The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27353888 |
30 |
Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-ß-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease. |
University of Delhi |
| 27190601 |
71 |
Structure-Activity Relationship Studies of Isomeric 2,4-Diaminoquinazolines onß-Amyloid Aggregation Kinetics. |
University of Waterloo |
| 27061983 |
48 |
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease. |
Guangzhou Medical University |
| 26945113 |
9 |
Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry. |
University of Waterloo |
| 26783181 |
24 |
Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's. |
Linyi People'S Hospital |
| 26632651 |
70 |
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography. |
China Pharmaceutical University |
| 26719209 |
7 |
Structural insights into mechanisms for inhibiting amyloidß42 aggregation by non-catechol-type flavonoids. |
Kyoto University |
| 26598460 |
14 |
Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid. |
Dalhousie University |
| 26288690 |
1 |
Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects. |
Virginia Commonwealth University |
| 26177091 |
138 |
Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands fora-Synuclein Fibrils. |
Washington University |
| 26099993 |
5 |
3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease. |
Sun Yat-Sen University |
| 26078011 |
7 |
NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease. |
Universit£ |
| 25978520 |
9 |
Nodulisporiviridins A-H, Bioactive Viridins from Nodulisporium sp. |
Jinan University |
| 24878198 |
4 |
Naturally occurring polyphenolic inhibitors of amyloid beta aggregation. |
Csiro Manufacturing Flagship (Biomedical) |
| 24944730 |
20 |
Imidazo[2,1]thiazol-3-one Derivatives Useful as Diagnostic Agents for Alzheimer's Disease. |
Temple University |
| 24131448 |
7 |
Oxidative stress in Alzheimer's disease: are we connecting the dots? |
University of Bologna |
| 24657049 |
5 |
Polyfluorinated bis-styrylbenzenes as amyloid-ß plaque binding ligands. |
Leiden University |
| 18954037 |
40 |
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer. |
University of Bologna |
| 18793854 |
25 |
Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation. |
Institute of Science and Technology |
| 17004725 |
13 |
Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. |
Sungkyunkwan University School of Medicine |
| 16162001 |
12 |
F-18 stilbenes as PET imaging agents for detecting beta-amyloid plaques in the brain. |
University of Pennsylvania |
| 21145738 |
5 |
Diphenylpropynone derivatives as probes for imagingß-amyloid plaques in Alzheimer's brains. |
Kyoto University |
| 20223661 |
48 |
Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors. |
Wyeth |
| 19959359 |
46 |
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors. |
Wyeth Research |
| 19275964 |
64 |
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor. |
Pfizer |
| 17761417 |
50 |
Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors. |
Schering-Plough Research Institute |
| 17418571 |
23 |
Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors. |
Pharmacopeia Drug Discovery |
| 16640346 |
24 |
Synthesis of biphenyltrienes as probes for beta-amyloid plaques. |
University of Pennsylvania |
| 16640332 |
8 |
Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains. |
Nagasaki University |
| 16574411 |
4 |
Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease. |
Emory University |
| 16473009 |
23 |
Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 16325402 |
15 |
Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. |
University of Pennsylvania |
| 16279784 |
12 |
Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. |
Nagasaki University |
| 16134939 |
67 |
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. |
Chiesi Farmaceutici |
| 15780628 |
15 |
Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors. |
Wyeth Research |
| 12801237 |
19 |
Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. |
University of Pittsburgh |
| 12519062 |
11 |
Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain. |
University of Pennsylvania |
| 11428920 |
6 |
Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain. |
University of Pennsylvania |
| 11384236 |
26 |
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. |
University of Pennsylvania |
| 31791817 |
12 |
Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their A?-aggregation inhibitory activity. |
Meiji Pharmaceutical University |
| 10882355 |
5 |
Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease. |
Amgen |
| 31437780 |
73 |
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease. |
Indian Institute of Technology (Banaras Hindu University) |
| 31563012 |
4 |
Ellagic acid a multi-target bioactive compound for drug discovery in CNS? A narrative review. |
University of Genoa |
| 31055149 |
22 |
A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer's disease. |
Jamia Millia Islamia (Central University) |
| 31176571 |
24 |
Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents. |
Jamia Millia Islamia (Central University) |
| 31138471 |
29 |
Naturally occurring biflavonoids with amyloid ? aggregation inhibitory activity for development of anti-Alzheimer agents. |
Meiji Pharmaceutical University |
| 30884327 |
18 |
Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease. |
Jining Medical University |
| 30470598 |
75 |
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. |
Sichuan University |
| 31352246 |
67 |
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships. |
Wuhan Institute of Technology |
| 31404860 |
5 |
Development of novel theranostic agents for in vivo amyloid imaging and protective effects on human neuroblastoma cells. |
Guangdong University of Technology |
| 30995567 |
5 |
Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review. |
Wuhan University of Technology |
| 30744931 |
170 |
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
Csir-Central Drug Research Institute |
| 31082225 |
26 |
Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms. |
China Pharmaceutical University |
| 30655952 |
89 |
Discovery of TD-0212, an Orally Active Dual Pharmacology AT |
Theravance Biopharma Us |
| 28128562 |
11 |
Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. |
University of Barcelona |
| 28216401 |
13 |
Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of ?-amyloid-42 aggregation for the treatment of Alzheimer's disease. |
Ac Immune |
| 28061347 |
12 |
Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, A? |
Zhejiang Chinese Medical University |
| 27256911 |
8 |
Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of ?-amyloid-42 aggregation. |
Ac Immune |
| 26435514 |
11 |
Preliminary evaluation of fluoro-pegylated benzyloxybenzenes for quantification of ?-amyloid plaques by positron emission tomography. |
Beijing Normal University |
| 26517152 |
28 |
Spiroindole Alkaloids and Spiroditerpenoids from Aspergillus duricaulis and Their Potential Neuroprotective Effects. |
Korea University |
| 25769517 |
2 |
?-sheet interfering molecules acting against ?-amyloid aggregation and fibrillogenesis. |
Sapienza University of Rome |
| 24936678 |
49 |
Radioiodinated benzyloxybenzene derivatives: a class of flexible ligands target to ?-amyloid plaques in Alzheimer's brains. |
Beijing Normal University |
| 24583352 |
13 |
Homoisoflavonoids as potential imaging agents for ?-amyloid plaques in Alzheimer's disease. |
Hefei University of Technology |
| 24393583 |
2 |
Danshen diversity defeating dementia. |
Rmit University |
| 24140444 |
30 |
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease. |
Alma Mater Studiorum University of Bologna |
| 23786711 |
27 |
Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase. |
Sun Yat-Sen University |
| 24900717 |
14 |
Structure-Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of ?-Amyloid Plaques. |
Kyoto University |
| 23673220 |
10 |
Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for ?-amyloid plaques. |
Beijing Normal University |
| 23601707 |
1 |
Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment. |
Korea Institute of Science and Technology |
| 23540646 |
14 |
Design, synthesis and biological activity of multifunctional ?,?-unsaturated carbonyl scaffolds for Alzheimer's disease. |
University of Massachusetts Boston |
| 23403086 |
3 |
Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-? aggregation inhibitors. |
Winthrop University |
| 23344363 |
9 |
Synthesis and biological evaluation of radioiodinated quinacrine-based derivatives for SPECT imaging of A? plaques. |
Nagasaki University |
| 24900338 |
19 |
Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as ?-Amyloid PET Ligands and Identification of MK-3328. |
Merck Research Laboratories |
| 23009151 |
4 |
Discovery of novel inhibitors of amyloid ?-peptide 1-42 aggregation. |
Universidad De Zaragoza |
| 22236086 |
3 |
Synthesis and evaluation of ¹?F-labeled styryltriazole and resveratrol derivatives for ?-amyloid plaque imaging. |
Sungkyunkwan University School of Medicine |
| 22921742 |
11 |
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid ?-protein. |
University of Tsukuba |
| 22420626 |
4 |
Design of ?-amyloid aggregation inhibitors from a predicted structural motif. |
Stanford University |
| 24936237 |
4 |
The ?-Amyloid Hypothesis in Alzheimer's Disease: Seeing Is Believing. |
University of Pennsylvania |
| 22831802 |
9 |
Small molecules that protect against ?-amyloid-induced cytotoxicity by inhibiting aggregation of ?-amyloid. |
Korea Institute of Science and Technology |
| 22647721 |
19 |
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as ¹?F-PET imaging agents for ?-amyloid plaques. |
Astrazeneca |
| 22011144 |
13 |
Multidentate (18)F-polypegylated styrylpyridines as imaging agents for A? plaques in cerebral amyloid angiopathy (CAA). |
University of Pennsylvania |
| 24900362 |
5 |
A Novel (18)F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of ?-Amyloid Plaques. |
Technische Universit£T M£Nchen |
| 22078413 |
8 |
Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes. |
Instituto Tecnol£Gico E Nuclear |
| 21478020 |
7 |
Aromatic radiofluorination and biological evaluation of 2-aryl-6-[18F]fluorobenzothiazoles as a potential positron emission tomography imaging probe for ?-amyloid plaques. |
Seoul National University Bundang Hospital |
| 21275403 |
4 |
Synthesis and evaluation of 11C-labeled imidazo[2,1-b]benzothiazoles (IBTs) as PET tracers for imaging ?-amyloid plaques in Alzheimer's disease. |
Technische Universit£T M£Nchen |
| 20153963 |
20 |
Synthesis and evaluation of 2-pyridylbenzothiazole, 2-pyridylbenzoxazole and 2-pyridylbenzofuran derivatives as 11C-PET imaging agents for beta-amyloid plaques. |
Astrazeneca |
| 20036557 |
13 |
Novel anilinophthalimide derivatives as potential probes for beta-amyloid plaque in the brain. |
Beijing Normal University |
| 19845387 |
29 |
18F stilbenes and styrylpyridines for PET imaging of A beta plaques in Alzheimer's disease: a miniperspective. |
University of Pennsylvania |
| 19877643 |
5 |
Synthesis and evaluation of three 18F-labeled aminophenylbenzothiazoles as amyloid imaging agents. |
Katholieke Universiteit Leuven |
| 18992967 |
4 |
11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid beta in Alzheimer's disease. |
K.U. Leuven |
| 19147351 |
2 |
Synthesis of 18F-labelled 2-(4'-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C]PIB. |
K.U.Leuven |
| 19216563 |
6 |
Synthesis and evaluation of 18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in Alzheimer's disease. |
Katholieke Universiteit Leuven |
| 18707879 |
2 |
Synthesis and evaluation of indolinyl- and indolylphenylacetylenes as PET imaging agents for beta-amyloid plaques. |
University of Pennsylvania |
| 18078311 |
6 |
Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease. |
National Institute of Mental Health |
| 17270435 |
35 |
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation. |
Korea Institute of Science and Technology |
| 17502139 |
8 |
Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for beta-amyloid plaque detection. |
University of Pennsylvania |
| 17722900 |
28 |
Synthesis and structure-affinity relationships of new 4-(6-iodo-H-imidazo[1,2-a]pyridin-2-yl)-N-dimethylbenzeneamine derivatives as ligands for human beta-amyloid plaques. |
National Institute of Mental Health |
| 17293116 |
10 |
Dibenzothiazoles as novel amyloid-imaging agents. |
Case Western Reserve University |
| 17447752 |
18 |
New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques. |
University of Pennsylvania |
| 17411026 |
12 |
Novel styrylpyridines as probes for SPECT imaging of amyloid plaques. |
University of Pennsylvania |
| 30227353 |
4 |
Rationally designed divalent caffeic amides inhibit amyloid-? fibrillization, induce fibril dissociation, and ameliorate cytotoxicity. |
Academia Sinica |
| 30360953 |
8 |
Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease. |
Zhejiang University |
| 30107970 |
2 |
Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. |
Sun Yat-Sen University |
| 29605809 |
19 |
Success stories of natural product-based hybrid molecules for multi-factorial diseases. |
Punjabi University |
| 29729985 |
13 |
Novel 8-hydroxyquinoline derivatives targeting ?-amyloid aggregation, metal chelation and oxidative stress against Alzheimer's disease. |
Pharmaceutical University |
| 29559198 |
54 |
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism. |
University of Lille |
| 29407994 |
4 |
Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects. |
Julius-Maximilians-Universit£T W£Rzburg |
| 29635167 |
4 |
Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation. |
Shenyang Pharmaceutical University |
| 28478343 |
55 |
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents. |
Jamia Millia Islamia (Central University) |
| 28810189 |
11 |
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease. |
Alma Mater Studiorum-University of Bologna |
| 28759879 |
25 |
Structure-activity relations of rosmarinic acid derivatives for the amyloid ? aggregation inhibition and antioxidant properties. |
Muroran Institute of Technology |
| 28759875 |
30 |
An overview of benzo[b]thiophene-based medicinal chemistry. |
Jain University |
| 29798827 |
5 |
Isoxazole-tethered diarylheptanoid analogs: Discovery of a new drug-like PAR2 antagonist. |
Advinus Therapeutics |
| 29706525 |
13 |
Structure-activity relationship of clovamide and its related compounds for the inhibition of amyloid? aggregation. |
University of Tsukuba |
| 28169518 |
6 |
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1. |
University of Cambridge |
| 18072721 |
28 |
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. |
Pfizer |
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