The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 8230117 |
4 |
The crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)- 4-methoxyphenyl)-pyrrolidin-2-one. |
Smithkline Beecham Pharmaceuticals |
| 1479586 |
8 |
New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones. |
Kyowa Hakko Kogyo |
| 1656043 |
4 |
New 5H-pyridazino[4,5-b]indole derivatives. Synthesis and studies as inhibitors of blood platelet aggregation and inotropics. |
Universidad De Navarra |
| 2153209 |
6 |
Synthesis and cardiotonic activity of novel biimidazoles. |
Merrell Dow Research Institute |
| 2738882 |
9 |
Synthesis of a tritium-labeled indolidan analogue and its use as a radioligand for phosphodiesterase-inhibitor cardiotonic binding sites. |
Eli Lilly |
| 2846840 |
20 |
Inhibitors of cyclic AMP phosphodiesterase. 4. Synthesis and evaluation of potential prodrugs of lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide, RS-82856). |
Syntex Research |
| 3039132 |
26 |
Cardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents. |
TBA |
| 3965705 |
10 |
2-(beta-Arylethylamino)- and 4-(beta-arylethylamino)quinazolines as phosphodiesterase inhibitors. |
TBA |
| 14980691 |
15 |
Orally active PDE4 inhibitors with therapeutic potential. |
Minase Research Institute |
| 14684291 |
14 |
New orally active PDE4 inhibitors with therapeutic potential. |
Minase Research Institute |
| 14684329 |
27 |
Highly potent PDE4 inhibitors with therapeutic potential. |
Minase Research Institute |
| 12668000 |
29 |
3D-QSAR studies on thieno[3,2-d]pyrimidines as phosphodiesterase IV inhibitors. |
National Institute Of Pharmaceutical Education And Research (Niper) |
| 12852946 |
69 |
Comparative molecular field analysis (CoMFA) of phthalazine derivatives as phosphodiesterase IV inhibitors. |
National Institute Of Pharmaceutical Education And Research |
| 12824031 |
26 |
Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors. |
Tanabe Seiyaku |
| 11814830 |
26 |
7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma. |
Celltech R&D |
| 12039576 |
17 |
Synthesis and profile of SCH351591, a novel PDE4 inhibitor. |
Schering-Plough |
| 12039575 |
18 |
8-Methoxyquinolines as PDE4 inhibitors. |
Schering-Plough |
| 12039574 |
16 |
8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma. |
Celltech R&D |
| 11738561 |
34 |
Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor. |
Zambon Group |
| 11140727 |
31 |
Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives. |
Zambon Group |
| 11128646 |
69 |
Synthesis and biological evaluation of 2,5-dihydropyrazol. |
RhôNe-Poulenc Rorer |
| 11012037 |
25 |
The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I. |
Zambon Group |
| 10999488 |
34 |
7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma. |
Celltech-Chiroscience |
| 10636238 |
71 |
Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors. |
Institut De Recherche Jouveinal-Parke Davis |
| 9871607 |
32 |
Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds. |
RhôNe-Poulenc Rorer |
| 9871693 |
46 |
Quaternary substituted PDE IV inhibitors II: the synthesis and in vitro evaluation of a novel series of gamma-lactams. |
Rh£Ne-Poulenc Rorer Central Research |
| 9873675 |
44 |
Orally active indole N-oxide PDE4 inhibitors. |
Rh£Ne-Poulenc Rorer Central Research |
| 9873649 |
25 |
PDE4 inhibitors: new xanthine analogues. |
Chiroscience |
| 9871649 |
26 |
Quaternary substituted PDE4 inhibitors I: the synthesis and in vitro evaluation of a novel series of oxindoles. |
Rh£Ne-Poulenc Rorer Central Research |
| 9873600 |
14 |
Thalidomide analogs and PDE4 inhibition. |
Celgene |
| 9873613 |
15 |
2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors. |
Rh£Ne-Poulenc Rorer |
| 9873593 |
15 |
Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma. |
Chiroscience |
| 9873449 |
49 |
The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I. |
Rh£Ne-Poulenc Rorer Central Research |
| 27597413 |
58 |
Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings. |
Southern Medical University |
| 26789933 |
100 |
Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. |
Intra-Cellular Therapies |
| 26681511 |
33 |
Preparation and optimization of pyrazolo[1,5-a]pyrimidines as new potent PDE4 inhibitors. |
Sanofi Research Center |
| 26562545 |
13 |
Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridinyl- and 1-pyridinyl-substituted imidazo[1,5-a]quinoxalines. |
Institute Of Radiopharmaceutical Cancer Research |
| 26526739 |
35 |
Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships. |
Southern Medical University |
| 26430878 |
102 |
Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate. |
Washington University |
| 26288683 |
43 |
Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms. |
Bristol-Myers Squibb R & D |
| 26288344 |
15 |
Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD). |
Novartis Institutes For Biomedical Research |
| 25592707 |
31 |
Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors. |
Washington University |
| 26005524 |
147 |
Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes. |
Merck Research Laboratories |
| 25801159 |
36 |
Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5. |
Csir-Indian Institute Of Integrative Medicine |
| 25736998 |
37 |
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors. |
Merck Serono |
| 24785301 |
83 |
Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. |
Astrazeneca |
| 9873708 |
16 |
N-arylrolipram derivatives as potent and selective PDE4 inhibitors. |
Novartis Horsham Research Center |
| 23421315 |
18 |
Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model. |
University Health Network |
| 23260348 |
91 |
Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors. |
Janssen-Cilag |
| 22963052 |
38 |
Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1. |
Vu University Amsterdam |
| 22891752 |
18 |
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors. |
Universidade Federal Do Rio De Janeiro |
| 22889281 |
36 |
Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate. |
Novartis Institutes For Biomedical Research |
| 21456625 |
41 |
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). |
University Of Glasgow |
| 18686943 |
28 |
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. |
Matrix Laboratories |
| 17228876 |
36 |
SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase. |
Pfizer |
| 16168647 |
80 |
Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor. |
Merck Frosst Centre For Therapeutic Research |
| 15887951 |
29 |
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. |
Monash University (Parkville Campus) |
| 11405657 |
123 |
Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives. |
Tanabe Seiyaku |
| 10691693 |
64 |
Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors. |
Novartis Pharma |
| 10090791 |
77 |
Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives. |
Tanabe Seiyaku |
| 8388468 |
37 |
Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. |
Smithkline Beecham Pharmaceuticals |
| 12824030 |
67 |
1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors. |
Tanabe Seiyaku |
| 12270195 |
15 |
Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters. |
Merck Frosst Centre For Therapeutic Research |
| 11755362 |
24 |
Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: a potent and selective phosphodiesterase type 4D inhibitor. |
Novartis Pharma |
| 12031319 |
46 |
Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor. |
Merck Frosst Centre For Therapeutic Research |
| 21988093 |
316 |
Highly potent, selective, and orally active phosphodiesterase 10A inhibitors. |
Pfizer |
| 21955943 |
47 |
Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region. |
Pfizer |
| 21983442 |
142 |
Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors. |
Biocrea |
| 21871695 |
46 |
Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors. |
RhôNe-Poulenc Rorer |
| 20933411 |
69 |
Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment. |
Merck Frosst Centre For Therapeutic Research |
| 20825218 |
69 |
Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors. |
RhôNe-Poulenc Rorer |
| 20709547 |
69 |
The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors. |
Merck Frosst Centre For Therapeutic Research |
| 20450197 |
80 |
Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. |
Biotie Therapies |
| 20196613 |
32 |
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5). |
Pfizer |
| 19631533 |
126 |
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one. |
Pfizer |
| | 5 |
The Gif system as a tool in medicinal chemistry: The oxidation of Sch 57726 under GoAggIII conditions |
TBA |
| 19339180 |
69 |
The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents. |
Pfizer |
| 18945617 |
50 |
Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. |
Pfizer |
| 18835163 |
41 |
Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor. |
Merck Frosst Center For Therapeutic Research |
| 16516471 |
114 |
Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors. |
Merck Frosst Center For Therapeutic Research |
| 16275071 |
26 |
A new chemical tool for exploring the physiological function of the PDE2 isozyme. |
Pfizer |
| 16263279 |
37 |
A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function. |
Pfizer |
| 15149695 |
24 |
New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors. |
Pfizer |
| 14521415 |
44 |
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. |
Glaxosmithkline |
| 12773045 |
27 |
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity. |
Merck Frosst Centre For Therapeutic Research |
| 12749899 |
17 |
Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors. |
Merck Frosst Centre For Therapeutic Research |
| 12639571 |
24 |
Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors. |
Merck Frosst Centre For Therapeutic Research |
| 12031318 |
45 |
CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors. |
Celltech R&D |
| 11958981 |
25 |
Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors. |
Bayer |
| 11052785 |
14 |
Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ). |
Merck Frosst Centre For Therapeutic Research |
| 10937713 |
186 |
Solid-phase synthesis of an arylsulfone hydroxamate library. |
Rhone-Poulenc Rorer |
| 10197972 |
133 |
1-Arylnaphthalene lignan: a novel scaffold for type 5 phosphodiesterase inhibitor. |
Tanabe Seiyaku |
| 10091677 |
15 |
Substituted furans as inhibitors of the PDE4 enzyme. |
Merck Frosst Centre For Therapeutic Research |
| 9873643 |
75 |
Quinazolines: combined type 3 and 4 phosphodiesterase inhibitors. |
Novartis Pharma |
| 9873594 |
44 |
Aryl sulfonamides as selective PDE4 inhibitors. |
Chiroscience |
| 9464356 |
24 |
Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4. |
Pfizer |
| 8496906 |
127 |
Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position. |
Hokuriku University |
| 2544722 |
94 |
Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues. |
Centre De Neurochimie Du Cnrs |
| 1331453 |
106 |
Effects of alkyl substitutions of xanthine skeleton on bronchodilation. |
Hokuriku University |
| 9349523 |
22 |
Cloning and expression of a human serotonin 5-HT4 receptor cDNA. |
Janssen Research Foundation |
| 9305929 |
19 |
Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover. |
Synaptic Pharmaceutical |
| 9303569 |
35 |
Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist. |
RhôNe-Poulenc Rorer |
| 17643112 |
12 |
Splicing factor SF3b as a target of the antitumor natural product pladienolide. |
Eisai |
| 18790640 |
22 |
Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. |
Abbott Laboratories |
| 17629487 |
20 |
Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists. |
Seoul National University |
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