Found 24 hits Enz. Inhib. hit(s) with all data for entry = 50021235 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222422
(6,7-diethoxy-4-(2-(3-(4-fluorophenyl)-1H-pyrazol-4...)Show SMILES CCOc1cc2ncnc(C#Cc3c[nH]nc3-c3ccc(F)cc3)c2cc1OCC Show InChI InChI=1S/C23H19FN4O2/c1-3-29-21-11-18-19(25-14-26-20(18)12-22(21)30-4-2)10-7-16-13-27-28-23(16)15-5-8-17(24)9-6-15/h5-6,8-9,11-14H,3-4H2,1-2H3,(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222428
((R)-4-(6,7-dimethoxyquinazolin-4-yl)-N,N-diethyl-2...)Show SMILES CCN(CC)C(C)(Cc1ccccc1)C#Cc1ncnc2cc(OC)c(OC)cc12 |w:5.5| Show InChI InChI=1S/C25H29N3O2/c1-6-28(7-2)25(3,17-19-11-9-8-10-12-19)14-13-21-20-15-23(29-4)24(30-5)16-22(20)27-18-26-21/h8-12,15-16,18H,6-7,17H2,1-5H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222430
((E)-6,7-dimethoxy-4-(4-phenylbut-1-enyl)quinazolin...)Show InChI InChI=1S/C20H20N2O2/c1-23-19-12-16-17(21-14-22-18(16)13-20(19)24-2)11-7-6-10-15-8-4-3-5-9-15/h3-5,7-9,11-14H,6,10H2,1-2H3/b11-7+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222431
((R)-1-(4-(6,7-diethoxyquinazolin-4-yl)-2-methyl-1-...)Show SMILES CCOc1cc2ncnc(C#C[C@@](C)(Cc3ccccc3)N3CCC(CC3)C(O)=O)c2cc1OCC Show InChI InChI=1S/C29H33N3O4/c1-4-35-26-17-23-24(30-20-31-25(23)18-27(26)36-5-2)11-14-29(3,19-21-9-7-6-8-10-21)32-15-12-22(13-16-32)28(33)34/h6-10,17-18,20,22H,4-5,12-13,15-16,19H2,1-3H3,(H,33,34)/t29-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222418
(6,7-diethoxy-4-(4-phenylbut-1-enyl)quinazoline | C...)Show InChI InChI=1S/C22H24N2O2/c1-3-25-21-14-18-19(13-9-8-12-17-10-6-5-7-11-17)23-16-24-20(18)15-22(21)26-4-2/h5-7,9-11,13-16H,3-4,8,12H2,1-2H3/b13-9+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222434
((R)-4-(6,7-dimethoxyquinazolin-4-yl)-2-methyl-1-ph...)Show SMILES COc1cc2ncnc(C#CC(C)(O)Cc3ccccc3)c2cc1OC |w:11.11| Show InChI InChI=1S/C21H20N2O3/c1-21(24,13-15-7-5-4-6-8-15)10-9-17-16-11-19(25-2)20(26-3)12-18(16)23-14-22-17/h4-8,11-12,14,24H,13H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222439
(6,7-diethoxy-4-(2-(3-phenyl-1H-pyrrol-2-yl)ethynyl...)Show SMILES CCOc1cc2ncnc(C#Cc3[nH]ccc3-c3ccccc3)c2cc1OCC Show InChI InChI=1S/C24H21N3O2/c1-3-28-23-14-19-21(26-16-27-22(19)15-24(23)29-4-2)11-10-20-18(12-13-25-20)17-8-6-5-7-9-17/h5-9,12-16,25H,3-4H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222437
(1-(4-(6,7-diethoxyquinazolin-4-yl)-2-methyl-1-phen...)Show SMILES CCOc1cc2ncnc(C#CC(C)(Cc3ccccc3)N3CCC(CC3)C(O)=O)c2cc1OCC |w:12.12| Show InChI InChI=1S/C29H33N3O4/c1-4-35-26-17-23-24(30-20-31-25(23)18-27(26)36-5-2)11-14-29(3,19-21-9-7-6-8-10-21)32-15-12-22(13-16-32)28(33)34/h6-10,17-18,20,22H,4-5,12-13,15-16,19H2,1-3H3,(H,33,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222438
(6,7-diethoxy-4-(2-(1-phenyl-1H-imidazol-2-yl)ethyn...)Show InChI InChI=1S/C23H20N4O2/c1-3-28-21-14-18-19(25-16-26-20(18)15-22(21)29-4-2)10-11-23-24-12-13-27(23)17-8-6-5-7-9-17/h5-9,12-16H,3-4H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222417
(4-(3,3-dimethyl-4-phenylbut-1-ynyl)-6,7-dimethoxyq...)Show InChI InChI=1S/C22H22N2O2/c1-22(2,14-16-8-6-5-7-9-16)11-10-18-17-12-20(25-3)21(26-4)13-19(17)24-15-23-18/h5-9,12-13,15H,14H2,1-4H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222435
(6,7-dimethoxy-4-(4-phenylbut-1-ynyl)quinazoline | ...)Show InChI InChI=1S/C20H18N2O2/c1-23-19-12-16-17(21-14-22-18(16)13-20(19)24-2)11-7-6-10-15-8-4-3-5-9-15/h3-5,8-9,12-14H,6,10H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222425
(6,7-diethoxy-4-styrylquinazoline | CHEMBL250925)Show InChI InChI=1S/C20H20N2O2/c1-3-23-19-12-16-17(11-10-15-8-6-5-7-9-15)21-14-22-18(16)13-20(19)24-4-2/h5-14H,3-4H2,1-2H3/b11-10+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222432
(6,7-dimethoxy-4-(3-phenoxyprop-1-ynyl)quinazoline ...)Show InChI InChI=1S/C19H16N2O3/c1-22-18-11-15-16(20-13-21-17(15)12-19(18)23-2)9-6-10-24-14-7-4-3-5-8-14/h3-5,7-8,11-13H,10H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222419
(4-biphenyl-2-ylethynyl-6,7-dimethoxy-quinazoline |...)Show InChI InChI=1S/C24H18N2O2/c1-27-23-14-20-21(25-16-26-22(20)15-24(23)28-2)13-12-18-10-6-7-11-19(18)17-8-4-3-5-9-17/h3-11,14-16H,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222436
((R)-1-(4-(6,7-dimethoxyquinazolin-4-yl)-2-methyl-1...)Show SMILES COc1cc2ncnc(C#CC(C)(Cc3ccccc3)N3CCC(CC3)C(O)=O)c2cc1OC |w:11.11| Show InChI InChI=1S/C27H29N3O4/c1-27(17-19-7-5-4-6-8-19,30-13-10-20(11-14-30)26(31)32)12-9-22-21-15-24(33-2)25(34-3)16-23(21)29-18-28-22/h4-8,15-16,18,20H,10-11,13-14,17H2,1-3H3,(H,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222421
(CHEMBL250524 | N-(4-(6,7-dimethoxyquinazolin-4-yl)...)Show InChI InChI=1S/C22H23N3O2/c1-22(2,25(3)16-9-7-6-8-10-16)12-11-18-17-13-20(26-4)21(27-5)14-19(17)24-15-23-18/h6-10,13-15H,1-5H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222427
((S)-4-(6,7-dimethoxyquinazolin-4-yl)-N,N-diethyl-2...)Show SMILES CCN(CC)C(C)(CCc1ncnc2cc(OC)c(OC)cc12)Cc1ccccc1 |w:5.5| Show InChI InChI=1S/C25H33N3O2/c1-6-28(7-2)25(3,17-19-11-9-8-10-12-19)14-13-21-20-15-23(29-4)24(30-5)16-22(20)27-18-26-21/h8-12,15-16,18H,6-7,13-14,17H2,1-5H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222440
(6,7-diethoxy-4-(5-phenylpent-1-enyl)quinazoline | ...)Show InChI InChI=1S/C23H26N2O2/c1-3-26-22-15-19-20(24-17-25-21(19)16-23(22)27-4-2)14-10-6-9-13-18-11-7-5-8-12-18/h5,7-8,10-12,14-17H,3-4,6,9,13H2,1-2H3/b14-10+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222429
((R)-4-(6,7-dimethoxyquinazolin-4-yl)-N,N-diethyl-2...)Show SMILES CCN(CC)C(C)(Cc1ccncc1)C#Cc1ncnc2cc(OC)c(OC)cc12 |w:5.5| Show InChI InChI=1S/C24H28N4O2/c1-6-28(7-2)24(3,16-18-9-12-25-13-10-18)11-8-20-19-14-22(29-4)23(30-5)15-21(19)27-17-26-20/h9-10,12-15,17H,6-7,16H2,1-5H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222426
((S)-1-(4-(6,7-diethoxyquinazolin-4-yl)-2-methyl-1-...)Show SMILES CCOc1cc2ncnc(C#C[C@](C)(Cc3ccccc3)N3CCC(CC3)C(O)=O)c2cc1OCC Show InChI InChI=1S/C29H33N3O4/c1-4-35-26-17-23-24(30-20-31-25(23)18-27(26)36-5-2)11-14-29(3,19-21-9-7-6-8-10-21)32-15-12-22(13-16-32)28(33)34/h6-10,17-18,20,22H,4-5,12-13,15-16,19H2,1-3H3,(H,33,34)/t29-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 662 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222420
((R)-1-cyclohexyl-4-(6,7-dimethoxyquinazolin-4-yl)-...)Show SMILES CCN(CC)C(C)(CC1CCCCC1)C#Cc1ncnc2cc(OC)c(OC)cc12 |w:5.5| Show InChI InChI=1S/C25H35N3O2/c1-6-28(7-2)25(3,17-19-11-9-8-10-12-19)14-13-21-20-15-23(29-4)24(30-5)16-22(20)27-18-26-21/h15-16,18-19H,6-12,17H2,1-5H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222423
((R)-1-(6,7-dimethoxyquinazolin-4-yl)-N,N-diethyl-3...)Show SMILES CCN(CC)C(C)(CCc1ccccc1)C#Cc1ncnc2cc(OC)c(OC)cc12 |w:5.5| Show InChI InChI=1S/C26H31N3O2/c1-6-29(7-2)26(3,15-13-20-11-9-8-10-12-20)16-14-22-21-17-24(30-4)25(31-5)18-23(21)28-19-27-22/h8-12,17-19H,6-7,13,15H2,1-5H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222433
(6,7-dimethoxy-4-(2-phenylethynyl)quinazoline | CHE...)Show InChI InChI=1S/C18H14N2O2/c1-21-17-10-14-15(9-8-13-6-4-3-5-7-13)19-12-20-16(14)11-18(17)22-2/h3-7,10-12H,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50222424
((R)-4-(6,7-dimethoxyquinazolin-4-yl)-N,N-diethyl-2...)Show SMILES CCN(CC)C(C)(C#Cc1ncnc2cc(OC)c(OC)cc12)c1ccccc1 |w:5.5| Show InChI InChI=1S/C24H27N3O2/c1-6-27(7-2)24(3,18-11-9-8-10-12-18)14-13-20-19-15-22(28-4)23(29-5)16-21(19)26-17-25-20/h8-12,15-17H,6-7H2,1-5H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation
Curated by ChEMBL
| Assay Description
Inhibition of partially purified EGFR tyrosine kinase from human A431 cells |
Bioorg Med Chem Lett 17: 5863-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.020
BindingDB Entry DOI: 10.7270/Q2H70FJ7 |
More data for this
Ligand-Target Pair | |
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