Compile Data Set for Download or QSAR

Found 162 hits with Last Name = 'strickland' and Initial = 'cl'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177232 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Farnesyltransferase quantified by modified SPA assay with improved sensitivity				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177232 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50109870 (4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo...) Show SMILES [O-][n+]1cccc(CNC(=NC#N)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)c1 |w:9.9| Show InChI InChI=1S/C27H25Br2ClN6O/c28-21-10-20-4-3-19-11-22(30)12-23(29)24(19)25(26(20)32-14-21)18-5-8-35(9-6-18)27(34-16-31)33-13-17-2-1-7-36(37)15-17/h1-2,7,10-12,14-15,18,25H,3-6,8-9,13H2,(H,33,34)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...				Bioorg Med Chem Lett 12: 601-5 (2002) BindingDB Entry DOI: 10.7270/Q2FF3RPB
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |r| Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Protein farnesyltransferase in Cos-1 monkey kidney cells expressing H-Ras-val				J Med Chem 45: 3854-64 (2002) BindingDB Entry DOI: 10.7270/Q2TD9WPB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |r| Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Farnesyl protein transferase				J Med Chem 42: 2125-35 (1999) Article DOI: 10.1021/jm990030g BindingDB Entry DOI: 10.7270/Q2ZS2VP9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177232 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM14457 ((+)-4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo...) Show SMILES [O-][n+]1ccc(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)cc1 |r| Show InChI InChI=1S/C26H24Br2ClN3O2/c27-20-12-19-2-1-18-13-21(29)14-22(28)24(18)25(26(19)30-15-20)17-5-7-31(8-6-17)23(33)11-16-3-9-32(34)10-4-16/h3-4,9-10,12-15,17,25H,1-2,5-8,11H2/t25-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Protein farnesyltransferase in Cos-1 monkey kidney cells expressing H-Ras-val				J Med Chem 45: 3854-64 (2002) BindingDB Entry DOI: 10.7270/Q2TD9WPB
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50117937 ((+)4-(2-{4-[9-bromo-4-chloro-1-methyl-(12R)-3,6,7,...) Show SMILES Cc1c[nH]c2c(Cl)cc3CCc4cc(Br)cnc4[C@H](C4CCN(CC4)C(=O)Cc4cc[n+]([O-])cc4)c3c12 Show InChI InChI=1S/C29H28BrClN4O2/c1-17-15-32-29-23(31)14-20-2-3-21-13-22(30)16-33-28(21)27(26(20)25(17)29)19-6-8-34(9-7-19)24(36)12-18-4-10-35(37)11-5-18/h4-5,10-11,13-16,19,27,32H,2-3,6-9,12H2,1H3/t27-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Protein farnesyltransferase in Cos-1 monkey kidney cells expressing H-Ras-val				J Med Chem 45: 3854-64 (2002) BindingDB Entry DOI: 10.7270/Q2TD9WPB
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50077853 (1-[4-(3,10-Dibromo-8-chloro-5,6-dihydro-benzo[5,6]...) Show SMILES [#8-]-[n+]1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ncc(Br)cc3-[#6]-[#6]-c3cc(Cl)cc(Br)c-23)cc1 Show InChI InChI=1S/C26H22Br2ClN3O2/c27-20-12-19-2-1-18-13-21(29)14-22(28)24(18)25(26(19)30-15-20)17-5-7-31(8-6-17)23(33)11-16-3-9-32(34)10-4-16/h3-4,9-10,12-15H,1-2,5-8,11H2	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Farnesyl protein transferase				J Med Chem 42: 2125-35 (1999) Article DOI: 10.1021/jm990030g BindingDB Entry DOI: 10.7270/Q2ZS2VP9
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177232 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177232 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177232 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177232 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM14471 ((-)-4-[2-[4-(3,7-Dibromo-8-chloro-6,11-dihydro-5H-...) Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ccc(Cl)c(Br)c3CCc3cc(Br)cnc23)CC1 |r| Show InChI InChI=1S/C27H31Br2ClN4O2/c28-19-14-18-1-2-21-20(3-4-22(30)25(21)29)24(26(18)32-15-19)17-7-11-33(12-8-17)23(35)13-16-5-9-34(10-6-16)27(31)36/h3-4,14-17,24H,1-2,5-13H2,(H2,31,36)/t24-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Farnesyltransferase				J Med Chem 42: 2125-35 (1999) Article DOI: 10.1021/jm990030g BindingDB Entry DOI: 10.7270/Q2ZS2VP9
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50177232 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Anchorage-independent growth of transformed NIH3T3 cells in soft agar				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50177232 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Anchorage-independent growth of transformed NIH3T3 cells in soft agar				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177263 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCc3cccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H36BrClN6O2/c33-24-15-23-9-8-22-16-25(34)10-11-27(22)30(29(23)36-19-24)39-13-14-40(32(42)38-26-6-2-1-3-7-26)28(20-39)31(41)37-18-21-5-4-12-35-17-21/h4-5,10-12,15-17,19,26,28,30H,1-3,6-9,13-14,18,20H2,(H,37,41)(H,38,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177231 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CCCCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C30H33BrClN5O2/c1-2-3-6-27(38)37-13-12-36(19-26(37)30(39)35-17-20-5-4-11-33-16-20)29-25-10-9-24(32)15-21(25)7-8-22-14-23(31)18-34-28(22)29/h4-5,9-11,14-16,18,26,29H,2-3,6-8,12-13,17,19H2,1H3,(H,35,39)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50117932 ((+/-)4-{2-[4-(9-bromo-4-chloro-1-methyl-3,6,7,12-t...) Show SMILES Cc1c[nH]c2c(Cl)cc3CCc4cc(Br)cnc4C(=C4CCN(CC4)C(=O)Cc4cc[n+]([O-])cc4)c3c12 |(13.66,-11.28,;13.26,-9.8,;14.73,-10.3,;15.66,-9.06,;14.77,-7.79,;15.1,-6.28,;16.57,-5.82,;13.96,-5.23,;12.49,-5.69,;11.53,-4.49,;9.99,-4.49,;9.04,-5.7,;7.57,-5.27,;6.45,-6.32,;4.98,-5.88,;6.81,-7.82,;8.27,-8.26,;9.39,-7.21,;10.76,-7.86,;10.76,-9.4,;12.09,-10.18,;12.09,-11.72,;10.76,-12.48,;9.45,-11.72,;9.45,-10.18,;10.76,-14.02,;9.43,-14.79,;12.11,-14.79,;12.11,-16.33,;10.76,-17.1,;10.76,-18.64,;12.09,-19.41,;12.09,-20.95,;13.44,-18.63,;13.42,-17.09,;12.16,-7.19,;13.28,-8.24,)| Show InChI InChI=1S/C29H26BrClN4O2/c1-17-15-32-29-23(31)14-20-2-3-21-13-22(30)16-33-28(21)27(26(20)25(17)29)19-6-8-34(9-7-19)24(36)12-18-4-10-35(37)11-5-18/h4-5,10-11,13-16,32H,2-3,6-9,12H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Protein farnesyltransferase in Cos-1 monkey kidney cells expressing H-Ras-val				J Med Chem 45: 3854-64 (2002) BindingDB Entry DOI: 10.7270/Q2TD9WPB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50109872 (4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohep...) Show SMILES [#8-]-[n+]1ccc(-[#6]-[#7]-[#6](=[#7]C#N)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cc(Br)cnc-23)cc1 |w:8.8| Show InChI InChI=1S/C27H24BrClN6O/c28-22-13-21-2-1-20-14-23(29)3-4-24(20)25(26(21)31-16-22)19-7-9-34(10-8-19)27(33-17-30)32-15-18-5-11-35(36)12-6-18/h3-6,11-14,16H,1-2,7-10,15H2,(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...				Bioorg Med Chem Lett 12: 601-5 (2002) BindingDB Entry DOI: 10.7270/Q2FF3RPB
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50109858 (4-({[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyc...) Show SMILES [#7]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6](-[#6]-[#7]-[#6](=[#7]C#N)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cc(Br)cnc-23)-[#6]-[#6]-1 |w:10.10| Show InChI InChI=1S/C28H31BrClN7O/c29-22-13-21-2-1-20-14-23(30)3-4-24(20)25(26(21)33-16-22)19-7-11-37(12-8-19)28(35-17-31)34-15-18-5-9-36(10-6-18)27(32)38/h3-4,13-14,16,18H,1-2,5-12,15H2,(H2,32,38)(H,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...				Bioorg Med Chem Lett 12: 601-5 (2002) BindingDB Entry DOI: 10.7270/Q2FF3RPB
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177258 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCc3cnc[nH]3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C31H37BrClN7O2/c32-22-14-21-7-6-20-15-23(33)8-9-26(20)29(28(21)36-16-22)39-12-13-40(31(42)38-24-4-2-1-3-5-24)27(18-39)30(41)35-11-10-25-17-34-19-37-25/h8-9,14-17,19,24,27,29H,1-7,10-13,18H2,(H,34,37)(H,35,41)(H,38,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177268 (5-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...) Show SMILES OC(=O)CCCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C30H31BrClN5O4/c31-22-13-21-7-6-20-14-23(32)8-9-24(20)29(28(21)34-17-22)36-11-12-37(26(38)4-1-5-27(39)40)25(18-36)30(41)35-16-19-3-2-10-33-15-19/h2-3,8-10,13-15,17,25,29H,1,4-7,11-12,16,18H2,(H,35,41)(H,39,40)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177265 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Cn1cncc1CCNC(=O)C1CN(CCN1C(=O)NC1CCCCC1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C32H39BrClN7O2/c1-39-20-35-18-26(39)11-12-36-31(42)28-19-40(13-14-41(28)32(43)38-25-5-3-2-4-6-25)30-27-10-9-24(34)16-21(27)7-8-22-15-23(33)17-37-29(22)30/h9-10,15-18,20,25,28,30H,2-8,11-14,19H2,1H3,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177239 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CC(C)CC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C30H33BrClN5O2/c1-19(2)12-27(38)37-11-10-36(18-26(37)30(39)35-16-20-4-3-9-33-15-20)29-25-8-7-24(32)14-21(25)5-6-22-13-23(31)17-34-28(22)29/h3-4,7-9,13-15,17,19,26,29H,5-6,10-12,16,18H2,1-2H3,(H,35,39)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50117931 ((-)4-(2-{4-[4-chloro-1-methyl-(12R)-3,6,7,12-tetra...) Show SMILES Cc1c[nH]c2c(Cl)cc3CCc4cccnc4[C@H](C4CCN(CC4)C(=O)Cc4cc[n+]([O-])cc4)c3c12 Show InChI InChI=1S/C29H29ClN4O2/c1-18-17-32-29-23(30)16-22-5-4-21-3-2-10-31-28(21)27(26(22)25(18)29)20-8-11-33(12-9-20)24(35)15-19-6-13-34(36)14-7-19/h2-3,6-7,10,13-14,16-17,20,27,32H,4-5,8-9,11-12,15H2,1H3/t27-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Protein farnesyltransferase in Cos-1 monkey kidney cells expressing H-Ras-val				J Med Chem 45: 3854-64 (2002) BindingDB Entry DOI: 10.7270/Q2TD9WPB
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50117931 ((-)4-(2-{4-[4-chloro-1-methyl-(12R)-3,6,7,12-tetra...) Show SMILES Cc1c[nH]c2c(Cl)cc3CCc4cccnc4[C@H](C4CCN(CC4)C(=O)Cc4cc[n+]([O-])cc4)c3c12 Show InChI InChI=1S/C29H29ClN4O2/c1-18-17-32-29-23(30)16-22-5-4-21-3-2-10-31-28(21)27(26(22)25(18)29)20-8-11-33(12-9-20)24(35)15-19-6-13-34(36)14-7-19/h2-3,6-7,10,13-14,16-17,20,27,32H,4-5,8-9,11-12,15H2,1H3/t27-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Protein farnesyltransferase in Cos-1 monkey kidney cells expressing H-Ras-val				J Med Chem 45: 3854-64 (2002) BindingDB Entry DOI: 10.7270/Q2TD9WPB
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177255 (6-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...) Show SMILES COC(=O)CCCCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C32H35BrClN5O4/c1-43-29(41)7-3-2-6-28(40)39-14-13-38(20-27(39)32(42)37-18-21-5-4-12-35-17-21)31-26-11-10-25(34)16-22(26)8-9-23-15-24(33)19-36-30(23)31/h4-5,10-12,15-17,19,27,31H,2-3,6-9,13-14,18,20H2,1H3,(H,37,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177257 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CCCCCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C31H35BrClN5O2/c1-2-3-4-7-28(39)38-14-13-37(20-27(38)31(40)36-18-21-6-5-12-34-17-21)30-26-11-10-25(33)16-22(26)8-9-23-15-24(32)19-35-29(23)30/h5-6,10-12,15-17,19,27,30H,2-4,7-9,13-14,18,20H2,1H3,(H,36,40)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177267 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CC(=O)CCCCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C32H35BrClN5O3/c1-21(40)5-2-3-7-29(41)39-14-13-38(20-28(39)32(42)37-18-22-6-4-12-35-17-22)31-27-11-10-26(34)16-23(27)8-9-24-15-25(33)19-36-30(24)31/h4,6,10-12,15-17,19,28,31H,2-3,5,7-9,13-14,18,20H2,1H3,(H,37,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177241 (4-(3-bromo-8-chloro-6,11-dihydro-5-benzo[5,6]cyclo...) Show SMILES CC(C)CNC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C30H34BrClN6O2/c1-19(2)14-36-30(40)38-11-10-37(18-26(38)29(39)35-16-20-4-3-9-33-15-20)28-25-8-7-24(32)13-21(25)5-6-22-12-23(31)17-34-27(22)28/h3-4,7-9,12-13,15,17,19,26,28H,5-6,10-11,14,16,18H2,1-2H3,(H,35,39)(H,36,40)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50109878 (1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...) Show SMILES [O-][n+]1cccc(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)c1 Show InChI InChI=1S/C26H24Br2ClN3O2/c27-20-11-19-4-3-18-12-21(29)13-22(28)24(18)25(26(19)30-14-20)17-5-8-31(9-6-17)23(33)10-16-2-1-7-32(34)15-16/h1-2,7,11-15,17,25H,3-6,8-10H2/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...				Bioorg Med Chem Lett 12: 601-5 (2002) BindingDB Entry DOI: 10.7270/Q2FF3RPB
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177250 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CC(=O)CCCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C31H33BrClN5O3/c1-20(39)4-2-6-28(40)38-13-12-37(19-27(38)31(41)36-17-21-5-3-11-34-16-21)30-26-10-9-25(33)15-22(26)7-8-23-14-24(32)18-35-29(23)30/h3,5,9-11,14-16,18,27,30H,2,4,6-8,12-13,17,19H2,1H3,(H,36,41)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177263 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCc3cccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H36BrClN6O2/c33-24-15-23-9-8-22-16-25(34)10-11-27(22)30(29(23)36-19-24)39-13-14-40(32(42)38-26-6-2-1-3-7-26)28(20-39)31(41)37-18-21-5-4-12-35-17-21/h4-5,10-12,15-17,19,26,28,30H,1-3,6-9,13-14,18,20H2,(H,37,41)(H,38,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177243 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCc3cccnc3)C(=O)NC3CCCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C33H38BrClN6O2/c34-25-16-24-10-9-23-17-26(35)11-12-28(23)31(30(24)37-20-25)40-14-15-41(33(43)39-27-7-3-1-2-4-8-27)29(21-40)32(42)38-19-22-6-5-13-36-18-22/h5-6,11-13,16-18,20,27,29,31H,1-4,7-10,14-15,19,21H2,(H,38,42)(H,39,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177235 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CCCCNC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C30H34BrClN6O2/c1-2-3-11-34-30(40)38-13-12-37(19-26(38)29(39)36-17-20-5-4-10-33-16-20)28-25-9-8-24(32)15-21(25)6-7-22-14-23(31)18-35-27(22)28/h4-5,8-10,14-16,18,26,28H,2-3,6-7,11-13,17,19H2,1H3,(H,34,40)(H,36,39)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177252 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCc3cnc[nH]3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-23-15-22-9-8-21-16-24(34)10-11-27(21)30(29(22)37-17-23)40-13-14-41(32(43)39-25-5-2-1-3-6-25)28(19-40)31(42)36-12-4-7-26-18-35-20-38-26/h10-11,15-18,20,25,28,30H,1-9,12-14,19H2,(H,35,38)(H,36,42)(H,39,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177234 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCc3cccnc3)C(=O)NCC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C33H38BrClN6O2/c34-26-15-25-9-8-24-16-27(35)10-11-28(24)31(30(25)37-20-26)40-13-14-41(33(43)39-18-22-5-2-1-3-6-22)29(21-40)32(42)38-19-23-7-4-12-36-17-23/h4,7,10-12,15-17,20,22,29,31H,1-3,5-6,8-9,13-14,18-19,21H2,(H,38,42)(H,39,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177266 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CN(C)C(=O)CCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C31H34BrClN6O3/c1-37(2)27(40)9-10-28(41)39-13-12-38(19-26(39)31(42)36-17-20-4-3-11-34-16-20)30-25-8-7-24(33)15-21(25)5-6-22-14-23(32)18-35-29(22)30/h3-4,7-8,11,14-16,18,26,30H,5-6,9-10,12-13,17,19H2,1-2H3,(H,36,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177229 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CC(=O)CCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C30H31BrClN5O3/c1-19(38)4-9-27(39)37-12-11-36(18-26(37)30(40)35-16-20-3-2-10-33-15-20)29-25-8-7-24(32)14-21(25)5-6-22-13-23(31)17-34-28(22)29/h2-3,7-8,10,13-15,17,26,29H,4-6,9,11-12,16,18H2,1H3,(H,35,40)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50063372 (1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...) Show SMILES [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@H]2c3ccc(Cl)cc3CCc3cc(Br)cnc23)cc1 Show InChI InChI=1S/C25H24BrClN4O2/c26-20-14-19-2-1-18-15-21(27)3-4-22(18)25(24(19)28-16-20)30-11-9-29(10-12-30)23(32)13-17-5-7-31(33)8-6-17/h3-8,14-16,25H,1-2,9-13H2/t25-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Farnesyl protein transferase				J Med Chem 42: 2125-35 (1999) Article DOI: 10.1021/jm990030g BindingDB Entry DOI: 10.7270/Q2ZS2VP9
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177262 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CCCCC(=O)N1CCN(CC1C(=O)NCCc1cnc[nH]1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C29H34BrClN6O2/c1-2-3-4-26(38)37-12-11-36(17-25(37)29(39)33-10-9-23-16-32-18-35-23)28-24-8-7-22(31)14-19(24)5-6-20-13-21(30)15-34-27(20)28/h7-8,13-16,18,25,28H,2-6,9-12,17H2,1H3,(H,32,35)(H,33,39)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177237 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CC(C)(C)CC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C31H35BrClN5O2/c1-31(2,3)15-27(39)38-12-11-37(19-26(38)30(40)36-17-20-5-4-10-34-16-20)29-25-9-8-24(33)14-21(25)6-7-22-13-23(32)18-35-28(22)29/h4-5,8-10,13-14,16,18,26,29H,6-7,11-12,15,17,19H2,1-3H3,(H,36,40)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177236 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCc3cccnc3)C(=O)C3CCCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C33H37BrClN5O2/c34-26-16-25-10-9-24-17-27(35)11-12-28(24)31(30(25)37-20-26)39-14-15-40(33(42)23-7-3-1-2-4-8-23)29(21-39)32(41)38-19-22-6-5-13-36-18-22/h5-6,11-13,16-18,20,23,29,31H,1-4,7-10,14-15,19,21H2,(H,38,41)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50109871 (4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohep...) Show SMILES [#8-]-[n+]1cccc(-[#6]-[#7]-[#6](=[#7]C#N)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2\c3ccc(Cl)cc3-[#6]-[#6]-c3cc(Br)cnc-23)c1 |w:9.9| Show InChI InChI=1S/C27H24BrClN6O/c28-22-12-21-4-3-20-13-23(29)5-6-24(20)25(26(21)31-15-22)19-7-10-34(11-8-19)27(33-17-30)32-14-18-2-1-9-35(36)16-18/h1-2,5-6,9,12-13,15-16H,3-4,7-8,10-11,14H2,(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...				Bioorg Med Chem Lett 12: 601-5 (2002) BindingDB Entry DOI: 10.7270/Q2FF3RPB
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177266 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES CN(C)C(=O)CCC(=O)N1CCN(CC1C(=O)NCc1cccnc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C31H34BrClN6O3/c1-37(2)27(40)9-10-28(41)39-13-12-38(19-26(39)31(42)36-17-20-4-3-11-34-16-20)30-25-8-7-24(33)15-21(25)5-6-22-14-23(32)18-35-29(22)30/h3-4,7-8,11,14-16,18,26,30H,5-6,9-10,12-13,17,19H2,1-2H3,(H,36,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50109868 (4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohep...) Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(Br)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](-[#7]-[#6]-c2ccncc2)=[#7]C#N)c1 |w:31.35| Show InChI InChI=1S/C27H24BrClN6/c28-22-13-21-2-1-20-14-23(29)3-4-24(20)25(26(21)32-16-22)19-7-11-35(12-8-19)27(34-17-30)33-15-18-5-9-31-10-6-18/h3-6,9-10,13-14,16H,1-2,7-8,11-12,15H2,(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...				Bioorg Med Chem Lett 12: 601-5 (2002) BindingDB Entry DOI: 10.7270/Q2FF3RPB
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177252 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCc3cnc[nH]3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H39BrClN7O2/c33-23-15-22-9-8-21-16-24(34)10-11-27(21)30(29(22)37-17-23)40-13-14-41(32(43)39-25-5-2-1-3-6-25)28(19-40)31(42)36-12-4-7-26-18-35-20-38-26/h10-11,15-18,20,25,28,30H,1-9,12-14,19H2,(H,35,38)(H,36,42)(H,39,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177265 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Cn1cncc1CCNC(=O)C1CN(CCN1C(=O)NC1CCCCC1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 Show InChI InChI=1S/C32H39BrClN7O2/c1-39-20-35-18-26(39)11-12-36-31(42)28-19-40(13-14-41(28)32(43)38-25-5-3-2-4-6-25)30-27-10-9-24(34)16-21(27)7-8-22-15-23(33)17-37-29(22)30/h9-10,15-18,20,25,28,30H,2-8,11-14,19H2,1H3,(H,36,42)(H,38,43)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177247 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCN3CCCC3=O)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C33H42BrClN6O3/c34-24-18-23-10-9-22-19-25(35)11-12-27(22)31(30(23)37-20-24)40-16-17-41(33(44)38-26-6-2-1-3-7-26)28(21-40)32(43)36-13-5-15-39-14-4-8-29(39)42/h11-12,18-20,26,28,31H,1-10,13-17,21H2,(H,36,43)(H,38,44)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair

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