Found 148 hits with Last Name = 'johannessen' and Initial = 'l' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109431
(CHEMBL3601113)Show SMILES CN(C)CCn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C21H25ClN8O/c1-4-19(31)26-16-7-5-6-15(10-16)11-23-20-18(22)13-24-21(28-20)27-17-12-25-30(14-17)9-8-29(2)3/h4-7,10,12-14H,1,8-9,11H2,2-3H3,(H,26,31)(H2,23,24,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109427
(CHEMBL3601109)Show SMILES CNC(=O)Cn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C20H21ClN8O2/c1-3-17(30)26-14-6-4-5-13(7-14)8-23-19-16(21)10-24-20(28-19)27-15-9-25-29(11-15)12-18(31)22-2/h3-7,9-11H,1,8,12H2,2H3,(H,22,31)(H,26,30)(H2,23,24,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109426
(CHEMBL3600393)Show SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C24H27ClN8O2/c1-3-22(35)29-18-6-4-5-17(11-18)12-26-23-21(25)14-27-24(31-23)30-19-13-28-33(15-19)20-7-9-32(10-8-20)16(2)34/h3-6,11,13-15,20H,1,7-10,12H2,2H3,(H,29,35)(H2,26,27,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109424
(CHEMBL3601107)Show SMILES FC(F)Cn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C19H18ClF2N7O/c1-2-17(30)26-13-5-3-4-12(6-13)7-23-18-15(20)9-24-19(28-18)27-14-8-25-29(10-14)11-16(21)22/h2-6,8-10,16H,1,7,11H2,(H,26,30)(H2,23,24,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109432
(CHEMBL3601114)Show SMILES Clc1cnc(Nc2cnn(CCN3CCOCC3)c2)nc1NCc1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C23H27ClN8O2/c1-2-21(33)28-18-5-3-4-17(12-18)13-25-22-20(24)15-26-23(30-22)29-19-14-27-32(16-19)7-6-31-8-10-34-11-9-31/h2-5,12,14-16H,1,6-11,13H2,(H,28,33)(H2,25,26,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109433
(CHEMBL3601116)Show SMILES CCOCCn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C21H24ClN7O2/c1-3-19(30)26-16-7-5-6-15(10-16)11-23-20-18(22)13-24-21(28-20)27-17-12-25-29(14-17)8-9-31-4-2/h3,5-7,10,12-14H,1,4,8-9,11H2,2H3,(H,26,30)(H2,23,24,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109490
(CHEMBL3601117)Show SMILES CC(C)OCCn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C22H26ClN7O2/c1-4-20(31)27-17-7-5-6-16(10-17)11-24-21-19(23)13-25-22(29-21)28-18-12-26-30(14-18)8-9-32-15(2)3/h4-7,10,12-15H,1,8-9,11H2,2-3H3,(H,27,31)(H2,24,25,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109528
(CHEMBL3601115)Show SMILES COCCn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C20H22ClN7O2/c1-3-18(29)25-15-6-4-5-14(9-15)10-22-19-17(21)12-23-20(27-19)26-16-11-24-28(13-16)7-8-30-2/h3-6,9,11-13H,1,7-8,10H2,2H3,(H,25,29)(H2,22,23,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109527
(CHEMBL3601120)Show SMILES OCCn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C19H20ClN7O2/c1-2-17(29)24-14-5-3-4-13(8-14)9-21-18-16(20)11-22-19(26-18)25-15-10-23-27(12-15)6-7-28/h2-5,8,10-12,28H,1,6-7,9H2,(H,24,29)(H2,21,22,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109428
(CHEMBL3601110)Show SMILES FC(F)(F)CNC(=O)Cn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C21H20ClF3N8O2/c1-2-17(34)30-14-5-3-4-13(6-14)7-26-19-16(22)9-27-20(32-19)31-15-8-29-33(10-15)11-18(35)28-12-21(23,24)25/h2-6,8-10H,1,7,11-12H2,(H,28,35)(H,30,34)(H2,26,27,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109502
(CHEMBL3601706)Show SMILES Cn1cc(Nc2ncc(Cl)c(NCc3ccc(NC(=O)C=C)cc3)n2)cn1 Show InChI InChI=1S/C18H18ClN7O/c1-3-16(27)23-13-6-4-12(5-7-13)8-20-17-15(19)10-21-18(25-17)24-14-9-22-26(2)11-14/h3-7,9-11H,1,8H2,2H3,(H,23,27)(H2,20,21,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109493
(CHEMBL3601121)Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C21H24ClN7O2/c1-4-18(30)26-15-7-5-6-14(8-15)9-23-19-17(22)11-24-20(28-19)27-16-10-25-29(12-16)13-21(2,3)31/h4-8,10-12,31H,1,9,13H2,2-3H3,(H,26,30)(H2,23,24,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109492
(CHEMBL3601119)Show SMILES COCC(C)(C)n1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C22H26ClN7O2/c1-5-19(31)27-16-8-6-7-15(9-16)10-24-20-18(23)12-25-21(29-20)28-17-11-26-30(13-17)22(2,3)14-32-4/h5-9,11-13H,1,10,14H2,2-4H3,(H,27,31)(H2,24,25,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109430
(CHEMBL3601112)Show SMILES Clc1cnc(Nc2cnn(CC(=O)N3CCOCC3)c2)nc1NCc1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C23H25ClN8O3/c1-2-20(33)28-17-5-3-4-16(10-17)11-25-22-19(24)13-26-23(30-22)29-18-12-27-32(14-18)15-21(34)31-6-8-35-9-7-31/h2-5,10,12-14H,1,6-9,11,15H2,(H,28,33)(H2,25,26,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109529
(CHEMBL3601242)Show SMILES Cn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C18H18ClN7O/c1-3-16(27)23-13-6-4-5-12(7-13)8-20-17-15(19)10-21-18(25-17)24-14-9-22-26(2)11-14/h3-7,9-11H,1,8H2,2H3,(H,23,27)(H2,20,21,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109509
(CHEMBL3601713)Show SMILES CN(Cc1cccc(NC(=O)C=C)c1)c1nc(Nc2cnn(C)c2)ncc1Cl Show InChI InChI=1S/C19H20ClN7O/c1-4-17(28)23-14-7-5-6-13(8-14)11-26(2)18-16(20)10-21-19(25-18)24-15-9-22-27(3)12-15/h4-10,12H,1,11H2,2-3H3,(H,23,28)(H,21,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109519
(CHEMBL3601723)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cccc(NC(=O)C=C)c4)c3n2)cc1 Show InChI InChI=1S/C27H29N7O/c1-3-25(35)29-23-6-4-5-20(17-23)19-34-12-11-21-18-28-27(31-26(21)34)30-22-7-9-24(10-8-22)33-15-13-32(2)14-16-33/h3-12,17-18H,1,13-16,19H2,2H3,(H,29,35)(H,28,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109491
(CHEMBL3601118)Show SMILES FC(F)OCCn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C20H20ClF2N7O2/c1-2-17(31)27-14-5-3-4-13(8-14)9-24-18-16(21)11-25-20(29-18)28-15-10-26-30(12-15)6-7-32-19(22)23/h2-5,8,10-12,19H,1,6-7,9H2,(H,27,31)(H2,24,25,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109425
(CHEMBL3601108)Show SMILES Clc1cnc(Nc2cnn(c2)C2CCOCC2)nc1NCc1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C22H24ClN7O2/c1-2-20(31)27-16-5-3-4-15(10-16)11-24-21-19(23)13-25-22(29-21)28-17-12-26-30(14-17)18-6-8-32-9-7-18/h2-5,10,12-14,18H,1,6-9,11H2,(H,27,31)(H2,24,25,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109501
(CHEMBL3601705)Show SMILES Clc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C24H25ClN6O2/c1-2-22(32)28-18-5-3-17(4-6-18)15-26-23-21(25)16-27-24(30-23)29-19-7-9-20(10-8-19)31-11-13-33-14-12-31/h2-10,16H,1,11-15H2,(H,28,32)(H2,26,27,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.870 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109413
(CHEMBL3601233)Show SMILES Fc1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)ccc1N1CCOCC1 Show InChI InChI=1S/C24H24ClFN6O2/c1-2-22(33)29-17-5-3-4-16(12-17)14-27-23-19(25)15-28-24(31-23)30-18-6-7-21(20(26)13-18)32-8-10-34-11-9-32/h2-7,12-13,15H,1,8-11,14H2,(H,29,33)(H2,27,28,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109408
(CHEMBL3601227)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cc1F Show InChI InChI=1S/C25H27ClFN7O/c1-3-23(35)30-18-6-4-5-17(13-18)15-28-24-20(26)16-29-25(32-24)31-19-7-8-22(21(27)14-19)34-11-9-33(2)10-12-34/h3-8,13-14,16H,1,9-12,15H2,2H3,(H,30,35)(H2,28,29,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109522
(CHEMBL3601726)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CNC(=O)N(Cc4cccc(NC(=O)C=C)c4)c3n2)cc1 Show InChI InChI=1S/C27H30N8O2/c1-3-24(36)30-22-6-4-5-19(15-22)18-35-25-20(17-29-27(35)37)16-28-26(32-25)31-21-7-9-23(10-8-21)34-13-11-33(2)12-14-34/h3-10,15-16H,1,11-14,17-18H2,2H3,(H,29,37)(H,30,36)(H,28,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109429
(CHEMBL3601111)Show SMILES CN(C)C(=O)Cn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C21H23ClN8O2/c1-4-18(31)26-15-7-5-6-14(8-15)9-23-20-17(22)11-24-21(28-20)27-16-10-25-30(12-16)13-19(32)29(2)3/h4-8,10-12H,1,9,13H2,2-3H3,(H,26,31)(H2,23,24,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109508
(CHEMBL3601712)Show SMILES Cn1cc(Nc2ncc(Cl)c(SCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C18H17ClN6OS/c1-3-16(26)22-13-6-4-5-12(7-13)11-27-17-15(19)9-20-18(24-17)23-14-8-21-25(2)10-14/h3-10H,1,11H2,2H3,(H,22,26)(H,20,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109407
(CHEMBL3601226)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cc1 Show InChI InChI=1S/C25H28ClN7O/c1-3-23(34)29-20-6-4-5-18(15-20)16-27-24-22(26)17-28-25(31-24)30-19-7-9-21(10-8-19)33-13-11-32(2)12-14-33/h3-10,15,17H,1,11-14,16H2,2H3,(H,29,34)(H2,27,28,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109504
(CHEMBL3601708)Show SMILES COCCn1cc(Nc2ncc(Cl)c(NCc3ccc(NC(=O)C=C)cc3)n2)cn1 Show InChI InChI=1S/C20H22ClN7O2/c1-3-18(29)25-15-6-4-14(5-7-15)10-22-19-17(21)12-23-20(27-19)26-16-11-24-28(13-16)8-9-30-2/h3-7,11-13H,1,8-10H2,2H3,(H,25,29)(H2,22,23,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109531
(CHEMBL3601231)Show SMILES Clc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C24H25ClN6O2/c1-2-22(32)28-19-5-3-4-17(14-19)15-26-23-21(25)16-27-24(30-23)29-18-6-8-20(9-7-18)31-10-12-33-13-11-31/h2-9,14,16H,1,10-13,15H2,(H,28,32)(H2,26,27,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109423
(CHEMBL3601106)Show SMILES FC(F)n1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C18H16ClF2N7O/c1-2-15(29)25-12-5-3-4-11(6-12)7-22-16-14(19)9-23-18(27-16)26-13-8-24-28(10-13)17(20)21/h2-6,8-10,17H,1,7H2,(H,25,29)(H2,22,23,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109412
(CHEMBL3601232)Show SMILES Fc1cc(ccc1Nc1ncc(Cl)c(NCc2cccc(NC(=O)C=C)c2)n1)N1CCOCC1 Show InChI InChI=1S/C24H24ClFN6O2/c1-2-22(33)29-17-5-3-4-16(12-17)14-27-23-19(25)15-28-24(31-23)30-21-7-6-18(13-20(21)26)32-8-10-34-11-9-32/h2-7,12-13,15H,1,8-11,14H2,(H,29,33)(H2,27,28,30,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109506
(CHEMBL3601710)Show SMILES COCCn1cc(Nc2ncc(Cl)c(NC(C)c3cccc(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C21H24ClN7O2/c1-4-19(30)26-16-7-5-6-15(10-16)14(2)25-20-18(22)12-23-21(28-20)27-17-11-24-29(13-17)8-9-31-3/h4-7,10-14H,1,8-9H2,2-3H3,(H,26,30)(H2,23,25,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109421
(CHEMBL3601243)Show SMILES Cc1nn(C)cc1Nc1ncc(Cl)c(NCc2cccc(NC(=O)C=C)c2)n1 Show InChI InChI=1S/C19H20ClN7O/c1-4-17(28)23-14-7-5-6-13(8-14)9-21-18-15(20)10-22-19(25-18)24-16-11-27(3)26-12(16)2/h4-8,10-11H,1,9H2,2-3H3,(H,23,28)(H2,21,22,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109409
(CHEMBL3601228)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cc1Cl Show InChI InChI=1S/C25H27Cl2N7O/c1-3-23(35)30-18-6-4-5-17(13-18)15-28-24-21(27)16-29-25(32-24)31-19-7-8-22(20(26)14-19)34-11-9-33(2)10-12-34/h3-8,13-14,16H,1,9-12,15H2,2H3,(H,30,35)(H2,28,29,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109503
(CHEMBL3601707)Show SMILES CNC(=O)Cn1cc(Nc2ncc(Cl)c(NCc3ccc(NC(=O)C=C)cc3)n2)cn1 Show InChI InChI=1S/C20H21ClN8O2/c1-3-17(30)26-14-6-4-13(5-7-14)8-23-19-16(21)10-24-20(28-19)27-15-9-25-29(11-15)12-18(31)22-2/h3-7,9-11H,1,8,12H2,2H3,(H,22,31)(H,26,30)(H2,23,24,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109526
(CHEMBL3601862)Show SMILES [H][C@]12CS[C@@H](CCCCC(=O)NCCOCCOCCOCCn3cc(Nc4ncc(Cl)c(NCc5cccc(NC(=O)C=C)c5)n4)cn3)[C@@]1([H])NC(=O)N2 |r| Show InChI InChI=1S/C35H47ClN10O6S/c1-2-30(47)41-25-7-5-6-24(18-25)19-38-33-27(36)21-39-34(45-33)42-26-20-40-46(22-26)11-13-51-15-17-52-16-14-50-12-10-37-31(48)9-4-3-8-29-32-28(23-53-29)43-35(49)44-32/h2,5-7,18,20-22,28-29,32H,1,3-4,8-17,19,23H2,(H,37,48)(H,41,47)(H2,43,44,49)(H2,38,39,42,45)/t28-,29-,32-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109511
(CHEMBL3601715)Show SMILES COc1cc(ccc1Nc1ncc(Br)c(NCc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 Show InChI InChI=1S/C26H30BrN7O2/c1-4-24(35)30-19-7-5-6-18(14-19)16-28-25-21(27)17-29-26(32-25)31-22-9-8-20(15-23(22)36-3)34-12-10-33(2)11-13-34/h4-9,14-15,17H,1,10-13,16H2,2-3H3,(H,30,35)(H2,28,29,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109422
(CHEMBL3601244)Show InChI InChI=1S/C17H15ClN6O2/c1-2-15(25)22-12-5-3-4-11(6-12)7-19-16-14(18)9-20-17(24-16)23-13-8-21-26-10-13/h2-6,8-10H,1,7H2,(H,22,25)(H2,19,20,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase SIK2
(Homo sapiens (Human)) | BDBM192712
(HG-9-91-01 (1))Show SMILES COc1ccc(N(C(=O)Nc2c(C)cccc2C)c2cc(Nc3ccc(cc3)N3CCN(C)CC3)ncn2)c(OC)c1 Show InChI InChI=1S/C32H37N7O3/c1-22-7-6-8-23(2)31(22)36-32(40)39(27-14-13-26(41-4)19-28(27)42-5)30-20-29(33-21-34-30)35-24-9-11-25(12-10-24)38-17-15-37(3)16-18-38/h6-14,19-21H,15-18H2,1-5H3,(H,36,40)(H,33,34,35) | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Broad Institute
| Assay Description IC50s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP... |
ACS Chem Biol 11: 2105-11 (2016)
Article DOI: 10.1021/acschembio.6b00217 BindingDB Entry DOI: 10.7270/Q23777H7 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109415
(CHEMBL3601236)Show SMILES CC(=O)N1CCN(CC1)c1c(F)cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cc1F Show InChI InChI=1S/C26H26ClF2N7O2/c1-3-23(38)32-18-6-4-5-17(11-18)14-30-25-20(27)15-31-26(34-25)33-19-12-21(28)24(22(29)13-19)36-9-7-35(8-10-36)16(2)37/h3-6,11-13,15H,1,7-10,14H2,2H3,(H,32,38)(H2,30,31,33,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109499
(CHEMBL3601127)Show SMILES Cn1cc(Nc2ncc(Cl)c(NCc3ccc(F)c(NC(=O)C=C)c3)n2)cn1 Show InChI InChI=1S/C18H17ClFN7O/c1-3-16(28)25-15-6-11(4-5-14(15)20)7-21-17-13(19)9-22-18(26-17)24-12-8-23-27(2)10-12/h3-6,8-10H,1,7H2,2H3,(H,25,28)(H2,21,22,24,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109411
(CHEMBL3601230)Show SMILES CN1CCN(CC1)c1cc(F)c(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cc1F Show InChI InChI=1S/C25H26ClF2N7O/c1-3-23(36)31-17-6-4-5-16(11-17)14-29-24-18(26)15-30-25(33-24)32-21-12-20(28)22(13-19(21)27)35-9-7-34(2)8-10-35/h3-6,11-13,15H,1,7-10,14H2,2H3,(H,31,36)(H2,29,30,32,33) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109532
(CHEMBL3601223)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(NCc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 Show InChI InChI=1S/C26H30ClN7O2/c1-4-24(35)30-19-7-5-6-18(14-19)16-28-25-21(27)17-29-26(32-25)31-22-9-8-20(15-23(22)36-3)34-12-10-33(2)11-13-34/h4-9,14-15,17H,1,10-13,16H2,2-3H3,(H,30,35)(H2,28,29,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109414
(CHEMBL3601234)Show SMILES Fc1cc(N2CCOCC2)c(F)cc1Nc1ncc(Cl)c(NCc2cccc(NC(=O)C=C)c2)n1 Show InChI InChI=1S/C24H23ClF2N6O2/c1-2-22(34)30-16-5-3-4-15(10-16)13-28-23-17(25)14-29-24(32-23)31-20-11-19(27)21(12-18(20)26)33-6-8-35-9-7-33/h2-5,10-12,14H,1,6-9,13H2,(H,30,34)(H2,28,29,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase SIK2
(Homo sapiens (Human)) | BDBM192714
(US11725011, Compound YKL-05-95 | YKL-05-095 (3))Show SMILES COc1ccc(nc1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12)c1c(C)cccc1Cl Show InChI InChI=1S/C30H31ClN8O2/c1-20-5-4-6-25(31)27(20)38-19-21-17-33-29(34-22-7-9-23(10-8-22)37-15-13-36(2)14-16-37)35-28(21)39(30(38)40)26-12-11-24(41-3)18-32-26/h4-12,17-18H,13-16,19H2,1-3H3,(H,33,34,35) | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Broad Institute
| Assay Description IC50s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP... |
ACS Chem Biol 11: 2105-11 (2016)
Article DOI: 10.1021/acschembio.6b00217 BindingDB Entry DOI: 10.7270/Q23777H7 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109417
(CHEMBL3601238)Show SMILES Fc1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cc(F)c1OCCN1CCOCC1 Show InChI InChI=1S/C26H27ClF2N6O3/c1-2-23(36)32-18-5-3-4-17(12-18)15-30-25-20(27)16-31-26(34-25)33-19-13-21(28)24(22(29)14-19)38-11-8-35-6-9-37-10-7-35/h2-5,12-14,16H,1,6-11,15H2,(H,32,36)(H2,30,31,33,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109505
(CHEMBL3601709)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(NC(C)c2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 Show InChI InChI=1S/C27H32ClN7O2/c1-5-25(36)31-20-8-6-7-19(15-20)18(2)30-26-22(28)17-29-27(33-26)32-23-10-9-21(16-24(23)37-4)35-13-11-34(3)12-14-35/h5-10,15-18H,1,11-14H2,2-4H3,(H,31,36)(H2,29,30,32,33) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109523
(CHEMBL3601727)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C)C(=O)N(Cc4cccc(NC(=O)C=C)c4)c3n2)cc1 Show InChI InChI=1S/C28H32N8O2/c1-4-25(37)30-23-7-5-6-20(16-23)18-36-26-21(19-34(3)28(36)38)17-29-27(32-26)31-22-8-10-24(11-9-22)35-14-12-33(2)13-15-35/h4-11,16-17H,1,12-15,18-19H2,2-3H3,(H,30,37)(H,29,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109416
(CHEMBL3601237)Show SMILES OC1CCN(CC1)c1c(F)cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C=C)c3)n2)cc1F Show InChI InChI=1S/C25H25ClF2N6O2/c1-2-22(36)31-16-5-3-4-15(10-16)13-29-24-19(26)14-30-25(33-24)32-17-11-20(27)23(21(28)12-17)34-8-6-18(35)7-9-34/h2-5,10-12,14,18,35H,1,6-9,13H2,(H,31,36)(H2,29,30,32,33) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50109495
(CHEMBL3601123)Show SMILES COCCn1cc(Nc2ncc(Cl)c(NCc3cccc(NC(=O)C(C)=C)c3)n2)cn1 Show InChI InChI=1S/C21H24ClN7O2/c1-14(2)20(30)26-16-6-4-5-15(9-16)10-23-19-18(22)12-24-21(28-19)27-17-11-25-29(13-17)7-8-31-3/h4-6,9,11-13H,1,7-8,10H2,2-3H3,(H,26,30)(H2,23,24,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of JAK3 (unknown origin) by Z'-Lyte assay |
J Med Chem 58: 6589-606 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00710 BindingDB Entry DOI: 10.7270/Q2833TSH |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 19
(Homo sapiens (Human)) | BDBM50353060
(CHEMBL4167193)Show SMILES [H][C@@]12CC[C@H](c3ccc4ccncc4c3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)N(C)C |r,t:28| Show InChI InChI=1S/C30H40N2/c1-29-14-11-24(32(3)4)18-23(29)7-8-25-27-10-9-26(30(27,2)15-12-28(25)29)21-6-5-20-13-16-31-19-22(20)17-21/h5-7,13,16-17,19,24-28H,8-12,14-15,18H2,1-4H3/t24-,25-,26+,27-,28-,29-,30+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute
Curated by ChEMBL
| Assay Description Inhibition of human CDK19 (M1 to N360 residues) expressed in bacterial expression system by KINOMEscan assay |
ACS Med Chem Lett 9: 540-545 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00011 BindingDB Entry DOI: 10.7270/Q2125W6Z |
More data for this Ligand-Target Pair | |