Found 68 hits of kd for UniProtKB: P11229 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50083652
(CHEMBL112297 | Hexadecanoic acid (S)-2-benzyloxyca...)Show SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1 Show InChI InChI=1S/C42H72N2O6/c1-3-5-7-9-11-13-15-16-18-20-22-24-29-33-41(47)49-36-38(42(48)50-35-37-30-26-25-27-31-37)44-40(46)34-43-39(45)32-28-23-21-19-17-14-12-10-8-6-4-2/h25-27,30-31,38H,3-24,28-29,32-36H2,1-2H3,(H,43,45)(H,44,46)/t38-/m0/s1 | UniProtKB/SwissProt
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GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a |
University of Toledo
Curated by ChEMBL
| Assay Description
Binding of [3H]-QNB to HM1 receptor was evaluated by saturation binding assay |
Bioorg Med Chem Lett 9: 3363-8 (2000)
BindingDB Entry DOI: 10.7270/Q2668CDH |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50083651
((S)-3-Hydroxy-2-(2-tetradecanoylamino-acetylamino)...)Show SMILES CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1 Show InChI InChI=1S/C26H42N2O5/c1-2-3-4-5-6-7-8-9-10-11-15-18-24(30)27-19-25(31)28-23(20-29)26(32)33-21-22-16-13-12-14-17-22/h12-14,16-17,23,29H,2-11,15,18-21H2,1H3,(H,27,30)(H,28,31)/t23-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a |
University of Toledo
Curated by ChEMBL
| Assay Description
Binding of [3H]-QNB to HM1 receptor was evaluated by saturation binding assay |
Bioorg Med Chem Lett 9: 3363-8 (2000)
BindingDB Entry DOI: 10.7270/Q2668CDH |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50601567
(CHEMBL5206565)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.N\C(NCCCc1nnc(N)s1)=N/C(=O)NCc1ccccc1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00692
BindingDB Entry DOI: 10.7270/Q2MP57CT |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50601574
(CHEMBL5201074)Show SMILES Cl.Cl.C[C@@H](NC(=O)\N=C(/N)NCCCc1ncn[nH]1)c1ccccc1 |r| | UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00692
BindingDB Entry DOI: 10.7270/Q2MP57CT |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50601551
(CHEMBL5207281)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CCCCCNC(=O)\N=C(/N)NCCCc1nnc(N)s1 | UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00692
BindingDB Entry DOI: 10.7270/Q2MP57CT |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50568740
(CHEMBL4860528) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00692
BindingDB Entry DOI: 10.7270/Q2MP57CT |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50412728
(CHEMBL521523)Show SMILES C[C@H]1CN(Cc2cccc(c2)-c2cc(CNC(=O)c3cccc(CC4CCNCC4)c3)ccc2F)CCN1 |r| Show InChI InChI=1S/C32H39FN4O/c1-23-21-37(15-14-35-23)22-27-5-3-6-28(18-27)30-19-26(8-9-31(30)33)20-36-32(38)29-7-2-4-25(17-29)16-24-10-12-34-13-11-24/h2-9,17-19,23-24,34-35H,10-16,20-22H2,1H3,(H,36,38)/t23-/m0/s1 | UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili... |
Bioorg Med Chem Lett 19: 1686-90 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50525143
(CHEMBL4471882)Show SMILES CCC(=O)NCc1cc(cc(c1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc34)CC2)CC1)C(=O)NCCN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C61H80N12O6/c1-2-56(74)64-42-45-39-46(58(76)62-24-33-68-29-20-48(21-30-68)71-31-22-49(23-32-71)72-54-16-7-5-14-52(54)66-61(72)79)41-47(40-45)59(77)63-25-34-69-37-35-67(36-38-69)26-10-9-11-44-18-27-70(28-19-44)43-57(75)73-53-15-6-3-12-50(53)60(78)65-51-13-4-8-17-55(51)73/h3-8,12-17,39-41,44,48-49H,2,9-11,18-38,42-43H2,1H3,(H,62,76)(H,63,77)(H,64,74)(H,65,78)(H,66,79) | UniProtKB/SwissProt
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 0.813 | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Displacement of [3H]-UR-SK259 human muscarinic M1 receptor |
J Med Chem 63: 4133-4154 (2020)
Article DOI: 10.1021/acs.jmedchem.9b02172
BindingDB Entry DOI: 10.7270/Q2R214WT |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50281909
((R)-2-[(E)-2-(9,10-Dihydro-anthracen-9-yl)-vinyl]-...)Show InChI InChI=1S/C22H25N/c1-23-15-7-6-10-19(23)13-14-22-20-11-4-2-8-17(20)16-18-9-3-5-12-21(18)22/h2-5,8-9,11-14,19,22H,6-7,10,15-16H2,1H3/b14-13+/t19-/m1/s1 | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-QNB from muscarinic receptor 1 expressed in CHO-K1 cells |
Bioorg Med Chem Lett 3: 1247-1252 (1993)
Article DOI: 10.1016/S0960-894X(00)80325-X
BindingDB Entry DOI: 10.7270/Q2348K91 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50413109
(CHEMBL553448)Show SMILES C[N+]1(Cc2ccc(O)cc2)CCC[C@@H](C1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(s1)C(=O)OC1CCCCC1 |r| Show InChI InChI=1S/C34H42N4O6S/c1-38(21-24-11-15-27(40)16-12-24)19-5-6-25(22-38)35-32(41)29(20-23-9-13-26(39)14-10-23)36-34(43)37-31-18-17-30(45-31)33(42)44-28-7-3-2-4-8-28/h9-18,25,28-29H,2-8,19-22H2,1H3,(H4-,35,36,37,39,40,41,42,43)/p+1/t25-,29-,38?/m0/s1 | UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.51 | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ... |
Bioorg Med Chem Lett 18: 5481-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.020
BindingDB Entry DOI: 10.7270/Q23B61CM |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50281902
((R)-2-[2-(10H-Anthracen-9-ylidene)-ethyl]-1-methyl...)Show SMILES [#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6@@H]-1-[#6]\[#6]=[#6]-1\c2ccccc2-[#6]-c2ccccc-12 Show InChI InChI=1S/C22H25N/c1-23-15-7-6-10-19(23)13-14-22-20-11-4-2-8-17(20)16-18-9-3-5-12-21(18)22/h2-5,8-9,11-12,14,19H,6-7,10,13,15-16H2,1H3/t19-/m1/s1 | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-QNB from muscarinic receptor 1 expressed in CHO-K1 cells |
Bioorg Med Chem Lett 3: 1247-1252 (1993)
Article DOI: 10.1016/S0960-894X(00)80325-X
BindingDB Entry DOI: 10.7270/Q2348K91 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50281906
(2-[(E)-2-(9,9a-Dihydro-4aH-xanthen-9-yl)-vinyl]-1-...)Show SMILES CN1CCCCC1\C=C\C1C2C=CC=CC2Oc2ccccc12 |c:12,14| Show InChI InChI=1S/C21H25NO/c1-22-15-7-6-8-16(22)13-14-17-18-9-2-4-11-20(18)23-21-12-5-3-10-19(17)21/h2-5,9-14,16-18,20H,6-8,15H2,1H3/b14-13+ | UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-QNB from muscarinic receptor 1 expressed in CHO-K1 cells |
Bioorg Med Chem Lett 3: 1247-1252 (1993)
Article DOI: 10.1016/S0960-894X(00)80325-X
BindingDB Entry DOI: 10.7270/Q2348K91 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50151218
(CHEMBL2368392 | difluoro(2-{[(2Z)-1-methyl-5-(2-{[...)Show SMILES F[B-]1(F)n2c(ccc2-c2cccs2)C=C2C=CC(CCC(=O)NCCOCCOCCOCCOCCOCCOCCN3CCN(CC(=O)N4c5ccccc5C(=O)Nc5cccnc45)CC3)=[N+]12 |c:17,t:15,73| Show InChI InChI=1S/C48H59BF2N8O9S/c50-49(51)58-37(9-10-38(58)35-39-11-13-43(59(39)49)44-8-4-34-69-44)12-14-45(60)52-16-22-63-24-26-65-28-30-67-32-33-68-31-29-66-27-25-64-23-21-55-17-19-56(20-18-55)36-46(61)57-42-7-2-1-5-40(42)48(62)54-41-6-3-15-53-47(41)57/h1-11,13,15,34-35H,12,14,16-33,36H2,(H,52,60)(H,54,62) | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a |
UMR CNRS/ULP 7081
Curated by ChEMBL
| Assay Description
Apparent dissociation constant for human muscarinic receptor M1 from FRET based binding assay |
J Med Chem 47: 4300-15 (2004)
Article DOI: 10.1021/jm040800a
BindingDB Entry DOI: 10.7270/Q2T43TVQ |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50281903
((S)-2-[(E)-2-(9,10-Dihydro-anthracen-9-yl)-vinyl]-...)Show InChI InChI=1S/C22H25N/c1-23-15-7-6-10-19(23)13-14-22-20-11-4-2-8-17(20)16-18-9-3-5-12-21(18)22/h2-5,8-9,11-14,19,22H,6-7,10,15-16H2,1H3/b14-13+/t19-/m0/s1 | UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-QNB from rat brain stem muscarinic receptor 2 (M2) |
Bioorg Med Chem Lett 3: 1247-1252 (1993)
Article DOI: 10.1016/S0960-894X(00)80325-X
BindingDB Entry DOI: 10.7270/Q2348K91 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50281903
((S)-2-[(E)-2-(9,10-Dihydro-anthracen-9-yl)-vinyl]-...)Show InChI InChI=1S/C22H25N/c1-23-15-7-6-10-19(23)13-14-22-20-11-4-2-8-17(20)16-18-9-3-5-12-21(18)22/h2-5,8-9,11-14,19,22H,6-7,10,15-16H2,1H3/b14-13+/t19-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | n/a | 4.92 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-QNB from muscarinic receptor 1 expressed in CHO-K1 cells |
Bioorg Med Chem Lett 3: 1247-1252 (1993)
Article DOI: 10.1016/S0960-894X(00)80325-X
BindingDB Entry DOI: 10.7270/Q2348K91 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50281905
(2-[3-(10H-Anthracen-9-ylidene)-propyl]-1-methyl-pi...)Show SMILES [#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1-[#6]-[#6]\[#6]=[#6]-1\c2ccccc2-[#6]-c2ccccc-12 Show InChI InChI=1S/C23H27N/c1-24-16-7-6-11-20(24)12-8-15-23-21-13-4-2-9-18(21)17-19-10-3-5-14-22(19)23/h2-5,9-10,13-15,20H,6-8,11-12,16-17H2,1H3 | UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-QNB from muscarinic receptor 1 expressed in CHO-K1 cells |
Bioorg Med Chem Lett 3: 1247-1252 (1993)
Article DOI: 10.1016/S0960-894X(00)80325-X
BindingDB Entry DOI: 10.7270/Q2348K91 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50281904
(2-[(E)-3-(9,10-Dihydro-anthracen-9-yl)-allyl]-1-me...)Show InChI InChI=1S/C23H27N/c1-24-16-7-6-11-20(24)12-8-15-23-21-13-4-2-9-18(21)17-19-10-3-5-14-22(19)23/h2-5,8-10,13-15,20,23H,6-7,11-12,16-17H2,1H3/b15-8+ | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
| n/a | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-QNB from muscarinic receptor 1 expressed in CHO-K1 cells |
Bioorg Med Chem Lett 3: 1247-1252 (1993)
Article DOI: 10.1016/S0960-894X(00)80325-X
BindingDB Entry DOI: 10.7270/Q2348K91 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50609879
(CHEMBL5271406) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50538312
(CHEMBL4641726)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC1(C)\C(=C/C=C/C=C/C2=[N+](CCCCS([O-])(=O)=O)c3ccccc3C2(C)C)N(CCCCCC(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc45)CC3)CC2)c2ccc(cc12)S(O)(=O)=O |c:21| Show InChI InChI=1S/C65H84N8O9S2/c1-64(2)52-23-11-14-26-56(52)71(38-19-20-46-83(77,78)79)59(64)28-7-5-8-29-60-65(3,4)53-47-50(84(80,81)82)31-32-57(53)72(60)37-17-6-9-30-61(74)66-35-41-69-44-42-68(43-45-69)36-18-16-21-49-33-39-70(40-34-49)48-62(75)73-55-25-13-10-22-51(55)63(76)67-54-24-12-15-27-58(54)73/h5,7-8,10-15,22-29,31-32,47,49H,6,9,16-21,30,33-46,48H2,1-4H3,(H3-,66,67,74,76,77,78,79,80,81,82) | UniProtKB/SwissProt
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Binding affinity to human muscarinic M1 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric ... |
J Med Chem 63: 4133-4154 (2020)
Article DOI: 10.1021/acs.jmedchem.9b02172
BindingDB Entry DOI: 10.7270/Q2R214WT |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50609879
(CHEMBL5271406) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50609883
(CHEMBL5285607) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50609883
(CHEMBL5285607) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | n/a | n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50538314
(CHEMBL4636899)Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC1(C)\C(=C/C=C/C=C/C2=[N+](CCCCS([O-])(=O)=O)c3ccccc3C2(C)C)N(CCCCCC(=O)NCc2cc(cc(c2)C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc45)CC3)cn2)C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc45)CC3)cn2)c2ccc(cc12)S(O)(=O)=O |c:27| Show InChI InChI=1S/C108H129N17O15S2/c1-107(2)86-31-12-17-36-92(86)122(59-25-26-64-141(135,136)137)96(107)39-7-5-8-40-97-108(3,4)87-68-83(142(138,139)140)44-45-93(87)123(97)58-22-6-9-41-98(126)113-69-78-65-79(103(131)111-54-52-109-99(127)46-42-81-70-120(74-114-81)56-23-20-27-76-48-60-118(61-49-76)72-101(129)124-90-34-15-10-29-84(90)105(133)116-88-32-13-18-37-94(88)124)67-80(66-78)104(132)112-55-53-110-100(128)47-43-82-71-121(75-115-82)57-24-21-28-77-50-62-119(63-51-77)73-102(130)125-91-35-16-11-30-85(91)106(134)117-89-33-14-19-38-95(89)125/h5,7-8,10-19,29-40,44-45,65-68,70-71,74-77H,6,9,20-28,41-43,46-64,69,72-73H2,1-4H3,(H8-,109,110,111,112,113,116,117,126,127,128,131,132,133,134,135,136,137,138,139,140) | UniProtKB/SwissProt
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University of Regensburg
Curated by ChEMBL
| Assay Description
Binding affinity to human muscarinic M1 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confo... |
J Med Chem 63: 4133-4154 (2020)
Article DOI: 10.1021/acs.jmedchem.9b02172
BindingDB Entry DOI: 10.7270/Q2R214WT |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50281902
((R)-2-[2-(10H-Anthracen-9-ylidene)-ethyl]-1-methyl...)Show SMILES [#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6@@H]-1-[#6]\[#6]=[#6]-1\c2ccccc2-[#6]-c2ccccc-12 Show InChI InChI=1S/C22H25N/c1-23-15-7-6-10-19(23)13-14-22-20-11-4-2-8-17(20)16-18-9-3-5-12-21(18)22/h2-5,8-9,11-12,14,19H,6-7,10,13,15-16H2,1H3/t19-/m1/s1 | UniProtKB/SwissProt
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TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-QNB from muscarinic receptor 1 expressed in CHO-K1 cells |
Bioorg Med Chem Lett 3: 1247-1252 (1993)
Article DOI: 10.1016/S0960-894X(00)80325-X
BindingDB Entry DOI: 10.7270/Q2348K91 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50151216
(CHEMBL2368391 | difluoro(2-{[(2Z)-1-methyl-5-{2-[(...)Show SMILES F[B-]1(F)n2c(ccc2-c2cccs2)C=C2C=CC(CCC(=O)NCCCCCC(=O)NCCCCCC(=O)NCCCCN3CCN(CC(=O)N4c5ccccc5C(=O)Nc5cccnc45)CC3)=[N+]12 |c:17,t:15,73| Show InChI InChI=1S/C50H61BF2N10O5S/c52-51(53)62-37(19-20-38(62)35-39-21-23-43(63(39)51)44-16-12-34-69-44)22-24-47(66)56-26-8-2-4-17-45(64)54-25-7-1-3-18-46(65)55-27-9-10-29-59-30-32-60(33-31-59)36-48(67)61-42-15-6-5-13-40(42)50(68)58-41-14-11-28-57-49(41)61/h5-6,11-16,19-21,23,28,34-35H,1-4,7-10,17-18,22,24-27,29-33,36H2,(H,54,64)(H,55,65)(H,56,66)(H,58,68) | UniProtKB/SwissProt
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UMR CNRS/ULP 7081
Curated by ChEMBL
| Assay Description
Apparent dissociation constant for human muscarinic receptor M1 from FRET based binding assay |
J Med Chem 47: 4300-15 (2004)
Article DOI: 10.1021/jm040800a
BindingDB Entry DOI: 10.7270/Q2T43TVQ |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50151212
(CHEMBL2368393 | difluoro(2-{[(2Z)-1-methyl-5-[2-({...)Show SMILES F[B-]1(F)n2c(ccc2-c2cccs2)C=C2C=CC(CCC(=O)NCCCCCCN3CCN(CC(=O)N4c5ccccc5C(=O)Nc5cccnc45)CC3)=[N+]12 |c:17,t:15,59| Show InChI InChI=1S/C40H43BF2N8O3S/c42-41(43)50-29(13-14-30(50)27-31-15-17-35(51(31)41)36-12-8-26-55-36)16-18-37(52)44-19-5-1-2-6-21-47-22-24-48(25-23-47)28-38(53)49-34-11-4-3-9-32(34)40(54)46-33-10-7-20-45-39(33)49/h3-4,7-15,17,20,26-27H,1-2,5-6,16,18-19,21-25,28H2,(H,44,52)(H,46,54) | UniProtKB/SwissProt
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UMR CNRS/ULP 7081
Curated by ChEMBL
| Assay Description
Apparent dissociation constant for human muscarinic receptor M1 from FRET based binding assay |
J Med Chem 47: 4300-15 (2004)
Article DOI: 10.1021/jm040800a
BindingDB Entry DOI: 10.7270/Q2T43TVQ |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50151213
(CHEMBL365702 | difluoro(2-{[(2Z)-1-methyl-5-(2-{[5...)Show SMILES C[N+]1=C(CCC(=O)NCCCCCC(=O)NCCCCN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)C=C\C1=C\c1ccc(-c2cccs2)n1[BH-](F)F |c:1,49| Show InChI InChI=1S/C45H54BF2N9O4S/c1-53-33(16-17-34(53)31-35-18-20-39(57(35)46(47)48)40-14-10-30-62-40)19-21-42(59)50-22-6-2-3-15-41(58)49-23-7-8-25-54-26-28-55(29-27-54)32-43(60)56-38-13-5-4-11-36(38)45(61)52-37-12-9-24-51-44(37)56/h4-5,9-14,16-18,20,24,30-31,46H,2-3,6-8,15,19,21-23,25-29,32H2,1H3,(H,49,58)(H,50,59)(H,52,61) | UniProtKB/SwissProt
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UMR CNRS/ULP 7081
Curated by ChEMBL
| Assay Description
Apparent dissociation constant for human muscarinic receptor M1 from FRET based binding assay |
J Med Chem 47: 4300-15 (2004)
Article DOI: 10.1021/jm040800a
BindingDB Entry DOI: 10.7270/Q2T43TVQ |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50413108
(CHEMBL540145)Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC=C)(Cc3cccc(O)c3)C2)cc1 |r| Show InChI InChI=1S/C35H42N4O6/c1-4-18-39(22-26-7-5-9-31(41)20-26)19-6-8-29(23-39)36-33(42)32(21-25-10-16-30(40)17-11-25)38-35(44)37-28-14-12-27(13-15-28)34(43)45-24(2)3/h4-5,7,9-17,20,24,29,32H,1,6,8,18-19,21-23H2,2-3H3,(H4-,36,37,38,40,41,42,43,44)/p+1/t29-,32-,39?/m0/s1 | UniProtKB/SwissProt
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GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ... |
Bioorg Med Chem Lett 18: 5481-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.020
BindingDB Entry DOI: 10.7270/Q23B61CM |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50412340
(CHEMBL540359)Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1 |r| Show InChI InChI=1S/C33H40N4O6/c1-22(2)43-32(41)25-11-13-26(14-12-25)35-33(42)36-30(19-23-9-15-28(38)16-10-23)31(40)34-27-7-5-17-37(3,21-27)20-24-6-4-8-29(39)18-24/h4,6,8-16,18,22,27,30H,5,7,17,19-21H2,1-3H3,(H4-,34,35,36,38,39,40,41,42)/p+1/t27-,30-,37?/m0/s1 | UniProtKB/SwissProt
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GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ... |
Bioorg Med Chem Lett 18: 5481-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.020
BindingDB Entry DOI: 10.7270/Q23B61CM |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50151215
(2-[6-(diethylamino)-3-(diethyliminiumyl)-3H-xanthe...)Show SMILES CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)N(C)CCCCCC(=O)NCCOCCOCCN3CCN(CC(=O)N4c5ccccc5C(=O)Nc5cccnc45)CC3)c3ccc(cc3oc2c1)=[N+](CC)CC |(17.71,10.63,;16.39,9.86,;16.39,8.32,;17.71,7.55,;19.06,8.32,;15.07,7.55,;15.07,6.01,;13.74,5.24,;12.39,6.01,;11.07,5.24,;11.07,3.7,;12.39,2.93,;12.39,1.39,;11.03,.65,;9.71,1.43,;9.71,2.96,;8.22,3.37,;6.9,2.6,;8.22,1.84,;6.9,4.15,;11.03,-.91,;9.49,-.91,;12.55,-.91,;10.24,-2.24,;10.23,-3.77,;8.76,-1.83,;7.4,-2.6,;6.08,-1.83,;4.74,-2.57,;3.4,-1.81,;2.06,-2.57,;2.06,-4.12,;.72,-1.81,;-.62,-1.04,;-1.97,-1.79,;-3.29,-1.03,;-4.62,-1.79,;-5.97,-1,;-7.3,-1.79,;-8.65,-2.56,;-9.97,-1.77,;-11.29,-2.53,;-12.69,-1.79,;-13.98,-2.57,;-13.97,-4.1,;-15.29,-4.91,;-15.26,-6.45,;-14.18,-7.52,;-16.61,-7.26,;-17.89,-6.39,;-17.56,-4.87,;-18.68,-3.84,;-20.14,-4.3,;-20.46,-5.83,;-19.34,-6.86,;-19.89,-8.26,;-21.45,-8.25,;-19.12,-9.61,;-17.6,-9.83,;-17.24,-11.34,;-15.78,-11.77,;-14.67,-10.7,;-15,-9.21,;-16.5,-8.76,;-12.62,-4.87,;-11.29,-4.08,;9.75,6.01,;8.43,5.24,;7.07,6.01,;7.07,7.55,;8.43,8.32,;9.75,7.55,;11.07,8.32,;12.39,7.55,;13.74,8.32,;5.58,7.95,;5.58,9.51,;4.25,10.3,;4.26,7.2,;2.76,7.59,)| Show InChI InChI=1S/C58H73N9O11S2/c1-6-65(7-2)42-20-23-46-51(38-42)78-52-39-43(66(8-3)9-4)21-24-47(52)56(46)48-25-22-44(40-53(48)80(73,74)75)79(71,72)62(5)28-14-10-11-19-54(68)59-27-34-76-36-37-77-35-33-63-29-31-64(32-30-63)41-55(69)67-50-18-13-12-16-45(50)58(70)61-49-17-15-26-60-57(49)67/h12-13,15-18,20-26,38-40H,6-11,14,19,27-37,41H2,1-5H3,(H2-,59,61,68,70,73,74,75) | UniProtKB/SwissProt
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UMR CNRS/ULP 7081
Curated by ChEMBL
| Assay Description
Apparent dissociation constant for human muscarinic receptor M1 from FRET based binding assay |
J Med Chem 47: 4300-15 (2004)
Article DOI: 10.1021/jm040800a
BindingDB Entry DOI: 10.7270/Q2T43TVQ |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM39341
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26) | UniProtKB/SwissProt
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UMR CNRS/ULP 7081
Curated by ChEMBL
| Assay Description
Apparent dissociation constant for human muscarinic receptor M1 from FRET based binding assay |
J Med Chem 47: 4300-15 (2004)
Article DOI: 10.1021/jm040800a
BindingDB Entry DOI: 10.7270/Q2T43TVQ |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50151214
(CHEMBL2368390 | difluoro(2-{[(2Z)-1-methyl-5-[2-({...)Show SMILES F[B-]1(F)n2c(ccc2-c2cccs2)C=C2C=CC(CCC(=O)NCCOCCOCCN3CCN(CC(=O)N4c5ccccc5C(=O)Nc5cccnc45)CC3)=[N+]12 |c:17,t:15,61| Show InChI InChI=1S/C40H43BF2N8O5S/c42-41(43)50-29(9-10-30(50)27-31-11-13-35(51(31)41)36-8-4-26-57-36)12-14-37(52)44-16-22-55-24-25-56-23-21-47-17-19-48(20-18-47)28-38(53)49-34-7-2-1-5-32(34)40(54)46-33-6-3-15-45-39(33)49/h1-11,13,15,26-27H,12,14,16-25,28H2,(H,44,52)(H,46,54) | UniProtKB/SwissProt
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UMR CNRS/ULP 7081
Curated by ChEMBL
| Assay Description
Apparent dissociation constant for human muscarinic receptor M1 from FRET based binding assay |
J Med Chem 47: 4300-15 (2004)
Article DOI: 10.1021/jm040800a
BindingDB Entry DOI: 10.7270/Q2T43TVQ |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50281907
((S)-2-[2-(10H-Anthracen-9-ylidene)-ethyl]-1-methyl...)Show SMILES [#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6@H]-1-[#6]\[#6]=[#6]-1\c2ccccc2-[#6]-c2ccccc-12 Show InChI InChI=1S/C22H25N/c1-23-15-7-6-10-19(23)13-14-22-20-11-4-2-8-17(20)16-18-9-3-5-12-21(18)22/h2-5,8-9,11-12,14,19H,6-7,10,13,15-16H2,1H3/t19-/m0/s1 | UniProtKB/SwissProt
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TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-QNB from muscarinic receptor 1 expressed in CHO-K1 cells |
Bioorg Med Chem Lett 3: 1247-1252 (1993)
Article DOI: 10.1016/S0960-894X(00)80325-X
BindingDB Entry DOI: 10.7270/Q2348K91 |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50538313
(CHEMBL4644612)Show SMILES OC(=O)C(F)(F)F.CC1(C)\C(=C/C=C/C=C/C2=[N+](CCCCS([O-])(=O)=O)c3ccccc3C2(C)C)N(CCCCCC(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc45)CC3)cn2)c2ccc(cc12)S(O)(=O)=O |c:15| Show InChI InChI=1S/C67H83N9O10S2/c1-66(2)53-23-11-14-26-57(53)74(41-19-20-44-87(81,82)83)60(66)28-7-5-8-29-61-67(3,4)54-45-51(88(84,85)86)32-33-58(54)75(61)40-17-6-9-30-62(77)68-37-38-69-63(78)34-31-50-46-73(48-70-50)39-18-16-21-49-35-42-72(43-36-49)47-64(79)76-56-25-13-10-22-52(56)65(80)71-55-24-12-15-27-59(55)76/h5,7-8,10-15,22-29,32-33,45-46,48-49H,6,9,16-21,30-31,34-44,47H2,1-4H3,(H4-,68,69,71,77,78,80,81,82,83,84,85,86) | UniProtKB/SwissProt
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University of Regensburg
Curated by ChEMBL
| Assay Description
Binding affinity to human muscarinic M1 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confo... |
J Med Chem 63: 4133-4154 (2020)
Article DOI: 10.1021/acs.jmedchem.9b02172
BindingDB Entry DOI: 10.7270/Q2R214WT |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50413110
(CHEMBL540148)Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1 |r| Show InChI InChI=1S/C31H38N4O6S/c1-20(2)41-30(39)27-14-15-28(42-27)34-31(40)33-26(17-21-6-10-24(36)11-7-21)29(38)32-23-5-4-16-35(3,19-23)18-22-8-12-25(37)13-9-22/h6-15,20,23,26H,4-5,16-19H2,1-3H3,(H4-,32,33,34,36,37,38,39,40)/p+1/t23-,26-,35?/m0/s1 | UniProtKB/SwissProt
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GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ... |
Bioorg Med Chem Lett 18: 5481-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.020
BindingDB Entry DOI: 10.7270/Q23B61CM |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50151219
((2E)-2-[(2E)-3-[3,3-dimethyl-1-(5-{[2-(2-{2-[4-(2-...)Show SMILES CCN1\C(=C\C=C\C2N(CCCCCC(=O)NCCOCCOCCN3CCN(CC(=O)N4c5ccccc5C(=O)Nc5cccnc45)CC3)c3ccc(cc3C2(C)C)S([O-])(=O)=O)C(C)(C)c2cc(ccc12)S([O-])(=O)=O Show InChI InChI=1S/C55H70N8O11S2/c1-6-61-46-22-20-39(75(67,68)69)36-42(46)54(2,3)48(61)17-12-18-49-55(4,5)43-37-40(76(70,71)72)21-23-47(43)62(49)26-11-7-8-19-50(64)56-25-32-73-34-35-74-33-31-59-27-29-60(30-28-59)38-51(65)63-45-16-10-9-14-41(45)53(66)58-44-15-13-24-57-52(44)63/h9-10,12-18,20-24,36-37,49H,6-8,11,19,25-35,38H2,1-5H3,(H,56,64)(H,58,66)(H,67,68,69)(H,70,71,72)/p-2/b18-12+,48-17+ | UniProtKB/SwissProt
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UMR CNRS/ULP 7081
Curated by ChEMBL
| Assay Description
Apparent dissociation constant for human muscarinic receptor M1 from FRET based binding assay |
J Med Chem 47: 4300-15 (2004)
Article DOI: 10.1021/jm040800a
BindingDB Entry DOI: 10.7270/Q2T43TVQ |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50413107
(CHEMBL550885)Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1 |r| Show InChI InChI=1S/C33H44N4O5/c1-22(2)42-32(40)26-11-13-27(14-12-26)35-33(41)36-30(18-23-9-15-29(38)16-10-23)31(39)34-28-4-3-17-37(21-28,19-24-5-6-24)20-25-7-8-25/h9-16,22,24-25,28,30H,3-8,17-21H2,1-2H3,(H3-,34,35,36,38,39,40,41)/p+1/t28-,30-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | 39.8 | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ... |
Bioorg Med Chem Lett 18: 5481-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.020
BindingDB Entry DOI: 10.7270/Q23B61CM |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50075198
(CHEMBL3414840)Show SMILES [Br-].C[N+](C)(CCCCNC(=O)c1cn(Cc2ccccc2)c2cc(Cl)c(F)cc2c1=O)CC#CCOC1=NOCC1 |t:38| Show InChI InChI=1S/C30H32ClFN4O4/c1-36(2,15-8-9-16-39-28-12-17-40-34-28)14-7-6-13-33-30(38)24-21-35(20-22-10-4-3-5-11-22)27-19-25(31)26(32)18-23(27)29(24)37/h3-5,10-11,18-19,21H,6-7,12-17,20H2,1-2H3/p+1 | UniProtKB/SwissProt
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University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of [3H]NMS from human muscarinic M1 acetylcholine receptor expressed in CHO cell membranes by radioligand binding assay |
J Med Chem 58: 560-76 (2015)
Article DOI: 10.1021/jm500860w
BindingDB Entry DOI: 10.7270/Q2125VCS |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50075200
(CHEMBL3414842)Show SMILES [Br-].C[N+](C)(CCCCCCNC(=O)c1cn(Cc2ccccc2)c2cc(Br)ccc2c1=O)CC#CCOC1=NOCC1 |t:39| Show InChI InChI=1S/C32H37BrN4O4/c1-37(2,19-10-11-20-40-30-16-21-41-35-30)18-9-4-3-8-17-34-32(39)28-24-36(23-25-12-6-5-7-13-25)29-22-26(33)14-15-27(29)31(28)38/h5-7,12-15,22,24H,3-4,8-9,16-21,23H2,1-2H3/p+1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of [3H]NMS from human muscarinic M1 acetylcholine receptor expressed in CHO cell membranes by radioligand binding assay |
J Med Chem 58: 560-76 (2015)
Article DOI: 10.1021/jm500860w
BindingDB Entry DOI: 10.7270/Q2125VCS |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50413106
(CHEMBL538360)Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(C2)CCCCCC3)cc1 |r| Show InChI InChI=1S/C31H42N4O5/c1-22(2)40-30(38)24-11-13-25(14-12-24)33-31(39)34-28(20-23-9-15-27(36)16-10-23)29(37)32-26-8-7-19-35(21-26)17-5-3-4-6-18-35/h9-16,22,26,28H,3-8,17-21H2,1-2H3,(H3-,32,33,34,36,37,38,39)/p+1/t26-,28-/m0/s1 | UniProtKB/SwissProt
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GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ... |
Bioorg Med Chem Lett 18: 5481-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.020
BindingDB Entry DOI: 10.7270/Q23B61CM |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50413113
(CHEMBL555706)Show SMILES CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1 |r| Show InChI InChI=1S/C33H41N5O5/c1-22(2)34-31(41)25-10-12-26(13-11-25)36-33(43)37-30(19-23-6-14-28(39)15-7-23)32(42)35-27-5-4-18-38(3,21-27)20-24-8-16-29(40)17-9-24/h6-17,22,27,30H,4-5,18-21H2,1-3H3,(H5-,34,35,36,37,39,40,41,42,43)/p+1/t27-,30-,38?/m0/s1 | UniProtKB/SwissProt
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GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ... |
Bioorg Med Chem Lett 18: 5481-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.020
BindingDB Entry DOI: 10.7270/Q23B61CM |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50413111
(CHEMBL540401)Show SMILES Cc1nc(no1)-c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1 |r| Show InChI InChI=1S/C32H36N6O5/c1-21-33-30(37-43-21)24-9-11-25(12-10-24)35-32(42)36-29(18-22-5-13-27(39)14-6-22)31(41)34-26-4-3-17-38(2,20-26)19-23-7-15-28(40)16-8-23/h5-16,26,29H,3-4,17-20H2,1-2H3,(H4-,34,35,36,37,39,40,41,42)/p+1/t26-,29-,38?/m0/s1 | UniProtKB/SwissProt
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GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ... |
Bioorg Med Chem Lett 18: 5481-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.020
BindingDB Entry DOI: 10.7270/Q23B61CM |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50075197
(CHEMBL3414839)Show SMILES [Br-].C[N+](C)(CCCCNC(=O)c1cn(Cc2ccccc2)c2cc(Br)ccc2c1=O)CC#CCOC1=NOCC1 |t:37| Show InChI InChI=1S/C30H33BrN4O4/c1-35(2,17-8-9-18-38-28-14-19-39-33-28)16-7-6-15-32-30(37)26-22-34(21-23-10-4-3-5-11-23)27-20-24(31)12-13-25(27)29(26)36/h3-5,10-13,20,22H,6-7,14-19,21H2,1-2H3/p+1 | UniProtKB/SwissProt
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| n/a | n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of [3H]NMS from human muscarinic M1 acetylcholine receptor expressed in CHO cell membranes by radioligand binding assay |
J Med Chem 58: 560-76 (2015)
Article DOI: 10.1021/jm500860w
BindingDB Entry DOI: 10.7270/Q2125VCS |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50076089
((3S,3aR,4R,4aS,8aR,9aS)-3-Methyl-4-[2-((R)-1-methy...)Show SMILES C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](\C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12 Show InChI InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1 | UniProtKB/SwissProt
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against M1 receptor expressed in CHO-K1 cells transfected with human muscarinic receptor sequence using radioligand [3H]-quinuclidin... |
Bioorg Med Chem Lett 5: 61-66 (1995)
Article DOI: 10.1016/0960-894X(94)00459-S
BindingDB Entry DOI: 10.7270/Q23778PW |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50075196
(CHEMBL3414838)Show SMILES [Br-].C[N+](C)(CCCCNC(=O)c1cn(Cc2ccccc2)c2c(F)cccc2c1=O)CC#CCOC1=NOCC1 |t:37| Show InChI InChI=1S/C30H33FN4O4/c1-35(2,18-8-9-19-38-27-15-20-39-33-27)17-7-6-16-32-30(37)25-22-34(21-23-11-4-3-5-12-23)28-24(29(25)36)13-10-14-26(28)31/h3-5,10-14,22H,6-7,15-21H2,1-2H3/p+1 | UniProtKB/SwissProt
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University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of [3H]NMS from human muscarinic M1 acetylcholine receptor expressed in CHO cell membranes by radioligand binding assay |
J Med Chem 58: 560-76 (2015)
Article DOI: 10.1021/jm500860w
BindingDB Entry DOI: 10.7270/Q2125VCS |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50075202
(CHEMBL3414844)Show SMILES [Br-].C[N+](C)(CCCCCCNC(=O)c1cn(Cc2ccccc2)c2ccc(F)cc2c1=O)CC#CCOC1=NOCC1 |t:39| Show InChI InChI=1S/C32H37FN4O4/c1-37(2,19-10-11-20-40-30-16-21-41-35-30)18-9-4-3-8-17-34-32(39)28-24-36(23-25-12-6-5-7-13-25)29-15-14-26(33)22-27(29)31(28)38/h5-7,12-15,22,24H,3-4,8-9,16-21,23H2,1-2H3/p+1 | UniProtKB/SwissProt
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University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of [3H]NMS from human muscarinic M1 acetylcholine receptor expressed in CHO cell membranes by radioligand binding assay |
J Med Chem 58: 560-76 (2015)
Article DOI: 10.1021/jm500860w
BindingDB Entry DOI: 10.7270/Q2125VCS |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50413112
(CHEMBL540146)Show SMILES Cc1noc(n1)-c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1 |r| Show InChI InChI=1S/C32H36N6O5/c1-21-33-31(43-37-21)24-9-11-25(12-10-24)35-32(42)36-29(18-22-5-13-27(39)14-6-22)30(41)34-26-4-3-17-38(2,20-26)19-23-7-15-28(40)16-8-23/h5-16,26,29H,3-4,17-20H2,1-2H3,(H4-,33,34,35,36,37,39,40,41,42)/p+1/t26-,29-,38?/m0/s1 | UniProtKB/SwissProt
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GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ... |
Bioorg Med Chem Lett 18: 5481-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.020
BindingDB Entry DOI: 10.7270/Q23B61CM |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50075195
(CHEMBL3414847)Show SMILES CC[C@@H]1SC2(CCNCC2)N(CCCCCCCCOc2ccc3cc(Cn4cc(C(O)=O)c(=O)c5cccc(F)c45)ccc3c2)C1=O |r| Show InChI InChI=1S/C38H44FN3O5S/c1-2-33-36(44)42(38(48-33)16-18-40-19-17-38)20-7-5-3-4-6-8-21-47-29-15-14-27-22-26(12-13-28(27)23-29)24-41-25-31(37(45)46)35(43)30-10-9-11-32(39)34(30)41/h9-15,22-23,25,33,40H,2-8,16-21,24H2,1H3,(H,45,46)/t33-/m0/s1 | UniProtKB/SwissProt
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University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of [3H]NMS from human muscarinic M1 acetylcholine receptor expressed in CHO cell membranes by radioligand binding assay |
J Med Chem 58: 560-76 (2015)
Article DOI: 10.1021/jm500860w
BindingDB Entry DOI: 10.7270/Q2125VCS |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50284319
((2S,6R)-1,2-Dimethyl-6-[(E)-2-((3S,3aR,4R,4aS,8aR,...)Show SMILES C[C@@H]1OC[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](\C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12 Show InChI InChI=1S/C22H37NO/c1-15-7-6-9-19(23(15)3)11-12-21-20-10-5-4-8-17(20)13-18-14-24-16(2)22(18)21/h11-12,15-22H,4-10,13-14H2,1-3H3/b12-11+/t15-,16-,17+,18+,19+,20-,21+,22-/m0/s1 | UniProtKB/SwissProt
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TBA
Curated by ChEMBL
| Assay Description
Binding affinity against M1 receptor expressed in CHO-K1 cells transfected with human muscarinic receptor sequence using radioligand [3H]-quinuclidin... |
Bioorg Med Chem Lett 5: 61-66 (1995)
Article DOI: 10.1016/0960-894X(94)00459-S
BindingDB Entry DOI: 10.7270/Q23778PW |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50076089
((3S,3aR,4R,4aS,8aR,9aS)-3-Methyl-4-[2-((R)-1-methy...)Show SMILES C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](\C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12 Show InChI InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1 | UniProtKB/SwissProt
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TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]-QNB from muscarinic receptor 1 expressed in CHO-K1 cells |
Bioorg Med Chem Lett 3: 1247-1252 (1993)
Article DOI: 10.1016/S0960-894X(00)80325-X
BindingDB Entry DOI: 10.7270/Q2348K91 |
More data for this
Ligand-Target Pair | |
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