Compile Data Set for Download or QSAR

Found 64 hits Enz. Inhib. hit(s) with all data for entry = 50026227   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50243699 (2-(trifluoromethyl)-7-(2-(4-(2-(trifluoromethyl)-1...) Show SMILES FC(F)(F)c1nc2cccc(OCCN3CCN(CC3)c3cccc4[nH]c(nc34)C(F)(F)F)c2[nH]1 Show InChI InChI=1S/C22H20F6N6O/c23-21(24,25)19-29-13-3-1-5-15(17(13)31-19)34-9-7-33(8-10-34)11-12-35-16-6-2-4-14-18(16)32-20(30-14)22(26,27)28/h1-6H,7-12H2,(H,29,31)(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Binding affinity to human 5HT1D receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50243700 (4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4...) Show SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C21H21F3N6OS/c22-21(23,24)19-25-13-3-1-5-15(17(13)27-19)30-9-7-29(8-10-30)11-12-31-16-6-2-4-14-18(16)28-20(32)26-14/h1-6H,7-12H2,(H,25,27)(H2,26,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Binding affinity to human 5HT1A receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50243699 (2-(trifluoromethyl)-7-(2-(4-(2-(trifluoromethyl)-1...) Show SMILES FC(F)(F)c1nc2cccc(OCCN3CCN(CC3)c3cccc4[nH]c(nc34)C(F)(F)F)c2[nH]1 Show InChI InChI=1S/C22H20F6N6O/c23-21(24,25)19-29-13-3-1-5-15(17(13)31-19)34-9-7-33(8-10-34)11-12-35-16-6-2-4-14-18(16)32-20(30-14)22(26,27)28/h1-6H,7-12H2,(H,29,31)(H,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Binding affinity to human 5HT1A receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM50243699 (2-(trifluoromethyl)-7-(2-(4-(2-(trifluoromethyl)-1...) Show SMILES FC(F)(F)c1nc2cccc(OCCN3CCN(CC3)c3cccc4[nH]c(nc34)C(F)(F)F)c2[nH]1 Show InChI InChI=1S/C22H20F6N6O/c23-21(24,25)19-29-13-3-1-5-15(17(13)31-19)34-9-7-33(8-10-34)11-12-35-16-6-2-4-14-18(16)32-20(30-14)22(26,27)28/h1-6H,7-12H2,(H,29,31)(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Binding affinity to human 5HT1B receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50244213 (5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CCn1cc(CN2CCN(CC2)c2cccc3[nH]c(nc23)-c2ccc(cc2)C(C)(C)C)c(=O)[nH]c1=O Show InChI InChI=1S/C28H34N6O2/c1-5-33-18-20(26(35)31-27(33)36)17-32-13-15-34(16-14-32)23-8-6-7-22-24(23)30-25(29-22)19-9-11-21(12-10-19)28(2,3)4/h6-12,18H,5,13-17H2,1-4H3,(H,29,30)(H,31,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Binding affinity to 5HT2A receptor (unknown origin)				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244213 (5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CCn1cc(CN2CCN(CC2)c2cccc3[nH]c(nc23)-c2ccc(cc2)C(C)(C)C)c(=O)[nH]c1=O Show InChI InChI=1S/C28H34N6O2/c1-5-33-18-20(26(35)31-27(33)36)17-32-13-15-34(16-14-32)23-8-6-7-22-24(23)30-25(29-22)19-9-11-21(12-10-19)28(2,3)4/h6-12,18H,5,13-17H2,1-4H3,(H,29,30)(H,31,35,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50243853 (4-(3-(4-(2-(Trifluoromethyl)-1H-benzo[d]imidazol-4...) Show SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(CCCOc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C22H23F3N6OS/c23-22(24,25)20-26-14-4-1-6-16(18(14)28-20)31-11-9-30(10-12-31)8-3-13-32-17-7-2-5-15-19(17)29-21(33)27-15/h1-2,4-7H,3,8-13H2,(H,26,28)(H2,27,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Binding affinity to human 5HT1A receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244213 (5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CCn1cc(CN2CCN(CC2)c2cccc3[nH]c(nc23)-c2ccc(cc2)C(C)(C)C)c(=O)[nH]c1=O Show InChI InChI=1S/C28H34N6O2/c1-5-33-18-20(26(35)31-27(33)36)17-32-13-15-34(16-14-32)23-8-6-7-22-24(23)30-25(29-22)19-9-11-21(12-10-19)28(2,3)4/h6-12,18H,5,13-17H2,1-4H3,(H,29,30)(H,31,35,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244211 (6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2ccc3[nH]c(=O)c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C30H32N6O2/c1-30(2,3)21-10-8-20(9-11-21)27-31-23-5-4-6-25(26(23)34-27)36-15-13-35(14-16-36)18-19-7-12-22-24(17-19)33-29(38)28(37)32-22/h4-12,17H,13-16,18H2,1-3H3,(H,31,34)(H,32,37)(H,33,38)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244212 (5-((4-(2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2c[nH]c(=O)[nH]c2=O)CC1 Show InChI InChI=1S/C26H30N6O2/c1-26(2,3)19-9-7-17(8-10-19)23-28-20-5-4-6-21(22(20)29-23)32-13-11-31(12-14-32)16-18-15-27-25(34)30-24(18)33/h4-10,15H,11-14,16H2,1-3H3,(H,28,29)(H2,27,30,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244176 (5-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=O)c(=O)[nH]c23)CC1 Show InChI InChI=1S/C30H32N6O2/c1-30(2,3)21-12-10-19(11-13-21)27-31-23-8-5-9-24(26(23)33-27)36-16-14-35(15-17-36)18-20-6-4-7-22-25(20)34-29(38)28(37)32-22/h4-13H,14-18H2,1-3H3,(H,31,33)(H,32,37)(H,34,38)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244135 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C29H32N6S/c1-29(2,3)21-12-10-19(11-13-21)27-30-23-8-5-9-24(26(23)32-27)35-16-14-34(15-17-35)18-20-6-4-7-22-25(20)33-28(36)31-22/h4-13H,14-18H2,1-3H3,(H,30,32)(H2,31,33,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244175 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=O)[nH]c23)CC1 Show InChI InChI=1S/C29H32N6O/c1-29(2,3)21-12-10-19(11-13-21)27-30-23-8-5-9-24(26(23)32-27)35-16-14-34(15-17-35)18-20-6-4-7-22-25(20)33-28(36)31-22/h4-13H,14-18H2,1-3H3,(H,30,32)(H2,31,33,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244211 (6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2ccc3[nH]c(=O)c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C30H32N6O2/c1-30(2,3)21-10-8-20(9-11-21)27-31-23-5-4-6-25(26(23)34-27)36-15-13-35(14-16-36)18-19-7-12-22-24(17-19)33-29(38)28(37)32-22/h4-12,17H,13-16,18H2,1-3H3,(H,31,34)(H,32,37)(H,33,38)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244212 (5-((4-(2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2c[nH]c(=O)[nH]c2=O)CC1 Show InChI InChI=1S/C26H30N6O2/c1-26(2,3)19-9-7-17(8-10-19)23-28-20-5-4-6-21(22(20)29-23)32-13-11-31(12-14-32)16-18-15-27-25(34)30-24(18)33/h4-10,15H,11-14,16H2,1-3H3,(H,28,29)(H2,27,30,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244135 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C29H32N6S/c1-29(2,3)21-12-10-19(11-13-21)27-30-23-8-5-9-24(26(23)32-27)35-16-14-34(15-17-35)18-20-6-4-7-22-25(20)33-28(36)31-22/h4-13H,14-18H2,1-3H3,(H,30,32)(H2,31,33,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244213 (5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CCn1cc(CN2CCN(CC2)c2cccc3[nH]c(nc23)-c2ccc(cc2)C(C)(C)C)c(=O)[nH]c1=O Show InChI InChI=1S/C28H34N6O2/c1-5-33-18-20(26(35)31-27(33)36)17-32-13-15-34(16-14-32)23-8-6-7-22-24(23)30-25(29-22)19-9-11-21(12-10-19)28(2,3)4/h6-12,18H,5,13-17H2,1-4H3,(H,29,30)(H,31,35,36)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244176 (5-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=O)c(=O)[nH]c23)CC1 Show InChI InChI=1S/C30H32N6O2/c1-30(2,3)21-12-10-19(11-13-21)27-31-23-8-5-9-24(26(23)33-27)36-16-14-35(15-17-36)18-20-6-4-7-22-25(20)34-29(38)28(37)32-22/h4-13H,14-18H2,1-3H3,(H,31,33)(H,32,37)(H,34,38)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244211 (6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2ccc3[nH]c(=O)c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C30H32N6O2/c1-30(2,3)21-10-8-20(9-11-21)27-31-23-5-4-6-25(26(23)34-27)36-15-13-35(14-16-36)18-19-7-12-22-24(17-19)33-29(38)28(37)32-22/h4-12,17H,13-16,18H2,1-3H3,(H,31,34)(H,32,37)(H,33,38)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at recombinant GnRH receptor in CO2 asphyxiated rat primary pituitary cells assessed as reduction in (D-Trp6)LHRH-induced LH rele...				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244212 (5-((4-(2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2c[nH]c(=O)[nH]c2=O)CC1 Show InChI InChI=1S/C26H30N6O2/c1-26(2,3)19-9-7-17(8-10-19)23-28-20-5-4-6-21(22(20)29-23)32-13-11-31(12-14-32)16-18-15-27-25(34)30-24(18)33/h4-10,15H,11-14,16H2,1-3H3,(H,28,29)(H2,27,30,33,34)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244211 (6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2ccc3[nH]c(=O)c(=O)[nH]c3c2)CC1 Show InChI InChI=1S/C30H32N6O2/c1-30(2,3)21-10-8-20(9-11-21)27-31-23-5-4-6-25(26(23)34-27)36-15-13-35(14-16-36)18-19-7-12-22-24(17-19)33-29(38)28(37)32-22/h4-12,17H,13-16,18H2,1-3H3,(H,31,34)(H,32,37)(H,33,38)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244212 (5-((4-(2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2c[nH]c(=O)[nH]c2=O)CC1 Show InChI InChI=1S/C26H30N6O2/c1-26(2,3)19-9-7-17(8-10-19)23-28-20-5-4-6-21(22(20)29-23)32-13-11-31(12-14-32)16-18-15-27-25(34)30-24(18)33/h4-10,15H,11-14,16H2,1-3H3,(H,28,29)(H2,27,30,33,34)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at recombinant GnRH receptor in CO2 asphyxiated rat primary pituitary cells assessed as reduction in (D-Trp6)LHRH-induced LH rele...				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244133 (2-(4-tert-Butylphenyl)-4-(4-(2-(2-(trifluoromethyl...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C31H33F3N6O/c1-30(2,3)21-12-10-20(11-13-21)28-35-22-6-4-8-24(26(22)37-28)40-16-14-39(15-17-40)18-19-41-25-9-5-7-23-27(25)38-29(36-23)31(32,33)34/h4-13H,14-19H2,1-3H3,(H,35,37)(H,36,38)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244213 (5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-...) Show SMILES CCn1cc(CN2CCN(CC2)c2cccc3[nH]c(nc23)-c2ccc(cc2)C(C)(C)C)c(=O)[nH]c1=O Show InChI InChI=1S/C28H34N6O2/c1-5-33-18-20(26(35)31-27(33)36)17-32-13-15-34(16-14-32)23-8-6-7-22-24(23)30-25(29-22)19-9-11-21(12-10-19)28(2,3)4/h6-12,18H,5,13-17H2,1-4H3,(H,29,30)(H,31,35,36)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at recombinant GnRH receptor in CO2 asphyxiated rat primary pituitary cells assessed as reduction in (D-Trp6)LHRH-induced LH rele...				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244175 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=O)[nH]c23)CC1 Show InChI InChI=1S/C29H32N6O/c1-29(2,3)21-12-10-19(11-13-21)27-30-23-8-5-9-24(26(23)32-27)35-16-14-34(15-17-35)18-20-6-4-7-22-25(20)33-28(36)31-22/h4-13H,14-18H2,1-3H3,(H,30,32)(H2,31,33,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244176 (5-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=O)c(=O)[nH]c23)CC1 Show InChI InChI=1S/C30H32N6O2/c1-30(2,3)21-12-10-19(11-13-21)27-31-23-8-5-9-24(26(23)33-27)36-16-14-35(15-17-36)18-20-6-4-7-22-25(20)34-29(38)28(37)32-22/h4-13H,14-18H2,1-3H3,(H,31,33)(H,32,37)(H,34,38)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244135 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C29H32N6S/c1-29(2,3)21-12-10-19(11-13-21)27-30-23-8-5-9-24(26(23)32-27)35-16-14-34(15-17-35)18-20-6-4-7-22-25(20)33-28(36)31-22/h4-13H,14-18H2,1-3H3,(H,30,32)(H2,31,33,36)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244132 (2-(4-Isopropylphenyl)-4-(4-(2-(2-(trifluoromethyl)...) Show SMILES CC(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C30H31F3N6O/c1-19(2)20-9-11-21(12-10-20)28-34-22-5-3-7-24(26(22)36-28)39-15-13-38(14-16-39)17-18-40-25-8-4-6-23-27(25)37-29(35-23)30(31,32)33/h3-12,19H,13-18H2,1-2H3,(H,34,36)(H,35,37)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244090 (4-(2-(4-(2-(4-Ethylphenyl)-1H-benzo[d]imidazol-4-y...) Show SMILES CCc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C28H30N6OS/c1-2-19-9-11-20(12-10-19)27-29-21-5-3-7-23(25(21)31-27)34-15-13-33(14-16-34)17-18-35-24-8-4-6-22-26(24)32-28(36)30-22/h3-12H,2,13-18H2,1H3,(H,29,31)(H2,30,32,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244089 (2-(4-Ethylphenyl)-4-(4-(2-(2-(trifluoromethyl)-1Hb...) Show SMILES CCc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C29H29F3N6O/c1-2-19-9-11-20(12-10-19)27-33-21-5-3-7-23(25(21)35-27)38-15-13-37(14-16-38)17-18-39-24-8-4-6-22-26(24)36-28(34-22)29(30,31)32/h3-12H,2,13-18H2,1H3,(H,33,35)(H,34,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244135 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C29H32N6S/c1-29(2,3)21-12-10-19(11-13-21)27-30-23-8-5-9-24(26(23)32-27)35-16-14-34(15-17-35)18-20-6-4-7-22-25(20)33-28(36)31-22/h4-13H,14-18H2,1-3H3,(H,30,32)(H2,31,33,36)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at recombinant GnRH receptor in CO2 asphyxiated rat primary pituitary cells assessed as reduction in (D-Trp6)LHRH-induced LH rele...				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244132 (2-(4-Isopropylphenyl)-4-(4-(2-(2-(trifluoromethyl)...) Show SMILES CC(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C30H31F3N6O/c1-19(2)20-9-11-21(12-10-20)28-34-22-5-3-7-24(26(22)36-28)39-15-13-38(14-16-39)17-18-40-25-8-4-6-23-27(25)37-29(35-23)30(31,32)33/h3-12,19H,13-18H2,1-2H3,(H,34,36)(H,35,37)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244176 (5-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=O)c(=O)[nH]c23)CC1 Show InChI InChI=1S/C30H32N6O2/c1-30(2,3)21-12-10-19(11-13-21)27-31-23-8-5-9-24(26(23)33-27)36-16-14-35(15-17-36)18-20-6-4-7-22-25(20)34-29(38)28(37)32-22/h4-13H,14-18H2,1-3H3,(H,31,33)(H,32,37)(H,34,38)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at recombinant GnRH receptor in CO2 asphyxiated rat primary pituitary cells assessed as reduction in (D-Trp6)LHRH-induced LH rele...				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50243900 (4-((4-(2-(Trifluoromethyl)-1H-benzo[d]imidazol-4-y...) Show SMILES FC(F)(F)c1nc2cccc(N3CCN(Cc4cccc5[nH]c(=S)[nH]c45)CC3)c2[nH]1 Show InChI InChI=1S/C20H19F3N6S/c21-20(22,23)18-24-14-5-2-6-15(17(14)26-18)29-9-7-28(8-10-29)11-12-3-1-4-13-16(12)27-19(30)25-13/h1-6H,7-11H2,(H,24,26)(H2,25,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244090 (4-(2-(4-(2-(4-Ethylphenyl)-1H-benzo[d]imidazol-4-y...) Show SMILES CCc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C28H30N6OS/c1-2-19-9-11-20(12-10-19)27-29-21-5-3-7-23(25(21)31-27)34-15-13-33(14-16-34)17-18-35-24-8-4-6-22-26(24)32-28(36)30-22/h3-12H,2,13-18H2,1H3,(H,29,31)(H2,30,32,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244175 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=O)[nH]c23)CC1 Show InChI InChI=1S/C29H32N6O/c1-29(2,3)21-12-10-19(11-13-21)27-30-23-8-5-9-24(26(23)32-27)35-16-14-34(15-17-35)18-20-6-4-7-22-25(20)33-28(36)31-22/h4-13H,14-18H2,1-3H3,(H,30,32)(H2,31,33,36)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244133 (2-(4-tert-Butylphenyl)-4-(4-(2-(2-(trifluoromethyl...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C31H33F3N6O/c1-30(2,3)21-12-10-20(11-13-21)28-35-22-6-4-8-24(26(22)37-28)40-16-14-39(15-17-40)18-19-41-25-9-5-7-23-27(25)38-29(36-23)31(32,33)34/h4-13H,14-19H2,1-3H3,(H,35,37)(H,36,38)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50243700 (4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4...) Show SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C21H21F3N6OS/c22-21(23,24)19-25-13-3-1-5-15(17(13)27-19)30-9-7-29(8-10-30)11-12-31-16-6-2-4-14-18(16)28-20(32)26-14/h1-6H,7-12H2,(H,25,27)(H2,26,28,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244132 (2-(4-Isopropylphenyl)-4-(4-(2-(2-(trifluoromethyl)...) Show SMILES CC(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C30H31F3N6O/c1-19(2)20-9-11-21(12-10-20)28-34-22-5-3-7-24(26(22)36-28)39-15-13-38(14-16-39)17-18-40-25-8-4-6-23-27(25)37-29(35-23)30(31,32)33/h3-12,19H,13-18H2,1-2H3,(H,34,36)(H,35,37)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244134 (4-(2-(4-(2-(2,4-Dimethylphenyl)-1H-benzo[d]imidazo...) Show SMILES Cc1ccc(-c2nc3c(cccc3[nH]2)N2CCN(CCOc3cccc4[nH]c(=S)[nH]c34)CC2)c(C)c1 Show InChI InChI=1S/C28H30N6OS/c1-18-9-10-20(19(2)17-18)27-29-21-5-3-7-23(25(21)31-27)34-13-11-33(12-14-34)15-16-35-24-8-4-6-22-26(24)32-28(36)30-22/h3-10,17H,11-16H2,1-2H3,(H,29,31)(H2,30,32,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244133 (2-(4-tert-Butylphenyl)-4-(4-(2-(2-(trifluoromethyl...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C31H33F3N6O/c1-30(2,3)21-12-10-20(11-13-21)28-35-22-6-4-8-24(26(22)37-28)40-16-14-39(15-17-40)18-19-41-25-9-5-7-23-27(25)38-29(36-23)31(32,33)34/h4-13H,14-19H2,1-3H3,(H,35,37)(H,36,38)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244088 (2-p-Tolyl-4-(4-(2-(2-(trifluoromethyl)-1Hbenzo[d]i...) Show SMILES Cc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C27H28N6OS/c1-18-8-10-19(11-9-18)26-28-20-4-2-6-22(24(20)30-26)33-14-12-32(13-15-33)16-17-34-23-7-3-5-21-25(23)31-27(35)29-21/h2-11H,12-17H2,1H3,(H,28,30)(H2,29,31,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50243699 (2-(trifluoromethyl)-7-(2-(4-(2-(trifluoromethyl)-1...) Show SMILES FC(F)(F)c1nc2cccc(OCCN3CCN(CC3)c3cccc4[nH]c(nc34)C(F)(F)F)c2[nH]1 Show InChI InChI=1S/C22H20F6N6O/c23-21(24,25)19-29-13-3-1-5-15(17(13)31-19)34-9-7-33(8-10-34)11-12-35-16-6-2-4-14-18(16)32-20(30-14)22(26,27)28/h1-6H,7-12H2,(H,29,31)(H,30,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244175 (4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-y...) Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2cccc3[nH]c(=O)[nH]c23)CC1 Show InChI InChI=1S/C29H32N6O/c1-29(2,3)21-12-10-19(11-13-21)27-30-23-8-5-9-24(26(23)32-27)35-16-14-34(15-17-35)18-20-6-4-7-22-25(20)33-28(36)31-22/h4-13H,14-18H2,1-3H3,(H,30,32)(H2,31,33,36)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at recombinant GnRH receptor in CO2 asphyxiated rat primary pituitary cells assessed as reduction in (D-Trp6)LHRH-induced LH rele...				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244089 (2-(4-Ethylphenyl)-4-(4-(2-(2-(trifluoromethyl)-1Hb...) Show SMILES CCc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1 Show InChI InChI=1S/C29H29F3N6O/c1-2-19-9-11-20(12-10-19)27-33-21-5-3-7-23(25(21)35-27)38-15-13-37(14-16-38)17-18-39-24-8-4-6-22-26(24)36-28(34-22)29(30,31)32/h3-12H,2,13-18H2,1H3,(H,33,35)(H,34,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50244088 (2-p-Tolyl-4-(4-(2-(2-(trifluoromethyl)-1Hbenzo[d]i...) Show SMILES Cc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C27H28N6OS/c1-18-8-10-19(11-9-18)26-28-20-4-2-6-22(24(20)30-26)33-14-12-32(13-15-33)16-17-34-23-7-3-5-21-25(23)31-27(35)29-21/h2-11H,12-17H2,1H3,(H,28,30)(H2,29,31,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50243853 (4-(3-(4-(2-(Trifluoromethyl)-1H-benzo[d]imidazol-4...) Show SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(CCCOc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C22H23F3N6OS/c23-22(24,25)20-26-14-4-1-6-16(18(14)28-20)31-11-9-30(10-12-31)8-3-13-32-17-7-2-5-15-19(17)29-21(33)27-15/h1-2,4-7H,3,8-13H2,(H,26,28)(H2,27,29,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50243900 (4-((4-(2-(Trifluoromethyl)-1H-benzo[d]imidazol-4-y...) Show SMILES FC(F)(F)c1nc2cccc(N3CCN(Cc4cccc5[nH]c(=S)[nH]c45)CC3)c2[nH]1 Show InChI InChI=1S/C20H19F3N6S/c21-20(22,23)18-24-14-5-2-6-15(17(14)26-18)29-9-7-28(8-10-29)11-12-3-1-4-13-16(12)27-19(30)25-13/h1-6H,7-11H2,(H,24,26)(H2,25,27,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50244090 (4-(2-(4-(2-(4-Ethylphenyl)-1H-benzo[d]imidazol-4-y...) Show SMILES CCc1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C28H30N6OS/c1-2-19-9-11-20(12-10-19)27-29-21-5-3-7-23(25(21)31-27)34-15-13-33(14-16-34)17-18-35-24-8-4-6-22-26(24)32-28(36)30-22/h3-12H,2,13-18H2,1H3,(H,29,31)(H2,30,32,36)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptor				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50243700 (4-(2-(4-(2-(trifluoromethyl)-1H-benzo[d]imidazol-4...) Show SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3[nH]c(=S)[nH]c23)CC1 Show InChI InChI=1S/C21H21F3N6OS/c22-21(23,24)19-25-13-3-1-5-15(17(13)27-19)30-9-7-29(8-10-30)11-12-31-16-6-2-4-14-18(16)28-20(32)26-14/h1-6H,7-12H2,(H,25,27)(H2,26,28,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol production				Bioorg Med Chem 16: 6617-40 (2008) Article DOI: 10.1016/j.bmc.2008.05.024 BindingDB Entry DOI: 10.7270/Q2FB52Q7
					More data for this Ligand-Target Pair

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