Found 46 hits Enz. Inhib. hit(s) with all data for entry = 50031346 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311657
(1-(9-(8-fluorochroman-4-yl)-8-oxo-8,9-dihydro-7H-p...)Show SMILES Fc1cccc2[C@@H](CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccc(cc12)C#N |r| Show InChI InChI=1S/C22H14FN7O2/c23-14-3-1-2-13-17(6-7-32-19(13)14)30-20-16(27-22(30)31)10-25-21(28-20)29-11-26-15-5-4-12(9-24)8-18(15)29/h1-5,8,10-11,17H,6-7H2,(H,27,31)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311656
(2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(8-fluoroc...)Show SMILES Fc1ccc2ncn(-c3ncc4[nH]c(=O)n([C@@H]5CCOc6c(F)cccc56)c4n3)c2c1 |r| Show InChI InChI=1S/C21H14F2N6O2/c22-11-4-5-14-17(8-11)28(10-25-14)20-24-9-15-19(27-20)29(21(30)26-15)16-6-7-31-18-12(16)2-1-3-13(18)23/h1-5,8-10,16H,6-7H2,(H,26,30)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311657
(1-(9-(8-fluorochroman-4-yl)-8-oxo-8,9-dihydro-7H-p...)Show SMILES Fc1cccc2[C@@H](CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccc(cc12)C#N |r| Show InChI InChI=1S/C22H14FN7O2/c23-14-3-1-2-13-17(6-7-32-19(13)14)30-20-16(27-22(30)31)10-25-21(28-20)29-11-26-15-5-4-12(9-24)8-18(15)29/h1-5,8,10-11,17H,6-7H2,(H,27,31)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311644
(1-(9-(2,6-difluorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)Show SMILES Fc1cccc(F)c1Cn1c2nc(ncc2[nH]c1=O)-n1cnc2ccc(cc12)C#N Show InChI InChI=1S/C20H11F2N7O/c21-13-2-1-3-14(22)12(13)9-28-18-16(26-20(28)30)8-24-19(27-18)29-10-25-15-5-4-11(7-23)6-17(15)29/h1-6,8,10H,9H2,(H,26,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311640
(1-(8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-...)Show SMILES O=c1[nH]c2cnc(nc2n1C1CCOCC1)-n1cnc2ccc(cc12)C#N Show InChI InChI=1S/C18H15N7O2/c19-8-11-1-2-13-15(7-11)24(10-21-13)17-20-9-14-16(23-17)25(18(26)22-14)12-3-5-27-6-4-12/h1-2,7,9-10,12H,3-6H2,(H,22,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311639
(2-(6-chloro-1H-benzo[d]imidazol-1-yl)-9-(tetrahydr...)Show SMILES Clc1ccc2ncn(-c3ncc4[nH]c(=O)n(C5CCOCC5)c4n3)c2c1 Show InChI InChI=1S/C17H15ClN6O2/c18-10-1-2-12-14(7-10)23(9-20-12)16-19-8-13-15(22-16)24(17(25)21-13)11-3-5-26-6-4-11/h1-2,7-9,11H,3-6H2,(H,21,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311655
(2-(6-chloro-1H-benzo[d]imidazol-1-yl)-9-(8-fluoroc...)Show SMILES Fc1cccc2[C@@H](CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccc(Cl)cc12 |r| Show InChI InChI=1S/C21H14ClFN6O2/c22-11-4-5-14-17(8-11)28(10-25-14)20-24-9-15-19(27-20)29(21(30)26-15)16-6-7-31-18-12(16)2-1-3-13(18)23/h1-5,8-10,16H,6-7H2,(H,26,30)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311642
(1-(9-(2,3-difluorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)Show SMILES Fc1cccc(Cn2c3nc(ncc3[nH]c2=O)-n2cnc3ccc(cc23)C#N)c1F Show InChI InChI=1S/C20H11F2N7O/c21-13-3-1-2-12(17(13)22)9-28-18-15(26-20(28)30)8-24-19(27-18)29-10-25-14-5-4-11(7-23)6-16(14)29/h1-6,8,10H,9H2,(H,26,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311656
(2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(8-fluoroc...)Show SMILES Fc1ccc2ncn(-c3ncc4[nH]c(=O)n([C@@H]5CCOc6c(F)cccc56)c4n3)c2c1 |r| Show InChI InChI=1S/C21H14F2N6O2/c22-11-4-5-14-17(8-11)28(10-25-14)20-24-9-15-19(27-20)29(21(30)26-15)16-6-7-31-18-12(16)2-1-3-13(18)23/h1-5,8-10,16H,6-7H2,(H,26,30)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311653
((R)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochroma...)Show SMILES Fc1cccc2[C@@H](CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 |r| Show InChI InChI=1S/C21H15FN6O2/c22-13-5-3-4-12-16(8-9-30-18(12)13)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-6-1-2-7-17(14)27/h1-7,10-11,16H,8-9H2,(H,25,29)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311648
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(6-fluorochro...)Show SMILES Fc1ccc2OCCC(c2c1)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15FN6O2/c22-12-5-6-18-13(9-12)16(7-8-30-18)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-3-1-2-4-17(14)27/h1-6,9-11,16H,7-8H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311644
(1-(9-(2,6-difluorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)Show SMILES Fc1cccc(F)c1Cn1c2nc(ncc2[nH]c1=O)-n1cnc2ccc(cc12)C#N Show InChI InChI=1S/C20H11F2N7O/c21-13-2-1-3-14(22)12(13)9-28-18-16(26-20(28)30)8-24-19(27-18)29-10-25-15-5-4-11(7-23)6-17(15)29/h1-6,8,10H,9H2,(H,26,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311651
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochro...)Show SMILES Fc1cccc2C(CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15FN6O2/c22-13-5-3-4-12-16(8-9-30-18(12)13)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-6-1-2-7-17(14)27/h1-7,10-11,16H,8-9H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311638
(2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(tetrahydr...)Show SMILES Fc1ccc2ncn(-c3ncc4[nH]c(=O)n(C5CCOCC5)c4n3)c2c1 Show InChI InChI=1S/C17H15FN6O2/c18-10-1-2-12-14(7-10)23(9-20-12)16-19-8-13-15(22-16)24(17(25)21-13)11-3-5-26-6-4-11/h1-2,7-9,11H,3-6H2,(H,21,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311647
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(5-fluorochro...)Show SMILES Fc1cccc2OCCC(c12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15FN6O2/c22-12-4-3-7-17-18(12)16(8-9-30-17)28-19-14(25-21(28)29)10-23-20(26-19)27-11-24-13-5-1-2-6-15(13)27/h1-7,10-11,16H,8-9H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311655
(2-(6-chloro-1H-benzo[d]imidazol-1-yl)-9-(8-fluoroc...)Show SMILES Fc1cccc2[C@@H](CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccc(Cl)cc12 |r| Show InChI InChI=1S/C21H14ClFN6O2/c22-11-4-5-14-17(8-11)28(10-25-14)20-24-9-15-19(27-20)29(21(30)26-15)16-6-7-31-18-12(16)2-1-3-13(18)23/h1-5,8-10,16H,6-7H2,(H,26,30)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311637
(9-(tetrahydro-2H-pyran-4-yl)-2-(6-(trifluoromethyl...)Show SMILES FC(F)(F)c1ccc2ncn(-c3ncc4[nH]c(=O)n(C5CCOCC5)c4n3)c2c1 Show InChI InChI=1S/C18H15F3N6O2/c19-18(20,21)10-1-2-12-14(7-10)26(9-23-12)16-22-8-13-15(25-16)27(17(28)24-13)11-3-5-29-6-4-11/h1-2,7-9,11H,3-6H2,(H,24,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311643
(9-(2,6-difluorobenzyl)-2-(6-fluoro-1H-benzo[d]imid...)Show SMILES Fc1ccc2ncn(-c3ncc4[nH]c(=O)n(Cc5c(F)cccc5F)c4n3)c2c1 Show InChI InChI=1S/C19H11F3N6O/c20-10-4-5-14-16(6-10)28(9-24-14)18-23-7-15-17(26-18)27(19(29)25-15)8-11-12(21)2-1-3-13(11)22/h1-7,9H,8H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311648
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(6-fluorochro...)Show SMILES Fc1ccc2OCCC(c2c1)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15FN6O2/c22-12-5-6-18-13(9-12)16(7-8-30-18)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-3-1-2-4-17(14)27/h1-6,9-11,16H,7-8H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311646
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(chroman-4-yl...)Show SMILES O=c1[nH]c2cnc(nc2n1C1CCOc2ccccc12)-n1cnc2ccccc12 Show InChI InChI=1S/C21H16N6O2/c28-21-24-15-11-22-20(26-12-23-14-6-2-3-7-17(14)26)25-19(15)27(21)16-9-10-29-18-8-4-1-5-13(16)18/h1-8,11-12,16H,9-10H2,(H,24,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311650
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(7-fluorochro...)Show SMILES Fc1ccc2C(CCOc2c1)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15FN6O2/c22-12-5-6-13-16(7-8-30-18(13)9-12)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-3-1-2-4-17(14)27/h1-6,9-11,16H,7-8H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311647
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(5-fluorochro...)Show SMILES Fc1cccc2OCCC(c12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15FN6O2/c22-12-4-3-7-17-18(12)16(8-9-30-17)28-19-14(25-21(28)29)10-23-20(26-19)27-11-24-13-5-1-2-6-15(13)27/h1-7,10-11,16H,8-9H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311641
(9-(2,3-difluorobenzyl)-2-(6-fluoro-1H-benzo[d]imid...)Show SMILES Fc1ccc2ncn(-c3ncc4[nH]c(=O)n(Cc5cccc(F)c5F)c4n3)c2c1 Show InChI InChI=1S/C19H11F3N6O/c20-11-4-5-13-15(6-11)28(9-24-13)18-23-7-14-17(26-18)27(19(29)25-14)8-10-2-1-3-12(21)16(10)22/h1-7,9H,8H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311635
(2-(1H-benzo[d]imidazol-1-yl)-9-(tetrahydro-2H-pyra...)Show InChI InChI=1S/C17H16N6O2/c24-17-20-13-9-18-16(22-10-19-12-3-1-2-4-14(12)22)21-15(13)23(17)11-5-7-25-8-6-11/h1-4,9-11H,5-8H2,(H,20,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311646
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(chroman-4-yl...)Show SMILES O=c1[nH]c2cnc(nc2n1C1CCOc2ccccc12)-n1cnc2ccccc12 Show InChI InChI=1S/C21H16N6O2/c28-21-24-15-11-22-20(26-12-23-14-6-2-3-7-17(14)26)25-19(15)27(21)16-9-10-29-18-8-4-1-5-13(16)18/h1-8,11-12,16H,9-10H2,(H,24,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311652
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-chlorochro...)Show SMILES Clc1cccc2C(CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15ClN6O2/c22-13-5-3-4-12-16(8-9-30-18(12)13)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-6-1-2-7-17(14)27/h1-7,10-11,16H,8-9H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311645
(1-(9-(2,6-dichlorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)Show SMILES Clc1cccc(Cl)c1Cn1c2nc(ncc2[nH]c1=O)-n1cnc2ccc(cc12)C#N Show InChI InChI=1S/C20H11Cl2N7O/c21-13-2-1-3-14(22)12(13)9-28-18-16(26-20(28)30)8-24-19(27-18)29-10-25-15-5-4-11(7-23)6-17(15)29/h1-6,8,10H,9H2,(H,26,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311636
(9-(tetrahydro-2H-pyran-4-yl)-2-(5-(trifluoromethyl...)Show SMILES FC(F)(F)c1ccc2n(cnc2c1)-c1ncc2[nH]c(=O)n(C3CCOCC3)c2n1 Show InChI InChI=1S/C18H15F3N6O2/c19-18(20,21)10-1-2-14-12(7-10)23-9-26(14)16-22-8-13-15(25-16)27(17(28)24-13)11-3-5-29-6-4-11/h1-2,7-9,11H,3-6H2,(H,24,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 245 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311650
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(7-fluorochro...)Show SMILES Fc1ccc2C(CCOc2c1)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15FN6O2/c22-12-5-6-13-16(7-8-30-18(13)9-12)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-3-1-2-4-17(14)27/h1-6,9-11,16H,7-8H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311642
(1-(9-(2,3-difluorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)Show SMILES Fc1cccc(Cn2c3nc(ncc3[nH]c2=O)-n2cnc3ccc(cc23)C#N)c1F Show InChI InChI=1S/C20H11F2N7O/c21-13-3-1-2-12(17(13)22)9-28-18-15(26-20(28)30)8-24-19(27-18)29-10-25-14-5-4-11(7-23)6-16(14)29/h1-6,8,10H,9H2,(H,26,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311651
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochro...)Show SMILES Fc1cccc2C(CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15FN6O2/c22-13-5-3-4-12-16(8-9-30-18(12)13)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-6-1-2-7-17(14)27/h1-7,10-11,16H,8-9H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 285 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311643
(9-(2,6-difluorobenzyl)-2-(6-fluoro-1H-benzo[d]imid...)Show SMILES Fc1ccc2ncn(-c3ncc4[nH]c(=O)n(Cc5c(F)cccc5F)c4n3)c2c1 Show InChI InChI=1S/C19H11F3N6O/c20-10-4-5-14-16(6-10)28(9-24-14)18-23-7-15-17(26-18)27(19(29)25-15)8-11-12(21)2-1-3-13(11)22/h1-7,9H,8H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311653
((R)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochroma...)Show SMILES Fc1cccc2[C@@H](CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 |r| Show InChI InChI=1S/C21H15FN6O2/c22-13-5-3-4-12-16(8-9-30-18(12)13)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-6-1-2-7-17(14)27/h1-7,10-11,16H,8-9H2,(H,25,29)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 333 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311649
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(6-chlorochro...)Show SMILES Clc1ccc2OCCC(c2c1)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15ClN6O2/c22-12-5-6-18-13(9-12)16(7-8-30-18)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-3-1-2-4-17(14)27/h1-6,9-11,16H,7-8H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 365 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311639
(2-(6-chloro-1H-benzo[d]imidazol-1-yl)-9-(tetrahydr...)Show SMILES Clc1ccc2ncn(-c3ncc4[nH]c(=O)n(C5CCOCC5)c4n3)c2c1 Show InChI InChI=1S/C17H15ClN6O2/c18-10-1-2-12-14(7-10)23(9-20-12)16-19-8-13-15(22-16)24(17(25)21-13)11-3-5-26-6-4-11/h1-2,7-9,11H,3-6H2,(H,21,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 393 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311640
(1-(8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-...)Show SMILES O=c1[nH]c2cnc(nc2n1C1CCOCC1)-n1cnc2ccc(cc12)C#N Show InChI InChI=1S/C18H15N7O2/c19-8-11-1-2-13-15(7-11)24(10-21-13)17-20-9-14-16(23-17)25(18(26)22-14)12-3-5-27-6-4-12/h1-2,7,9-10,12H,3-6H2,(H,22,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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| CHEMBL
PC cid
PC sid
UniChem
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Similars
| Article
PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311649
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(6-chlorochro...)Show SMILES Clc1ccc2OCCC(c2c1)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15ClN6O2/c22-12-5-6-18-13(9-12)16(7-8-30-18)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-3-1-2-4-17(14)27/h1-6,9-11,16H,7-8H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50311654
((S)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochroma...)Show SMILES Fc1cccc2[C@H](CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 |r| Show InChI InChI=1S/C21H15FN6O2/c22-13-5-3-4-12-16(8-9-30-18(12)13)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-6-1-2-7-17(14)27/h1-7,10-11,16H,8-9H2,(H,25,29)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 (508-1124) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311637
(9-(tetrahydro-2H-pyran-4-yl)-2-(6-(trifluoromethyl...)Show SMILES FC(F)(F)c1ccc2ncn(-c3ncc4[nH]c(=O)n(C5CCOCC5)c4n3)c2c1 Show InChI InChI=1S/C18H15F3N6O2/c19-18(20,21)10-1-2-12-14(7-10)26(9-23-12)16-22-8-13-15(25-16)27(17(28)24-13)11-3-5-29-6-4-11/h1-2,7-9,11H,3-6H2,(H,24,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311652
((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-chlorochro...)Show SMILES Clc1cccc2C(CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 Show InChI InChI=1S/C21H15ClN6O2/c22-13-5-3-4-12-16(8-9-30-18(12)13)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-6-1-2-7-17(14)27/h1-7,10-11,16H,8-9H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311641
(9-(2,3-difluorobenzyl)-2-(6-fluoro-1H-benzo[d]imid...)Show SMILES Fc1ccc2ncn(-c3ncc4[nH]c(=O)n(Cc5cccc(F)c5F)c4n3)c2c1 Show InChI InChI=1S/C19H11F3N6O/c20-11-4-5-13-15(6-11)28(9-24-13)18-23-7-14-17(26-18)27(19(29)25-14)8-10-2-1-3-12(21)16(10)22/h1-7,9H,8H2,(H,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311645
(1-(9-(2,6-dichlorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)Show SMILES Clc1cccc(Cl)c1Cn1c2nc(ncc2[nH]c1=O)-n1cnc2ccc(cc12)C#N Show InChI InChI=1S/C20H11Cl2N7O/c21-13-2-1-3-14(22)12(13)9-28-18-16(26-20(28)30)8-24-19(27-18)29-10-25-15-5-4-11(7-23)6-17(15)29/h1-6,8,10H,9H2,(H,26,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311636
(9-(tetrahydro-2H-pyran-4-yl)-2-(5-(trifluoromethyl...)Show SMILES FC(F)(F)c1ccc2n(cnc2c1)-c1ncc2[nH]c(=O)n(C3CCOCC3)c2n1 Show InChI InChI=1S/C18H15F3N6O2/c19-18(20,21)10-1-2-14-12(7-10)23-9-26(14)16-22-8-13-15(25-16)27(17(28)24-13)11-3-5-29-6-4-11/h1-2,7-9,11H,3-6H2,(H,24,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311635
(2-(1H-benzo[d]imidazol-1-yl)-9-(tetrahydro-2H-pyra...)Show InChI InChI=1S/C17H16N6O2/c24-17-20-13-9-18-16(22-10-19-12-3-1-2-4-14(12)22)21-15(13)23(17)11-5-7-25-8-6-11/h1-4,9-11H,5-8H2,(H,20,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311638
(2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(tetrahydr...)Show SMILES Fc1ccc2ncn(-c3ncc4[nH]c(=O)n(C5CCOCC5)c4n3)c2c1 Show InChI InChI=1S/C17H15FN6O2/c18-10-1-2-12-14(7-10)23(9-20-12)16-19-8-13-15(22-16)24(17(25)21-13)11-3-5-26-6-4-11/h1-2,7-9,11H,3-6H2,(H,21,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50311654
((S)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochroma...)Show SMILES Fc1cccc2[C@H](CCOc12)n1c2nc(ncc2[nH]c1=O)-n1cnc2ccccc12 |r| Show InChI InChI=1S/C21H15FN6O2/c22-13-5-3-4-12-16(8-9-30-18(12)13)28-19-15(25-21(28)29)10-23-20(26-19)27-11-24-14-6-1-2-7-17(14)27/h1-7,10-11,16H,8-9H2,(H,25,29)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human JAK2 (532-1132) by time resolved fluorescence assay |
Bioorg Med Chem Lett 19: 6788-92 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.080
BindingDB Entry DOI: 10.7270/Q24B31G4 |
More data for this
Ligand-Target Pair | |
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