Compile Data Set for Download or QSAR

Found 69 hits Enz. Inhib. hit(s) with all data for entry = 50028591   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259015 (5-(3-chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]p...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1cccc(Cl)c1)[nH]c2=O Show InChI InChI=1S/C15H15ClN4O/c1-8(2)12-13-14(20-19-12)15(21)18-11(17-13)7-9-4-3-5-10(16)6-9/h3-6,8H,7H2,1-2H3,(H,19,20)(H,17,18,21)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50259015 (5-(3-chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]p...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1cccc(Cl)c1)[nH]c2=O Show InChI InChI=1S/C15H15ClN4O/c1-8(2)12-13-14(20-19-12)15(21)18-11(17-13)7-9-4-3-5-10(16)6-9/h3-6,8H,7H2,1-2H3,(H,19,20)(H,17,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM50259015 (5-(3-chlorobenzyl)-3-isopropyl-1H-pyrazolo[4,3-d]p...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1cccc(Cl)c1)[nH]c2=O Show InChI InChI=1S/C15H15ClN4O/c1-8(2)12-13-14(20-19-12)15(21)18-11(17-13)7-9-4-3-5-10(16)6-9/h3-6,8H,7H2,1-2H3,(H,19,20)(H,17,18,21)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259016 (3-isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyra...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OC(F)(F)F)[nH]c2=O Show InChI InChI=1S/C16H15F3N4O2/c1-8(2)12-13-14(23-22-12)15(24)21-11(20-13)7-9-5-3-4-6-10(9)25-16(17,18)19/h3-6,8H,7H2,1-2H3,(H,22,23)(H,20,21,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM50259058 (3-isopropyl-1-methyl-5-(2-(2-morpholinoethoxy)benz...) Show SMILES CC(C)c1nn(C)c2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C22H29N5O3/c1-15(2)19-20-21(26(3)25-19)22(28)24-18(23-20)14-16-6-4-5-7-17(16)30-13-10-27-8-11-29-12-9-27/h4-7,15H,8-14H2,1-3H3,(H,23,24,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259058 (3-isopropyl-1-methyl-5-(2-(2-morpholinoethoxy)benz...) Show SMILES CC(C)c1nn(C)c2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C22H29N5O3/c1-15(2)19-20-21(26(3)25-19)22(28)24-18(23-20)14-16-6-4-5-7-17(16)30-13-10-27-8-11-29-12-9-27/h4-7,15H,8-14H2,1-3H3,(H,23,24,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE8a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE8b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE7b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE3a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE3b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4d				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50259148 ((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O |r| Show InChI InChI=1S/C21H24F3N7O3/c1-9(2)14-15-16(31-30-14)18(32)28-13(27-15)7-10-5-3-4-6-12(10)26-20-25-8-11(19(33)34)17(29-20)21(22,23)24/h8-10,12H,3-7H2,1-2H3,(H,30,31)(H,33,34)(H,25,26,29)(H,27,28,32)/t10-,12+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE7a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259017 (5-(2-(benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCc1ccccc1)[nH]c2=O Show InChI InChI=1S/C22H22N4O2/c1-14(2)19-20-21(26-25-19)22(27)24-18(23-20)12-16-10-6-7-11-17(16)28-13-15-8-4-3-5-9-15/h3-11,14H,12-13H2,1-2H3,(H,25,26)(H,23,24,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM50259017 (5-(2-(benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCc1ccccc1)[nH]c2=O Show InChI InChI=1S/C22H22N4O2/c1-14(2)19-20-21(26-25-19)22(27)24-18(23-20)12-16-10-6-7-11-17(16)28-13-15-8-4-3-5-9-15/h3-11,14H,12-13H2,1-2H3,(H,25,26)(H,23,24,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50259108 ((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O |r| Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259059 (3-isopropyl-5-{[(1S,2R)-2-(2-morpholin-4-ylethoxy)...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1OCCN1CCOCC1)[nH]c2=O |r| Show InChI InChI=1S/C21H33N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h14-16H,3-13H2,1-2H3,(H,24,25)(H,22,23,27)/t15-,16+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM50259016 (3-isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyra...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OC(F)(F)F)[nH]c2=O Show InChI InChI=1S/C16H15F3N4O2/c1-8(2)12-13-14(23-22-12)15(24)21-11(20-13)7-9-5-3-4-6-10(9)25-16(17,18)19/h3-6,8H,7H2,1-2H3,(H,22,23)(H,20,21,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50259017 (5-(2-(benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCc1ccccc1)[nH]c2=O Show InChI InChI=1S/C22H22N4O2/c1-14(2)19-20-21(26-25-19)22(27)24-18(23-20)12-16-10-6-7-11-17(16)28-13-15-8-4-3-5-9-15/h3-11,14H,12-13H2,1-2H3,(H,25,26)(H,23,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50259016 (3-isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyra...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OC(F)(F)F)[nH]c2=O Show InChI InChI=1S/C16H15F3N4O2/c1-8(2)12-13-14(23-22-12)15(24)21-11(20-13)7-9-5-3-4-6-10(9)25-16(17,18)19/h3-6,8H,7H2,1-2H3,(H,22,23)(H,20,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259105 (CHEMBL466680 | N-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1NC(=O)CC1CCOCC1)[nH]c2=O |r| Show InChI InChI=1S/C22H33N5O3/c1-13(2)19-20-21(27-26-19)22(29)25-17(24-20)12-15-5-3-4-6-16(15)23-18(28)11-14-7-9-30-10-8-14/h13-16H,3-12H2,1-2H3,(H,23,28)(H,26,27)(H,24,25,29)/t15-,16+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259106 (1-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1NC(=O)NCCCN1CCOCC1)[nH]c2=O |r| Show InChI InChI=1S/C23H37N7O3/c1-15(2)19-20-21(29-28-19)22(31)27-18(26-20)14-16-6-3-4-7-17(16)25-23(32)24-8-5-9-30-10-12-33-13-11-30/h15-17H,3-14H2,1-2H3,(H,28,29)(H2,24,25,32)(H,26,27,31)/t16-,17+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259108 ((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O |r| Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM50259107 (3-isopropyl-5-(((1S, 2R)-2-(6-methylpyridazin-3-yl...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ccc(C)nn1)[nH]c2=O |r| Show InChI InChI=1S/C20H27N7O/c1-11(2)17-18-19(27-26-17)20(28)23-16(22-18)10-13-6-4-5-7-14(13)21-15-9-8-12(3)24-25-15/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,21,25)(H,26,27)(H,22,23,28)/t13-,14+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM50259108 ((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O |r| Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50259058 (3-isopropyl-1-methyl-5-(2-(2-morpholinoethoxy)benz...) Show SMILES CC(C)c1nn(C)c2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C22H29N5O3/c1-15(2)19-20-21(26(3)25-19)22(28)24-18(23-20)14-16-6-4-5-7-17(16)30-13-10-27-8-11-29-12-9-27/h4-7,15H,8-14H2,1-3H3,(H,23,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50259108 ((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O |r| Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE1b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE3a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE3b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4d				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE7a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE7b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE8a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (Homo sapiens (Human))	BDBM50259057 (3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-py...) Show SMILES CC(C)c1[nH]nc2c1nc(Cc1ccccc1OCCN1CCOCC1)[nH]c2=O Show InChI InChI=1S/C21H27N5O3/c1-14(2)18-19-20(25-24-18)21(27)23-17(22-19)13-15-5-3-4-6-16(15)29-12-9-26-7-10-28-11-8-26/h3-6,14H,7-13H2,1-2H3,(H,24,25)(H,22,23,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE8b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50259108 ((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O |r| Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE3a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50259108 ((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O |r| Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE3b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50259108 ((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O |r| Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4a				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50259108 ((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O |r| Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4b				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human))	BDBM50259108 ((-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)...) Show SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncccn1)[nH]c2=O |r| Show InChI InChI=1S/C19H25N7O/c1-11(2)15-16-17(26-25-15)18(27)24-14(23-16)10-12-6-3-4-7-13(12)22-19-20-8-5-9-21-19/h5,8-9,11-13H,3-4,6-7,10H2,1-2H3,(H,25,26)(H,20,21,22)(H,23,24,27)/t12-,13+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE4c				Bioorg Med Chem Lett 19: 2537-41 (2009) Article DOI: 10.1016/j.bmcl.2009.03.024 BindingDB Entry DOI: 10.7270/Q2RB74GG
					More data for this Ligand-Target Pair

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