Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM350085![]() (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | 0.148 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt... | US Patent US10822331 (2020) BindingDB Entry DOI: 10.7270/Q2V98C59 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM350085![]() (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | 0.148 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Incorporated US Patent | Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt... | US Patent US10208027 (2019) BindingDB Entry DOI: 10.7270/Q27S7QX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM350085![]() (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Incorporated US Patent | Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt... | US Patent US10208027 (2019) BindingDB Entry DOI: 10.7270/Q27S7QX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM350085![]() (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt... | US Patent US10822331 (2020) BindingDB Entry DOI: 10.7270/Q2V98C59 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM350085![]() (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt... | US Patent US10822331 (2020) BindingDB Entry DOI: 10.7270/Q2V98C59 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM350085![]() (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VERTEX PHARMACEUTICALS INCORPORATED US Patent | Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt... | US Patent US10822331 (2020) BindingDB Entry DOI: 10.7270/Q2V98C59 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM350085![]() (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Incorporated US Patent | Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt... | US Patent US10208027 (2019) BindingDB Entry DOI: 10.7270/Q27S7QX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM350085![]() (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Incorporated US Patent | Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt... | US Patent US10208027 (2019) BindingDB Entry DOI: 10.7270/Q27S7QX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthase (Trypanosoma cruzi) | BDBM50052351![]() (3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi squalene synthase | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50173799![]() ((3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50180152![]() ((9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisph...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50173799![]() ((3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50180152![]() ((9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisph...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50173799![]() ((3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50180152![]() ((9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisph...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50180152![]() ((9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisph...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50180152![]() ((9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisph...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50173799![]() ((3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50180152![]() ((9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisph...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50098386![]() ((1-hydroxy-1-phosphono-2-pyridin-4-yl-ethyl)-phosp...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50173799![]() ((3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50098386![]() ((1-hydroxy-1-phosphono-2-pyridin-4-yl-ethyl)-phosp...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50098386![]() ((1-hydroxy-1-phosphono-2-pyridin-4-yl-ethyl)-phosp...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50098386![]() ((1-hydroxy-1-phosphono-2-pyridin-4-yl-ethyl)-phosp...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50180152![]() ((9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisph...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2 | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50098386![]() ((1-hydroxy-1-phosphono-2-pyridin-4-yl-ethyl)-phosp...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2 | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50098386![]() ((1-hydroxy-1-phosphono-2-pyridin-4-yl-ethyl)-phosp...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50173799![]() ((3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2 | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50098386![]() ((1-hydroxy-1-phosphono-2-pyridin-4-yl-ethyl)-phosp...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of ATP, 2 mM D-glucose and 3 mM MgCl2 by competitive inhibition assay | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50098386![]() ((1-hydroxy-1-phosphono-2-pyridin-4-yl-ethyl)-phosp...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2 | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthase (Homo sapiens (Human)) | BDBM50208574![]() ((R)-3-((2-benzyl-6-((3R,4S)-3-hydroxy-4-methoxypyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto de Parasitolog£a y Biomedicina"L£pez-Neyra Curated by ChEMBL | Assay Description Inhibition of human recombinant squalene synthase | Antimicrob Agents Chemother 51: 2123-9 (2007) Article DOI: 10.1128/AAC.01454-06 BindingDB Entry DOI: 10.7270/Q2BC40DD | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Squalene synthase (Homo sapiens (Human)) | BDBM50208577![]() ((R)-3-((2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto de Parasitolog£a y Biomedicina"L£pez-Neyra Curated by ChEMBL | Assay Description Inhibition of human recombinant squalene synthase | Antimicrob Agents Chemother 51: 2123-9 (2007) Article DOI: 10.1128/AAC.01454-06 BindingDB Entry DOI: 10.7270/Q2BC40DD | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Squalene synthase (Leishmania major) | BDBM50208574![]() ((R)-3-((2-benzyl-6-((3R,4S)-3-hydroxy-4-methoxypyr...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthase (Leishmania major) | BDBM50052351![]() (3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthase (Leishmania major) | BDBM50208577![]() ((R)-3-((2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl)...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthase (Leishmania major) | BDBM50270321![]() (3-[1'-{4'-(Benzyloxy)-phenyl}]-quinuclidine-2-ene ...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyprenyl synthetase family protein (Plasmodium falciparum (isolate 3D7)) | BDBM50098390![]() ((3-methylpyridin-2-ylamino)methylenediphosphonic a...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign Curated by ChEMBL | Assay Description Inhibitory activity against FPPS in Leishmania major | J Med Chem 49: 215-23 (2006) Article DOI: 10.1021/jm0582625 BindingDB Entry DOI: 10.7270/Q2BV7G6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyprenyl synthetase family protein (Plasmodium falciparum (isolate 3D7)) | BDBM12576![]() (Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign Curated by ChEMBL | Assay Description Inhibitory activity against FPPS in Leishmania major | J Med Chem 49: 215-23 (2006) Article DOI: 10.1021/jm0582625 BindingDB Entry DOI: 10.7270/Q2BV7G6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthase (Leishmania major) | BDBM50208573![]() (3-[1'-{4'-(Ethoxycarbonyl)-phenyl}]-quinuclidine-2...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyprenyl synthetase family protein (Plasmodium falciparum (isolate 3D7)) | BDBM50180147![]() ((cycloheptylamino-hydroxy-phosphono-methyl)-phosph...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 228 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign Curated by ChEMBL | Assay Description Inhibitory activity against FPPS in Leishmania major | J Med Chem 49: 215-23 (2006) Article DOI: 10.1021/jm0582625 BindingDB Entry DOI: 10.7270/Q2BV7G6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthase (Homo sapiens (Human)) | BDBM50375842![]() (CHEMBL261776) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto de Parasitolog£a y Biomedicina"L£pez-Neyra Curated by ChEMBL | Assay Description Inhibition of human recombinant squalene synthase | Antimicrob Agents Chemother 51: 2123-9 (2007) Article DOI: 10.1128/AAC.01454-06 BindingDB Entry DOI: 10.7270/Q2BC40DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthase (Homo sapiens (Human)) | BDBM50270321![]() (3-[1'-{4'-(Benzyloxy)-phenyl}]-quinuclidine-2-ene ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21(DE3 pLysS) by liquid scintillation counter | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyprenyl synthetase family protein (Plasmodium falciparum (isolate 3D7)) | BDBM50138041![]() (1-hydroxy-3-(methyl(2-phenoxyethyl)amino)propane-1...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign Curated by ChEMBL | Assay Description Inhibitory activity against FPPS in Leishmania major | J Med Chem 49: 215-23 (2006) Article DOI: 10.1021/jm0582625 BindingDB Entry DOI: 10.7270/Q2BV7G6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthase (Leishmania major) | BDBM50270302![]() (3-[7'-(Methoxy)-napht-2'-yl]-quinuclidine-2-ene | ...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthase (Homo sapiens (Human)) | BDBM50269921![]() (3-[1'-{2'-(4''-Ethyl ethanoatephenyl)-ethynyl]-3-q...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21(DE3 pLysS) by liquid scintillation counter | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50180152![]() ((9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisph...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign Curated by ChEMBL | Assay Description Inhibitory activity against Trypanosoma cruzi hexokinase | J Med Chem 49: 215-23 (2006) Article DOI: 10.1021/jm0582625 BindingDB Entry DOI: 10.7270/Q2BV7G6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50173787![]() ((3-(hydroxymethyl)phenylamino)methylenediphosphoni...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50173794![]() ((3',4'-difluorobiphenyl-3-ylamino)methylenediphosp...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50138040![]() ((biphenyl-3-ylamino)methylenediphosphonic acid | B...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphotransferase (Trypanosoma cruzi) | BDBM50173768![]() ((biphenyl-3-yl-hydroxy-phosphono-methyl)-phosphoni...) | UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Venezolano de Investigaciones Cient£ficas Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi hexokinase | J Biol Chem 282: 12377-87 (2007) Article DOI: 10.1074/jbc.M607286200 BindingDB Entry DOI: 10.7270/Q2FT8MXH | |||||||||||
More data for this Ligand-Target Pair |
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