Compile Data Set for Download or QSAR

Found 1828 hits of ki data for polymerid = 10255,10467,10624,10881,1268,20,7767,8031,8122,8648,8963,9219,9609,9732   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM106896 (US8592455, 96) Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:7.8,wD:1.0,5.5,(-6,2.69,;-4.67,1.93,;-4.67,.38,;-3.33,-.38,;-2,.38,;-2,1.93,;-.67,2.69,;-3.33,2.69,;-3.33,4.23,;-3.33,-1.93,;-4.67,-2.69,;-4.67,-4.23,;-3.33,-5,;-2,-4.23,;-2,-2.69,;-.67,-1.93,;.67,-2.69,;.67,-4.23,;2,-1.93,;3.33,-2.69,;4.67,-1.93,;4.67,-.38,;6,.38,;3.33,.38,;2,-.38,;3.33,1.93,;4.67,2.69,;6,1.93,;4.67,4.23,;3.33,5,;2,4.23,;2,2.69,;.67,1.93,)| Show InChI InChI=1S/C23H22F3N5O2/c1-12-10-31(11-16(27)22(12)32)19-7-8-28-9-18(19)30-23(33)17-6-5-15(26)21(29-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,22,32H,10-11,27H2,1H3,(H,30,33)/t12-,16+,22+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	0.00100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin)				ACS Med Chem Lett 4: 1193-7 (2013) Article DOI: 10.1021/ml400307j BindingDB Entry DOI: 10.7270/Q23X8840
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM106803 (US8592455, 3) Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F |r,wU:7.8,wD:1.0,5.5,(-6,2.69,;-4.67,1.93,;-4.67,.38,;-3.33,-.38,;-2,.38,;-2,1.93,;-.67,2.69,;-3.33,2.69,;-3.33,4.23,;-3.33,-1.93,;-4.67,-2.69,;-4.67,-4.23,;-3.33,-5,;-2,-4.23,;-2,-2.69,;-.67,-1.93,;.67,-2.69,;.67,-4.23,;2,-1.93,;2,-.38,;3.33,.38,;4.67,-.38,;6,.38,;4.67,-1.93,;3.33,-2.69,;3.33,-4.23,;3.33,1.93,;2,2.69,;.67,1.93,;2,4.23,;3.33,5,;4.67,4.23,;4.67,2.69,;6,1.93,)| Show InChI InChI=1S/C23H23F3N6O2/c1-11-9-32(10-16(28)22(11)33)18-5-6-29-8-17(18)30-23(34)21-15(27)7-14(26)20(31-21)19-12(24)3-2-4-13(19)25/h2-8,11,16,22,33H,9-10,27-28H2,1H3,(H,30,34)/t11-,16+,22+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.00100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin)				ACS Med Chem Lett 4: 1193-7 (2013) Article DOI: 10.1021/ml400307j BindingDB Entry DOI: 10.7270/Q23X8840
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227334 (US9328106, 285) Show SMILES CCOc1ccc(F)c(-c2nc(cs2)C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c1F |r| Show InChI InChI=1S/C22H24F3N5O3S/c1-3-32-16-6-4-11(23)18(19(16)25)22-29-15(10-34-22)21(31)28-14-8-27-30(2)20(14)17-7-5-13(26)12(24)9-33-17/h4,6,8,10,12-13,17H,3,5,7,9,26H2,1-2H3,(H,28,31)/t12-,13-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00100	-16.4	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227278 (US9328106, 229) Show SMILES COc1ccc(F)c(-c2nc(cs2)C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c1F |r| Show InChI InChI=1S/C21H22F3N5O3S/c1-29-19(16-6-4-12(25)11(23)8-32-16)13(7-26-29)27-20(30)14-9-33-21(28-14)17-10(22)3-5-15(31-2)18(17)24/h3,5,7,9,11-12,16H,4,6,8,25H2,1-2H3,(H,27,30)/t11-,12-,16+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00100	-16.4	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227253 (US9328106, 204) Show SMILES Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cc(cc2F)C2(O)CC2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r,wU:31.35,wD:28.31,33.37,(-5.58,4.02,;-5.58,2.48,;-6.83,1.58,;-6.35,.11,;-4.81,.11,;-4.04,-1.22,;-4.04,-2.76,;-5.38,-3.53,;-2.71,-3.53,;-2.71,-5.07,;-1.38,-5.84,;-.04,-5.07,;1.29,-5.84,;-.04,-3.53,;-1.38,-2.76,;1.29,-2.76,;1.29,-1.22,;-.04,-.45,;2.62,-.45,;3.96,-1.22,;3.96,-2.76,;2.62,-3.53,;2.62,-5.07,;5.29,-.45,;6.06,-1.78,;6.83,-.45,;6.06,.88,;-4.34,1.58,;-3.01,2.35,;-3.01,3.89,;-1.8,4.85,;-.3,4.51,;.47,5.84,;.37,3.12,;1.86,2.72,;-.3,1.73,;-1.8,1.39,)| Show InChI InChI=1S/C25H25F4N5O3/c1-34-23(20-5-3-17(30)16(29)11-37-20)19(10-31-34)33-24(35)18-4-2-13(26)22(32-18)21-14(27)8-12(9-15(21)28)25(36)6-7-25/h2,4,8-10,16-17,20,36H,3,5-7,11,30H2,1H3,(H,33,35)/t16-,17-,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00100	-16.4	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM393298 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...) Show SMILES C[C@H](F)c1cc(F)c(-c2nc(cs2)C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(F)c1 |r| Show InChI InChI=1S/C22H23F4N5O2S/c1-10(23)11-5-12(24)19(13(25)6-11)22-30-17(9-34-22)21(32)29-16-7-28-31(2)20(16)18-4-3-15(27)14(26)8-33-18/h5-7,9-10,14-15,18H,3-4,8,27H2,1-2H3,(H,29,32)/t10-,14+,15+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Institute for Medical Research					Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...				Chem Biol Drug Des 71: 131-9 (2008) BindingDB Entry DOI: 10.7270/Q22B91B0
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110797 (US8614206, 346) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)ccc(I)c2F)c1N1CC[C@@H](N)CC(F)(F)C1 |r| Show InChI InChI=1S/C20H20F4IN7OS/c1-31-19(32-5-4-9(26)6-20(23,24)8-32)12(7-28-31)29-17(33)15-16(27)34-18(30-15)13-10(21)2-3-11(25)14(13)22/h2-3,7,9H,4-6,8,26-27H2,1H3,(H,29,33)/t9-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00200	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110798 (US8614206, 347) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)ccc(I)c2F)c1N1CC[C@H](N)CC(F)(F)C1 |r| Show InChI InChI=1S/C20H20F4IN7OS/c1-31-19(32-5-4-9(26)6-20(23,24)8-32)12(7-28-31)29-17(33)15-16(27)34-18(30-15)13-10(21)2-3-11(25)14(13)22/h2-3,7,9H,4-6,8,26-27H2,1H3,(H,29,33)/t9-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00200	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110726 (US8614206, 252 | US8614206, 254 | US8614206, 352 |...) Show SMILES COC1(C)CC(N)CCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C Show InChI InChI=1S/C22H27F2N7O2S/c1-22(33-3)9-12(25)7-8-31(11-22)21-15(10-27-30(21)2)28-19(32)17-18(26)34-20(29-17)16-13(23)5-4-6-14(16)24/h4-6,10,12H,7-9,11,25-26H2,1-3H3,(H,28,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00200	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227169 (US9328106, 117) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1[C@@]12CC[C@@H](O1)[C@@H](N)CC2 |r| Show InChI InChI=1S/C21H22F2N6O2S/c1-29-17(21-7-5-12(24)14(31-21)6-8-21)13(9-26-29)27-19(30)16-18(25)32-20(28-16)15-10(22)3-2-4-11(15)23/h2-4,9,12,14H,5-8,24-25H2,1H3,(H,27,30)/t12-,14+,21+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00200	-15.9	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227362 (US9328106, 313) Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2ccc(Cl)cc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C20H20ClF2N5O2S/c1-28-18(17-5-4-14(24)13(23)8-30-17)15(7-25-28)26-19(29)16-9-31-20(27-16)11-3-2-10(21)6-12(11)22/h2-3,6-7,9,13-14,17H,4-5,8,24H2,1H3,(H,26,29)/t13-,14-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00200	-15.9	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227443 (US9328106, 396) Show SMILES Cn1ncc(NC(=O)c2csc(n2)-n2cc3ccccc3n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C21H22FN7O2S/c1-28-19(18-7-6-14(23)13(22)10-31-18)16(8-24-28)25-20(30)17-11-32-21(26-17)29-9-12-4-2-3-5-15(12)27-29/h2-5,8-9,11,13-14,18H,6-7,10,23H2,1H3,(H,25,30)/t13-,14-,18+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00200	-15.9	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50445133 (CHEMBL3103869) Show SMILES N[C@@H]1CN(CC[C@H]1O)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C22H22F2N6O2/c23-12-2-1-3-13(24)20(12)16-5-4-14(25)21(28-16)22(32)29-17-10-27-8-6-18(17)30-9-7-19(31)15(26)11-30/h1-6,8,10,15,19,31H,7,9,11,25-26H2,(H,29,32)/t15-,19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.00200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin)				ACS Med Chem Lett 4: 1193-7 (2013) Article DOI: 10.1021/ml400307j BindingDB Entry DOI: 10.7270/Q23X8840
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50445124 (CHEMBL3103868) Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C22H22F2N6O/c23-14-4-1-5-15(24)20(14)17-7-6-16(26)21(28-17)22(31)29-18-11-27-9-8-19(18)30-10-2-3-13(25)12-30/h1,4-9,11,13H,2-3,10,12,25-26H2,(H,29,31)/t13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.00200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by AlphaScreen assay				ACS Med Chem Lett 4: 1193-7 (2013) Article DOI: 10.1021/ml400307j BindingDB Entry DOI: 10.7270/Q23X8840
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227267 (US9328106, 218) Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2c(F)cc(O[C@H]3CCOC3)cc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C24H26F3N5O4S/c1-32-22(20-3-2-17(28)16(27)10-35-20)18(8-29-32)30-23(33)19-11-37-24(31-19)21-14(25)6-13(7-15(21)26)36-12-4-5-34-9-12/h6-8,11-12,16-17,20H,2-5,9-10,28H2,1H3,(H,30,33)/t12-,16+,17+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00224	-15.9	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50053685 (CHEMBL3318855 | US9328106, 341) Show SMILES C[C@H]1O[C@H](C[C@@H](N)[C@]1(C)O)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C |r| Show InChI InChI=1S/C21H23F2N5O3S/c1-10-21(2,30)16(24)7-15(31-10)18-13(8-25-28(18)3)26-19(29)14-9-32-20(27-14)17-11(22)5-4-6-12(17)23/h4-6,8-10,15-16,30H,7,24H2,1-3H3,(H,26,29)/t10-,15-,16-,21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.00300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin)				ACS Med Chem Lett 5: 730-1 (2014) Article DOI: 10.1021/ml5001678 BindingDB Entry DOI: 10.7270/Q2SN0BMH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50434655 (CHEMBL2387464) Show SMILES F[C@H]1CNCC[C@@H]1CNc1ccn2ncc(C(=O)Nc3c[nH]c4ncc(cc34)-c3ccccc3F)c2n1 |r| Show InChI InChI=1S/C26H24F2N8O/c27-20-4-2-1-3-17(20)16-9-18-22(14-32-24(18)31-11-16)34-26(37)19-12-33-36-8-6-23(35-25(19)36)30-10-15-5-7-29-13-21(15)28/h1-4,6,8-9,11-12,14-15,21,29H,5,7,10,13H2,(H,30,35)(H,31,32)(H,34,37)/t15-,21+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	0.00300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP				Bioorg Med Chem Lett 23: 3149-53 (2013) Article DOI: 10.1016/j.bmcl.2013.04.020 BindingDB Entry DOI: 10.7270/Q2PC33S9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110961 (US8614206, 518) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@@](C)(N)CC(F)(F)C1 |r| Show InChI InChI=1S/C21H23F4N7OS/c1-20(27)6-7-32(10-21(24,25)9-20)19-13(8-28-31(19)2)29-17(33)15-16(26)34-18(30-15)14-11(22)4-3-5-12(14)23/h3-5,8H,6-7,9-10,26-27H2,1-2H3,(H,29,33)/t20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.00300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of recombinant human PIM1 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay				J Med Chem 62: 2140-2153 (2019) Article DOI: 10.1021/acs.jmedchem.8b01857 BindingDB Entry DOI: 10.7270/Q2Q52SVB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110712 (US8614206, 167) Show SMILES CN=C(C(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)C=N)N1CC[C@@H](N)CC(F)(F)C1 |r,w:1.0| Show InChI InChI=1S/C20H23F4N7OS/c1-28-17(31-6-5-10(26)7-20(23,24)9-31)13(8-25)29-18(32)15-16(27)33-19(30-15)14-11(21)3-2-4-12(14)22/h2-4,8,10,13,25H,5-7,9,26-27H2,1H3,(H,29,32)/t10-,13?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00300	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110938 (US8614206, 495) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC(C)(N)CC(F)(F)C1 Show InChI InChI=1S/C21H23F4N7OS/c1-20(27)6-7-32(10-21(24,25)9-20)19-13(8-28-31(19)2)29-17(33)15-16(26)34-18(30-15)14-11(22)4-3-5-12(14)23/h3-5,8H,6-7,9-10,26-27H2,1-2H3,(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00300	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227440 (US9328106, 393) Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2ccc(cc2F)C2(C)COC2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C24H27F2N5O3S/c1-24(11-33-12-24)13-3-4-14(15(25)7-13)23-30-19(10-35-23)22(32)29-18-8-28-31(2)21(18)20-6-5-17(27)16(26)9-34-20/h3-4,7-8,10,16-17,20H,5-6,9,11-12,27H2,1-2H3,(H,29,32)/t16-,17-,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00300	-15.7	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227266 (US9328106, 217) Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2c(F)cc(O[C@@H]3CCOC3)cc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C24H26F3N5O4S/c1-32-22(20-3-2-17(28)16(27)10-35-20)18(8-29-32)30-23(33)19-11-37-24(31-19)21-14(25)6-13(7-15(21)26)36-12-4-5-34-9-12/h6-8,11-12,16-17,20H,2-5,9-10,28H2,1H3,(H,30,33)/t12-,16-,17-,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00300	-15.7	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227361 (US9328106, 312) Show SMILES Cc1cc(F)c(-c2nc(cs2)C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(F)c1 |r| Show InChI InChI=1S/C21H22F3N5O2S/c1-10-5-11(22)18(12(23)6-10)21-28-16(9-32-21)20(30)27-15-7-26-29(2)19(15)17-4-3-14(25)13(24)8-31-17/h5-7,9,13-14,17H,3-4,8,25H2,1-2H3,(H,27,30)/t13-,14-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00300	-15.7	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227381 (US9328106, 332) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)ccc(F)c2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C20H20F4N6O2S/c1-30-17(13-5-4-11(25)10(23)7-32-13)12(6-27-30)28-19(31)16-18(26)33-20(29-16)14-8(21)2-3-9(22)15(14)24/h2-3,6,10-11,13H,4-5,7,25-26H2,1H3,(H,28,31)/t10-,11-,13+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00300	-15.7	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50053685 (CHEMBL3318855 | US9328106, 341) Show SMILES C[C@H]1O[C@H](C[C@@H](N)[C@]1(C)O)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C |r| Show InChI InChI=1S/C21H23F2N5O3S/c1-10-21(2,30)16(24)7-15(31-10)18-13(8-25-28(18)3)26-19(29)14-9-32-20(27-14)17-11(22)5-4-6-12(17)23/h4-6,8-10,15-16,30H,7,24H2,1-3H3,(H,26,29)/t10-,15-,16-,21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	0.00300	-15.7	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227173 (US9328106, 121) Show SMILES C[C@@H]1C[C@@H](N)CC[C@@H](O1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C |r| Show InChI InChI=1S/C21H24F2N6O2S/c1-10-8-11(24)6-7-15(31-10)18-14(9-26-29(18)2)27-20(30)17-19(25)32-21(28-17)16-12(22)4-3-5-13(16)23/h3-5,9-11,15H,6-8,24-25H2,1-2H3,(H,27,30)/t10-,11+,15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00300	-15.7	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227227 (US9328106, 177) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C20H21F3N6O2S/c1-29-17(14-6-5-12(24)11(23)8-31-14)13(7-26-29)27-19(30)16-18(25)32-20(28-16)15-9(21)3-2-4-10(15)22/h2-4,7,11-12,14H,5-6,8,24-25H2,1H3,(H,27,30)/t11-,12-,14+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00342	-15.6	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM393426 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...) Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2c(F)cc3[C@H](O)CCOc3c2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C23H24F3N5O4S/c1-31-20(17-3-2-13(27)12(25)8-35-17)14(7-28-31)29-22(33)15-9-36-23(30-15)18-11(24)6-10-16(32)4-5-34-21(10)19(18)26/h6-7,9,12-13,16-17,32H,2-5,8,27H2,1H3,(H,29,33)/t12-,13-,16-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Institute for Medical Research					Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...				Chem Biol Drug Des 71: 131-9 (2008) BindingDB Entry DOI: 10.7270/Q22B91B0
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110701 (US8614206, 121) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC(N)CC(F)(F)C1 Show InChI InChI=1S/C20H21F4N7OS/c1-30-19(31-6-5-10(25)7-20(23,24)9-31)13(8-27-30)28-17(32)15-16(26)33-18(29-15)14-11(21)3-2-4-12(14)22/h2-4,8,10H,5-7,9,25-26H2,1H3,(H,28,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00400	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110749 (US8614206, 282) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2cc(F)ccc2F)c1N1CC[C@H](N)CC(F)(F)C1 |r| Show InChI InChI=1S/C20H21F4N7OS/c1-30-19(31-5-4-11(25)7-20(23,24)9-31)14(8-27-30)28-17(32)15-16(26)33-18(29-15)12-6-10(21)2-3-13(12)22/h2-3,6,8,11H,4-5,7,9,25-26H2,1H3,(H,28,32)/t11-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00400	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227445 (US9328106, 398) Show SMILES Cc1cccnc1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(N)s1 |r| Show InChI InChI=1S/C20H24FN7O2S/c1-10-4-3-7-24-15(10)20-27-16(18(23)31-20)19(29)26-13-8-25-28(2)17(13)14-6-5-12(22)11(21)9-30-14/h3-4,7-8,11-12,14H,5-6,9,22-23H2,1-2H3,(H,26,29)/t11-,12-,14+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00400	-15.5	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM206677 (US9260425, 438) Show SMILES CCc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCNCC1 Show InChI InChI=1S/C22H23N7/c1-2-15-10-16(13-24-12-15)19-11-17-20(14-25-19)27-28-22(17)18-4-3-5-21(26-18)29-8-6-23-7-9-29/h3-5,10-14,23H,2,6-9H2,1H3,(H,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00400	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genetech, Inc. US Patent					Assay Description PIM-1, PIM-2, and PIM-3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J....				US Patent US9260425 (2016) BindingDB Entry DOI: 10.7270/Q2RR1X3X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227230 (US9328106, 181) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2cccc(F)c2F)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 |r| Show InChI InChI=1S/C20H21F3N6O2S/c1-29-17(14-6-5-12(24)11(22)8-31-14)13(7-26-29)27-19(30)16-18(25)32-20(28-16)9-3-2-4-10(21)15(9)23/h2-4,7,11-12,14H,5-6,8,24-25H2,1H3,(H,27,30)/t11-,12+,14-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00400	-15.5	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227309 (US9328106, 260) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)ccc(F)c2F)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 |r| Show InChI InChI=1S/C20H20F4N6O2S/c1-30-17(13-5-4-11(25)10(23)7-32-13)12(6-27-30)28-19(31)16-18(26)33-20(29-16)14-8(21)2-3-9(22)15(14)24/h2-3,6,10-11,13H,4-5,7,25-26H2,1H3,(H,28,31)/t10-,11+,13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00400	-15.5	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110963 (US8614206, 520 | US8614206, 521) Show SMILES COC1C(N)CCN(CC11CC1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C Show InChI InChI=1S/C23H27F2N7O2S/c1-31-22(32-9-6-14(26)18(34-2)23(11-32)7-8-23)15(10-28-31)29-20(33)17-19(27)35-21(30-17)16-12(24)4-3-5-13(16)25/h3-5,10,14,18H,6-9,11,26-27H2,1-2H3,(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00400	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM393434 (N-(5-((2S,5R,6R,7S)-5-amino-6- fluoro-7-methyloxep...) Show SMILES C[C@@H]1O[C@@H](CC[C@@H](N)[C@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C |r| Show InChI InChI=1S/C21H22F3N5O2S/c1-10-18(24)13(25)6-7-16(31-10)19-14(8-26-29(19)2)27-20(30)15-9-32-21(28-15)17-11(22)4-3-5-12(17)23/h3-5,8-10,13,16,18H,6-7,25H2,1-2H3,(H,27,30)/t10-,13+,16-,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Institute for Medical Research					Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...				Chem Biol Drug Des 71: 131-9 (2008) BindingDB Entry DOI: 10.7270/Q22B91B0
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50505052 (CHEMBL3623150) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@@H](N)CC(F)(F)C1 |r| Show InChI InChI=1S/C20H21F4N7OS/c1-30-19(31-6-5-10(25)7-20(23,24)9-31)13(8-27-30)28-17(32)15-16(26)33-18(29-15)14-11(21)3-2-4-12(14)22/h2-4,8,10H,5-7,9,25-26H2,1H3,(H,28,32)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.00500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of recombinant human PIM1 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay				J Med Chem 62: 2140-2153 (2019) Article DOI: 10.1021/acs.jmedchem.8b01857 BindingDB Entry DOI: 10.7270/Q2Q52SVB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227366 (US9328106, 317) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2ccccc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C20H22F2N6O2S/c1-28-17(15-7-6-13(23)12(22)9-30-15)14(8-25-28)26-19(29)16-18(24)31-20(27-16)10-4-2-3-5-11(10)21/h2-5,8,12-13,15H,6-7,9,23-24H2,1H3,(H,26,29)/t12-,13-,15+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00509	-15.4	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50053679 (CHEMBL3318853 | US9328106, 115) Show SMILES [H][C@]12CC[C@](CC[C@@H]1N)(O2)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C |r| Show InChI InChI=1S/C21H22F2N6O2S/c1-29-17(21-7-5-12(24)14(31-21)6-8-21)13(9-26-29)27-19(30)16-18(25)32-20(28-16)15-10(22)3-2-4-11(15)23/h2-4,9,12,14H,5-8,24-25H2,1H3,(H,27,30)/t12-,14-,21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.00600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin)				ACS Med Chem Lett 5: 730-1 (2014) Article DOI: 10.1021/ml5001678 BindingDB Entry DOI: 10.7270/Q2SN0BMH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM393431 (N-(5-((2S,5R,6S,7R)-5-amino-6- methoxy-7-methyloxe...) Show SMILES CO[C@H]1[C@H](N)CC[C@H](O[C@@H]1C)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C |r| Show InChI InChI=1S/C22H25F2N5O3S/c1-11-20(31-3)14(25)7-8-17(32-11)19-15(9-26-29(19)2)27-21(30)16-10-33-22(28-16)18-12(23)5-4-6-13(18)24/h4-6,9-11,14,17,20H,7-8,25H2,1-3H3,(H,27,30)/t11-,14-,17+,20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Institute for Medical Research					Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...				Chem Biol Drug Des 71: 131-9 (2008) BindingDB Entry DOI: 10.7270/Q22B91B0
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM106870 (US8592455, 70) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:6.8,3.3,1.0,(-.67,2.69,;-2,1.93,;-3.33,2.69,;-4.67,1.93,;-6,2.69,;-4.67,.38,;-3.33,-.38,;-2,.38,;-3.33,-1.93,;-4.67,-2.69,;-4.67,-4.23,;-3.33,-5,;-2,-4.23,;-2,-2.69,;-.67,-1.93,;.67,-2.69,;.67,-4.23,;2,-1.93,;3.33,-2.69,;4.67,-1.93,;4.67,-.38,;6,.38,;3.33,.38,;2,-.38,;3.33,1.93,;4.67,2.69,;6,1.93,;4.67,4.23,;3.33,5,;2,4.23,;2,2.69,;.67,1.93,)| Show InChI InChI=1S/C24H23F3N4O/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26/h2-8,12-15H,9-11,28H2,1H3,(H,31,32)/t13-,14+,15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	0.00600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PIM1 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assay				J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227170 (US9328106, 118) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1[C@@]12CC[C@@H](O1)[C@H](N)CC2 |r| Show InChI InChI=1S/C21H22F2N6O2S/c1-29-17(21-7-5-12(24)14(31-21)6-8-21)13(9-26-29)27-19(30)16-18(25)32-20(28-16)15-10(22)3-2-4-11(15)23/h2-4,9,12,14H,5-8,24-25H2,1H3,(H,27,30)/t12-,14-,21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.00600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of recombinant human PIM1 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay				J Med Chem 62: 2140-2153 (2019) Article DOI: 10.1021/acs.jmedchem.8b01857 BindingDB Entry DOI: 10.7270/Q2Q52SVB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM602107 (US11643417, Ex. No. 120) Show SMILES OCC1(O)CCC(CC1)C(F)(F)CN1CCNC(=O)c2oc3ccc(cc3c12)C(F)(F)F |(7.13,.13,;5.59,.13,;4.82,1.46,;6.31,1.86,;3.67,.45,;2.21,.95,;1.91,2.46,;3.07,3.47,;4.53,2.98,;.45,2.96,;-.56,4.12,;.95,4.42,;-.71,1.94,;-2.16,2.44,;-2.35,3.97,;-3.66,4.78,;-5.11,4.26,;-5.61,2.8,;-7.13,2.62,;-4.78,1.51,;-5.4,.1,;-4.26,-.93,;-4.26,-2.47,;-2.92,-3.24,;-1.59,-2.47,;-1.59,-.93,;-2.92,-.16,;-3.25,1.35,;-.26,-3.24,;1.08,-2.47,;-.26,-4.78,;1.08,-4.01,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		0.00600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2R49VQ0
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50053679 (CHEMBL3318853 | US9328106, 115) Show SMILES [H][C@]12CC[C@](CC[C@@H]1N)(O2)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C |r| Show InChI InChI=1S/C21H22F2N6O2S/c1-29-17(21-7-5-12(24)14(31-21)6-8-21)13(9-26-29)27-19(30)16-18(25)32-20(28-16)15-10(22)3-2-4-11(15)23/h2-4,9,12,14H,5-8,24-25H2,1H3,(H,27,30)/t12-,14-,21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	0.00600	-15.3	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110820 (US8614206, 371 | US8614206, 372) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC(O)CC(F)(F)C1 Show InChI InChI=1S/C20H20F4N6O2S/c1-29-19(30-6-5-10(31)7-20(23,24)9-30)13(8-26-29)27-17(32)15-16(25)33-18(28-15)14-11(21)3-2-4-12(14)22/h2-4,8,10,31H,5-7,9,25H2,1H3,(H,27,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00600	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110906 (US8614206, 459) Show SMILES COc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CCC(N)CC(F)(F)C3)c(N)s2)c(F)c1 Show InChI InChI=1S/C21H23F4N7O2S/c1-31-20(32-4-3-10(26)7-21(24,25)9-32)14(8-28-31)29-18(33)16-17(27)35-19(30-16)15-12(22)5-11(34-2)6-13(15)23/h5-6,8,10H,3-4,7,9,26-27H2,1-2H3,(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00600	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227171 (US9328106, 119 | US9328106, 129) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CC[C@@H](N)[C@@H](F)CO1 |r| Show InChI InChI=1S/C20H21F3N6O2S/c1-29-17(14-6-5-12(24)11(23)8-31-14)13(7-26-29)27-19(30)16-18(25)32-20(28-16)15-9(21)3-2-4-10(15)22/h2-4,7,11-12,14H,5-6,8,24-25H2,1H3,(H,27,30)/t11-,12+,14?/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00600	-15.3	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227245 (US9328106, 196) Show SMILES Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cc(cc2F)C2(O)CCOCC2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r,wU:34.38,wD:31.34,36.40,(-6.15,4.02,;-6.15,2.48,;-7.39,1.58,;-6.92,.11,;-5.38,.11,;-4.61,-1.22,;-4.61,-2.76,;-5.94,-3.53,;-3.27,-3.53,;-3.27,-5.07,;-1.94,-5.84,;-.61,-5.07,;.73,-5.84,;-.61,-3.53,;-1.94,-2.76,;.73,-2.76,;.73,-1.22,;-.61,-.45,;2.06,-.45,;3.39,-1.22,;3.39,-2.76,;2.06,-3.53,;2.06,-5.07,;4.73,-.45,;4.73,-1.99,;6.06,-1.22,;7.39,-.45,;7.39,1.09,;6.06,1.86,;4.73,1.09,;-4.9,1.58,;-3.57,2.35,;-3.57,3.89,;-2.37,4.85,;-.86,4.51,;-.09,5.84,;-.2,3.12,;1.29,2.72,;-.86,1.73,;-2.37,1.39,)| Show InChI InChI=1S/C27H29F4N5O4/c1-36-25(22-5-3-19(32)18(31)13-40-22)21(12-33-36)35-26(37)20-4-2-15(28)24(34-20)23-16(29)10-14(11-17(23)30)27(38)6-8-39-9-7-27/h2,4,10-12,18-19,22,38H,3,5-9,13,32H2,1H3,(H,35,37)/t18-,19-,22+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00600	-15.3	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM110711 (US8614206, 166) Show SMILES CN=C(C(NC(=O)c1nc(sc1N)-c1c(F)cccc1F)C=N)N1CC[C@H](N)CC(F)(F)C1 |r,w:1.0| Show InChI InChI=1S/C20H23F4N7OS/c1-28-17(31-6-5-10(26)7-20(23,24)9-31)13(8-25)29-18(32)15-16(27)33-19(30-15)14-11(21)3-2-4-12(14)22/h2-4,8,10,13,25H,5-7,9,26-27H2,1H3,(H,29,32)/t10-,13?/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.00600	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US8614206 (2013) BindingDB Entry DOI: 10.7270/Q2W66JFG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50434654 (CHEMBL2387465) Show SMILES F[C@H]1CNCC[C@@H]1CNc1ccn2ncc(C(=O)Nc3c[nH]c4ncc(cc34)-c3c(F)cccc3F)c2n1 |r| Show InChI InChI=1S/C26H23F3N8O/c27-18-2-1-3-19(28)23(18)15-8-16-21(13-33-24(16)32-10-15)35-26(38)17-11-34-37-7-5-22(36-25(17)37)31-9-14-4-6-30-12-20(14)29/h1-3,5,7-8,10-11,13-14,20,30H,4,6,9,12H2,(H,31,36)(H,32,33)(H,35,38)/t14-,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.00700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP				Bioorg Med Chem Lett 23: 3149-53 (2013) Article DOI: 10.1016/j.bmcl.2013.04.020 BindingDB Entry DOI: 10.7270/Q2PC33S9
					More data for this Ligand-Target Pair

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