112 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28182408	126	Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.	Universit£
27989417	34	1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability.	University of M£Nster
27309570	102	Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.	Alma Mater Studiorum-University of Bologna
27189675	38	The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors.	Janssen Pharmaceutical Companies of Johnson & Johnson
27117424	7	Design, synthesis and biological evaluation of potent FAAH inhibitors.	Univ. Lille
26888301	34	Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.	University of Siena
26774927	120	Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.	Fondazione Istituto Italiano Di Tecnologia
26850005	89	Arylboronic acids as dual-action FAAH and TRPV1 ligands.	Sapienza University of Rome
25701254	48	Novel tail and head group prostamide probes.	Northeastern University
25065940	77	Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.	Universit£
25037918	33	Discovery libraries targeting the major enzyme classes: the serine hydrolases.	The Scripps Research Institute
24944750	24	Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.	Merck Research Laboratories
24690529	43	a-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.	The Scripps Research Institute
24456116	105	Design, synthesis, and characterization ofa-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase.	The Scripps Research Institute
24513048	88	1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.	Janssen Pharmaceutical Companies of Johnson & Johnson
24440478	22	Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.	Takeda Pharmaceutical
24433863	76	Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase.	Janssen Research and Development
24083878	61	Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.	University of Eastern Finland
23822179	17	Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.	Fondazione Istituto Italiano Di Tecnologia
23712084	2	Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase.	Centre For Addiction and Mental Health
24900701	36	Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.	Merck Research Laboratories
23474898	161	Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.	Sapienza University of Rome
23455058	84	(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).	University of M£Nster
23218778	49	Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.	Takeda Pharmaceutical
23214511	4	Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.	Centre For Addiction and Mental Health
23206861	113	Tetrahydro-ß-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.	Sapienza University of Rome
21820769	20	Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability.	Universit£
19719235	19	Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain.	Ghent University
23141911	60	Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.	Janssen Research and Development
23043222	125	Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.	Istituto Italiano Di Tecnologia
22738638	59	Assay and inhibition of diacylglycerol lipase activity.	Northeastern University
24900385	51	Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.	TBA
24900454	43	The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?	TBA
22185522	159	Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.	Universidad Complutense De Madrid
21666860	14	Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.	Pfizer
18983142	135	Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.	Johnson & Johnson Pharmaceutical Research and Development
18630870	236	Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.	Institute For Chemical Biology
18424134	114	New tetrazole-based selective anandamide uptake inhibitors.	Sapienza University of Rome
18053726	364	Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.	Johnson & Johnson Pharmaceutical Research & Development
18247553	174	Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.	The Scripps Research Institute
17561406	67	Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors.	Universit£
16279794	46	Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors.	Universit£
16213718	93	New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies.	Institute of Biomolecular Chemistry
16078824	48	The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.	Universit£
12672252	104	Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.	Universidad Complutense
22209458	114	Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.	Vernalis (R&D)
22196515	14	Design, synthesis and evaluation of polar head group containing 2-keto-oxazole inhibitors of FAAH.	Max Planck Institute of Molecular Physiology
21764305	79	The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).	The Scripps Research Institute
21428410	78	Reversible competitivea-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.	The Scripps Research Institute
21392988	87	Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.	Amgen
19875281	73	Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.	Sapienza University of Rome
19850474	5	Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.	Renovis
20005725	61	1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase.	University of M£Nster
20143779	28	Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors.	University of Cagliari
19924997	2	X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.	The Scripps Research Institute
19539407	18	Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.	Helsinki University of Technology
19515560	24	Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.	Vernalis (R&D)
19232787	71	The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.	University of Kuopio
19054678	12	Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH.	Ghent University
18831576	66	Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism.	Sapienza University of Rome
18693015	85	Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.	Johnson & Johnson Pharmaceutical Research and Development
18639454	55	Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.	The Scripps Research Institute
18507372	31	Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.	Università
17452063	30	Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.	Sapienza University of Rome
17764163	61	Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase.	Universidad Complutense
17665899	16	Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors.	Helsinki University of Technology
16854070	12	Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system.	University of Kuopio
16570928	16	Development of the first potential covalent inhibitors of anandamide cellular uptake.	Institute of Biomolecular Chemistry
15771430	129	Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.	The Scripps Research Institute
15582420	37	Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase.	The Scripps Research Institute
15456244	25	Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies.	Università
12951114	18	Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.	University of California
12781177	7	Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues.	Umr Cnrs 5074
12773040	41	Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.	Università
11412972	13	alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution.	The Scripps Research Institute
32429662	39	Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors.	China Pharmaceutical University
30816712	78	Plant-Based Modulators of Endocannabinoid Signaling.	Concordia University Wisconsin
30446439	64	Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment.	Mak Scientific
30340141	64	Tetrazolylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability.	University of M£Nster
10021942	46	Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition.	Scripps Research Institute
30503633	73	Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.	Advinus Therapeutics
31629610	96	Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology.	Northeastern University
31714779	37	Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines.	Universit£
31407888	4	New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation.	Universit£
30126274	44	Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit.	Universit£
29366648	98	Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.	University of California Davis
27766867	109	Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.	Universit£
28535469	69	Novel propanamides as fatty acid amide hydrolase inhibitors.	University of Cagliari
23839942	19	Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs.	Université Montpellier 1
7590751	11	The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.	Addiction Research Foundation
3010074	129	Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.	Warner-Lambert/Parke-Davis Pharmaceutical Research
19374401	103	Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.	Kalypsys
8765511	14	Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation.	University of Illinois At Chicago