9,14H,5-6,10H2,(H3,21,22)(H,23,27)(H,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISA |
Bioorg Med Chem Lett 10: 385-9 (2000)
BindingDB Entry DOI: 10.7270/Q2FB5252 |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50082933
(CHEMBL323720 | [6-(4-Carbamimidoyl-benzoylamino)-c...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2OC(CC(O)=O)CCc2c1 Show InChI InChI=1S/C19H19N3O4/c20-18(21)11-1-3-12(4-2-11)19(25)22-14-6-8-16-13(9-14)5-7-15(26-16)10-17(23)24/h1-4,6,8-9,15H,5,7,10H2,(H3,20,21)(H,22,25)(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISA |
Bioorg Med Chem Lett 10: 385-9 (2000)
BindingDB Entry DOI: 10.7270/Q2FB5252 |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50082933
(CHEMBL323720 | [6-(4-Carbamimidoyl-benzoylamino)-c...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2OC(CC(O)=O)CCc2c1 Show InChI InChI=1S/C19H19N3O4/c20-18(21)11-1-3-12(4-2-11)19(25)22-14-6-8-16-13(9-14)5-7-15(26-16)10-17(23)24/h1-4,6,8-9,15H,5,7,10H2,(H3,20,21)(H,22,25)(H,23,24) | PDB
KEGG
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin (GP IIb-IIIa) |
J Med Chem 42: 4875-89 (1999)
BindingDB Entry DOI: 10.7270/Q2NC60DZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50058914
(CHEMBL303597 | [6-(4-Carbamimidoyl-benzoylamino)-1...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2C(=O)N(CC(O)=O)CCc2c1 Show InChI InChI=1S/C19H18N4O4/c20-17(21)11-1-3-12(4-2-11)18(26)22-14-5-6-15-13(9-14)7-8-23(19(15)27)10-16(24)25/h1-6,9H,7-8,10H2,(H3,20,21)(H,22,26)(H,24,25) | PDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified Human alphaIIb-beta3 integrin in ELISA with 1% bovine serum albumin (BSA) |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50058928
(CHEMBL292795 | [6-(4-Carbamimidoyl-phenylcarbamoyl...)Show SMILES NC(=N)c1ccc(NC(=O)c2ccc3C(=O)N(CC(O)=O)CCc3c2)cc1 Show InChI InChI=1S/C19H18N4O4/c20-17(21)11-1-4-14(5-2-11)22-18(26)13-3-6-15-12(9-13)7-8-23(19(15)27)10-16(24)25/h1-6,9H,7-8,10H2,(H3,20,21)(H,22,26)(H,24,25) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to reduce binding of fibrinogen to purified Fibrinogen Receptor by 50% using ELISA |
J Med Chem 40: 2085-101 (1997)
Article DOI: 10.1021/jm9701076
BindingDB Entry DOI: 10.7270/Q23T9GBH |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50085605
(CHEMBL126411 | [6-(4-Carbamimidoyl-2-fluoro-benzoy...)Show SMILES NC(=N)c1ccc(C(=O)Nc2ccc3C(=O)C(CC(O)=O)CCc3c2)c(F)c1 Show InChI InChI=1S/C20H18FN3O4/c21-16-8-12(19(22)23)3-5-15(16)20(28)24-13-4-6-14-10(7-13)1-2-11(18(14)27)9-17(25)26/h3-8,11H,1-2,9H2,(H3,22,23)(H,24,28)(H,25,26) | PDB
KEGG
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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Similars
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISA |
Bioorg Med Chem Lett 10: 385-9 (2000)
BindingDB Entry DOI: 10.7270/Q2FB5252 |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50058914
(CHEMBL303597 | [6-(4-Carbamimidoyl-benzoylamino)-1...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2C(=O)N(CC(O)=O)CCc2c1 Show InChI InChI=1S/C19H18N4O4/c20-17(21)11-1-3-12(4-2-11)18(26)22-14-5-6-15-13(9-14)7-8-23(19(15)27)10-16(24)25/h1-6,9H,7-8,10H2,(H3,20,21)(H,22,26)(H,24,25) | PDB
KEGG
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin (GP IIb-IIIa) |
J Med Chem 42: 4875-89 (1999)
BindingDB Entry DOI: 10.7270/Q2NC60DZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50082932
(CHEMBL147258 | [6-(4-Carbamimidoyl-benzoylamino)-1...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2CC(CC(O)=O)CCc2c1 Show InChI InChI=1S/C20H21N3O3/c21-19(22)13-3-5-14(6-4-13)20(26)23-17-8-7-15-9-12(10-18(24)25)1-2-16(15)11-17/h3-8,11-12H,1-2,9-10H2,(H3,21,22)(H,23,26)(H,24,25) | PDB
KEGG
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antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin (GP IIb-IIIa) |
J Med Chem 42: 4875-89 (1999)
BindingDB Entry DOI: 10.7270/Q2NC60DZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50082931
(CHEMBL148205 | [6-(4-Carbamimidoyl-benzoylamino)-3...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2CN(CC(O)=O)CCc2c1 Show InChI InChI=1S/C19H20N4O3/c20-18(21)12-1-3-13(4-2-12)19(26)22-16-6-5-15-10-23(11-17(24)25)8-7-14(15)9-16/h1-6,9H,7-8,10-11H2,(H3,20,21)(H,22,26)(H,24,25) | PDB
KEGG
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin (GP IIb-IIIa) |
J Med Chem 42: 4875-89 (1999)
BindingDB Entry DOI: 10.7270/Q2NC60DZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50085612
(CHEMBL126485 | [6-(4-Carbamimidoyl-2,6-difluoro-be...)Show SMILES NC(=N)c1cc(F)c(C(=O)Nc2ccc3C(=O)C(CC(O)=O)CCc3c2)c(F)c1 Show InChI InChI=1S/C20H17F2N3O4/c21-14-6-11(19(23)24)7-15(22)17(14)20(29)25-12-3-4-13-9(5-12)1-2-10(18(13)28)8-16(26)27/h3-7,10H,1-2,8H2,(H3,23,24)(H,25,29)(H,26,27) | PDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISA |
Bioorg Med Chem Lett 10: 385-9 (2000)
BindingDB Entry DOI: 10.7270/Q2FB5252 |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290317
(4-{1-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihy...)Show SMILES COC(=O)c1ccc(cc1)C(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C28H27N3O6/c1-36-28(35)20-8-6-18(7-9-20)24(15-25(32)33)31-13-12-21-14-22(10-11-23(21)27(31)34)37-16-17-2-4-19(5-3-17)26(29)30/h2-11,14,24H,12-13,15-16H2,1H3,(H3,29,30)(H,32,33) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA test |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290324
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES NC(=N)c1ccc(COc2ccc3C(=O)N(CCc3c2)C(CC(O)=O)c2ccccc2)cc1 Show InChI InChI=1S/C26H25N3O4/c27-25(28)19-8-6-17(7-9-19)16-33-21-10-11-22-20(14-21)12-13-29(26(22)32)23(15-24(30)31)18-4-2-1-3-5-18/h1-11,14,23H,12-13,15-16H2,(H3,27,28)(H,30,31) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP). |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290319
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES COc1ccc(cc1)C(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C27H27N3O5/c1-34-21-8-6-18(7-9-21)24(15-25(31)32)30-13-12-20-14-22(10-11-23(20)27(30)33)35-16-17-2-4-19(5-3-17)26(28)29/h2-11,14,24H,12-13,15-16H2,1H3,(H3,28,29)(H,31,32) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA test |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50085611
(CHEMBL127680 | {6-[(6-Carbamimidoyl-pyridine-3-car...)Show SMILES NC(=N)c1ccc(cn1)C(=O)Nc1ccc2C(=O)C(CC(O)=O)CCc2c1 Show InChI InChI=1S/C19H18N4O4/c20-18(21)15-6-3-12(9-22-15)19(27)23-13-4-5-14-10(7-13)1-2-11(17(14)26)8-16(24)25/h3-7,9,11H,1-2,8H2,(H3,20,21)(H,23,27)(H,24,25) | PDB
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| CHEMBL
PC cid
PC sid
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Patents
| PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISA |
Bioorg Med Chem Lett 10: 385-9 (2000)
BindingDB Entry DOI: 10.7270/Q2FB5252 |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50085614
(CHEMBL338485 | [6-(4-Carbamimidoyl-2-chloro-benzoy...)Show SMILES NC(=N)c1ccc(C(=O)Nc2ccc3C(=O)C(CC(O)=O)CCc3c2)c(Cl)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-8-12(19(22)23)3-5-15(16)20(28)24-13-4-6-14-10(7-13)1-2-11(18(14)27)9-17(25)26/h3-8,11H,1-2,9H2,(H3,22,23)(H,24,28)(H,25,26) | PDB
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISA |
Bioorg Med Chem Lett 10: 385-9 (2000)
BindingDB Entry DOI: 10.7270/Q2FB5252 |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50059694
(7-[(6-Carbamimidoyl-1H-indazole-3-carbonyl)-amino]...)Show InChI InChI=1S/C16H21N5O3/c17-15(18)10-6-7-11-12(9-10)20-21-14(11)16(24)19-8-4-2-1-3-5-13(22)23/h6-7,9H,1-5,8H2,(H3,17,18)(H,19,24)(H,20,21)(H,22,23) | PDB
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PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonism of fibrinogen binding to a purified human fibrinogen receptor preparation. |
J Med Chem 40: 2843-57 (1997)
Article DOI: 10.1021/jm970020k
BindingDB Entry DOI: 10.7270/Q24M93MS |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290325
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C25H31N3O4/c1-2-3-4-5-20(15-23(29)30)28-13-12-19-14-21(10-11-22(19)25(28)31)32-16-17-6-8-18(9-7-17)24(26)27/h6-11,14,20H,2-5,12-13,15-16H2,1H3,(H3,26,27)(H,29,30) | PDB
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PC cid
PC sid
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| Article
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP). |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290325
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C25H31N3O4/c1-2-3-4-5-20(15-23(29)30)28-13-12-19-14-21(10-11-22(19)25(28)31)32-16-17-6-8-18(9-7-17)24(26)27/h6-11,14,20H,2-5,12-13,15-16H2,1H3,(H3,26,27)(H,29,30) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA test |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50085607
(CHEMBL126365 | [1-Oxo-6-((E)-3-piperidin-4-yl-acry...)Show SMILES OC(=O)CC1CCc2cc(NC(=O)\C=C\C3CCNCC3)ccc2C1=O Show InChI InChI=1S/C20H24N2O4/c23-18(6-1-13-7-9-21-10-8-13)22-16-4-5-17-14(11-16)2-3-15(20(17)26)12-19(24)25/h1,4-6,11,13,15,21H,2-3,7-10,12H2,(H,22,23)(H,24,25)/b6-1+ | PDB
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Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISA |
Bioorg Med Chem Lett 10: 385-9 (2000)
BindingDB Entry DOI: 10.7270/Q2FB5252 |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50082927
(CHEMBL344117 | [6-(4-Carbamimidoyl-benzyloxy)-1-ox...)Show SMILES NC(=N)c1ccc(COc2ccc3C(=O)C(CC(O)=O)CCc3c2)cc1 Show InChI InChI=1S/C20H20N2O4/c21-20(22)13-3-1-12(2-4-13)11-26-16-7-8-17-14(9-16)5-6-15(19(17)25)10-18(23)24/h1-4,7-9,15H,5-6,10-11H2,(H3,21,22)(H,23,24) | PDB
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin (GP IIb-IIIa) |
J Med Chem 42: 4875-89 (1999)
BindingDB Entry DOI: 10.7270/Q2NC60DZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50082928
(CHEMBL439620 | [6-(4-Carbamimidoyl-benzyloxy)-3,4-...)Show InChI InChI=1S/C19H21N3O3/c20-19(21)14-3-1-13(2-4-14)12-25-17-6-5-16-10-22(11-18(23)24)8-7-15(16)9-17/h1-6,9H,7-8,10-12H2,(H3,20,21)(H,23,24) | PDB
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Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin (GP IIb-IIIa) |
J Med Chem 42: 4875-89 (1999)
BindingDB Entry DOI: 10.7270/Q2NC60DZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50058924
(CHEMBL68183 | [6-(4-Carbamimidoyl-phenylethynyl)-1...)Show SMILES NC(=N)c1ccc(cc1)C#Cc1ccc2C(=O)N(CC(O)=O)CCc2c1 Show InChI InChI=1S/C20H17N3O3/c21-19(22)15-6-3-13(4-7-15)1-2-14-5-8-17-16(11-14)9-10-23(20(17)26)12-18(24)25/h3-8,11H,9-10,12H2,(H3,21,22)(H,24,25) | PDB
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| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to reduce binding of fibrinogen to purified Fibrinogen Receptor by 50% using ELISA |
J Med Chem 40: 2085-101 (1997)
Article DOI: 10.1021/jm9701076
BindingDB Entry DOI: 10.7270/Q23T9GBH |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50031565
((S)-3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propion...)Show SMILES NC(=N)c1ccc(NC(=O)CCC(=O)N[C@@H](CC(O)=O)C#C)cc1 Show InChI InChI=1S/C16H18N4O4/c1-2-11(9-15(23)24)19-13(21)7-8-14(22)20-12-5-3-10(4-6-12)16(17)18/h1,3-6,11H,7-9H2,(H3,17,18)(H,19,21)(H,20,22)(H,23,24)/t11-/m1/s1 | PDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition ADP-induced (fibrinogen-mediated) platelet aggregation in human platelet-rich plasma (PRP) |
J Med Chem 40: 2843-57 (1997)
Article DOI: 10.1021/jm970020k
BindingDB Entry DOI: 10.7270/Q24M93MS |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50082926
(CHEMBL144408 | [6-(4-Carbamimidoyl-benzyloxy)-chro...)Show InChI InChI=1S/C19H20N2O4/c20-19(21)13-3-1-12(2-4-13)11-24-15-7-8-17-14(9-15)5-6-16(25-17)10-18(22)23/h1-4,7-9,16H,5-6,10-11H2,(H3,20,21)(H,22,23) | PDB
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Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin (GP IIb-IIIa) |
J Med Chem 42: 4875-89 (1999)
BindingDB Entry DOI: 10.7270/Q2NC60DZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290316
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C24H29N3O4/c1-2-3-4-19(14-22(28)29)27-12-11-18-13-20(9-10-21(18)24(27)30)31-15-16-5-7-17(8-6-16)23(25)26/h5-10,13,19H,2-4,11-12,14-15H2,1H3,(H3,25,26)(H,28,29) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP). |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290325
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C25H31N3O4/c1-2-3-4-5-20(15-23(29)30)28-13-12-19-14-21(10-11-22(19)25(28)31)32-16-17-6-8-18(9-7-17)24(26)27/h6-11,14,20H,2-5,12-13,15-16H2,1H3,(H3,26,27)(H,29,30) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP). |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50059679
(7-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-...)Show InChI InChI=1S/C17H21N3O4/c18-16(19)11-6-7-13-12(9-11)10-14(24-13)17(23)20-8-4-2-1-3-5-15(21)22/h6-7,9-10H,1-5,8H2,(H3,18,19)(H,20,23)(H,21,22) | PDB
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| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonism of fibrinogen binding to a purified human fibrinogen receptor preparation. |
J Med Chem 40: 2843-57 (1997)
Article DOI: 10.1021/jm970020k
BindingDB Entry DOI: 10.7270/Q24M93MS |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290321
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCCCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C26H33N3O4/c1-2-3-4-5-6-21(16-24(30)31)29-14-13-20-15-22(11-12-23(20)26(29)32)33-17-18-7-9-19(10-8-18)25(27)28/h7-12,15,21H,2-6,13-14,16-17H2,1H3,(H3,27,28)(H,30,31) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA test |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290321
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCCCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C26H33N3O4/c1-2-3-4-5-6-21(16-24(30)31)29-14-13-20-15-22(11-12-23(20)26(29)32)33-17-18-7-9-19(10-8-18)25(27)28/h7-12,15,21H,2-6,13-14,16-17H2,1H3,(H3,27,28)(H,30,31) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA test |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290320
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C22H25N3O4/c1-2-17(12-20(26)27)25-10-9-16-11-18(7-8-19(16)22(25)28)29-13-14-3-5-15(6-4-14)21(23)24/h3-8,11,17H,2,9-10,12-13H2,1H3,(H3,23,24)(H,26,27) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified Human alphaIIb-beta3 integrin in ELISA with 4.5% bovine serum albumin (BSA) |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290326
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C23H27N3O4/c1-2-3-18(13-21(27)28)26-11-10-17-12-19(8-9-20(17)23(26)29)30-14-15-4-6-16(7-5-15)22(24)25/h4-9,12,18H,2-3,10-11,13-14H2,1H3,(H3,24,25)(H,27,28) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA test |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50058908
(CHEMBL67520 | {6-[(E)-2-(4-Carbamimidoyl-phenyl)-v...)Show SMILES NC(=N)c1ccc(\C=C\c2ccc3C(=O)N(CC(O)=O)CCc3c2)cc1 Show InChI InChI=1S/C20H19N3O3/c21-19(22)15-6-3-13(4-7-15)1-2-14-5-8-17-16(11-14)9-10-23(20(17)26)12-18(24)25/h1-8,11H,9-10,12H2,(H3,21,22)(H,24,25)/b2-1+ | PDB
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| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to reduce binding of fibrinogen to purified Fibrinogen Receptor by 50% using ELISA |
J Med Chem 40: 2085-101 (1997)
Article DOI: 10.1021/jm9701076
BindingDB Entry DOI: 10.7270/Q23T9GBH |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290323
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES COCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C24H29N3O5/c1-31-12-2-3-19(14-22(28)29)27-11-10-18-13-20(8-9-21(18)24(27)30)32-15-16-4-6-17(7-5-16)23(25)26/h4-9,13,19H,2-3,10-12,14-15H2,1H3,(H3,25,26)(H,28,29) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP). |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290315
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCOCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C25H31N3O5/c1-2-32-13-3-4-20(15-23(29)30)28-12-11-19-14-21(9-10-22(19)25(28)31)33-16-17-5-7-18(8-6-17)24(26)27/h5-10,14,20H,2-4,11-13,15-16H2,1H3,(H3,26,27)(H,29,30) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA test |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290315
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCOCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C25H31N3O5/c1-2-32-13-3-4-20(15-23(29)30)28-12-11-19-14-21(9-10-22(19)25(28)31)33-16-17-5-7-18(8-6-17)24(26)27/h5-10,14,20H,2-4,11-13,15-16H2,1H3,(H3,26,27)(H,29,30) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP). |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50085610
(CHEMBL127200 | [1-Oxo-6-(3-piperidin-4-yl-propiony...)Show InChI InChI=1S/C20H26N2O4/c23-18(6-1-13-7-9-21-10-8-13)22-16-4-5-17-14(11-16)2-3-15(20(17)26)12-19(24)25/h4-5,11,13,15,21H,1-3,6-10,12H2,(H,22,23)(H,24,25) | PDB
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| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISA |
Bioorg Med Chem Lett 10: 385-9 (2000)
BindingDB Entry DOI: 10.7270/Q2FB5252 |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50085606
(CHEMBL127355 | [6-(4-Carbamimidoyl-2-trifluorometh...)Show SMILES NC(=N)c1ccc(C(=O)Nc2ccc3C(=O)C(CC(O)=O)CCc3c2)c(c1)C(F)(F)F Show InChI InChI=1S/C21H18F3N3O4/c22-21(23,24)16-8-12(19(25)26)3-5-15(16)20(31)27-13-4-6-14-10(7-13)1-2-11(18(14)30)9-17(28)29/h3-8,11H,1-2,9H2,(H3,25,26)(H,27,31)(H,28,29) | PDB
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| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISA |
Bioorg Med Chem Lett 10: 385-9 (2000)
BindingDB Entry DOI: 10.7270/Q2FB5252 |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290315
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCOCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C25H31N3O5/c1-2-32-13-3-4-20(15-23(29)30)28-12-11-19-14-21(9-10-22(19)25(28)31)33-16-17-5-7-18(8-6-17)24(26)27/h5-10,14,20H,2-4,11-13,15-16H2,1H3,(H3,26,27)(H,29,30) | PDB
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| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified Human alphaIIb-beta3 integrin in ELISA with 4.5% bovine serum albumin (BSA) |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50058914
(CHEMBL303597 | [6-(4-Carbamimidoyl-benzoylamino)-1...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2C(=O)N(CC(O)=O)CCc2c1 Show InChI InChI=1S/C19H18N4O4/c20-17(21)11-1-3-12(4-2-11)18(26)22-14-5-6-15-13(9-14)7-8-23(19(15)27)10-16(24)25/h1-6,9H,7-8,10H2,(H3,20,21)(H,22,26)(H,24,25) | PDB
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| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to reduce binding of fibrinogen to purified Fibrinogen Receptor by 50% using ELISA |
J Med Chem 40: 2085-101 (1997)
Article DOI: 10.1021/jm9701076
BindingDB Entry DOI: 10.7270/Q23T9GBH |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290321
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCCCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C26H33N3O4/c1-2-3-4-5-6-21(16-24(30)31)29-14-13-20-15-22(11-12-23(20)26(29)32)33-17-18-7-9-19(10-8-18)25(27)28/h7-12,15,21H,2-6,13-14,16-17H2,1H3,(H3,27,28)(H,30,31) | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified Human alphaIIb-beta3 integrin in ELISA with 0.1% bovine serum albumin (BSA) |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290322
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES COCCOCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C24H29N3O6/c1-31-10-11-32-15-19(13-22(28)29)27-9-8-18-12-20(6-7-21(18)24(27)30)33-14-16-2-4-17(5-3-16)23(25)26/h2-7,12,19H,8-11,13-15H2,1H3,(H3,25,26)(H,28,29) | PDB
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| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP). |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50058914
(CHEMBL303597 | [6-(4-Carbamimidoyl-benzoylamino)-1...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccc2C(=O)N(CC(O)=O)CCc2c1 Show InChI InChI=1S/C19H18N4O4/c20-17(21)11-1-3-12(4-2-11)18(26)22-14-5-6-15-13(9-14)7-8-23(19(15)27)10-16(24)25/h1-6,9H,7-8,10H2,(H3,20,21)(H,22,26)(H,24,25) | PDB
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| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP) |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290325
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C25H31N3O4/c1-2-3-4-5-20(15-23(29)30)28-13-12-19-14-21(10-11-22(19)25(28)31)32-16-17-6-8-18(9-7-17)24(26)27/h6-11,14,20H,2-5,12-13,15-16H2,1H3,(H3,26,27)(H,29,30) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP). |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290328
(CHEMBL87318 | [(5S,8S,14S,22R,24aS)-22-Carbamoyl-1...)Show SMILES CC1(C)SSCCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N2CCC[C@H]2C(=O)N[C@@H]1C(N)=O Show InChI InChI=1S/C36H51N11O9S2/c1-36(2)29(30(37)52)46-33(55)25-10-6-13-47(25)34(56)24(15-19-17-41-21-8-4-3-7-20(19)21)45-32(54)23(16-28(50)51)44-27(49)18-42-31(53)22(9-5-12-40-35(38)39)43-26(48)11-14-57-58-36/h3-4,7-8,17,22-25,29,41H,5-6,9-16,18H2,1-2H3,(H2,37,52)(H,42,53)(H,43,48)(H,44,49)(H,45,54)(H,46,55)(H,50,51)(H4,38,39,40)/t22-,23-,24-,25-,29+/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP). |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50059688
(7-[(6-Carbamimidoyl-1H-indole-3-carbonyl)-amino]-h...)Show InChI InChI=1S/C17H22N4O3/c18-16(19)11-6-7-12-13(10-21-14(12)9-11)17(24)20-8-4-2-1-3-5-15(22)23/h6-7,9-10,21H,1-5,8H2,(H3,18,19)(H,20,24)(H,22,23) | PDB
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonism of fibrinogen binding to a purified human fibrinogen receptor preparation. |
J Med Chem 40: 2843-57 (1997)
Article DOI: 10.1021/jm970020k
BindingDB Entry DOI: 10.7270/Q24M93MS |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290315
(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)Show SMILES CCOCCCC(CC(O)=O)N1CCc2cc(OCc3ccc(cc3)C(N)=N)ccc2C1=O Show InChI InChI=1S/C25H31N3O5/c1-2-32-13-3-4-20(15-23(29)30)28-12-11-19-14-21(9-10-22(19)25(28)31)33-16-17-5-7-18(8-6-17)24(26)27/h5-10,14,20H,2-4,11-13,15-16H2,1H3,(H3,26,27)(H,29,30) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA test |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50290328
(CHEMBL87318 | [(5S,8S,14S,22R,24aS)-22-Carbamoyl-1...)Show SMILES CC1(C)SSCCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N2CCC[C@H]2C(=O)N[C@@H]1C(N)=O Show InChI InChI=1S/C36H51N11O9S2/c1-36(2)29(30(37)52)46-33(55)25-10-6-13-47(25)34(56)24(15-19-17-41-21-8-4-3-7-20(19)21)45-32(54)23(16-28(50)51)44-27(49)18-42-31(53)22(9-5-12-40-35(38)39)43-26(48)11-14-57-58-36/h3-4,7-8,17,22-25,29,41H,5-6,9-16,18H2,1-2H3,(H2,37,52)(H,42,53)(H,43,48)(H,44,49)(H,45,54)(H,46,55)(H,50,51)(H4,38,39,40)/t22-,23-,24-,25-,29+/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of fibrinogen binding to purified Human alphaIIb-beta3 integrin in ELISA with 1% bovine serum albumin (BSA) |
Bioorg Med Chem Lett 7: 2537-2542 (1997)
Article DOI: 10.1016/S0960-894X(97)10014-2
BindingDB Entry DOI: 10.7270/Q2WD40KZ |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50059688
(7-[(6-Carbamimidoyl-1H-indole-3-carbonyl)-amino]-h...)Show InChI InChI=1S/C17H22N4O3/c18-16(19)11-6-7-12-13(10-21-14(12)9-11)17(24)20-8-4-2-1-3-5-15(22)23/h6-7,9-10,21H,1-5,8H2,(H3,18,19)(H,20,24)(H,22,23) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of Vascular endothelial growth factor receptor 2 (KDR) |
Bioorg Med Chem Lett 6: 81-86 (1996)
Article DOI: 10.1016/0960-894X(95)00563-9
BindingDB Entry DOI: 10.7270/Q2445MGV |
More data for this
Ligand-Target Pair | |
Integrin alpha-IIb/beta-3
(Homo sapiens (Human)) | BDBM50058920
(CHEMBL66669 | {6-[2-(4-Carbamimidoyl-phenyl)-ethyl...)Show SMILES NC(=N)c1ccc(CCc2ccc3C(=O)N(CC(O)=O)CCc3c2)cc1 Show InChI InChI=1S/C20H21N3O3/c21-19(22)15-6-3-13(4-7-15)1-2-14-5-8-17-16(11-14)9-10-23(20(17)26)12-18(24)25/h3-8,11H,1-2,9-10,12H2,(H3,21,22)(H,24,25) | PDB
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to reduce binding of fibrinogen to purified Fibrinogen Receptor by 50% using ELISA |
J Med Chem 40: 2085-101 (1997)
Article DOI: 10.1021/jm9701076
BindingDB Entry DOI: 10.7270/Q23T9GBH |
More data for this
Ligand-Target Pair | |
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