217 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
1732545	27	Phenyl-substituted analogues of oxotremorine as muscarinic antagonists.	University of Uppsala
1995893	81	Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships.	Ferrosan
2299626	18	Beta-lactam analogues of oxotremorine. 3- and 4-methyl-substituted 2-azetidinones.	University of Uppsala
2258904	21	Resolved pyrrolidine, piperidine, and perhydroazepine analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.	Uppsala University
3346873	24	Derivatives of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.	University of Uppsala
3336015	8	Dimethylsulfonium and thiolanium analogues of the muscarinic agent oxotremorine.	University of California
3494849	3	6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent.	TBA
12113806	40	Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists.	Ghent University
11354386	90	Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands.	University of Mainz
27876250	60	Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH	Jagiellonian University Medical College
27939174	84	Challenges in the development of an M	Vanderbilt University Medical Center
27839919	192	Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.	University of Kansas
27185330	60	Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.	Vanderbilt University Medical Center
26988801	55	Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.	Jagiellonian University Medical College
26428869	7	Discovery of dihydroquinazolinone derivatives as potent, selective, and CNS-penetrant M(1) and M(4) muscarinic acetylcholine receptors agonists.	Sumitomo Dainippon Pharma
26471092	23	Molecular hybridization yields triazole bronchodilators for the treatment of COPD.	Pfizer
26299349	66	Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists.	Eli Lilly
25893046	77	Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5.	Bristol-Myers Squibb
24980056	44	Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.	Universit£
24856064	9	Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M1 and M4 muscarinic acetylcholine receptors selective agonists.	Dainippon Sumitomo Pharma
25275964	171	Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1).	Universit£
25147929	105	Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).	Vanderbilt University Medical Center
24852118	7	Discovery of N-sulfonyl-7-azaindoline derivatives as potent, orally available and selective M(4) muscarinic acetylcholine receptor agonists.	Dainippon Sumitomo Pharma
24805037	380	Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia.	Adamed
24690494	92	Antagonists of the kappa opioid receptor.	The Scripps Research Institute
18077164	40	Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide.	Universit£
24900656	9	Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists.	Dainippon Sumitomo Pharma
23379472	187	Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.	University of Arkansas For Medical Sciences
23200253	67	Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism.	Vanderbilt University Medical Center
23177787	59	Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.	Vanderbilt University Medical Center
13678406	7	Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders.	The University of Toledo
22738637	19	Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor.	Vanderbilt University Medical Center
21036043	78	The discovery of new spirocyclic muscarinic M3 antagonists.	Astrazeneca
20709550	80	The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists.	Glaxosmithkline
20483611	89	2' biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR.	Glaxosmithkline
20483599	81	2' biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling.	Glaxosmithkline
19896386	85	Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.	Universit£
19928767	88	Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure.	Universita Di Firenze
18543900	105	Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists.	Universit£
18595721	32	Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics.	Alma Mater Studiorum-University of Bologna
18455407	125	Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives.	Universit£
	20	Design, synthesis and biological activity of some 4-DAMP- related compounds	TBA
23084435	17	Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors.	Savannah State University
22959245	175	As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).	The University of Sydney
23062550	59	Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists.	Vanderbilt University Medical Center
22335555	43	1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.	Neuraxon
24900202	38	Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists.	TBA
22677319	64	Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.	H. Lundbeck
22749871	92	Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012.	Vanderbilt University Medical Center
22243489	75	1,4-dioxane, a suitable scaffold for the development of novel M3 muscarinic receptor antagonists.	Universit£
22607684	50	7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands.	The University of Sydney
22313227	78	Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.	National Institute of Mental Health
22507963	73	Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.	Vanderbilt University Medical Center
22148921	48	Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c	Cephalon
21207959	69	Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.	National Institute of Mental Health
20684563	176	Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.	H. Lundbeck
19963380	38	Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.	Hunter College and The Graduate Center of The City University of New York
18468904	48	High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand.	Purdue University
18395442	5	Diphenidol-related diamines as novel muscarinic M4 receptor antagonists.	University of Bologna
18042383	20	Design and synthesis of a fluorescent muscarinic antagonist.	Pfizer
17483457	58	A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.	Abbott Laboratories
17889543	90	Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.	Universit£
16198561	99	Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.	Novartis Institutes For Biomedical Research
14998318	112	Selective optimization of side activities: another way for drug discovery.	Prestwick Chemical
11831911	15	Cyclohexylmethylpiperidinyltriphenylpropioamide: a selective muscarinic M(3) antagonist discriminating against the other receptor subtypes.	Banyu Tsukuba Research Institute
9986705	290	Identification and characterization of m1 selective muscarinic receptor antagonists1.	Warner-Lambert
9622546	109	6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.	National Institute of Diabetes and Digestive and Kidney Diseases
1956033	121	Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.	Research Triangle Institute
2153827	12	Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides.	Niddk
15203136	39	(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.	Virginia Commonwealth University
9873472	102	Identification and characterization of m4 selective muscarinic antagonists.	Parke-Davis Pharmaceutical Research
	24	1,1-diphenyl-3-dialkylamino-1-silacyclopentane derivatives: A new class of potent and selective 5-HT2A antagonists	TBA
22226656	75	Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test.	Cephalon
22197142	42	Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012.	Vanderbilt University Medical Center
22030026	13	Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.	Vanderbilt University Medical Center
21930376	92	Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.	Vanderbilt University Medical Center
21870878	61	Inhalation by design: novel tertiary amine muscarinic M3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.	Pfizer
21788137	33	N-Arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (s) receptor ligands.	The University of Sydney
21865048	29	2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A.	Dainippon Sumitomo Pharma
21194936	39	Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe.	Vanderbilt Institute of Chemical Biology/Chemical Synthesis Core
21195614	56	Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.	Pfizer
21146989	46	Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.	The University of Sydney
20812727	157	Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.	National Institute of Mental Health
20801651	25	Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.	Vanderbilt University Medical Center
20202841	47	Synthesis and SAR of N-(4-(4-alklylpiperazin-1-yl)phenyl)benzamides as muscarinic acetylcholine receptor subtype 1 (M1) anatgonists.	Vanderbilt University Medical Center
20043678	92	Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.	Pfizer
19646882	72	Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.	University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj
19616432	176	Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.	Pfizer
7673927	6	Isolation and Structure of Two Novel Muscarinic Receptor Antagonists	TBA
	32	The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053)	TBA
	44	5-O-Carboxymethyl piperazide derivatives of serotonin: a new class of potent and selective 5-HT1D receptor agonists	TBA
	37	The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists.	TBA
	31	3-Lithioquinuclidin-2-ene: A novel intermediate for the synthesis of muscarinic agonists and antagonists	TBA
	74	New indole derivatives as potent and selective serotonin uptake inhibitors	TBA
19208472	52	Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.	Novartis Institutes For Biomedical Research
18829311	74	Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen.	Vanderbilt University Medical Center
18805692	99	Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties.	Vanderbilt University Medical Center
18701276	97	Highly functionalized 7-azaindoles as selective PPAR gamma modulators.	Merck Research Laboratories
16038549	20	Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674.	Mitsubishi Pharma
15844951	5	Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata.	Mitsubishi Pharma
17571866	49	Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.	National Institute of Mental Health
17317171	91	M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds.	University of Strathclyde
16970392	91	Identification of a novel 4-aminomethylpiperidine class of M3 muscarinic receptor antagonists and structural insight into their M3 selectivity.	Tsukuba Research Institute
16722655	28	Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.	Pfizer
16722631	87	An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.	Predix Pharmaceuticals
16458504	37	Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.	Columbia University College of Physicians and Surgeons
16392798	46	Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.	Columbia University College of Physicians and Surgeons
16143528	213	Synthesis of potent and selective serotonin 5-HT1B receptor ligands.	Columbia University College of Physicians and Surgeons
14643338	124	Binding of beta-carbolines at 5-HT(2) serotonin receptors.	Virginia Commonwealth University
12747793	32	C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists.	University of North Carolina At Chapel Hill
12361399	17	Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding.	Universita Di Camerino
11741475	56	Design, synthesis, and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as selective muscarinic agonists.	The University of Toledo
11708906	15	Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.	University of Bologna
11378358	254	Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.	Columbia University College of Physicians and Surgeons
32374602	190	Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus.	Universit£
32227883	40	Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge	University of Mississippi
31787491	54	Discovery of structurally distinct tricyclic M	Vanderbilt University
31784320	31	Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M	Vanderbilt University
32233403	135	Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M	University of Regensburg
11012031	57	Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency.	Schering-Plough Research Institute
27476142	104	Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.	Vanderbilt University School of Medicine
27503678	32	Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes.	Vanderbilt University
10891110	87	6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.	National Institute of Diabetes and Digestive and Kidney Diseases
32342685	325	Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D	National Institute of Neurological Disorders and Stroke
10498210	27	A new class of selective and potent inhibitors of neuronal nitric oxide synthase.	Pfizer
31074983	202	Conjugation of Short Peptides to Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Determines M	University of Regensburg
31021617	136	Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D	University of Pennsylvania
31248774	45	SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M	Vanderbilt University
30580918	36	Novel M	Vanderbilt University
30554957	105	Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low subtype selectivity for human M	University of Kentucky
31913038	13	Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity.	University of Florida
9651157	52	Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.	Warner-Lambert
9438027	30	Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.	Novo Nordisk
9435896	36	Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere.	Smithkline Beecham Pharmaceuticals
30106578	10	Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.	TBA
31620230	283	3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT	University of Minnesota Twin Cities
31223452	49	Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres.	Pfizer
24074052	24	Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor.	Monash University
23523385	73	Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods.	Walter Reed Army Institute of Research
7783150	33	Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors.	Royal Danish School of Pharmacy
21075638	105	Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists.	Drug Discovery Laboratory
32353859	59	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	Qbi Covid-19 Research Group (Qcrg)
17880057	131	Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.	Solvay Pharma
17084634	24	Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists.	Universit£
16539379	95	Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.	Universit£
16153841	24	Activity and QSAR study of baogongteng A and its derivatives as muscarinic agonists.	Shanghai Second Medical University
12593665	188	Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.	Johannes Gutenberg-University of Mainz
12086495	130	Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.	Pfizer
9371246	159	Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships.	Uppsala University
8765510	100	3-(2-Benzofuranyl)quinuclidin-2-ene derivatives: novel muscarinic antagonists.	Uppsala University
3712371	49	A novel class of conformationally restricted heterocyclic muscarinic agonists.	TBA
30258541	94	VU6007477, a Novel M	Vanderbilt Univercity
30128067	12	Allosteric Modulators of the M4 Muscarinic Acetylcholine Receptor.	Usona Institute
29089231	49	Challenges in the development of an M	Vanderbilt University School of Medicine
30052039	172	Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties.	Emory University
29656199	148	Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties.	University of Texas At Austin
29795757	100	Discovery of	Emory University
29348805	56	Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists.	Emory University
28609709	75	Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments.	Universit£
28633897	73	Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists.	Vanderbilt University School of Medicine
28388054	72	Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M	University of Regensburg
29589445	154	1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D	Universit£
28866269	61	Discovery of a novel, CNS penetrant M	Vanderbilt University
1674541	24	Conformational properties of semirigid antipsychotic drugs: the pharmacophore for dopamine D-2 antagonist activity.	Harvard Medical School
28522253	83	Challenges in the development of an M	Vanderbilt University School of Medicine
1560441	35	Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues).	Institute of Research
28442253	68	Optimization of M	Vanderbilt University Medical Center
28598634	26	Design and Synthesis of?- and?-Lactam M	Pfizer
28427812	74	Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.	Vanderbilt University School of Medicine
26833890	18	Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.	Yogi Vemana University
23548908	1	Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis.	University of Washington
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