Found 446 hits with Last Name = 'masuda' and Initial = 's' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50396071
(CHEMBL2170582 | US10828301, Compound R921303)Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1 Show InChI InChI=1S/C21H17F3N6O4/c1-25-17(31)10-33-13-4-2-3-11(7-13)28-20-26-9-14(22)18(30-20)27-12-5-6-16-15(8-12)29-19(32)21(23,24)34-16/h2-9H,10H2,1H3,(H,25,31)(H,29,32)(H2,26,27,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of SYK |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50325991
(2-(7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-...)Show SMILES COc1ccc(cc1OC)-c1cc2nccn2c(Nc2ncccc2C(N)=O)n1 Show InChI InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
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CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of SYK |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50396074
(CHEMBL2170585)Show SMILES COc1ccc(cc1OC)-c1cc2nccn2c(Nc2ccc3cn[nH]c3c2)n1 Show InChI InChI=1S/C21H18N6O2/c1-28-18-6-4-13(9-19(18)29-2)16-11-20-22-7-8-27(20)21(25-16)24-15-5-3-14-12-23-26-17(14)10-15/h3-12H,1-2H3,(H,23,26)(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of SYK |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM60665
(BDBM50249542 | US9145414, R406 | US9212178, R406)Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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PC cid
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PDB
UniChem
Similars
| DrugBank
Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of SYK |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lyn
(Homo sapiens (Human)) | BDBM50396071
(CHEMBL2170582 | US10828301, Compound R921303)Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1 Show InChI InChI=1S/C21H17F3N6O4/c1-25-17(31)10-33-13-4-2-3-11(7-13)28-20-26-9-14(22)18(30-20)27-12-5-6-16-15(8-12)29-19(32)21(23,24)34-16/h2-9H,10H2,1H3,(H,25,31)(H,29,32)(H2,26,27,28,30) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lyn |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50396071
(CHEMBL2170582 | US10828301, Compound R921303)Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1 Show InChI InChI=1S/C21H17F3N6O4/c1-25-17(31)10-33-13-4-2-3-11(7-13)28-20-26-9-14(22)18(30-20)27-12-5-6-16-15(8-12)29-19(32)21(23,24)34-16/h2-9H,10H2,1H3,(H,25,31)(H,29,32)(H2,26,27,28,30) | PDB
MMDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of EGFR |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50249090
(3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)di...)Show InChI InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21) | PDB
MMDB
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| Article
PubMed
| 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amarit Bioscience, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of SYK (unknown origin) |
Bioorg Med Chem Lett 25: 2117-21 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50249090
(3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)di...)Show InChI InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21) | PDB
MMDB
NCI pathway
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KEGG
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| Article
PubMed
| 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of SYK |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50396071
(CHEMBL2170582 | US10828301, Compound R921303)Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1 Show InChI InChI=1S/C21H17F3N6O4/c1-25-17(31)10-33-13-4-2-3-11(7-13)28-20-26-9-14(22)18(30-20)27-12-5-6-16-15(8-12)29-19(32)21(23,24)34-16/h2-9H,10H2,1H3,(H,25,31)(H,29,32)(H2,26,27,28,30) | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 116 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of LCK |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50396071
(CHEMBL2170582 | US10828301, Compound R921303)Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1 Show InChI InChI=1S/C21H17F3N6O4/c1-25-17(31)10-33-13-4-2-3-11(7-13)28-20-26-9-14(22)18(30-20)27-12-5-6-16-15(8-12)29-19(32)21(23,24)34-16/h2-9H,10H2,1H3,(H,25,31)(H,29,32)(H2,26,27,28,30) | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of JAK2 |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50290422
(4-(4-Methyl-piperazin-1-ylmethyl)-N-[3-(4-pyridin-...)Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2cccc(Nc3nccc(n3)-c3cccnc3)c2)CC1 Show InChI InChI=1S/C28H29N7O/c1-34-14-16-35(17-15-34)20-21-7-9-22(10-8-21)27(36)31-24-5-2-6-25(18-24)32-28-30-13-11-26(33-28)23-4-3-12-29-19-23/h2-13,18-19H,14-17,20H2,1H3,(H,31,36)(H,30,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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PC cid
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PDB
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| Article
PubMed
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of SYK |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM50396071
(CHEMBL2170582 | US10828301, Compound R921303)Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1 Show InChI InChI=1S/C21H17F3N6O4/c1-25-17(31)10-33-13-4-2-3-11(7-13)28-20-26-9-14(22)18(30-20)27-12-5-6-16-15(8-12)29-19(32)21(23,24)34-16/h2-9H,10H2,1H3,(H,25,31)(H,29,32)(H2,26,27,28,30) | PDB
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PC cid
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UniChem
| Article
PubMed
| 217 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of FGFR4 |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | |
Solute carrier organic anion transporter family member 1A3
(Rattus norvegicus) | BDBM50367055
(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)Show SMILES Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 |r| Show InChI InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1 | Reactome pathway
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| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells |
J Pharmacol Exp Ther 293: 1034-9 (2000)
BindingDB Entry DOI: 10.7270/Q2PK0HFQ |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM81945
(CAS_39484 | CHEMBL105891 | CHEMBL108926 | CHEMBL27...)Show InChI InChI=1S/C12H12N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3/q+1 | UniProtKB/SwissProt
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| 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50593320
(A-301 | ATI-502 | Ati-502 | IFIDANCITINIB | Ifidan...)Show SMILES COc1cc(Nc2ncc(C)c(Nc3ccc4oc(=O)[nH]c4c3)n2)cc(C)c1F | PDB
MMDB
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| Article
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00411
BindingDB Entry DOI: 10.7270/Q2QR523S |
More data for this
Ligand-Target Pair | |
Solute carrier organic anion transporter family member 1A3
(Rattus norvegicus) | BDBM50391007
(LEVOMEFOLIC ACID | LMSR)Show SMILES CN1[C@@H](CNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2nc(N)[nH]c(=O)c12 |r| Show InChI InChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12-,13-/m0/s1 | Reactome pathway
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| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells |
J Pharmacol Exp Ther 293: 1034-9 (2000)
BindingDB Entry DOI: 10.7270/Q2PK0HFQ |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM81945
(CAS_39484 | CHEMBL105891 | CHEMBL108926 | CHEMBL27...)Show InChI InChI=1S/C12H12N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3/q+1 | UniProtKB/SwissProt
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| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM16173
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) | UniProtKB/SwissProt
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| 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM13530
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) | PDB
MMDB
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| PDB
Article
PubMed
| 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of SYK |
J Med Chem 55: 3614-43 (2012)
Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Solute carrier family 22 member 1
(RAT) | BDBM50403559
(Brumetadina | CIMETIDINE)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | UniProtKB/SwissProt
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Similars
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| 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50593319
(CHEMBL5188333)Show SMILES COc1cc(Nc2ncc(C)c(Nc3ccc4oc(=O)[nH]c4c3)n2)cc(C)c1C | PDB
MMDB
Reactome pathway
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antibodypedia
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| PC cid
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| Article
PubMed
| 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00411
BindingDB Entry DOI: 10.7270/Q2QR523S |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM16173
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) | UniProtKB/SwissProt
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| 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier organic anion transporter family member 1A3
(Rattus norvegicus) | BDBM286
((2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,...)Show SMILES Nc1nc2NC[C@H](CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N(C=O)c2c(=O)[nH]1 Show InChI InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1 | Reactome pathway
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Similars
| PubMed
| 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells |
J Pharmacol Exp Ther 293: 1034-9 (2000)
BindingDB Entry DOI: 10.7270/Q2PK0HFQ |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50403559
(Brumetadina | CIMETIDINE)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | UniProtKB/SwissProt
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| 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier organic anion transporter family member 1A3
(Rattus norvegicus) | BDBM50367343
((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...)Show SMILES Nc1nc2ncc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)nc2c(=O)[nH]1 |r| Show InChI InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 | Reactome pathway
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Similars
| PubMed
| 1.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells |
J Pharmacol Exp Ther 293: 1034-9 (2000)
BindingDB Entry DOI: 10.7270/Q2PK0HFQ |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM50017681
((1S,2R,4S,5R)-2-[(S)-Hydroxy-(6-methoxy-quinolin-4...)Show SMILES COc1ccc2nccc([C@H](O)C3CC4CCN3CC4C=C)c2c1 |TLB:10:12:18.19:16.15,20:19:12.13:16.15| Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13?,14?,19?,20-/m0/s1 | UniProtKB/SwissProt
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| 1.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50017681
((1S,2R,4S,5R)-2-[(S)-Hydroxy-(6-methoxy-quinolin-4...)Show SMILES COc1ccc2nccc([C@H](O)C3CC4CCN3CC4C=C)c2c1 |TLB:10:12:18.19:16.15,20:19:12.13:16.15| Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13?,14?,19?,20-/m0/s1 | UniProtKB/SwissProt
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| 1.91E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier organic anion transporter family member 1A3
(Rattus norvegicus) | BDBM50390979
(BROMOSULFOPHTHALEIN)Show SMILES Oc1ccc(cc1S([O-])(=O)=O)C1(OC(=O)c2c1c(Br)c(Br)c(Br)c2Br)c1ccc(O)c(c1)S([O-])(=O)=O Show InChI InChI=1S/C20H10Br4O10S2/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33/h1-6,25-26H,(H,28,29,30)(H,31,32,33)/p-2 | Reactome pathway
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Similars
| PubMed
| 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells |
J Pharmacol Exp Ther 293: 1034-9 (2000)
BindingDB Entry DOI: 10.7270/Q2PK0HFQ |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50028893
(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)Show InChI InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25) | UniProtKB/SwissProt
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| 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM39344
(4-amino-N-[2-(diethylamino)ethyl]benzamide;hydroch...)Show InChI InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17) | UniProtKB/SwissProt
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| PubMed
| 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM50149890
(CHEMBL9324 | tetraethylammonium)Show InChI InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1 | UniProtKB/SwissProt
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| PubMed
| 4.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM39344
(4-amino-N-[2-(diethylamino)ethyl]benzamide;hydroch...)Show InChI InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17) | UniProtKB/SwissProt
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| PubMed
| 4.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | UniProtKB/SwissProt
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| 5.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50149890
(CHEMBL9324 | tetraethylammonium)Show InChI InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1 | UniProtKB/SwissProt
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| 5.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (apical to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM50028893
(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)Show InChI InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25) | UniProtKB/SwissProt
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| PubMed
| 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | UniProtKB/SwissProt
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| PubMed
| 6.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM7966
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | UniProtKB/SwissProt
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| 1.41E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM7966
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | UniProtKB/SwissProt
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| 1.71E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier organic anion transporter family member 1A3
(Rattus norvegicus) | BDBM50375594
(TAUROCHOLATE)Show SMILES C[C@H](CCC(=O)NCCS(O)(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C |r| Show InChI InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 | Reactome pathway
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Similars
| PubMed
| 1.83E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells |
J Pharmacol Exp Ther 293: 1034-9 (2000)
BindingDB Entry DOI: 10.7270/Q2PK0HFQ |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM10755
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 | UniProtKB/SwissProt
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| 2.42E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | UniProtKB/SwissProt
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| 3.47E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM10755
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 | UniProtKB/SwissProt
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| 3.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50420177
(NICOTINYL METHYLAMIDE)Show InChI InChI=1S/C7H8N2O/c1-8-7(10)6-3-2-4-9-5-6/h2-5H,1H3,(H,8,10) | UniProtKB/SwissProt
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| PubMed
| 4.03E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | UniProtKB/SwissProt
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Similars
| PubMed
| 6.03E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50373877
(Betaxin | CA inhibitor, 3 | THIAMINE (VIT B1) | Th...)Show InChI InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1 | UniProtKB/SwissProt
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MCE
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Similars
| PubMed
| 6.46E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM50420177
(NICOTINYL METHYLAMIDE)Show InChI InChI=1S/C7H8N2O/c1-8-7(10)6-3-2-4-9-5-6/h2-5H,1H3,(H,8,10) | UniProtKB/SwissProt
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MCE
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Similars
| PubMed
| 6.69E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 2
(RAT) | BDBM50420178
(GUANIDINE) | UniProtKB/SwissProt
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| PubMed
| 7.14E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM50420178
(GUANIDINE) | UniProtKB/SwissProt
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MMDB
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| PubMed
| 7.24E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Solute carrier family 22 member 1
(RAT) | BDBM50373877
(Betaxin | CA inhibitor, 3 | THIAMINE (VIT B1) | Th...)Show InChI InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1 | UniProtKB/SwissProt
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| PubMed
| 7.36E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Solute carrier organic anion transporter family member 1A3
(Rattus norvegicus) | BDBM17638
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1 Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23) | Reactome pathway
KEGG
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CHEMBL
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Similars
| PubMed
| 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing LLC-PK1 cells |
J Pharmacol Exp Ther 283: 1039-42 (1998)
BindingDB Entry DOI: 10.7270/Q2028SMX |
More data for this
Ligand-Target Pair | |
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