The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 8101878 |
61 |
Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. |
National Defense Medical Center |
| 1495016 |
3 |
2-Substituted 1-azabicycloalkanes, a new class of non-opiate antinociceptive agents. |
R. W. Johnson Pharmaceutical Research Institute |
| 1671705 |
126 |
Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1 ,6] naphthyridines at alpha-adrenoceptors. |
Syntex Research |
| 2153822 |
77 |
1,9-Alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines with affinity for the alpha 2-adrenoceptor and the 5-HT1A receptor. |
Syntex Research |
| 2153820 |
86 |
Affinity of 2-(tetrahydroisoquinolin-2-ylmethyl)- and 2-(isoindolin-2-ylmethyl)imidazolines for alpha-adrenoceptors. Differential affinity of imidazolines for the [3H]idazoxan-labeled alpha 2-adrenoceptor vs the [3H]yohimbine-labeled site. |
Syntex Research |
| 2570150 |
10 |
(8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro- 3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridi ne, a potent and highly selective alpha 2-adrenoceptor antagonist. |
Syntex Research |
| 2567783 |
1 |
Heteroaromatic analogues of the alpha 2-adrenoreceptor partial agonist clonidine. |
Reckitt & Colman |
| 2542561 |
48 |
New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties. |
Institut De Pharmacologie (Ua 589 Cnrs) |
| 2900899 |
4 |
Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity. |
University of Camerino |
| 2896247 |
14 |
Indoline analogues of idazoxan: potent alpha 2-antagonists and alpha 1-agonists. |
Reckitt and Colman |
| 2896246 |
5 |
1,3-Diamino-6,7-dimethoxyisoquinoline derivatives as potential alpha 1-adrenoceptor antagonists. |
Pfizer |
| 2896245 |
19 |
2,4-Diamino-6,7-dimethoxyquinoline derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents. |
Pfizer |
| 2894465 |
18 |
2,4-Diamino-6,7-dimethoxyquinazolines. 4. 2-[4-(substituted oxyethoxy) piperidino] derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents. |
Pfizer |
| 2887657 |
52 |
Alpha 2-adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines. |
TBA |
| 3039138 |
23 |
Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives. |
TBA |
| 2884316 |
34 |
2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents. |
TBA |
| 2884313 |
10 |
Conformationally defined adrenergic agents. 5. Resolution, absolute configuration, and pharmacological characterization of the enantiomers of 2-(5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthyl)imidazoline: a potent agonist at alpha-adrenoceptors. |
TBA |
| 2888896 |
20 |
2,4-Diamino-6,7-dimethoxyquinazolines. 3. 2-(4-Heterocyclylpiperazin-1-yl) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents. |
Pfizer |
| 2879919 |
21 |
2,4-diamino-6,7-dimethoxyquinazolines. 1. 2-[4-(1,4-benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents. |
TBA |
| 3016265 |
94 |
4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors. |
TBA |
| 2879913 |
5 |
Two stereoisomeric imidazoline derivatives: synthesis and optical and alpha 2-adrenoceptor activities. |
TBA |
| 2870187 |
20 |
Conformationally defined adrenergic agents. 2. Catechol imidazoline derivatives: biological effects at alpha 1 and alpha 2 adrenergic receptors. |
TBA |
| 2876101 |
18 |
Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists. |
TBA |
| 2863377 |
10 |
6,7-Dihydro-5-[[(cis-2-hydroxy-trans-3-phenoxycyclopentyl)amino] methyl]-2-methylbenzo[b]thiophen-4(5H)-one: a novel alpha 1-adrenergic receptor antagonist and renal vasodilator. |
TBA |
| 3973904 |
30 |
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine. |
TBA |
| 2999398 |
2 |
Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors. |
TBA |
| 4045929 |
30 |
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide. |
TBA |
| 2864446 |
66 |
Conformationally defined adrenergic agents. 1. Design and synthesis of novel alpha 2 selective adrenergic agents: electrostatic repulsion based conformational prototypes. |
TBA |
| 6094811 |
56 |
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists. |
TBA |
| 6133954 |
6 |
Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones. |
TBA |
| 6124637 |
18 |
Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols. |
TBA |
| 6296387 |
15 |
alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. |
TBA |
| 6123600 |
10 |
1-(alkylamino)isochromans: hypotensives with peripheral and central activities. |
TBA |
| 7328588 |
9 |
Synthesis and adrenoceptor affinity of some highly polar beta-substituted catecholamines. |
TBA |
| 6248642 |
38 |
Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines. |
TBA |
| 12482437 |
42 |
Discovery of a series of (4,5-dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists. |
Pfizer |
| 11814815 |
13 |
alpha(1)-Adrenoceptor antagonists. Rational design, synthesis and biological evaluation of new trazodone-like compounds. |
Universit£ |
| 10091706 |
176 |
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT. |
University of Kansas |
| 3373482 |
50 |
Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor. |
Merrell Dow Research Institute |
| 9871765 |
14 |
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist. |
University of Bologna |
| 11300868 |
37 |
Alpha(2) adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes. |
The R. W. Johnson Pharmaceutical Research Institute |
| 8254623 |
54 |
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 8246241 |
34 |
18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. |
University of Pennsylvania |
| 8230093 |
34 |
Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives. |
Universit£ |
| 1573641 |
60 |
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype. |
Searle Research and Development |
| 1313109 |
40 |
Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors. |
Universit£ |
| 1361578 |
99 |
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. |
Bristol-Myers Squibb |
| 1995885 |
15 |
Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds. |
Dainippon Pharmaceutical |
| 1671416 |
15 |
Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones. |
Warner-Lambert |
| 2542551 |
89 |
The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity. |
Bristol-Myers |
| 3039136 |
328 |
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships. |
TBA |
| 2869146 |
72 |
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents. |
TBA |
| 6142954 |
70 |
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. |
TBA |
| 6139481 |
32 |
alpha-Adrenergic activities of some substituted 2-(aminomethyl)imidazolines. |
TBA |
| 14695828 |
107 |
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents. |
Universit£ |
| | 48 |
Novel pyridazino[4,5-b][1,5]oxazepines and -thiazepines as 5-HT1A receptor ligands |
TBA |
| 15013010 |
9 |
Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. |
Virginia Commonwealth University |
| 15013009 |
28 |
Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. |
Virginia Commonwealth University |
| 14698196 |
8 |
Binding of an imidazopyridoindole at imidazoline I2 receptors. |
Virginia Commonwealth University |
| 12951084 |
8 |
1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists. |
F. Hoffmann-La Roche |
| 12482441 |
45 |
Development of a presynaptic 5-HT1A antagonist. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 12482417 |
23 |
alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus. |
Università |
| 11294383 |
16 |
Cis- and trans-N-benzyl-octahydrobenzo[g]quinolines. Adrenergic and dopaminergic activity studies. |
University of Crete |
| 10753480 |
27 |
Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor. |
The R. W. Johnson Pharmaceutical Research Institute |
| 10743949 |
76 |
(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents. |
Università |
| 10741563 |
4 |
Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand. |
University of Bristol |
| 10360740 |
35 |
N-substituted-3-arylpyrrolidines: potent and selective ligands at serotonin 1A receptor. |
Postech |
| 9871719 |
144 |
Serotonergic ergoline derivatives. |
Pharmacia & Upjohn |
| 8558529 |
195 |
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease. |
Hoechst-Roussel Pharmaceuticals |
| 8496920 |
14 |
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. |
Wyeth Research (Uk) |
| 8411007 |
392 |
Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. |
Mayo Foundation |
| 8410999 |
81 |
3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. |
Eli Lilly |
| 25282262 |
39 |
Fluorinated analogues of marsanidine, a highly ?2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities. |
Medical University of Gdansk |
| 42798 |
4 |
Ultraviolet photoelectron spectroscopy of cyclic amidines. 1. Electronic structure of some alpha-adrenergic benzylimidazolines. |
TBA |
| 231654 |
16 |
Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines. |
TBA |
| 17749 |
5 |
Absolute configuration of glycerol derivatives. 4. Synthesis and pharmacological activity of chiral 2-alkylaminomethylbenzodioxans, competitive alpha-adrenergic antagonists. |
TBA |
| 23792350 |
53 |
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
Universidade Federal Do Rio De Janeiro |
| 23245804 |
17 |
Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone. |
Jagiellonian University Medical College |
| 20801048 |
11 |
Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI. |
Universit£ |
| 19647907 |
16 |
Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2. |
Rzesz£W University of Technology |
| 17880057 |
131 |
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs. |
Solvay Pharma |
| 12747788 |
41 |
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. |
Universit£ |
| 11754577 |
26 |
Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole. |
Universit£ |
| 11262089 |
213 |
Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties. |
Institut De Recherches Servier |
| 6192241 |
15 |
Synthesis and biological properties of thiophene ring analogues of mianserin. |
TBA |
| 11405649 |
118 |
Synthesis, biological evaluation, and pharmacophore generation of new pyridazinone derivatives with affinity toward alpha(1)- and alpha(2)-adrenoceptors. |
Universit£ |
| 10602691 |
35 |
Alpha(2) adrenoceptor agonists as potential analgesic agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles. |
The R. W. Johnson Pharmaceutical Research Institute |
| 10514291 |
51 |
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors. |
University of Bologna |
| 10425105 |
51 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes. |
University of Camerino |
| 10425083 |
22 |
2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors. |
Universit£ |
| 9301663 |
28 |
Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with alpha 2-adrenoceptors involving a "methyl pocket". |
University of Tennessee |
| 9240350 |
9 |
A novel series of 2,5-substituted tryptamine derivatives as vascular 5HT1B/1D receptor antagonists. |
Monash University |
| 8917649 |
60 |
Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
University of Camerino |
| 8709134 |
26 |
Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine. |
Ohio State University |
| 30383372 |
190 |
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics. |
Huazhong University of Science and Technology |
| 3746815 |
15 |
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin. |
TBA |
| 29730027 |
99 |
Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system. |
Jagiellonian University Medical College |
| 2999400 |
12 |
N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist. |
TBA |
| 2892936 |
21 |
Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
Warner-Lambert |
| 2875184 |
57 |
(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents. |
TBA |
| 28943244 |
136 |
New 5-HT |
Dipartimento Di Farmacia Universit£ |
| 29425815 |
76 |
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT |
Jagiellonian University Medical College |
| 29631962 |
252 |
Identification and biological evaluation of thiazole-based inverse agonists of ROR?t. |
Phenex Pharmaceuticals |
| 1827843 |
27 |
Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors. |
University of California |
| 1652023 |
179 |
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
Abbott Laboratories |
| 27049670 |
47 |
Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. |
Max Planck Institute of Molecular Physiology |
| 26943478 |
16 |
Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives. |
Chulabhorn Research Institute |
| 26218629 |
26 |
Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). |
Oregon Health & Science University |
| 26364932 |
22 |
Structure and Inhibition of Microbiome ß-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. |
University of North Carolina At Chapel Hill |
| 25590533 |
245 |
Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. |
University of North Carolina At Chapel Hill |
| 25864869 |
10 |
Direct Staudinger-Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De-N-acetylases. |
University of Toronto |
| 10747922 |
12 |
Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase. A calorimetric study. |
Swiss Federal Institute of Technology |
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