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PubMed code 19773173

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33271
PNG
(azo-sulfonamide, 1f)
Show SMILES CN(CS([O-])(=O)=O)c1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O5S2/c1-18(10-24(19,20)21)13-6-2-11(3-7-13)16-17-12-4-8-14(9-5-12)25(15,22)23/h2-9H,10H2,1H3,(H2,15,22,23)(H,19,20,21)/p-1/b17-16+
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3.5n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM10884
PNG
((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Show SMILES CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|
Show InChI InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
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3.5n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33268
PNG
(azo-sulfonamide, 1c)
Show SMILES CNc1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C13H14N4O2S/c1-15-10-2-4-11(5-3-10)16-17-12-6-8-13(9-7-12)20(14,18)19/h2-9,15H,1H3,(H2,14,18,19)/b17-16+
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4.90n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33266
PNG
(CHEMBL379206 | azo-sulfonamide, 1a | p-Phenyldiaze...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N=Nc1ccc(O)cc1 |w:10.10|
Show InChI InChI=1S/C12H11N3O3S/c13-19(17,18)12-7-3-10(4-8-12)15-14-9-1-5-11(16)6-2-9/h1-8,16H,(H2,13,17,18)
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5n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33270
PNG
(azo-sulfonamide, 1e)
Show SMILES NS(=O)(=O)c1ccc(cc1)\N=N\c1ccc(NCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C13H14N4O5S2/c14-24(21,22)13-7-5-12(6-8-13)17-16-11-3-1-10(2-4-11)15-9-23(18,19)20/h1-8,15H,9H2,(H2,14,21,22)(H,18,19,20)/p-1/b17-16+
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5.40n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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5.70n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33273
PNG
(azo-sulfonamide, 2b)
Show SMILES Nc1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C12H12N4O2S/c13-9-4-6-10(7-5-9)15-16-11-2-1-3-12(8-11)19(14,17)18/h1-8H,13H2,(H2,14,17,18)/b16-15+
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5.90n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33267
PNG
(azo-sulfonamide, 1b)
Show SMILES Nc1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H12N4O2S/c13-9-1-3-10(4-2-9)15-16-11-5-7-12(8-6-11)19(14,17)18/h1-8H,13H2,(H2,14,17,18)/b16-15+
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6n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33272
PNG
(azo-sulfonamide, 2a)
Show SMILES NS(=O)(=O)c1cccc(c1)N=Nc1ccc(O)cc1 |w:10.10|
Show InChI InChI=1S/C12H11N3O3S/c13-19(17,18)12-3-1-2-10(8-12)15-14-9-4-6-11(16)7-5-9/h1-8,16H,(H2,13,17,18)
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6.10n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33270
PNG
(azo-sulfonamide, 1e)
Show SMILES NS(=O)(=O)c1ccc(cc1)\N=N\c1ccc(NCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C13H14N4O5S2/c14-24(21,22)13-7-5-12(6-8-13)17-16-11-3-1-10(2-4-11)15-9-23(18,19)20/h1-8,15H,9H2,(H2,14,21,22)(H,18,19,20)/p-1/b17-16+
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6.10n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33271
PNG
(azo-sulfonamide, 1f)
Show SMILES CN(CS([O-])(=O)=O)c1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O5S2/c1-18(10-24(19,20)21)13-6-2-11(3-7-13)16-17-12-4-8-14(9-5-12)25(15,22)23/h2-9H,10H2,1H3,(H2,15,22,23)(H,19,20,21)/p-1/b17-16+
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6.30n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33266
PNG
(CHEMBL379206 | azo-sulfonamide, 1a | p-Phenyldiaze...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N=Nc1ccc(O)cc1 |w:10.10|
Show InChI InChI=1S/C12H11N3O3S/c13-19(17,18)12-7-3-10(4-8-12)15-14-9-1-5-11(16)6-2-9/h1-8,16H,(H2,13,17,18)
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6.40n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33274
PNG
(azo-sulfonamide, 2d)
Show SMILES CN(C)c1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O2S/c1-18(2)13-8-6-11(7-9-13)16-17-12-4-3-5-14(10-12)21(15,19)20/h3-10H,1-2H3,(H2,15,19,20)/b17-16+
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6.40n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33269
PNG
(CHEMBL277836 | azo-sulfonamide, 1d | cid_75522 | p...)
Show SMILES CN(C)c1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O2S/c1-18(2)13-7-3-11(4-8-13)16-17-12-5-9-14(10-6-12)21(15,19)20/h3-10H,1-2H3,(H2,15,19,20)/b17-16+
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6.60n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33275
PNG
(azo-sulfonamide, 2e)
Show SMILES NS(=O)(=O)c1cccc(c1)\N=N\c1ccc(NCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C13H14N4O5S2/c14-24(21,22)13-3-1-2-12(8-13)17-16-11-6-4-10(5-7-11)15-9-23(18,19)20/h1-8,15H,9H2,(H2,14,21,22)(H,18,19,20)/p-1/b17-16+
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7.20n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33267
PNG
(azo-sulfonamide, 1b)
Show SMILES Nc1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H12N4O2S/c13-9-1-3-10(4-2-9)15-16-11-5-7-12(8-6-11)19(14,17)18/h1-8H,13H2,(H2,14,17,18)/b16-15+
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7.30n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33273
PNG
(azo-sulfonamide, 2b)
Show SMILES Nc1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C12H12N4O2S/c13-9-4-6-10(7-5-9)15-16-11-2-1-3-12(8-11)19(14,17)18/h1-8H,13H2,(H2,14,17,18)/b16-15+
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7.30n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33272
PNG
(azo-sulfonamide, 2a)
Show SMILES NS(=O)(=O)c1cccc(c1)N=Nc1ccc(O)cc1 |w:10.10|
Show InChI InChI=1S/C12H11N3O3S/c13-19(17,18)12-3-1-2-10(8-12)15-14-9-4-6-11(16)7-5-9/h1-8,16H,(H2,13,17,18)
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7.30n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33276
PNG
(azo-sulfonamide, 2f)
Show SMILES CN(CS([O-])(=O)=O)c1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O5S2/c1-18(10-24(19,20)21)13-7-5-11(6-8-13)16-17-12-3-2-4-14(9-12)25(15,22)23/h2-9H,10H2,1H3,(H2,15,22,23)(H,19,20,21)/p-1/b17-16+
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7.40n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33269
PNG
(CHEMBL277836 | azo-sulfonamide, 1d | cid_75522 | p...)
Show SMILES CN(C)c1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O2S/c1-18(2)13-7-3-11(4-8-13)16-17-12-5-9-14(10-6-12)21(15,19)20/h3-10H,1-2H3,(H2,15,19,20)/b17-16+
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7.90n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33274
PNG
(azo-sulfonamide, 2d)
Show SMILES CN(C)c1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O2S/c1-18(2)13-8-6-11(7-9-13)16-17-12-4-3-5-14(10-12)21(15,19)20/h3-10H,1-2H3,(H2,15,19,20)/b17-16+
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7.90n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM10884
PNG
((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Show SMILES CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|
Show InChI InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
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9 -45.9n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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12 -45.2n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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25n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM10884
PNG
((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Show SMILES CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|
Show InChI InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
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52n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33275
PNG
(azo-sulfonamide, 2e)
Show SMILES NS(=O)(=O)c1cccc(c1)\N=N\c1ccc(NCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C13H14N4O5S2/c14-24(21,22)13-3-1-2-12(8-13)17-16-11-6-4-10(5-7-11)15-9-23(18,19)20/h1-8,15H,9H2,(H2,14,21,22)(H,18,19,20)/p-1/b17-16+
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57n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33276
PNG
(azo-sulfonamide, 2f)
Show SMILES CN(CS([O-])(=O)=O)c1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O5S2/c1-18(10-24(19,20)21)13-7-5-11(6-8-13)16-17-12-3-2-4-14(9-12)25(15,22)23/h2-9H,10H2,1H3,(H2,15,22,23)(H,19,20,21)/p-1/b17-16+
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63n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33268
PNG
(azo-sulfonamide, 1c)
Show SMILES CNc1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C13H14N4O2S/c1-15-10-2-4-11(5-3-10)16-17-12-6-8-13(9-7-12)20(14,18)19/h2-9,15H,1H3,(H2,14,18,19)/b17-16+
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69.4n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33273
PNG
(azo-sulfonamide, 2b)
Show SMILES Nc1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C12H12N4O2S/c13-9-4-6-10(7-5-9)15-16-11-2-1-3-12(8-11)19(14,17)18/h1-8H,13H2,(H2,14,17,18)/b16-15+
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88 -40.3n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33268
PNG
(azo-sulfonamide, 1c)
Show SMILES CNc1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C13H14N4O2S/c1-15-10-2-4-11(5-3-10)16-17-12-6-8-13(9-7-12)20(14,18)19/h2-9,15H,1H3,(H2,14,18,19)/b17-16+
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93 -40.1n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33272
PNG
(azo-sulfonamide, 2a)
Show SMILES NS(=O)(=O)c1cccc(c1)N=Nc1ccc(O)cc1 |w:10.10|
Show InChI InChI=1S/C12H11N3O3S/c13-19(17,18)12-3-1-2-10(8-12)15-14-9-4-6-11(16)7-5-9/h1-8,16H,(H2,13,17,18)
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95 -40.1n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33267
PNG
(azo-sulfonamide, 1b)
Show SMILES Nc1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H12N4O2S/c13-9-1-3-10(4-2-9)15-16-11-5-7-12(8-6-11)19(14,17)18/h1-8H,13H2,(H2,14,17,18)/b16-15+
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95 -40.1n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33273
PNG
(azo-sulfonamide, 2b)
Show SMILES Nc1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C12H12N4O2S/c13-9-4-6-10(7-5-9)15-16-11-2-1-3-12(8-11)19(14,17)18/h1-8H,13H2,(H2,14,17,18)/b16-15+
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96 -40.1n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33271
PNG
(azo-sulfonamide, 1f)
Show SMILES CN(CS([O-])(=O)=O)c1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O5S2/c1-18(10-24(19,20)21)13-6-2-11(3-7-13)16-17-12-4-8-14(9-5-12)25(15,22)23/h2-9H,10H2,1H3,(H2,15,22,23)(H,19,20,21)/p-1/b17-16+
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96 -40.1n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33271
PNG
(azo-sulfonamide, 1f)
Show SMILES CN(CS([O-])(=O)=O)c1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O5S2/c1-18(10-24(19,20)21)13-6-2-11(3-7-13)16-17-12-4-8-14(9-5-12)25(15,22)23/h2-9H,10H2,1H3,(H2,15,22,23)(H,19,20,21)/p-1/b17-16+
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104 -39.9n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33274
PNG
(azo-sulfonamide, 2d)
Show SMILES CN(C)c1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O2S/c1-18(2)13-8-6-11(7-9-13)16-17-12-4-3-5-14(10-12)21(15,19)20/h3-10H,1-2H3,(H2,15,19,20)/b17-16+
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105 -39.8n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33270
PNG
(azo-sulfonamide, 1e)
Show SMILES NS(=O)(=O)c1ccc(cc1)\N=N\c1ccc(NCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C13H14N4O5S2/c14-24(21,22)13-7-5-12(6-8-13)17-16-11-3-1-10(2-4-11)15-9-23(18,19)20/h1-8,15H,9H2,(H2,14,21,22)(H,18,19,20)/p-1/b17-16+
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105 -39.8n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33267
PNG
(azo-sulfonamide, 1b)
Show SMILES Nc1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H12N4O2S/c13-9-1-3-10(4-2-9)15-16-11-5-7-12(8-6-11)19(14,17)18/h1-8H,13H2,(H2,14,17,18)/b16-15+
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106 -39.8n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33272
PNG
(azo-sulfonamide, 2a)
Show SMILES NS(=O)(=O)c1cccc(c1)N=Nc1ccc(O)cc1 |w:10.10|
Show InChI InChI=1S/C12H11N3O3S/c13-19(17,18)12-3-1-2-10(8-12)15-14-9-4-6-11(16)7-5-9/h1-8,16H,(H2,13,17,18)
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106 -39.8n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33270
PNG
(azo-sulfonamide, 1e)
Show SMILES NS(=O)(=O)c1ccc(cc1)\N=N\c1ccc(NCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C13H14N4O5S2/c14-24(21,22)13-7-5-12(6-8-13)17-16-11-3-1-10(2-4-11)15-9-23(18,19)20/h1-8,15H,9H2,(H2,14,21,22)(H,18,19,20)/p-1/b17-16+
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106 -39.8n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33275
PNG
(azo-sulfonamide, 2e)
Show SMILES NS(=O)(=O)c1cccc(c1)\N=N\c1ccc(NCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C13H14N4O5S2/c14-24(21,22)13-3-1-2-12(8-13)17-16-11-6-4-10(5-7-11)15-9-23(18,19)20/h1-8,15H,9H2,(H2,14,21,22)(H,18,19,20)/p-1/b17-16+
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107 -39.8n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33276
PNG
(azo-sulfonamide, 2f)
Show SMILES CN(CS([O-])(=O)=O)c1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O5S2/c1-18(10-24(19,20)21)13-7-5-11(6-8-13)16-17-12-3-2-4-14(9-12)25(15,22)23/h2-9H,10H2,1H3,(H2,15,22,23)(H,19,20,21)/p-1/b17-16+
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109 -39.7n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33274
PNG
(azo-sulfonamide, 2d)
Show SMILES CN(C)c1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O2S/c1-18(2)13-8-6-11(7-9-13)16-17-12-4-3-5-14(10-12)21(15,19)20/h3-10H,1-2H3,(H2,15,19,20)/b17-16+
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113 -39.7n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33268
PNG
(azo-sulfonamide, 1c)
Show SMILES CNc1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C13H14N4O2S/c1-15-10-2-4-11(5-3-10)16-17-12-6-8-13(9-7-12)20(14,18)19/h2-9,15H,1H3,(H2,14,18,19)/b17-16+
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170 -38.6n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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250 -37.7n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33266
PNG
(CHEMBL379206 | azo-sulfonamide, 1a | p-Phenyldiaze...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N=Nc1ccc(O)cc1 |w:10.10|
Show InChI InChI=1S/C12H11N3O3S/c13-19(17,18)12-7-3-10(4-8-12)15-14-9-1-5-11(16)6-2-9/h1-8,16H,(H2,13,17,18)
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393 -36.6n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33269
PNG
(CHEMBL277836 | azo-sulfonamide, 1d | cid_75522 | p...)
Show SMILES CN(C)c1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O2S/c1-18(2)13-7-3-11(4-8-13)16-17-12-5-9-14(10-6-12)21(15,19)20/h3-10H,1-2H3,(H2,15,19,20)/b17-16+
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621 -35.4n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33269
PNG
(CHEMBL277836 | azo-sulfonamide, 1d | cid_75522 | p...)
Show SMILES CN(C)c1ccc(cc1)\N=N\c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O2S/c1-18(2)13-7-3-11(4-8-13)16-17-12-5-9-14(10-6-12)21(15,19)20/h3-10H,1-2H3,(H2,15,19,20)/b17-16+
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638 -35.4n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33266
PNG
(CHEMBL379206 | azo-sulfonamide, 1a | p-Phenyldiaze...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N=Nc1ccc(O)cc1 |w:10.10|
Show InChI InChI=1S/C12H11N3O3S/c13-19(17,18)12-7-3-10(4-8-12)15-14-9-1-5-11(16)6-2-9/h1-8,16H,(H2,13,17,18)
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665 -35.3n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33276
PNG
(azo-sulfonamide, 2f)
Show SMILES CN(CS([O-])(=O)=O)c1ccc(cc1)\N=N\c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C14H16N4O5S2/c1-18(10-24(19,20)21)13-7-5-11(6-8-13)16-17-12-3-2-4-14(9-12)25(15,22)23/h2-9H,10H2,1H3,(H2,15,22,23)(H,19,20,21)/p-1/b17-16+
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2.44E+3 -32.0n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33277
PNG
(sulfonate, 3)
Show SMILES [O-]S(=O)(=O)CNc1ccccc1
Show InChI InChI=1S/C7H9NO3S/c9-12(10,11)6-8-7-4-2-1-3-5-7/h1-5,8H,6H2,(H,9,10,11)/p-1
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5.10E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM33278
PNG
(sulfonate, 4)
Show SMILES CN(CS([O-])(=O)=O)c1ccccc1
Show InChI InChI=1S/C8H11NO3S/c1-9(7-13(10,11)12)8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,10,11,12)/p-1
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5.85E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33278
PNG
(sulfonate, 4)
Show SMILES CN(CS([O-])(=O)=O)c1ccccc1
Show InChI InChI=1S/C8H11NO3S/c1-9(7-13(10,11)12)8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,10,11,12)/p-1
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5.93E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM33277
PNG
(sulfonate, 3)
Show SMILES [O-]S(=O)(=O)CNc1ccccc1
Show InChI InChI=1S/C7H9NO3S/c9-12(10,11)6-8-7-4-2-1-3-5-7/h1-5,8H,6H2,(H,9,10,11)/p-1
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6.25E+3n/an/an/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33277
PNG
(sulfonate, 3)
Show SMILES [O-]S(=O)(=O)CNc1ccccc1
Show InChI InChI=1S/C7H9NO3S/c9-12(10,11)6-8-7-4-2-1-3-5-7/h1-5,8H,6H2,(H,9,10,11)/p-1
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2.52E+4 -26.2n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33275
PNG
(azo-sulfonamide, 2e)
Show SMILES NS(=O)(=O)c1cccc(c1)\N=N\c1ccc(NCS([O-])(=O)=O)cc1
Show InChI InChI=1S/C13H14N4O5S2/c14-24(21,22)13-3-1-2-12(8-13)17-16-11-6-4-10(5-7-11)15-9-23(18,19)20/h1-8,15H,9H2,(H2,14,21,22)(H,18,19,20)/p-1/b17-16+
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3.45E+4 -25.5n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM10884
PNG
((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Show SMILES CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|
Show InChI InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
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5.00E+4 -24.5n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM33278
PNG
(sulfonate, 4)
Show SMILES CN(CS([O-])(=O)=O)c1ccccc1
Show InChI InChI=1S/C8H11NO3S/c1-9(7-13(10,11)12)8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,10,11,12)/p-1
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5.60E+4 -24.3n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33277
PNG
(sulfonate, 3)
Show SMILES [O-]S(=O)(=O)CNc1ccccc1
Show InChI InChI=1S/C7H9NO3S/c9-12(10,11)6-8-7-4-2-1-3-5-7/h1-5,8H,6H2,(H,9,10,11)/p-1
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5.83E+4 -24.2n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM33278
PNG
(sulfonate, 4)
Show SMILES CN(CS([O-])(=O)=O)c1ccccc1
Show InChI InChI=1S/C8H11NO3S/c1-9(7-13(10,11)12)8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,10,11,12)/p-1
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6.36E+4 -24.0n/an/an/an/an/a7.425



Universita degli Studi di Firenze



Assay Description
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...


Bioorg Med Chem 17: 7093-9 (2009)


Article DOI: 10.1016/j.bmc.2009.09.003
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%