Affinity Data by PubMed id=16274990

PubMed code 16274990

Found 21 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176475 (((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176486 ((5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176480 ((5,8-dichloro-1-propyl-3,4-dihydro-1H-benzo[4,5]th...) Show SMILES CCCC1(CC(O)=O)OCCc2c1sc1c(Cl)ccc(Cl)c21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176488 (((R)-5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benz...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176479 ((5-bromo-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,...) Show SMILES CCCC1(CC(O)=O)OCCc2c1sc1c(C)ccc(Br)c21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176476 ((5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,...) Show SMILES CCCC1(CC(O)=O)OCCc2c1sc1c(C)ccc(C#N)c21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176483 ((1-butyl-5,8-dichloro-3,4-dihydro-1H-benzo[4,5]thi...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176489 ((5,8-dichloro-1-propyl-3,4-dihydro-1H-benzo[4,5]fu...) Show SMILES CCCC1(CC(O)=O)OCCc2c1oc1c(Cl)ccc(Cl)c21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176481 ((5,8-dichloro-1-ethyl-3,4-dihydro-1H-benzo[4,5]thi...) Show SMILES CCC1(CC(O)=O)OCCc2c1sc1c(Cl)ccc(Cl)c21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176485 (((S)-5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benz...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176482 ((1-butyl-5,8-dichloro-3,4-dihydro-1H-benzo[4,5]fur...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176487 (((S)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176490 ((5,8-dichloro-1-ethyl-3,4-dihydro-1H-benzo[4,5]fur...) Show SMILES CCC1(CC(O)=O)OCCc2c1oc1c(Cl)ccc(Cl)c21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176477 ((5,8-dichloro-1-methyl-3,4-dihydro-1H-benzo[4,5]th...) Show SMILES CC1(CC(O)=O)OCCc2c1sc1c(Cl)ccc(Cl)c21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176484 ((1-propyl-3,4-dihydro-1H-benzo[4,5]furo[2,3-c]pyra...) Show SMILES CCCC1(CC(O)=O)OCCc2c1oc1ccccc21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176478 ((6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4...) Show SMILES CCCC1(CC(O)=O)OCCc2c1sc1c(C)cc(F)cc21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176474 ((5,8-dichloro-1-methyl-3,4-dihydro-1H-benzo[4,5]fu...) Show SMILES CC1(CC(O)=O)OCCc2c1oc1c(Cl)ccc(Cl)c21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176491 ((1-propyl-3,4-dihydro-1H-benzo[4,5]thieno[2,3-c]py...) Show SMILES CCCC1(CC(O)=O)OCCc2c1sc1ccccc21 Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus)	BDBM50176475 (((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>7.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of HCV NS3 helicase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50176475 (((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of HIV reverse transcriptase				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50176475 (((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Reduction of viral RNA and protein in Huh7 cells containing HCV sub-genomic replicon				Bioorg Med Chem Lett 16: 457-60 (2005) Article DOI: 10.1016/j.bmcl.2005.08.114 BindingDB Entry DOI: 10.7270/Q25X28H8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%