Found 213 hits of ic50 for UniProtKB: P55157 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391864
(CHEMBL2147287)Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H39FN4O3/c1-43(2,3)33-20-16-29(17-21-33)35-12-8-9-13-36(35)41(50)46-38-25-19-31-26-32(18-24-37(31)45-38)40(49)47-39(30-10-6-5-7-11-30)42(51)48(4)27-28-14-22-34(44)23-15-28/h5-26,39H,27H2,1-4H3,(H,47,49)(H,45,46,50)/t39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391863
(CHEMBL2147286)Show SMILES CC(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O3/c1-27(2)29-15-17-30(18-16-29)35-11-7-8-12-36(35)41(49)45-38-24-20-32-25-33(19-23-37(32)44-38)40(48)46-39(31-9-5-4-6-10-31)42(50)47(3)26-28-13-21-34(43)22-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.00100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391858
(CHEMBL2147281)Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C40H30F4N4O3/c1-48(24-25-11-19-31(41)20-12-25)39(51)36(27-7-3-2-4-8-27)47-37(49)29-15-21-34-28(23-29)16-22-35(45-34)46-38(50)33-10-6-5-9-32(33)26-13-17-30(18-14-26)40(42,43)44/h2-23,36H,24H2,1H3,(H,47,49)(H,45,46,50)/t36-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.00100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391867
(CHEMBL2147290)Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O4/c1-27(2)51-34-21-15-29(16-22-34)35-11-7-8-12-36(35)41(49)45-38-24-18-31-25-32(17-23-37(31)44-38)40(48)46-39(30-9-5-4-6-10-30)42(50)47(3)26-28-13-19-33(43)20-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.00200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391860
(CHEMBL2147283)Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(C)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C40H33FN4O3/c1-26-12-16-28(17-13-26)33-10-6-7-11-34(33)39(47)43-36-23-19-30-24-31(18-22-35(30)42-36)38(46)44-37(29-8-4-3-5-9-29)40(48)45(2)25-27-14-20-32(41)21-15-27/h3-24,37H,25H2,1-2H3,(H,44,46)(H,42,43,47)/t37-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50204367
(CHEMBL410414 | dirlotapide)Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1 |r| Show InChI InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.0110 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50098322
(9-(4-{5-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)Show SMILES Cc1ccc2n(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc34)cnc2c1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C42H34F6N4O2/c1-26-16-21-35-37(36(26)51-38(53)32-13-3-2-10-29(32)27-17-19-28(20-18-27)42(46,47)48)50-25-52(35)23-9-8-22-40(39(54)49-24-41(43,44)45)33-14-6-4-11-30(33)31-12-5-7-15-34(31)40/h2-7,10-21,25H,8-9,22-24H2,1H3,(H,49,54)(H,51,53) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay |
J Med Chem 44: 851-6 (2001)
BindingDB Entry DOI: 10.7270/Q2N015S8 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391875
(CHEMBL2147296)Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C36H34N4O3/c1-36(2,3)27-18-14-23(15-19-27)28-12-8-9-13-29(28)34(42)39-31-21-17-25-22-26(16-20-30(25)38-31)33(41)40-32(35(43)37-4)24-10-6-5-7-11-24/h5-22,32H,1-4H3,(H,37,43)(H,40,41)(H,38,39,42)/t32-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0210 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391876
(CHEMBL2147292)Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)CO)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H39FN4O4/c1-43(2,27-49)33-19-15-29(16-20-33)35-11-7-8-12-36(35)41(51)46-38-24-18-31-25-32(17-23-37(31)45-38)40(50)47-39(30-9-5-4-6-10-30)42(52)48(3)26-28-13-21-34(44)22-14-28/h4-25,39,49H,26-27H2,1-3H3,(H,47,50)(H,45,46,51)/t39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50098321
(9-(4-{2,5-Dimethyl-4-[(4'-trifluoromethyl-biphenyl...)Show SMILES Cc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)c(C)ccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12 Show InChI InChI=1S/C43H36F6N4O2/c1-26-17-22-36-38(37(26)52-39(54)33-14-4-3-11-30(33)28-18-20-29(21-19-28)43(47,48)49)51-27(2)53(36)24-10-9-23-41(40(55)50-25-42(44,45)46)34-15-7-5-12-31(34)32-13-6-8-16-35(32)41/h3-8,11-22H,9-10,23-25H2,1-2H3,(H,50,55)(H,52,54) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay |
J Med Chem 44: 851-6 (2001)
BindingDB Entry DOI: 10.7270/Q2N015S8 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391866
(CHEMBL2147294)Show SMILES CC(C)(CO)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O4/c1-42(2,26-48)32-18-14-28(15-19-32)34-10-6-7-11-35(34)40(50)46-37-23-17-30-24-31(16-22-36(30)45-37)39(49)47-38(29-8-4-3-5-9-29)41(51)44-25-27-12-20-33(43)21-13-27/h3-24,38,48H,25-26H2,1-2H3,(H,44,51)(H,47,49)(H,45,46,50)/t38-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0580 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50098326
(9-(4-{2-Isopropyl-4-[(4'-trifluoromethyl-biphenyl-...)Show SMILES CC(C)c1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12 Show InChI InChI=1S/C44H38F6N4O2/c1-27(2)39-53-38-36(52-40(55)33-15-4-3-12-30(33)28-20-22-29(23-21-28)44(48,49)50)18-11-19-37(38)54(39)25-10-9-24-42(41(56)51-26-43(45,46)47)34-16-7-5-13-31(34)32-14-6-8-17-35(32)42/h3-8,11-23,27H,9-10,24-26H2,1-2H3,(H,51,56)(H,52,55) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay |
J Med Chem 44: 851-6 (2001)
BindingDB Entry DOI: 10.7270/Q2N015S8 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391877
(CHEMBL2147293)Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C(O)=O)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H37FN4O5/c1-43(2,42(52)53)32-19-15-28(16-20-32)34-11-7-8-12-35(34)40(50)46-37-24-18-30-25-31(17-23-36(30)45-37)39(49)47-38(29-9-5-4-6-10-29)41(51)48(3)26-27-13-21-33(44)22-14-27/h4-25,38H,26H2,1-3H3,(H,47,49)(H,52,53)(H,45,46,50)/t38-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0660 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391869
(CHEMBL2147301)Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(OC(C)C)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C35H32N4O4/c1-22(2)43-27-17-13-23(14-18-27)28-11-7-8-12-29(28)34(41)38-31-20-16-25-21-26(15-19-30(25)37-31)33(40)39-32(35(42)36-3)24-9-5-4-6-10-24/h4-22,32H,1-3H3,(H,36,42)(H,39,40)(H,37,38,41)/t32-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.101 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391871
(CHEMBL2147298)Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(O)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C39H31FN4O4/c1-44(24-25-11-17-30(40)18-12-25)39(48)36(27-7-3-2-4-8-27)43-37(46)29-15-21-34-28(23-29)16-22-35(41-34)42-38(47)33-10-6-5-9-32(33)26-13-19-31(45)20-14-26/h2-23,36,45H,24H2,1H3,(H,43,46)(H,41,42,47)/t36-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.105 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391872
(CHEMBL2147299)Show SMILES CC(CO)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O5/c1-27(26-48)52-34-20-14-29(15-21-34)35-10-6-7-11-36(35)41(50)45-38-23-17-31-24-32(16-22-37(31)44-38)40(49)46-39(30-8-4-3-5-9-30)42(51)47(2)25-28-12-18-33(43)19-13-28/h3-24,27,39,48H,25-26H2,1-2H3,(H,46,49)(H,44,45,50)/t27?,39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.122 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50098324
(9-(4-{2-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)Show SMILES Cc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12 Show InChI InChI=1S/C42H34F6N4O2/c1-26-50-37-35(51-38(53)32-14-3-2-11-29(32)27-19-21-28(22-20-27)42(46,47)48)17-10-18-36(37)52(26)24-9-8-23-40(39(54)49-25-41(43,44)45)33-15-6-4-12-30(33)31-13-5-7-16-34(31)40/h2-7,10-22H,8-9,23-25H2,1H3,(H,49,54)(H,51,53) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay |
J Med Chem 44: 851-6 (2001)
BindingDB Entry DOI: 10.7270/Q2N015S8 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50098325
(9-(4-{4-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-...)Show SMILES FC(F)(F)CNC(=O)C1(CCCCn2cnc3c(NC(=O)c4ccccc4-c4ccc(cc4)C(F)(F)F)cccc23)c2ccccc2-c2ccccc12 Show InChI InChI=1S/C41H32F6N4O2/c42-40(43,44)24-48-38(53)39(32-14-5-3-11-29(32)30-12-4-6-15-33(30)39)22-7-8-23-51-25-49-36-34(16-9-17-35(36)51)50-37(52)31-13-2-1-10-28(31)26-18-20-27(21-19-26)41(45,46)47/h1-6,9-21,25H,7-8,22-24H2,(H,48,53)(H,50,52) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay |
J Med Chem 44: 851-6 (2001)
BindingDB Entry DOI: 10.7270/Q2N015S8 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391874
(CHEMBL2147295)Show SMILES CC(C)(C(O)=O)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H35FN4O5/c1-42(2,41(51)52)31-18-14-27(15-19-31)33-10-6-7-11-34(33)39(49)46-36-23-17-29-24-30(16-22-35(29)45-36)38(48)47-37(28-8-4-3-5-9-28)40(50)44-25-26-12-20-32(43)21-13-26/h3-24,37H,25H2,1-2H3,(H,44,50)(H,47,48)(H,51,52)(H,45,46,49)/t37-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.253 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391857
(CHEMBL2147280)Show SMILES Cn1c(cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc12)C(=O)N[C@H](C(N)=O)c1ccccc1 |r| Show InChI InChI=1S/C32H25F3N4O3/c1-39-26-16-15-23(17-21(26)18-27(39)31(42)38-28(29(36)40)20-7-3-2-4-8-20)37-30(41)25-10-6-5-9-24(25)19-11-13-22(14-12-19)32(33,34)35/h2-18,28H,1H3,(H2,36,40)(H,37,41)(H,38,42)/t28-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.345 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391856
(CHEMBL2147279)Show SMILES CNC(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1 |r| Show InChI InChI=1S/C33H27F3N4O3/c1-37-32(43)29(21-8-4-3-5-9-21)39-31(42)28-19-22-18-24(16-17-27(22)40(28)2)38-30(41)26-11-7-6-10-25(26)20-12-14-23(15-13-20)33(34,35)36/h3-19,29H,1-2H3,(H,37,43)(H,38,41)(H,39,42)/t29-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.378 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391862
(CHEMBL2147285)Show SMILES CCCc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O3/c1-3-9-28-14-18-30(19-15-28)35-12-7-8-13-36(35)41(49)45-38-25-21-32-26-33(20-24-37(32)44-38)40(48)46-39(31-10-5-4-6-11-31)42(50)47(2)27-29-16-22-34(43)23-17-29/h4-8,10-26,39H,3,9,27H2,1-2H3,(H,46,48)(H,44,45,49)/t39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391870
(CHEMBL2147300)Show SMILES CC(Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1)C(O)=O |r| Show InChI InChI=1S/C42H35FN4O6/c1-26(42(51)52)53-33-20-14-28(15-21-33)34-10-6-7-11-35(34)40(49)45-37-23-17-30-24-31(16-22-36(30)44-37)39(48)46-38(29-8-4-3-5-9-29)41(50)47(2)25-27-12-18-32(43)19-13-27/h3-24,26,38H,25H2,1-2H3,(H,46,48)(H,51,52)(H,44,45,49)/t26?,38-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.484 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391861
(CHEMBL2147284)Show SMILES CCc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C41H35FN4O3/c1-3-27-13-17-29(18-14-27)34-11-7-8-12-35(34)40(48)44-37-24-20-31-25-32(19-23-36(31)43-37)39(47)45-38(30-9-5-4-6-10-30)41(49)46(2)26-28-15-21-33(42)22-16-28/h4-25,38H,3,26H2,1-2H3,(H,45,47)(H,43,44,48)/t38-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391875
(CHEMBL2147296)Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C36H34N4O3/c1-36(2,3)27-18-14-23(15-19-27)28-12-8-9-13-29(28)34(42)39-31-21-17-25-22-26(16-20-30(25)38-31)33(41)40-32(35(43)37-4)24-10-6-5-7-11-24/h5-22,32H,1-4H3,(H,37,43)(H,40,41)(H,38,39,42)/t32-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391863
(CHEMBL2147286)Show SMILES CC(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O3/c1-27(2)29-15-17-30(18-16-29)35-11-7-8-12-36(35)41(49)45-38-24-20-32-25-33(19-23-37(32)44-38)40(48)46-39(31-9-5-4-6-10-31)42(50)47(3)26-28-13-21-34(43)22-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50277189
((R)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)Show SMILES Cc1cccc(C(=O)Nc2ccc3C[C@H](Cc3c2)NCc2nccs2)c1-c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C28H24F3N3OS/c1-17-3-2-4-24(26(17)18-5-8-21(9-6-18)28(29,30)31)27(35)34-22-10-7-19-13-23(15-20(19)14-22)33-16-25-32-11-12-36-25/h2-12,14,23,33H,13,15-16H2,1H3,(H,34,35)/t23-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISA |
Bioorg Med Chem Lett 19: 328-31 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.096 BindingDB Entry DOI: 10.7270/Q29887ZN |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391869
(CHEMBL2147301)Show SMILES CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(OC(C)C)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C35H32N4O4/c1-22(2)43-27-17-13-23(14-18-27)28-11-7-8-12-29(28)34(41)38-31-20-16-25-21-26(15-19-30(25)37-31)33(40)39-32(35(42)36-3)24-9-5-4-6-10-24/h4-22,32H,1-3H3,(H,36,42)(H,39,40)(H,37,38,41)/t32-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391858
(CHEMBL2147281)Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C40H30F4N4O3/c1-48(24-25-11-19-31(41)20-12-25)39(51)36(27-7-3-2-4-8-27)47-37(49)29-15-21-34-28(23-29)16-22-35(45-34)46-38(50)33-10-6-5-9-32(33)26-13-17-30(18-14-26)40(42,43)44/h2-23,36H,24H2,1H3,(H,47,49)(H,45,46,50)/t36-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.740 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391867
(CHEMBL2147290)Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)N(C)Cc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O4/c1-27(2)51-34-21-15-29(16-22-34)35-11-7-8-12-36(35)41(49)45-38-24-18-31-25-32(17-23-37(31)44-38)40(48)46-39(30-9-5-4-6-10-30)42(50)47(3)26-28-13-19-33(43)20-14-28/h4-25,27,39H,26H2,1-3H3,(H,46,48)(H,44,45,49)/t39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50098320
(9-(4-{4-[(4''-Trifluoromethyl-biphenyl-2-carbonyl)...)Show SMILES FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c2ccccc2-c2ccccc12 Show InChI InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay |
J Med Chem 44: 851-6 (2001)
BindingDB Entry DOI: 10.7270/Q2N015S8 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391865
(CHEMBL2147291)Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(OC(C)(C)C)cc3)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H39FN4O4/c1-43(2,3)52-34-22-16-29(17-23-34)35-12-8-9-13-36(35)41(50)46-38-25-19-31-26-32(18-24-37(31)45-38)40(49)47-39(30-10-6-5-7-11-30)42(51)48(4)27-28-14-20-33(44)21-15-28/h5-26,39H,27H2,1-4H3,(H,47,49)(H,45,46,50)/t39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.830 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50107789
((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)Show SMILES COC(=O)N[C@@H]1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1 |r| Show InChI InChI=1S/C26H23F3N2O3/c1-15-4-3-5-22(23(15)16-6-9-19(10-7-16)26(27,28)29)24(32)30-20-11-8-17-12-21(14-18(17)13-20)31-25(33)34-2/h3-11,13,21H,12,14H2,1-2H3,(H,30,32)(H,31,33)/t21-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISA |
Bioorg Med Chem Lett 19: 328-31 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.096 BindingDB Entry DOI: 10.7270/Q29887ZN |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50098322
(9-(4-{5-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)Show SMILES Cc1ccc2n(CCCCC3(C(=O)NCC(F)(F)F)c4ccccc4-c4ccccc34)cnc2c1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C42H34F6N4O2/c1-26-16-21-35-37(36(26)51-38(53)32-13-3-2-10-29(32)27-17-19-28(20-18-27)42(46,47)48)50-25-52(35)23-9-8-22-40(39(54)49-24-41(43,44)45)33-14-6-4-11-30(33)31-12-5-7-15-34(31)40/h2-7,10-21,25H,8-9,22-24H2,1H3,(H,49,54)(H,51,53) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay) |
J Med Chem 44: 851-6 (2001)
BindingDB Entry DOI: 10.7270/Q2N015S8 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50098324
(9-(4-{2-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)Show SMILES Cc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12 Show InChI InChI=1S/C42H34F6N4O2/c1-26-50-37-35(51-38(53)32-14-3-2-11-29(32)27-19-21-28(22-20-27)42(46,47)48)17-10-18-36(37)52(26)24-9-8-23-40(39(54)49-25-41(43,44)45)33-15-6-4-12-30(33)31-13-5-7-16-34(31)40/h2-7,10-22H,8-9,23-25H2,1H3,(H,49,54)(H,51,53) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay) |
J Med Chem 44: 851-6 (2001)
BindingDB Entry DOI: 10.7270/Q2N015S8 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50098321
(9-(4-{2,5-Dimethyl-4-[(4'-trifluoromethyl-biphenyl...)Show SMILES Cc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)c(C)ccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12 Show InChI InChI=1S/C43H36F6N4O2/c1-26-17-22-36-38(37(26)52-39(54)33-14-4-3-11-30(33)28-18-20-29(21-19-28)43(47,48)49)51-27(2)53(36)24-10-9-23-41(40(55)50-25-42(44,45)46)34-15-7-5-12-31(34)32-13-6-8-16-35(32)41/h3-8,11-22H,9-10,23-25H2,1-2H3,(H,50,55)(H,52,54) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay) |
J Med Chem 44: 851-6 (2001)
BindingDB Entry DOI: 10.7270/Q2N015S8 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184105
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-19-25(39-31(41)27-10-6-5-9-26(27)22-13-15-24(16-14-22)34(35,36)37)17-18-28(29)32(42)40-30(23-7-3-2-4-8-23)33(43)38-20-21-11-12-21/h2-10,13-19,21,30H,11-12,20H2,1H3,(H,38,43)(H,39,41)(H,40,42)/t30-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.01 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391876
(CHEMBL2147292)Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)CO)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H39FN4O4/c1-43(2,27-49)33-19-15-29(16-20-33)35-11-7-8-12-36(35)41(51)46-38-24-18-31-25-32(17-23-37(31)45-38)40(50)47-39(30-9-5-4-6-10-30)42(52)48(3)26-28-13-21-34(44)22-14-28/h4-25,39,49H,26-27H2,1-3H3,(H,47,50)(H,45,46,51)/t39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391873
(CHEMBL2147297)Show SMILES CC(C)(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O3/c1-42(2,3)32-19-15-28(16-20-32)34-11-7-8-12-35(34)40(49)46-37-24-18-30-25-31(17-23-36(30)45-37)39(48)47-38(29-9-5-4-6-10-29)41(50)44-26-27-13-21-33(43)22-14-27/h4-25,38H,26H2,1-3H3,(H,44,50)(H,47,48)(H,45,46,49)/t38-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391864
(CHEMBL2147287)Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(C)(C)C)ccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C43H39FN4O3/c1-43(2,3)33-20-16-29(17-21-33)35-12-8-9-13-36(35)41(50)46-38-25-19-31-26-32(18-24-37(31)45-38)40(49)47-39(30-10-6-5-7-11-30)42(51)48(4)27-28-14-22-34(44)23-15-28/h5-26,39H,27H2,1-4H3,(H,47,49)(H,45,46,50)/t39-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391873
(CHEMBL2147297)Show SMILES CC(C)(C)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C42H37FN4O3/c1-42(2,3)32-19-15-28(16-20-32)34-11-7-8-12-35(34)40(49)46-37-24-18-30-25-31(17-23-36(30)45-37)39(48)47-38(29-9-5-4-6-10-29)41(50)44-26-27-13-21-33(43)22-14-27/h4-25,38H,26H2,1-3H3,(H,44,50)(H,47,48)(H,45,46,49)/t38-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391868
(CHEMBL2146489)Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C41H35FN4O4/c1-26(2)50-33-20-14-28(15-21-33)34-10-6-7-11-35(34)40(48)45-37-23-17-30-24-31(16-22-36(30)44-37)39(47)46-38(29-8-4-3-5-9-29)41(49)43-25-27-12-18-32(42)19-13-27/h3-24,26,38H,25H2,1-2H3,(H,43,49)(H,46,47)(H,44,45,48)/t38-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391868
(CHEMBL2146489)Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1C(=O)Nc1ccc2cc(ccc2n1)C(=O)N[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C41H35FN4O4/c1-26(2)50-33-20-14-28(15-21-33)34-10-6-7-11-35(34)40(48)45-37-23-17-30-24-31(16-22-36(30)44-37)39(47)46-38(29-8-4-3-5-9-29)41(49)43-25-27-12-18-32(42)19-13-27/h3-24,26,38H,25H2,1-2H3,(H,43,49)(H,46,47)(H,44,45,48)/t38-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.21 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391857
(CHEMBL2147280)Show SMILES Cn1c(cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc12)C(=O)N[C@H](C(N)=O)c1ccccc1 |r| Show InChI InChI=1S/C32H25F3N4O3/c1-39-26-16-15-23(17-21(26)18-27(39)31(42)38-28(29(36)40)20-7-3-2-4-8-20)37-30(41)25-10-6-5-9-24(25)19-11-13-22(14-12-19)32(33,34)35/h2-18,28H,1H3,(H2,36,40)(H,37,41)(H,38,42)/t28-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184109
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...)Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(C)c1)c1ccccc1 Show InChI InChI=1S/C33H30F3N3O3/c1-3-19-37-32(42)29(23-9-5-4-6-10-23)39-30(40)24-15-18-28(21(2)20-24)38-31(41)27-12-8-7-11-26(27)22-13-16-25(17-14-22)33(34,35)36/h4-18,20,29H,3,19H2,1-2H3,(H,37,42)(H,38,41)(H,39,40)/t29-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.64 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184153
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-19-24(31(41)40-30(23-7-3-2-4-8-23)33(43)38-20-21-11-12-21)15-18-28(29)39-32(42)27-10-6-5-9-26(27)22-13-16-25(17-14-22)34(35,36)37/h2-10,13-19,21,30H,11-12,20H2,1H3,(H,38,43)(H,39,42)(H,40,41)/t30-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.68 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184111
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...)Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-21-24(31(41)39-30(23-9-3-2-4-10-23)33(43)40-19-7-8-20-40)15-18-28(29)38-32(42)27-12-6-5-11-26(27)22-13-16-25(17-14-22)34(35,36)37/h2-6,9-18,21,30H,7-8,19-20H2,1H3,(H,38,42)(H,39,41)/t30-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184165
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES Cc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O3/c1-21-19-25(31(41)40-30(24-7-3-2-4-8-24)33(43)38-20-22-11-12-22)15-18-29(21)39-32(42)28-10-6-5-9-27(28)23-13-16-26(17-14-23)34(35,36)37/h2-10,13-19,22,30H,11-12,20H2,1H3,(H,38,43)(H,39,42)(H,40,41)/t30-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.78 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50391856
(CHEMBL2147279)Show SMILES CNC(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1 |r| Show InChI InChI=1S/C33H27F3N4O3/c1-37-32(43)29(21-8-4-3-5-9-21)39-31(42)28-19-22-18-24(16-17-27(22)40(28)2)38-30(41)26-11-7-6-10-25(26)20-12-14-23(15-13-20)33(34,35)36/h3-19,29H,1-2H3,(H,37,43)(H,38,41)(H,39,42)/t29-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA |
Bioorg Med Chem Lett 21: 4150-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.099 BindingDB Entry DOI: 10.7270/Q2B27WCR |
More data for this Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50098323
(9-(4-{2-Propyl-4-[(4'-trifluoromethyl-biphenyl-2-c...)Show SMILES CCCc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12 Show InChI InChI=1S/C44H38F6N4O2/c1-2-12-38-53-39-36(52-40(55)33-16-4-3-13-30(33)28-21-23-29(24-22-28)44(48,49)50)19-11-20-37(39)54(38)26-10-9-25-42(41(56)51-27-43(45,46)47)34-17-7-5-14-31(34)32-15-6-8-18-35(32)42/h3-8,11,13-24H,2,9-10,12,25-27H2,1H3,(H,51,56)(H,52,55) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay) |
J Med Chem 44: 851-6 (2001)
BindingDB Entry DOI: 10.7270/Q2N015S8 |
More data for this Ligand-Target Pair | |