Found 169 hits with Last Name = 'veltri' and Initial = 'a' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 1
(RAT) | BDBM50224406
(9-(4-chlorophenyl)-2,3-dihydro-3(R)-methyl-1H-pyri...)Show SMILES C[C@@H]1CNc2c(O1)cnc1sc3c(ncn(-c4ccc(Cl)cc4)c3=O)c21 Show InChI InChI=1S/C18H13ClN4O2S/c1-9-6-20-14-12(25-9)7-21-17-13(14)15-16(26-17)18(24)23(8-22-15)11-4-2-10(19)3-5-11/h2-5,7-9,20H,6H2,1H3/t9-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224407
(2,3-dihydro-9-(4-methoxyphenyl)-3(R)-methyl-1H-pyr...)Show SMILES COc1ccc(cc1)-n1cnc2c(sc3ncc4O[C@H](C)CNc4c23)c1=O Show InChI InChI=1S/C19H16N4O3S/c1-10-7-20-15-13(26-10)8-21-18-14(15)16-17(27-18)19(24)23(9-22-16)11-3-5-12(25-2)6-4-11/h3-6,8-10,20H,7H2,1-2H3/t10-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364723
(CHEMBL1951662)Show SMILES CN(C)c1ccnc2sc3c(ccn(-c4ccc(Br)cc4)c3=O)c12 Show InChI InChI=1S/C18H14BrN3OS/c1-21(2)14-7-9-20-17-15(14)13-8-10-22(18(23)16(13)24-17)12-5-3-11(19)4-6-12/h3-10H,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224391
(9-(4-chlorophenyl)-2,3-dihydro-1H-pyrimido[4'',5''...)Show InChI InChI=1S/C17H11ClN4O2S/c18-9-1-3-10(4-2-9)22-8-21-14-12-13-11(24-6-5-19-13)7-20-16(12)25-15(14)17(22)23/h1-4,7-8,19H,5-6H2 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224392
(9-(4-chlorophenyl)-2,3-dihydro-2(S)-methyl-1H-pyri...)Show SMILES C[C@H]1COc2cnc3sc4c(ncn(-c5ccc(Cl)cc5)c4=O)c3c2N1 Show InChI InChI=1S/C18H13ClN4O2S/c1-9-7-25-12-6-20-17-13(14(12)22-9)15-16(26-17)18(24)23(8-21-15)11-4-2-10(19)3-5-11/h2-6,8-9,22H,7H2,1H3/t9-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224395
(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)Show InChI InChI=1S/C18H14N4O2S/c1-10-2-4-11(5-3-10)22-9-21-15-13-14-12(24-7-6-19-14)8-20-17(13)25-16(15)18(22)23/h2-5,8-9,19H,6-7H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224400
(2,3-dihydro-3(R)-methyl-9-(4-methylphenyl)-1H-pyri...)Show SMILES C[C@@H]1CNc2c(O1)cnc1sc3c(ncn(-c4ccc(C)cc4)c3=O)c21 Show InChI InChI=1S/C19H16N4O2S/c1-10-3-5-12(6-4-10)23-9-22-16-14-15-13(25-11(2)7-20-15)8-21-18(14)26-17(16)19(23)24/h3-6,8-9,11,20H,7H2,1-2H3/t11-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224405
(2,3-dihydro-9-(4-methoxyphenyl)-1H-pyrimido[4'',5'...)Show InChI InChI=1S/C18H14N4O3S/c1-24-11-4-2-10(3-5-11)22-9-21-15-13-14-12(25-7-6-19-14)8-20-17(13)26-16(15)18(22)23/h2-5,8-9,19H,6-7H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224396
(9-(4-chlorophenyl)-2,3-dihydro-3(S)-methyl-1H-pyri...)Show SMILES C[C@H]1CNc2c(O1)cnc1sc3c(ncn(-c4ccc(Cl)cc4)c3=O)c21 Show InChI InChI=1S/C18H13ClN4O2S/c1-9-6-20-14-12(25-9)7-21-17-13(14)15-16(26-17)18(24)23(8-22-15)11-4-2-10(19)3-5-11/h2-5,7-9,20H,6H2,1H3/t9-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364720
(CHEMBL1951659)Show InChI InChI=1S/C19H17N3OS/c1-12-4-6-13(7-5-12)22-11-9-14-16-15(21(2)3)8-10-20-18(16)24-17(14)19(22)23/h4-11H,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364722
(CHEMBL1951661)Show SMILES CN(C)c1ccnc2sc3c(ccn(-c4ccc(Cl)cc4)c3=O)c12 Show InChI InChI=1S/C18H14ClN3OS/c1-21(2)14-7-9-20-17-15(14)13-8-10-22(18(23)16(13)24-17)12-5-3-11(19)4-6-12/h3-10H,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224402
(8-(4-chlorophenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)Show SMILES Clc1ccc(cc1)-n1cnc2c(sc3ncc4cc[nH]c4c23)c1=O Show InChI InChI=1S/C17H9ClN4OS/c18-10-1-3-11(4-2-10)22-8-21-14-12-13-9(5-6-19-13)7-20-16(12)24-15(14)17(22)23/h1-8,19H | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364710
(CHEMBL1951882)Show SMILES Brc1ccc(cc1)-n1ccc2c(sc3nccc(NC4CC4)c23)c1=O Show InChI InChI=1S/C19H14BrN3OS/c20-11-1-5-13(6-2-11)23-10-8-14-16-15(22-12-3-4-12)7-9-21-18(16)25-17(14)19(23)24/h1-2,5-10,12H,3-4H2,(H,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364692
(CHEMBL1951683)Show SMILES COc1ccc(cc1)-n1ccc2c(sc3nccc(NC4CC4)c23)c1=O Show InChI InChI=1S/C20H17N3O2S/c1-25-14-6-4-13(5-7-14)23-11-9-15-17-16(22-12-2-3-12)8-10-21-19(17)26-18(15)20(23)24/h4-12H,2-3H2,1H3,(H,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364700
(CHEMBL1951872)Show InChI InChI=1S/C17H12BrN3OS/c1-19-13-6-8-20-16-14(13)12-7-9-21(17(22)15(12)23-16)11-4-2-10(18)3-5-11/h2-9H,1H3,(H,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364731
(CHEMBL1951670)Show InChI InChI=1S/C18H14N2O3S/c1-22-12-5-3-11(4-6-12)20-10-8-13-15-14(23-2)7-9-19-17(15)24-16(13)18(20)21/h3-10H,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364708
(CHEMBL1951880)Show SMILES Clc1ccc(cc1)-n1ccc2c(sc3nccc(NC4CC4)c23)c1=O Show InChI InChI=1S/C19H14ClN3OS/c20-11-1-5-13(6-2-11)23-10-8-14-16-15(22-12-3-4-12)7-9-21-18(16)25-17(14)19(23)24/h1-2,5-10,12H,3-4H2,(H,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 7.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364709
(CHEMBL1951881)Show InChI InChI=1S/C18H14BrN3OS/c1-2-20-14-7-9-21-17-15(14)13-8-10-22(18(23)16(13)24-17)12-5-3-11(19)4-6-12/h3-10H,2H2,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 7.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224397
(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)Show SMILES COc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C18H16N4O2S/c1-21(2)13-8-9-19-17-14(13)15-16(25-17)18(23)22(10-20-15)11-4-6-12(24-3)7-5-11/h4-10H,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 7.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364690
(CHEMBL1951681)Show InChI InChI=1S/C19H17N3O2S/c1-3-20-15-8-10-21-18-16(15)14-9-11-22(19(23)17(14)25-18)12-4-6-13(24-2)7-5-12/h4-11H,3H2,1-2H3,(H,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 8.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224409
(9-(4-chlorophenyl)-2,3-dihydro-2(R)-methyl-1H-pyri...)Show SMILES C[C@@H]1COc2cnc3sc4c(ncn(-c5ccc(Cl)cc5)c4=O)c3c2N1 Show InChI InChI=1S/C18H13ClN4O2S/c1-9-7-25-12-6-20-17-13(14(12)22-9)15-16(26-17)18(24)23(8-21-15)11-4-2-10(19)3-5-11/h2-6,8-9,22H,7H2,1H3/t9-/m1/s1 | PDB
UniProtKB/SwissProt
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| Article
PubMed
| 9.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364707
(CHEMBL1951879)Show InChI InChI=1S/C18H14ClN3OS/c1-2-20-14-7-9-21-17-15(14)13-8-10-22(18(23)16(13)24-17)12-5-3-11(19)4-6-12/h3-10H,2H2,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364705
(CHEMBL1951877)Show InChI InChI=1S/C19H17N3OS/c1-3-20-15-8-10-21-18-16(15)14-9-11-22(19(23)17(14)24-18)13-6-4-12(2)5-7-13/h4-11H,3H2,1-2H3,(H,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 9.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364729
(CHEMBL1951668)Show SMILES CN(C)c1ccnc2sc3c(ccn(-c4ccc5scnc5c4)c3=O)c12 Show InChI InChI=1S/C19H14N4OS2/c1-22(2)14-5-7-20-18-16(14)12-6-8-23(19(24)17(12)26-18)11-3-4-15-13(9-11)21-10-25-15/h3-10H,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
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| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364726
(CHEMBL1951665)Show InChI InChI=1S/C18H21N3OS/c1-20(2)14-8-10-19-17-15(14)13-9-11-21(18(22)16(13)23-17)12-6-4-3-5-7-12/h8-12H,3-7H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224393
(8-(4-chlorophenyl)-1h-imidazo[4'',5'':4',5']pyrido...)Show SMILES Clc1ccc(cc1)-n1cnc2c(sc3ncc4[nH]cnc4c23)c1=O Show InChI InChI=1S/C16H8ClN5OS/c17-8-1-3-9(4-2-8)22-7-21-13-11-12-10(19-6-20-12)5-18-15(11)24-14(13)16(22)23/h1-7H,(H,19,20) | PDB
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| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364730
(CHEMBL1951669)Show SMILES CN(C)c1ccnc2sc3c(ccn(-c4ccc5ncsc5c4)c3=O)c12 Show InChI InChI=1S/C19H14N4OS2/c1-22(2)14-5-7-20-18-16(14)12-6-8-23(19(24)17(12)26-18)11-3-4-13-15(9-11)25-10-21-13/h3-10H,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
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| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364706
(CHEMBL1951878)Show SMILES Cc1ccc(cc1)-n1ccc2c(sc3nccc(NC4CC4)c23)c1=O Show InChI InChI=1S/C20H17N3OS/c1-12-2-6-14(7-3-12)23-11-9-15-17-16(22-13-4-5-13)8-10-21-19(17)25-18(15)20(23)24/h2-3,6-11,13H,4-5H2,1H3,(H,21,22) | PDB
UniProtKB/SwissProt
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| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364714
(CHEMBL1951886)Show SMILES COc1ccc(cc1)-n1ccc2c(sc3ncnc(NC4CC4)c23)c1=O Show InChI InChI=1S/C19H16N4O2S/c1-25-13-6-4-12(5-7-13)23-9-8-14-15-17(22-11-2-3-11)20-10-21-18(15)26-16(14)19(23)24/h4-11H,2-3H2,1H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
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| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364727
(CHEMBL1951666)Show SMILES COc1ccc(cc1F)-n1ccc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H16FN3O2S/c1-22(2)14-6-8-21-18-16(14)12-7-9-23(19(24)17(12)26-18)11-4-5-15(25-3)13(20)10-11/h4-10H,1-3H3 | PDB
UniProtKB/SwissProt
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| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364699
(CHEMBL1951690)Show InChI InChI=1S/C17H12ClN3OS/c1-19-13-6-8-20-16-14(13)12-7-9-21(17(22)15(12)23-16)11-4-2-10(18)3-5-11/h2-9H,1H3,(H,19,20) | PDB
UniProtKB/SwissProt
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PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364738
(CHEMBL1951677)Show InChI InChI=1S/C17H18N2O2S/c1-21-13-7-9-18-16-14(13)12-8-10-19(17(20)15(12)22-16)11-5-3-2-4-6-11/h7-11H,2-6H2,1H3 | PDB
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| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364697
(CHEMBL1951688)Show InChI InChI=1S/C18H15N3OS/c1-11-3-5-12(6-4-11)21-10-8-13-15-14(19-2)7-9-20-17(15)23-16(13)18(21)22/h3-10H,1-2H3,(H,19,20) | PDB
UniProtKB/SwissProt
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| CHEMBL
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| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364719
(CHEMBL1951658)Show SMILES COc1ccc(cc1)-n1ccc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H17N3O2S/c1-21(2)15-8-10-20-18-16(15)14-9-11-22(19(23)17(14)25-18)12-4-6-13(24-3)7-5-12/h4-11H,1-3H3 | PDB
UniProtKB/SwissProt
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| CHEMBL
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| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224390
(8-(4-methylphenyl)-1h-pyrrolo[2'',3'':4',5']pyrido...)Show SMILES Cc1ccc(cc1)-n1cnc2c(sc3ncc4cc[nH]c4c23)c1=O Show InChI InChI=1S/C18H12N4OS/c1-10-2-4-12(5-3-10)22-9-21-15-13-14-11(6-7-19-14)8-20-17(13)24-16(15)18(22)23/h2-9,19H,1H3 | PDB
UniProtKB/SwissProt
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| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224403
(8-(4-methylphenyl)-1H-pyrazolo[3'',4'':4',5']pyrid...)Show SMILES Cc1ccc(cc1)-n1cnc2c(sc3ncc4c[nH]nc4c23)c1=O Show InChI InChI=1S/C17H11N5OS/c1-9-2-4-11(5-3-9)22-8-19-14-12-13-10(7-20-21-13)6-18-16(12)24-15(14)17(22)23/h2-8H,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
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| Article
PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364725
(CHEMBL1951664)Show SMILES CCc1ccc(cc1)-n1ccc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C20H19N3OS/c1-4-13-5-7-14(8-6-13)23-12-10-15-17-16(22(2)3)9-11-21-19(17)25-18(15)20(23)24/h5-12H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
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| Article
PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364741
(CHEMBL1951680)Show InChI InChI=1S/C18H15N3O2S/c1-19-14-7-9-20-17-15(14)13-8-10-21(18(22)16(13)24-17)11-3-5-12(23-2)6-4-11/h3-10H,1-2H3,(H,19,20) | PDB
UniProtKB/SwissProt
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PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364728
(CHEMBL1951667)Show SMILES COc1ccc(c(F)c1)-n1ccc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H16FN3O2S/c1-22(2)15-6-8-21-18-16(15)12-7-9-23(19(24)17(12)26-18)14-5-4-11(25-3)10-13(14)20/h4-10H,1-3H3 | PDB
UniProtKB/SwissProt
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PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364711
(CHEMBL1951883)Show SMILES COc1ccc(cc1)-n1ccc2c(sc3ncnc(N(C)C)c23)c1=O Show InChI InChI=1S/C18H16N4O2S/c1-21(2)16-14-13-8-9-22(11-4-6-12(24-3)7-5-11)18(23)15(13)25-17(14)20-10-19-16/h4-10H,1-3H3 | PDB
UniProtKB/SwissProt
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PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224401
(8-(4-chlorophenyl)-1h-pyrazolo[3'',4'':4',5']pyrid...)Show SMILES Clc1ccc(cc1)-n1cnc2c(sc3ncc4c[nH]nc4c23)c1=O Show InChI InChI=1S/C16H8ClN5OS/c17-9-1-3-10(4-2-9)22-7-19-13-11-12-8(6-20-21-12)5-18-15(11)24-14(13)16(22)23/h1-7H,(H,20,21) | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364718
(CHEMBL1951890)Show SMILES Cc1ccc(cc1)-n1ccc2c(sc3ncnc(NC4CC4)c23)c1=O Show InChI InChI=1S/C19H16N4OS/c1-11-2-6-13(7-3-11)23-9-8-14-15-17(22-12-4-5-12)20-10-21-18(15)25-16(14)19(23)24/h2-3,6-10,12H,4-5H2,1H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
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PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364691
(CHEMBL1951682)Show InChI InChI=1S/C20H19N3O2S/c1-3-10-21-16-8-11-22-19-17(16)15-9-12-23(20(24)18(15)26-19)13-4-6-14(25-2)7-5-13/h4-9,11-12H,3,10H2,1-2H3,(H,21,22) | PDB
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PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364715
(CHEMBL1951887)Show InChI InChI=1S/C18H16N4OS/c1-11-4-6-12(7-5-11)22-9-8-13-14-16(21(2)3)19-10-20-17(14)24-15(13)18(22)23/h4-10H,1-3H3 | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50224398
(8-(4-methoxyphenyl)-1h-pyrrolo[2'',3'':4',5']pyrid...)Show SMILES COc1ccc(cc1)-n1cnc2c(sc3ncc4cc[nH]c4c23)c1=O Show InChI InChI=1S/C18H12N4O2S/c1-24-12-4-2-11(3-5-12)22-9-21-15-13-14-10(6-7-19-14)8-20-17(13)25-16(15)18(22)23/h2-9,19H,1H3 | PDB
UniProtKB/SwissProt
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane |
J Med Chem 50: 5550-3 (2007)
Article DOI: 10.1021/jm070590c
BindingDB Entry DOI: 10.7270/Q2D50MQX |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364721
(CHEMBL1951660)Show InChI InChI=1S/C18H14FN3OS/c1-21(2)14-7-9-20-17-15(14)13-8-10-22(18(23)16(13)24-17)12-5-3-11(19)4-6-12/h3-10H,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364703
(CHEMBL1951875)Show InChI InChI=1S/C18H14FN3O2S/c1-20-13-5-7-21-17-15(13)11-6-8-22(18(23)16(11)25-17)14-4-3-10(24-2)9-12(14)19/h3-9H,1-2H3,(H,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
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UniChem
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PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364713
(CHEMBL1951885)Show InChI InChI=1S/C18H16N4O2S/c1-3-19-16-14-13-8-9-22(11-4-6-12(24-2)7-5-11)18(23)15(13)25-17(14)21-10-20-16/h4-10H,3H2,1-2H3,(H,19,20,21) | PDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364735
(CHEMBL1951674)Show InChI InChI=1S/C19H16N2O3S/c1-11-10-12(23-2)4-5-14(11)21-9-7-13-16-15(24-3)6-8-20-18(16)25-17(13)19(21)22/h4-10H,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50364702
(CHEMBL1951874)Show SMILES CNc1ccnc2sc3c(ccn(-c4ccc(OC)c(F)c4)c3=O)c12 Show InChI InChI=1S/C18H14FN3O2S/c1-20-13-5-7-21-17-15(13)11-6-8-22(18(23)16(11)25-17)10-3-4-14(24-2)12(19)9-10/h3-9H,1-2H3,(H,20,21) | PDB
UniProtKB/SwissProt
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UniChem
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PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat metabotropic glutamate receptor 1 |
Bioorg Med Chem Lett 22: 1575-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.131
BindingDB Entry DOI: 10.7270/Q2F19063 |
More data for this
Ligand-Target Pair | |
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