Compile Data Set for Download or QSAR

Found 69 hits Enz. Inhib. hit(s) with all data for entry = 915   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7240 ((3Z)-N-methyl-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3...) Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C17H15N3O5S/c1-18-26(23,24)9-2-3-14-11(6-9)12(16(21)20-14)7-15-10-4-5-25-17(22)13(10)8-19-15/h2-3,6-8,18-19H,4-5H2,1H3,(H,20,21)/b12-7-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7244 ((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...) Show SMILES OC(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C17H12N2O5/c20-15-11(10-5-8(16(21)22)1-2-13(10)19-15)6-14-9-3-4-24-17(23)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)(H,21,22)/b11-6-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7254 ((3Z)-N-methyl-2-oxo-3-({4-oxo-2H,4H,5H,6H,7H-pyrro...) Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1 Show InChI InChI=1S/C17H16N4O4S/c1-18-26(24,25)9-2-3-14-11(6-9)12(17(23)21-14)7-15-10-4-5-19-16(22)13(10)8-20-15/h2-3,6-8,18,20H,4-5H2,1H3,(H,19,22)(H,21,23)/b12-7-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7250 ((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...) Show SMILES O=C1Nc2cccc(C3CCNCC3)c2\C1=C\c1[nH]cc2c1CCOC2=O Show InChI InChI=1S/C21H21N3O3/c25-20-15(10-18-14-6-9-27-21(26)16(14)11-23-18)19-13(2-1-3-17(19)24-20)12-4-7-22-8-5-12/h1-3,10-12,22-23H,4-9H2,(H,24,25)/b15-10-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7241 ((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...) Show SMILES NS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C16H13N3O5S/c17-25(22,23)8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-24-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)(H2,17,22,23)/b11-6-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7249 ((3Z)-4-(2-hydroxyethyl)-3-({4-oxo-2H,4H,6H,7H-pyra...) Show SMILES OCCc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12 Show InChI InChI=1S/C18H16N2O4/c21-6-4-10-2-1-3-14-16(10)12(17(22)20-14)8-15-11-5-7-24-18(23)13(11)9-19-15/h1-3,8-9,19,21H,4-7H2,(H,20,22)/b12-8-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7243 ((3Z)-N,N-dimethyl-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyra...) Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C18H17N3O5S/c1-21(2)27(24,25)10-3-4-15-12(7-10)13(17(22)20-15)8-16-11-5-6-26-18(23)14(11)9-19-16/h3-4,7-9,19H,5-6H2,1-2H3,(H,20,22)/b13-8-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7239 ((3Z)-5-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...) Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-14-11(6-9)12(16(20)19-14)7-15-10-4-5-23-17(21)13(10)8-18-15/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7260 ((3Z)-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]pyridi...) Show SMILES O=C1Nc2cccc(C3CCNCC3)c2\C1=C\c1[nH]cc2c1CCNC2=O Show InChI InChI=1S/C21H22N4O2/c26-20-16-11-24-18(14(16)6-9-23-20)10-15-19-13(12-4-7-22-8-5-12)2-1-3-17(19)25-21(15)27/h1-3,10-12,22,24H,4-9H2,(H,23,26)(H,25,27)/b15-10-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7242 ((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...) Show SMILES CC(C)NS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C19H19N3O5S/c1-10(2)22-28(25,26)11-3-4-16-13(7-11)14(18(23)21-16)8-17-12-5-6-27-19(24)15(12)9-20-17/h3-4,7-10,20,22H,5-6H2,1-2H3,(H,21,23)/b14-8-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7256 ((3Z)-2-oxo-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]...) Show SMILES OC(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1 Show InChI InChI=1S/C17H13N3O4/c21-15-12-7-19-14(9(12)3-4-18-15)6-11-10-5-8(17(23)24)1-2-13(10)20-16(11)22/h1-2,5-7,19H,3-4H2,(H,18,21)(H,20,22)(H,23,24)/b11-6-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7255 ((3Z)-N,N-dimethyl-2-oxo-3-({4-oxo-2H,4H,5H,6H,7H-p...) Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1 Show InChI InChI=1S/C18H18N4O4S/c1-22(2)27(25,26)10-3-4-15-12(7-10)13(18(24)21-15)8-16-11-5-6-19-17(23)14(11)9-20-16/h3-4,7-9,20H,5-6H2,1-2H3,(H,19,23)(H,21,24)/b13-8-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7245 ((3Z)-5-fluoro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...) Show SMILES Fc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C16H11FN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7246 ((3Z)-5-chloro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...) Show SMILES Clc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C16H11ClN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7238 ((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...) Show SMILES COc1ccc2NC(=O)C(=Cc3cnc[nH]3)c2c1 |w:10.10| Show InChI InChI=1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-7H,1H3,(H,14,15)(H,16,17)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7238 ((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...) Show SMILES COc1ccc2NC(=O)C(=Cc3cnc[nH]3)c2c1 |w:10.10| Show InChI InChI=1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-7H,1H3,(H,14,15)(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7247 ((3Z)-5-bromo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]py...) Show SMILES Brc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C16H11BrN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7253 ((3Z)-5-methoxy-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,...) Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1 Show InChI InChI=1S/C17H15N3O3/c1-23-9-2-3-14-11(6-9)12(17(22)20-14)7-15-10-4-5-18-16(21)13(10)8-19-15/h2-3,6-8,19H,4-5H2,1H3,(H,18,21)(H,20,22)/b12-7-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7248 ((3Z)-4-methyl-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...) Show SMILES Cc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12 Show InChI InChI=1S/C17H14N2O3/c1-9-3-2-4-13-15(9)11(16(20)19-13)7-14-10-5-6-22-17(21)12(10)8-18-14/h2-4,7-8,18H,5-6H2,1H3,(H,19,20)/b11-7-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7257 ((3Z)-5-fluoro-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4...) Show SMILES Fc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1 Show InChI InChI=1S/C16H12FN3O2/c17-8-1-2-13-10(5-8)11(16(22)20-13)6-14-9-3-4-18-15(21)12(9)7-19-14/h1-2,5-7,19H,3-4H2,(H,18,21)(H,20,22)/b11-6-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7259 ((3Z)-4-(2-hydroxyethyl)-3-({4-oxo-2H,4H,5H,6H,7H-p...) Show SMILES OCCc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c12 Show InChI InChI=1S/C18H17N3O3/c22-7-5-10-2-1-3-14-16(10)12(18(24)21-14)8-15-11-4-6-19-17(23)13(11)9-20-15/h1-3,8-9,20,22H,4-7H2,(H,19,23)(H,21,24)/b12-8-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7250 ((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...) Show SMILES O=C1Nc2cccc(C3CCNCC3)c2\C1=C\c1[nH]cc2c1CCOC2=O Show InChI InChI=1S/C21H21N3O3/c25-20-15(10-18-14-6-9-27-21(26)16(14)11-23-18)19-13(2-1-3-17(19)24-20)12-4-7-22-8-5-12/h1-3,10-12,22-23H,4-9H2,(H,24,25)/b15-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7258 ((3Z)-5-bromo-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-...) Show SMILES Brc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1 Show InChI InChI=1S/C16H12BrN3O2/c17-8-1-2-13-10(5-8)11(16(22)20-13)6-14-9-3-4-18-15(21)12(9)7-19-14/h1-2,5-7,19H,3-4H2,(H,18,21)(H,20,22)/b11-6-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM7250 ((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...) Show SMILES O=C1Nc2cccc(C3CCNCC3)c2\C1=C\c1[nH]cc2c1CCOC2=O Show InChI InChI=1S/C21H21N3O3/c25-20-15(10-18-14-6-9-27-21(26)16(14)11-23-18)19-13(2-1-3-17(19)24-20)12-4-7-22-8-5-12/h1-3,10-12,22-23H,4-9H2,(H,24,25)/b15-10-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM7252 ((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...) Show SMILES O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCOC2=O)-c1ccccc1 Show InChI InChI=1S/C22H16N2O3/c25-21-17(11-19-16-8-9-27-22(26)18(16)12-23-19)15-7-6-14(10-20(15)24-21)13-4-2-1-3-5-13/h1-7,10-12,23H,8-9H2,(H,24,25)/b17-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM7250 ((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...) Show SMILES O=C1Nc2cccc(C3CCNCC3)c2\C1=C\c1[nH]cc2c1CCOC2=O Show InChI InChI=1S/C21H21N3O3/c25-20-15(10-18-14-6-9-27-21(26)16(14)11-23-18)19-13(2-1-3-17(19)24-20)12-4-7-22-8-5-12/h1-3,10-12,22-23H,4-9H2,(H,24,25)/b15-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7249 ((3Z)-4-(2-hydroxyethyl)-3-({4-oxo-2H,4H,6H,7H-pyra...) Show SMILES OCCc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12 Show InChI InChI=1S/C18H16N2O4/c21-6-4-10-2-1-3-14-16(10)12(17(22)20-14)8-15-11-5-7-24-18(23)13(11)9-19-15/h1-3,8-9,19,21H,4-7H2,(H,20,22)/b12-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM7251 ((3Z)-6-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...) Show SMILES COc1ccc2\C(=C\c3[nH]cc4c3CCOC4=O)C(=O)Nc2c1 Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-10-12(16(20)19-15(10)6-9)7-14-11-4-5-23-17(21)13(11)8-18-14/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7251 ((3Z)-6-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...) Show SMILES COc1ccc2\C(=C\c3[nH]cc4c3CCOC4=O)C(=O)Nc2c1 Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-10-12(16(20)19-15(10)6-9)7-14-11-4-5-23-17(21)13(11)8-18-14/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7252 ((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...) Show SMILES O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCOC2=O)-c1ccccc1 Show InChI InChI=1S/C22H16N2O3/c25-21-17(11-19-16-8-9-27-22(26)18(16)12-23-19)15-7-6-14(10-20(15)24-21)13-4-2-1-3-5-13/h1-7,10-12,23H,8-9H2,(H,24,25)/b17-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM7246 ((3Z)-5-chloro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...) Show SMILES Clc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C16H11ClN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7261 ((3Z)-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]pyridi...) Show SMILES O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCNC2=O)-c1ccccc1 Show InChI InChI=1S/C22H17N3O2/c26-21-18-12-24-19(16(18)8-9-23-21)11-17-15-7-6-14(10-20(15)25-22(17)27)13-4-2-1-3-5-13/h1-7,10-12,24H,8-9H2,(H,23,26)(H,25,27)/b17-11-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7244 ((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...) Show SMILES OC(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C17H12N2O5/c20-15-11(10-5-8(16(21)22)1-2-13(10)19-15)6-14-9-3-4-24-17(23)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)(H,21,22)/b11-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7240 ((3Z)-N-methyl-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3...) Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C17H15N3O5S/c1-18-26(23,24)9-2-3-14-11(6-9)12(16(21)20-14)7-15-10-4-5-25-17(22)13(10)8-19-15/h2-3,6-8,18-19H,4-5H2,1H3,(H,20,21)/b12-7-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7241 ((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...) Show SMILES NS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C16H13N3O5S/c17-25(22,23)8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-24-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)(H2,17,22,23)/b11-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7242 ((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...) Show SMILES CC(C)NS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C19H19N3O5S/c1-10(2)22-28(25,26)11-3-4-16-13(7-11)14(18(23)21-16)8-17-12-5-6-27-19(24)15(12)9-20-17/h3-4,7-10,20,22H,5-6H2,1-2H3,(H,21,23)/b14-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM7252 ((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...) Show SMILES O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCOC2=O)-c1ccccc1 Show InChI InChI=1S/C22H16N2O3/c25-21-17(11-19-16-8-9-27-22(26)18(16)12-23-19)15-7-6-14(10-20(15)24-21)13-4-2-1-3-5-13/h1-7,10-12,23H,8-9H2,(H,24,25)/b17-11-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM7252 ((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...) Show SMILES O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCOC2=O)-c1ccccc1 Show InChI InChI=1S/C22H16N2O3/c25-21-17(11-19-16-8-9-27-22(26)18(16)12-23-19)15-7-6-14(10-20(15)24-21)13-4-2-1-3-5-13/h1-7,10-12,23H,8-9H2,(H,24,25)/b17-11-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7245 ((3Z)-5-fluoro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...) Show SMILES Fc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C16H11FN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM7238 ((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...) Show SMILES COc1ccc2NC(=O)C(=Cc3cnc[nH]3)c2c1 |w:10.10| Show InChI InChI=1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-7H,1H3,(H,14,15)(H,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7247 ((3Z)-5-bromo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]py...) Show SMILES Brc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C16H11BrN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM7241 ((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...) Show SMILES NS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C16H13N3O5S/c17-25(22,23)8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-24-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)(H2,17,22,23)/b11-6-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM7247 ((3Z)-5-bromo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]py...) Show SMILES Brc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C16H11BrN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM7238 ((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...) Show SMILES COc1ccc2NC(=O)C(=Cc3cnc[nH]3)c2c1 |w:10.10| Show InChI InChI=1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-7H,1H3,(H,14,15)(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7243 ((3Z)-N,N-dimethyl-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyra...) Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C18H17N3O5S/c1-21(2)27(24,25)10-3-4-15-12(7-10)13(17(22)20-15)8-16-11-5-6-26-18(23)14(11)9-19-16/h3-4,7-9,19H,5-6H2,1-2H3,(H,20,22)/b13-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM7248 ((3Z)-4-methyl-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...) Show SMILES Cc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12 Show InChI InChI=1S/C17H14N2O3/c1-9-3-2-4-13-15(9)11(16(20)19-13)7-14-10-5-6-22-17(21)12(10)8-18-14/h2-4,7-8,18H,5-6H2,1H3,(H,19,20)/b11-7-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM7249 ((3Z)-4-(2-hydroxyethyl)-3-({4-oxo-2H,4H,6H,7H-pyra...) Show SMILES OCCc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12 Show InChI InChI=1S/C18H16N2O4/c21-6-4-10-2-1-3-14-16(10)12(17(22)20-14)8-15-11-5-7-24-18(23)13(11)9-19-15/h1-3,8-9,19,21H,4-7H2,(H,20,22)/b12-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7251 ((3Z)-6-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...) Show SMILES COc1ccc2\C(=C\c3[nH]cc4c3CCOC4=O)C(=O)Nc2c1 Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-10-12(16(20)19-15(10)6-9)7-14-11-4-5-23-17(21)13(11)8-18-14/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM7248 ((3Z)-4-methyl-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...) Show SMILES Cc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12 Show InChI InChI=1S/C17H14N2O3/c1-9-3-2-4-13-15(9)11(16(20)19-13)7-14-10-5-6-22-17(21)12(10)8-18-14/h2-4,7-8,18H,5-6H2,1H3,(H,19,20)/b11-7-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM7239 ((3Z)-5-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...) Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1 Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-14-11(6-9)12(16(20)19-14)7-15-10-4-5-23-17(21)13(10)8-18-15/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	25
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 69 total )  |  Next  |  Last  >>

Jump to: