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Compile Data Set for Download or QSAR

Found 98 hits Enz. Inhib. hit(s) with all data for entry = 50005164   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191520
PNG
(2-[4-(biphenyl-2-ylmethoxy)-2-methoxyphenyl]-1-cyc...)
Show SMILES COc1cc(OCc2ccccc2-c2ccccc2)ccc1-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C34H32N2O4/c1-39-32-21-27(40-22-25-12-8-9-15-28(25)23-10-4-2-5-11-23)17-18-29(32)33-35-30-20-24(34(37)38)16-19-31(30)36(33)26-13-6-3-7-14-26/h2,4-5,8-12,15-21,26H,3,6-7,13-14,22H2,1H3,(H,37,38)
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n/an/a 9.09E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191520
PNG
(2-[4-(biphenyl-2-ylmethoxy)-2-methoxyphenyl]-1-cyc...)
Show SMILES COc1cc(OCc2ccccc2-c2ccccc2)ccc1-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C34H32N2O4/c1-39-32-21-27(40-22-25-12-8-9-15-28(25)23-10-4-2-5-11-23)17-18-29(32)33-35-30-20-24(34(37)38)16-19-31(30)36(33)26-13-6-3-7-14-26/h2,4-5,8-12,15-21,26H,3,6-7,13-14,22H2,1H3,(H,37,38)
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n/an/a 9.10E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191535
PNG
(2-[4-(biphenyl-2-ylmethoxy)-2-trifluoromethylpheny...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccccc2-c2ccccc2)cc1C(F)(F)F
Show InChI InChI=1S/C34H29F3N2O3/c35-34(36,37)29-20-26(42-21-24-11-7-8-14-27(24)22-9-3-1-4-10-22)16-17-28(29)32-38-30-19-23(33(40)41)15-18-31(30)39(32)25-12-5-2-6-13-25/h1,3-4,7-11,14-20,25H,2,5-6,12-13,21H2,(H,40,41)
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n/an/a 1.07E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191535
PNG
(2-[4-(biphenyl-2-ylmethoxy)-2-trifluoromethylpheny...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccccc2-c2ccccc2)cc1C(F)(F)F
Show InChI InChI=1S/C34H29F3N2O3/c35-34(36,37)29-20-26(42-21-24-11-7-8-14-27(24)22-9-3-1-4-10-22)16-17-28(29)32-38-30-19-23(33(40)41)15-18-31(30)39(32)25-12-5-2-6-13-25/h1,3-4,7-11,14-20,25H,2,5-6,12-13,21H2,(H,40,41)
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n/an/a 1.08E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191536
PNG
(2-{4-[5-(4-chlorophenyl)-2-methyloxazol-4-ylmethox...)
Show SMILES Cc1nc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C31H28ClN3O4/c1-19-33-27(29(39-19)20-7-12-23(32)13-8-20)18-38-25-14-9-21(10-15-25)30-34-26-17-22(31(36)37)11-16-28(26)35(30)24-5-3-2-4-6-24/h7-17,24H,2-6,18H2,1H3,(H,36,37)
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n/an/a 1.72E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191536
PNG
(2-{4-[5-(4-chlorophenyl)-2-methyloxazol-4-ylmethox...)
Show SMILES Cc1nc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C31H28ClN3O4/c1-19-33-27(29(39-19)20-7-12-23(32)13-8-20)18-38-25-14-9-21(10-15-25)30-34-26-17-22(31(36)37)11-16-28(26)35(30)24-5-3-2-4-6-24/h7-17,24H,2-6,18H2,1H3,(H,36,37)
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n/an/a 1.73E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191504
PNG
(1-cyclohexyl-2-[4-(4,3'-dichlorobiphenyl-2-ylmetho...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C33H28Cl2N2O3/c34-25-6-4-5-22(17-25)29-15-12-26(35)18-24(29)20-40-28-13-9-21(10-14-28)32-36-30-19-23(33(38)39)11-16-31(30)37(32)27-7-2-1-3-8-27/h4-6,9-19,27H,1-3,7-8,20H2,(H,38,39)
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n/an/a 2.08E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191504
PNG
(1-cyclohexyl-2-[4-(4,3'-dichlorobiphenyl-2-ylmetho...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C33H28Cl2N2O3/c34-25-6-4-5-22(17-25)29-15-12-26(35)18-24(29)20-40-28-13-9-21(10-14-28)32-36-30-19-23(33(38)39)11-16-31(30)37(32)27-7-2-1-3-8-27/h4-6,9-19,27H,1-3,7-8,20H2,(H,38,39)
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n/an/a 2.08E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191509
PNG
(2-[4-(biphenyl-2-ylmethoxy)-3-fluorophenyl]-1-cycl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccccc2-c2ccccc2)c(F)c1
Show InChI InChI=1S/C33H29FN2O3/c34-28-19-23(16-18-31(28)39-21-25-11-7-8-14-27(25)22-9-3-1-4-10-22)32-35-29-20-24(33(37)38)15-17-30(29)36(32)26-12-5-2-6-13-26/h1,3-4,7-11,14-20,26H,2,5-6,12-13,21H2,(H,37,38)
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n/an/a 2.63E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191509
PNG
(2-[4-(biphenyl-2-ylmethoxy)-3-fluorophenyl]-1-cycl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccccc2-c2ccccc2)c(F)c1
Show InChI InChI=1S/C33H29FN2O3/c34-28-19-23(16-18-31(28)39-21-25-11-7-8-14-27(25)22-9-3-1-4-10-22)32-35-29-20-24(33(37)38)15-17-30(29)36(32)26-12-5-2-6-13-26/h1,3-4,7-11,14-20,26H,2,5-6,12-13,21H2,(H,37,38)
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n/an/a 2.63E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191546
PNG
(2-[4-(biphenyl-2-ylmethoxy)-2-chlorophenyl]-1-cycl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccccc2-c2ccccc2)cc1Cl
Show InChI InChI=1S/C33H29ClN2O3/c34-29-20-26(39-21-24-11-7-8-14-27(24)22-9-3-1-4-10-22)16-17-28(29)32-35-30-19-23(33(37)38)15-18-31(30)36(32)25-12-5-2-6-13-25/h1,3-4,7-11,14-20,25H,2,5-6,12-13,21H2,(H,37,38)
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n/an/a 2.85E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191546
PNG
(2-[4-(biphenyl-2-ylmethoxy)-2-chlorophenyl]-1-cycl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccccc2-c2ccccc2)cc1Cl
Show InChI InChI=1S/C33H29ClN2O3/c34-29-20-26(39-21-24-11-7-8-14-27(24)22-9-3-1-4-10-22)16-17-28(29)32-35-30-19-23(33(37)38)15-18-31(30)36(32)25-12-5-2-6-13-25/h1,3-4,7-11,14-20,25H,2,5-6,12-13,21H2,(H,37,38)
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n/an/a 2.86E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191517
PNG
(2-[4-(5-chloro-2-pyridin-3-yl-benzyloxy)phenyl]-1-...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2cccnc2)cc1
Show InChI InChI=1S/C32H28ClN3O3/c33-25-11-14-28(23-5-4-16-34-19-23)24(17-25)20-39-27-12-8-21(9-13-27)31-35-29-18-22(32(37)38)10-15-30(29)36(31)26-6-2-1-3-7-26/h4-5,8-19,26H,1-3,6-7,20H2,(H,37,38)
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n/an/a 3.45E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191517
PNG
(2-[4-(5-chloro-2-pyridin-3-yl-benzyloxy)phenyl]-1-...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2cccnc2)cc1
Show InChI InChI=1S/C32H28ClN3O3/c33-25-11-14-28(23-5-4-16-34-19-23)24(17-25)20-39-27-12-8-21(9-13-27)31-35-29-18-22(32(37)38)10-15-30(29)36(31)26-6-2-1-3-7-26/h4-5,8-19,26H,1-3,6-7,20H2,(H,37,38)
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n/an/a 3.45E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191545
PNG
(2-[4-(4-Chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclo...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1
Show InChI InChI=1S/C33H29ClN2O3/c34-26-14-17-29(22-7-3-1-4-8-22)25(19-26)21-39-28-15-11-23(12-16-28)32-35-30-20-24(33(37)38)13-18-31(30)36(32)27-9-5-2-6-10-27/h1,3-4,7-8,11-20,27H,2,5-6,9-10,21H2,(H,37,38)
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n/an/a 5.00E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191545
PNG
(2-[4-(4-Chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclo...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1
Show InChI InChI=1S/C33H29ClN2O3/c34-26-14-17-29(22-7-3-1-4-8-22)25(19-26)21-39-28-15-11-23(12-16-28)32-35-30-20-24(33(37)38)13-18-31(30)36(32)27-9-5-2-6-10-27/h1,3-4,7-8,11-20,27H,2,5-6,9-10,21H2,(H,37,38)
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n/an/a 5.00E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50488701
PNG
(CHEMBL2296656)
Show SMILES Cc1ncc(COc2ccc(-c3nc4cc(ccc4n3C3CCCCC3)C(O)=O)c(F)c2)c(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C32H28ClFN4O3/c1-19-35-17-22(30(36-19)20-7-10-23(33)11-8-20)18-41-25-12-13-26(27(34)16-25)31-37-28-15-21(32(39)40)9-14-29(28)38(31)24-5-3-2-4-6-24/h7-17,24H,2-6,18H2,1H3,(H,39,40)
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n/an/a 5.32E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50488701
PNG
(CHEMBL2296656)
Show SMILES Cc1ncc(COc2ccc(-c3nc4cc(ccc4n3C3CCCCC3)C(O)=O)c(F)c2)c(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C32H28ClFN4O3/c1-19-35-17-22(30(36-19)20-7-10-23(33)11-8-20)18-41-25-12-13-26(27(34)16-25)31-37-28-15-21(32(39)40)9-14-29(28)38(31)24-5-3-2-4-6-24/h7-17,24H,2-6,18H2,1H3,(H,39,40)
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n/an/a 5.32E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191523
PNG
(2-{4-[5-(4-chlorophenyl)-2-methylthiazol-4-ylmetho...)
Show SMILES Cc1nc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C31H28ClN3O3S/c1-19-33-27(29(39-19)20-7-12-23(32)13-8-20)18-38-25-14-9-21(10-15-25)30-34-26-17-22(31(36)37)11-16-28(26)35(30)24-5-3-2-4-6-24/h7-17,24H,2-6,18H2,1H3,(H,36,37)
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n/an/a 5.88E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191523
PNG
(2-{4-[5-(4-chlorophenyl)-2-methylthiazol-4-ylmetho...)
Show SMILES Cc1nc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C31H28ClN3O3S/c1-19-33-27(29(39-19)20-7-12-23(32)13-8-20)18-38-25-14-9-21(10-15-25)30-34-26-17-22(31(36)37)11-16-28(26)35(30)24-5-3-2-4-6-24/h7-17,24H,2-6,18H2,1H3,(H,36,37)
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n/an/a 5.89E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191521
PNG
(2-{4-[3-(4-chlorophenyl)pyridin-2-ylmethoxy]phenyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ncccc2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C32H28ClN3O3/c33-24-13-8-21(9-14-24)27-7-4-18-34-29(27)20-39-26-15-10-22(11-16-26)31-35-28-19-23(32(37)38)12-17-30(28)36(31)25-5-2-1-3-6-25/h4,7-19,25H,1-3,5-6,20H2,(H,37,38)
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n/an/a 6.66E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191521
PNG
(2-{4-[3-(4-chlorophenyl)pyridin-2-ylmethoxy]phenyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ncccc2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C32H28ClN3O3/c33-24-13-8-21(9-14-24)27-7-4-18-34-29(27)20-39-26-15-10-22(11-16-26)31-35-28-19-23(32(37)38)12-17-30(28)36(31)25-5-2-1-3-6-25/h4,7-19,25H,1-3,5-6,20H2,(H,37,38)
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n/an/a 6.67E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191516
PNG
(2-[4-(4-chloro-4'-methoxybiphenyl-2-ylmethoxy)phen...)
Show SMILES COc1ccc(cc1)-c1ccc(Cl)cc1COc1ccc(cc1)-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C34H31ClN2O4/c1-40-28-13-7-22(8-14-28)30-17-12-26(35)19-25(30)21-41-29-15-9-23(10-16-29)33-36-31-20-24(34(38)39)11-18-32(31)37(33)27-5-3-2-4-6-27/h7-20,27H,2-6,21H2,1H3,(H,38,39)
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n/an/a 9.99E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191550
PNG
(2-[4-(biphenyl-2-ylmethoxy)-2-fluorophenyl]-1-cycl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccccc2-c2ccccc2)cc1F
Show InChI InChI=1S/C33H29FN2O3/c34-29-20-26(39-21-24-11-7-8-14-27(24)22-9-3-1-4-10-22)16-17-28(29)32-35-30-19-23(33(37)38)15-18-31(30)36(32)25-12-5-2-6-13-25/h1,3-4,7-11,14-20,25H,2,5-6,12-13,21H2,(H,37,38)
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n/an/a 9.99E+6n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191516
PNG
(2-[4-(4-chloro-4'-methoxybiphenyl-2-ylmethoxy)phen...)
Show SMILES COc1ccc(cc1)-c1ccc(Cl)cc1COc1ccc(cc1)-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C34H31ClN2O4/c1-40-28-13-7-22(8-14-28)30-17-12-26(35)19-25(30)21-41-29-15-9-23(10-16-29)33-36-31-20-24(34(38)39)11-18-32(31)37(33)27-5-3-2-4-6-27/h7-20,27H,2-6,21H2,1H3,(H,38,39)
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n/an/a 1.00E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191550
PNG
(2-[4-(biphenyl-2-ylmethoxy)-2-fluorophenyl]-1-cycl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccccc2-c2ccccc2)cc1F
Show InChI InChI=1S/C33H29FN2O3/c34-29-20-26(39-21-24-11-7-8-14-27(24)22-9-3-1-4-10-22)16-17-28(29)32-35-30-19-23(33(37)38)15-18-31(30)36(32)25-12-5-2-6-13-25/h1,3-4,7-11,14-20,25H,2,5-6,12-13,21H2,(H,37,38)
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n/an/a 1.00E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191528
PNG
(2-[4-(4-chloro-4'-methylbiphenyl-2-ylmethoxy)pheny...)
Show SMILES Cc1ccc(cc1)-c1ccc(Cl)cc1COc1ccc(cc1)-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C34H31ClN2O3/c1-22-7-9-23(10-8-22)30-17-14-27(35)19-26(30)21-40-29-15-11-24(12-16-29)33-36-31-20-25(34(38)39)13-18-32(31)37(33)28-5-3-2-4-6-28/h7-20,28H,2-6,21H2,1H3,(H,38,39)
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n/an/a 1.02E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191528
PNG
(2-[4-(4-chloro-4'-methylbiphenyl-2-ylmethoxy)pheny...)
Show SMILES Cc1ccc(cc1)-c1ccc(Cl)cc1COc1ccc(cc1)-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C34H31ClN2O3/c1-22-7-9-23(10-8-22)30-17-14-27(35)19-26(30)21-40-29-15-11-24(12-16-29)33-36-31-20-25(34(38)39)13-18-32(31)37(33)28-5-3-2-4-6-28/h7-20,28H,2-6,21H2,1H3,(H,38,39)
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n/an/a 1.02E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191534
PNG
(2-{4-[4-(4-chlorophenyl)-2-methylthiazol-5-ylmetho...)
Show SMILES Cc1nc(c(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C31H28ClN3O3S/c1-19-33-29(20-7-12-23(32)13-8-20)28(39-19)18-38-25-14-9-21(10-15-25)30-34-26-17-22(31(36)37)11-16-27(26)35(30)24-5-3-2-4-6-24/h7-17,24H,2-6,18H2,1H3,(H,36,37)
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n/an/a 1.11E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191534
PNG
(2-{4-[4-(4-chlorophenyl)-2-methylthiazol-5-ylmetho...)
Show SMILES Cc1nc(c(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)s1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C31H28ClN3O3S/c1-19-33-29(20-7-12-23(32)13-8-20)28(39-19)18-38-25-14-9-21(10-15-25)30-34-26-17-22(31(36)37)11-16-27(26)35(30)24-5-3-2-4-6-24/h7-17,24H,2-6,18H2,1H3,(H,36,37)
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n/an/a 1.11E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191507
PNG
(2-[4-(4'-carbamoyl-4-chlorobiphenyl-2-ylmethoxy)ph...)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(Cl)cc1COc1ccc(cc1)-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C34H30ClN3O4/c35-26-13-16-29(21-6-8-22(9-7-21)32(36)39)25(18-26)20-42-28-14-10-23(11-15-28)33-37-30-19-24(34(40)41)12-17-31(30)38(33)27-4-2-1-3-5-27/h6-19,27H,1-5,20H2,(H2,36,39)(H,40,41)
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n/an/a 1.44E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191507
PNG
(2-[4-(4'-carbamoyl-4-chlorobiphenyl-2-ylmethoxy)ph...)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(Cl)cc1COc1ccc(cc1)-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C34H30ClN3O4/c35-26-13-16-29(21-6-8-22(9-7-21)32(36)39)25(18-26)20-42-28-14-10-23(11-15-28)33-37-30-19-24(34(40)41)12-17-31(30)38(33)27-4-2-1-3-5-27/h6-19,27H,1-5,20H2,(H2,36,39)(H,40,41)
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n/an/a 1.45E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191540
PNG
(2-[4-(4'-chloro-4-dimethylaminobiphenyl-2-ylmethox...)
Show SMILES CN(C)c1ccc(c(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C35H34ClN3O3/c1-38(2)29-15-18-31(23-8-13-27(36)14-9-23)26(20-29)22-42-30-16-10-24(11-17-30)34-37-32-21-25(35(40)41)12-19-33(32)39(34)28-6-4-3-5-7-28/h8-21,28H,3-7,22H2,1-2H3,(H,40,41)
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n/an/a 1.58E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191540
PNG
(2-[4-(4'-chloro-4-dimethylaminobiphenyl-2-ylmethox...)
Show SMILES CN(C)c1ccc(c(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C35H34ClN3O3/c1-38(2)29-15-18-31(23-8-13-27(36)14-9-23)26(20-29)22-42-30-16-10-24(11-17-30)34-37-32-21-25(35(40)41)12-19-33(32)39(34)28-6-4-3-5-7-28/h8-21,28H,3-7,22H2,1-2H3,(H,40,41)
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n/an/a 1.59E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191530
PNG
(2-[4-(4'-carboxy-4-chlorobiphenyl-2-ylmethoxy)phen...)
Show SMILES OC(=O)c1ccc(cc1)-c1ccc(Cl)cc1COc1ccc(cc1)-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C34H29ClN2O5/c35-26-13-16-29(21-6-8-23(9-7-21)33(38)39)25(18-26)20-42-28-14-10-22(11-15-28)32-36-30-19-24(34(40)41)12-17-31(30)37(32)27-4-2-1-3-5-27/h6-19,27H,1-5,20H2,(H,38,39)(H,40,41)
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n/an/a 1.72E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191530
PNG
(2-[4-(4'-carboxy-4-chlorobiphenyl-2-ylmethoxy)phen...)
Show SMILES OC(=O)c1ccc(cc1)-c1ccc(Cl)cc1COc1ccc(cc1)-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C34H29ClN2O5/c35-26-13-16-29(21-6-8-23(9-7-21)33(38)39)25(18-26)20-42-28-14-10-22(11-15-28)32-36-30-19-24(34(40)41)12-17-31(30)37(32)27-4-2-1-3-5-27/h6-19,27H,1-5,20H2,(H,38,39)(H,40,41)
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n/an/a 1.73E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191547
PNG
(2-[4-(4-chloro-4'-cyanobiphenyl-2-ylmethoxy)phenyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C34H28ClN3O3/c35-27-13-16-30(23-8-6-22(20-36)7-9-23)26(18-27)21-41-29-14-10-24(11-15-29)33-37-31-19-25(34(39)40)12-17-32(31)38(33)28-4-2-1-3-5-28/h6-19,28H,1-5,21H2,(H,39,40)
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n/an/a 1.81E+7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191547
PNG
(2-[4-(4-chloro-4'-cyanobiphenyl-2-ylmethoxy)phenyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C34H28ClN3O3/c35-27-13-16-30(23-8-6-22(20-36)7-9-23)26(18-27)21-41-29-14-10-24(11-15-29)33-37-31-19-25(34(39)40)12-17-32(31)38(33)28-4-2-1-3-5-28/h6-19,28H,1-5,21H2,(H,39,40)
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n/an/a 1.82E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191514
PNG
(2-{4-[2-(4-chlorophenyl)pyridin-3-ylmethoxy]phenyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cccnc2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C32H28ClN3O3/c33-25-13-8-21(9-14-25)30-24(5-4-18-34-30)20-39-27-15-10-22(11-16-27)31-35-28-19-23(32(37)38)12-17-29(28)36(31)26-6-2-1-3-7-26/h4-5,8-19,26H,1-3,6-7,20H2,(H,37,38)
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n/an/a 1.88E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191514
PNG
(2-{4-[2-(4-chlorophenyl)pyridin-3-ylmethoxy]phenyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cccnc2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C32H28ClN3O3/c33-25-13-8-21(9-14-25)30-24(5-4-18-34-30)20-39-27-15-10-22(11-16-27)31-35-28-19-23(32(37)38)12-17-29(28)36(31)26-6-2-1-3-7-26/h4-5,8-19,26H,1-3,6-7,20H2,(H,37,38)
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n/an/a 1.89E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191522
PNG
(1-cyclohexyl-2-[4-(4,4'-dichlorobiphenyl-2-ylmetho...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C33H28Cl2N2O3/c34-25-11-6-21(7-12-25)29-16-13-26(35)18-24(29)20-40-28-14-8-22(9-15-28)32-36-30-19-23(33(38)39)10-17-31(30)37(32)27-4-2-1-3-5-27/h6-19,27H,1-5,20H2,(H,38,39)
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n/an/a 1.99E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191512
PNG
(2-[4-(4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cycl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C33H29ClN2O3/c34-26-15-10-22(11-16-26)29-9-5-4-6-25(29)21-39-28-17-12-23(13-18-28)32-35-30-20-24(33(37)38)14-19-31(30)36(32)27-7-2-1-3-8-27/h4-6,9-20,27H,1-3,7-8,21H2,(H,37,38)
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n/an/a 1.99E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191512
PNG
(2-[4-(4'-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cycl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C33H29ClN2O3/c34-26-15-10-22(11-16-26)29-9-5-4-6-25(29)21-39-28-17-12-23(13-18-28)32-35-30-20-24(33(37)38)14-19-31(30)36(32)27-7-2-1-3-8-27/h4-6,9-20,27H,1-3,7-8,21H2,(H,37,38)
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n/an/a 2.00E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191522
PNG
(1-cyclohexyl-2-[4-(4,4'-dichlorobiphenyl-2-ylmetho...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C33H28Cl2N2O3/c34-25-11-6-21(7-12-25)29-16-13-26(35)18-24(29)20-40-28-14-8-22(9-15-28)32-36-30-19-23(33(38)39)10-17-31(30)37(32)27-4-2-1-3-5-27/h6-19,27H,1-5,20H2,(H,38,39)
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n/an/a 2.00E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191506
PNG
(2-[4-(4'-chloro-4-cyanobiphenyl-2-ylmethoxy)phenyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(ccc2-c2ccc(Cl)cc2)C#N)cc1
Show InChI InChI=1S/C34H28ClN3O3/c35-27-12-7-23(8-13-27)30-16-6-22(20-36)18-26(30)21-41-29-14-9-24(10-15-29)33-37-31-19-25(34(39)40)11-17-32(31)38(33)28-4-2-1-3-5-28/h6-19,28H,1-5,21H2,(H,39,40)
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n/an/a 2.43E+7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191506
PNG
(2-[4-(4'-chloro-4-cyanobiphenyl-2-ylmethoxy)phenyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(ccc2-c2ccc(Cl)cc2)C#N)cc1
Show InChI InChI=1S/C34H28ClN3O3/c35-27-12-7-23(8-13-27)30-16-6-22(20-36)18-26(30)21-41-29-14-9-24(10-15-29)33-37-31-19-25(34(39)40)11-17-32(31)38(33)28-4-2-1-3-5-28/h6-19,28H,1-5,21H2,(H,39,40)
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n/an/a 2.44E+7n/an/an/an/an/an/a


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Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50126676
PNG
(2-[4-(4'-Chloro-4-methoxy-biphenyl-2-ylmethoxy)-ph...)
Show SMILES COc1ccc(c(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C34H31ClN2O4/c1-40-29-16-17-30(22-7-12-26(35)13-8-22)25(19-29)21-41-28-14-9-23(10-15-28)33-36-31-20-24(34(38)39)11-18-32(31)37(33)27-5-3-2-4-6-27/h7-20,27H,2-6,21H2,1H3,(H,38,39)
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n/an/a 2.70E+7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50126676
PNG
(2-[4-(4'-Chloro-4-methoxy-biphenyl-2-ylmethoxy)-ph...)
Show SMILES COc1ccc(c(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C34H31ClN2O4/c1-40-29-16-17-30(22-7-12-26(35)13-8-22)25(19-29)21-41-28-14-9-23(10-15-28)33-36-31-20-24(34(38)39)11-18-32(31)37(33)27-5-3-2-4-6-27/h7-20,27H,2-6,21H2,1H3,(H,38,39)
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n/an/a 2.70E+7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191539
PNG
(2-{4-[4'-chloro-4-(isobutyrylmethylamino)biphenyl-...)
Show SMILES CC(C)C(=O)N(C)c1ccc(c(COc2ccc(-c3nc4cc(ccc4n3C3CCCCC3)C(O)=O)c(F)c2)c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C38H37ClFN3O4/c1-23(2)37(44)42(3)29-14-16-31(24-9-12-27(39)13-10-24)26(19-29)22-47-30-15-17-32(33(40)21-30)36-41-34-20-25(38(45)46)11-18-35(34)43(36)28-7-5-4-6-8-28/h9-21,23,28H,4-8,22H2,1-3H3,(H,45,46)
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n/an/a 3.12E+7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus genotype 1)		BDBM50191510
PNG
(2-[4-(4'-chloro-5-dimethylcarbamoylbiphenyl-2-ylme...)
Show SMILES CN(C)C(=O)c1ccc(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C36H34ClN3O4/c1-39(2)35(41)25-8-9-27(31(20-25)23-10-15-28(37)16-11-23)22-44-30-17-12-24(13-18-30)34-38-32-21-26(36(42)43)14-19-33(32)40(34)29-6-4-3-5-7-29/h8-21,29H,3-7,22H2,1-2H3,(H,42,43)
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n/an/a 3.12E+7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 min

Citation and Details

Article DOI: 10.1007/s00044-012-0186-8
BindingDB Entry DOI: 10.7270/Q2NC6441
More data for this
Ligand-Target Pair
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